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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26989

FusionGeneSummary for PHKB_ZNF841

check button Fusion gene summary
Fusion gene informationFusion gene name: PHKB_ZNF841
Fusion gene ID: 26989
HgeneTgene
Gene symbol

PHKB

ZNF841

Gene ID

5257

284371

Gene namephosphorylase kinase regulatory subunit betazinc finger protein 841
Synonyms--
Cytomap

16q12.1

19q13.41

Type of geneprotein-codingprotein-coding
Descriptionphosphorylase b kinase regulatory subunit betaphosphorylase kinase beta-subunitphosphorylase kinase subunit betaphosphorylase kinase, betazinc finger protein 841
Modification date2018052320180403
UniProtAcc

Q93100

Q6ZN19

Ensembl transtripts involved in fusion geneENST00000566044, ENST00000455779, 
ENST00000299167, ENST00000323584, 
ENST00000567402, 
ENST00000594295, 
ENST00000426391, ENST00000389534, 
ENST00000359973, 
Fusion gene scores* DoF score4 X 4 X 3=482 X 2 X 2=8
# samples 42
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: PHKB [Title/Abstract] AND ZNF841 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG992384PHKBchr16

47734722

-ZNF841chr19

52785414

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000566044ENST00000594295PHKBchr16

47734722

-ZNF841chr19

52785414

-
intron-intronENST00000566044ENST00000426391PHKBchr16

47734722

-ZNF841chr19

52785414

-
intron-intronENST00000566044ENST00000389534PHKBchr16

47734722

-ZNF841chr19

52785414

-
intron-intronENST00000566044ENST00000359973PHKBchr16

47734722

-ZNF841chr19

52785414

-
3UTR-intronENST00000455779ENST00000594295PHKBchr16

47734722

-ZNF841chr19

52785414

-
3UTR-intronENST00000455779ENST00000426391PHKBchr16

47734722

-ZNF841chr19

52785414

-
3UTR-intronENST00000455779ENST00000389534PHKBchr16

47734722

-ZNF841chr19

52785414

-
3UTR-intronENST00000455779ENST00000359973PHKBchr16

47734722

-ZNF841chr19

52785414

-
3UTR-intronENST00000299167ENST00000594295PHKBchr16

47734722

-ZNF841chr19

52785414

-
3UTR-intronENST00000299167ENST00000426391PHKBchr16

47734722

-ZNF841chr19

52785414

-
3UTR-intronENST00000299167ENST00000389534PHKBchr16

47734722

-ZNF841chr19

52785414

-
3UTR-intronENST00000299167ENST00000359973PHKBchr16

47734722

-ZNF841chr19

52785414

-
intron-intronENST00000323584ENST00000594295PHKBchr16

47734722

-ZNF841chr19

52785414

-
intron-intronENST00000323584ENST00000426391PHKBchr16

47734722

-ZNF841chr19

52785414

-
intron-intronENST00000323584ENST00000389534PHKBchr16

47734722

-ZNF841chr19

52785414

-
intron-intronENST00000323584ENST00000359973PHKBchr16

47734722

-ZNF841chr19

52785414

-
intron-intronENST00000567402ENST00000594295PHKBchr16

47734722

-ZNF841chr19

52785414

-
intron-intronENST00000567402ENST00000426391PHKBchr16

47734722

-ZNF841chr19

52785414

-
intron-intronENST00000567402ENST00000389534PHKBchr16

47734722

-ZNF841chr19

52785414

-
intron-intronENST00000567402ENST00000359973PHKBchr16

47734722

-ZNF841chr19

52785414

-

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FusionProtFeatures for PHKB_ZNF841


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHKB

Q93100

ZNF841

Q6ZN19

Phosphorylase b kinase catalyzes the phosphorylation ofserine in certain substrates, including troponin I. The beta chainacts as a regulatory unit and modulates the activity of theholoenzyme in response to phosphorylation. May be involved in transcriptional regulation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PHKB_ZNF841


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PHKB_ZNF841


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PHKB_ZNF841


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PHKB_ZNF841


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePHKBC0543514Glycogen Storage Disease IXB1CTD_human;ORPHANET;UNIPROT