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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26998

FusionGeneSummary for PHLDB1_ITGA9

check button Fusion gene summary
Fusion gene informationFusion gene name: PHLDB1_ITGA9
Fusion gene ID: 26998
HgeneTgene
Gene symbol

PHLDB1

ITGA9

Gene ID

23187

3680

Gene namepleckstrin homology like domain family B member 1integrin subunit alpha 9
SynonymsLL5AALPHA-RLC|ITGA4L|RLC
Cytomap

11q23.3

3p22.2

Type of geneprotein-codingprotein-coding
Descriptionpleckstrin homology-like domain family B member 1LL5alphapleckstrin homology-like domain family B member 1 variant 3pleckstrin homology-like domain family B member 1 variant 4protein LL5-alphaintegrin alpha-9integrin alpha-RLC
Modification date2018052020180519
UniProtAcc

Q86UU1

Q13797

Ensembl transtripts involved in fusion geneENST00000361417, ENST00000356063, 
ENST00000534672, ENST00000527898, 
ENST00000524713, 
ENST00000264741, 
ENST00000422441, 
Fusion gene scores* DoF score10 X 9 X 5=4506 X 6 X 4=144
# samples 106
** MAII scorelog2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHLDB1 [Title/Abstract] AND ITGA9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF748867PHLDB1chr11

118480181

-ITGA9chr3

37634981

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000361417ENST00000264741PHLDB1chr11

118480181

-ITGA9chr3

37634981

+
intron-intronENST00000361417ENST00000422441PHLDB1chr11

118480181

-ITGA9chr3

37634981

+
intron-intronENST00000356063ENST00000264741PHLDB1chr11

118480181

-ITGA9chr3

37634981

+
intron-intronENST00000356063ENST00000422441PHLDB1chr11

118480181

-ITGA9chr3

37634981

+
intron-intronENST00000534672ENST00000264741PHLDB1chr11

118480181

-ITGA9chr3

37634981

+
intron-intronENST00000534672ENST00000422441PHLDB1chr11

118480181

-ITGA9chr3

37634981

+
intron-intronENST00000527898ENST00000264741PHLDB1chr11

118480181

-ITGA9chr3

37634981

+
intron-intronENST00000527898ENST00000422441PHLDB1chr11

118480181

-ITGA9chr3

37634981

+
intron-intronENST00000524713ENST00000264741PHLDB1chr11

118480181

-ITGA9chr3

37634981

+
intron-intronENST00000524713ENST00000422441PHLDB1chr11

118480181

-ITGA9chr3

37634981

+

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FusionProtFeatures for PHLDB1_ITGA9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHLDB1

Q86UU1

ITGA9

Q13797

Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor forVCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PHLDB1_ITGA9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PHLDB1_ITGA9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PHLDB1_ITGA9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PHLDB1_ITGA9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePHLDB1C0017638Glioma1CTD_human
TgeneITGA9C0005586Bipolar Disorder1PSYGENET
TgeneITGA9C1839839MAJOR AFFECTIVE DISORDER 21PSYGENET