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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26987

FusionGeneSummary for PHKB_PDE3A

check button Fusion gene summary
Fusion gene informationFusion gene name: PHKB_PDE3A
Fusion gene ID: 26987
HgeneTgene
Gene symbol

PHKB

PDE3A

Gene ID

5257

5139

Gene namephosphorylase kinase regulatory subunit betaphosphodiesterase 3A
Synonyms-CGI-PDE|CGI-PDE A|CGI-PDE-A|HTNB
Cytomap

16q12.1

12p12.2

Type of geneprotein-codingprotein-coding
Descriptionphosphorylase b kinase regulatory subunit betaphosphorylase kinase beta-subunitphosphorylase kinase subunit betaphosphorylase kinase, betacGMP-inhibited 3',5'-cyclic phosphodiesterase AcAMP phosphodiesterase, myocardial cGMP-inhibitedcyclic GMP-inhibited phosphodiesterase Aphosphodiesterase 3A, cGMP-inhibited
Modification date2018052320180519
UniProtAcc

Q93100

Q14432

Ensembl transtripts involved in fusion geneENST00000566044, ENST00000455779, 
ENST00000299167, ENST00000323584, 
ENST00000567402, 
ENST00000359062, 
ENST00000544307, 
Fusion gene scores* DoF score4 X 4 X 3=483 X 2 X 2=12
# samples 43
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PHKB [Title/Abstract] AND PDE3A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDE3A

GO:0006198

cAMP catabolic process

17704206

TgenePDE3A

GO:0071321

cellular response to cGMP

17704206


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-MN-A4N5-01APHKBchr16

47703328

+PDE3Achr12

20799424

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000566044ENST00000359062PHKBchr16

47703328

+PDE3Achr12

20799424

+
5CDS-3UTRENST00000566044ENST00000544307PHKBchr16

47703328

+PDE3Achr12

20799424

+
Frame-shitENST00000455779ENST00000359062PHKBchr16

47703328

+PDE3Achr12

20799424

+
5CDS-3UTRENST00000455779ENST00000544307PHKBchr16

47703328

+PDE3Achr12

20799424

+
Frame-shitENST00000299167ENST00000359062PHKBchr16

47703328

+PDE3Achr12

20799424

+
5CDS-3UTRENST00000299167ENST00000544307PHKBchr16

47703328

+PDE3Achr12

20799424

+
Frame-shitENST00000323584ENST00000359062PHKBchr16

47703328

+PDE3Achr12

20799424

+
5CDS-3UTRENST00000323584ENST00000544307PHKBchr16

47703328

+PDE3Achr12

20799424

+
intron-3CDSENST00000567402ENST00000359062PHKBchr16

47703328

+PDE3Achr12

20799424

+
intron-3UTRENST00000567402ENST00000544307PHKBchr16

47703328

+PDE3Achr12

20799424

+

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FusionProtFeatures for PHKB_PDE3A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHKB

Q93100

PDE3A

Q14432

Phosphorylase b kinase catalyzes the phosphorylation ofserine in certain substrates, including troponin I. The beta chainacts as a regulatory unit and modulates the activity of theholoenzyme in response to phosphorylation. Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are keyregulators of many important physiological processes.{ECO:0000250|UniProtKB:Q9Z0X4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PHKB_PDE3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PHKB_PDE3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PHKBC20orf27, HNRNPC, UBE3A, RAVER1, BRAF, DCP2, AURKB, TP53, CAMK2B, CALM1, DOK4, MPPED1, CORO1B, CORO1C, NTRK1, MED23, HERC2, PHKG2, PTPRT, EYA2, VBP1, TULP3, LGALS3BPPDE3AYWHAQ, ATP6V1B2, CSDE1, GANAB, GMPPB, JUP, MMS19, DPYSL2, MSH2, RANBP6, TRMT1, UBE4B, AKT1, PRKACA, HSPA5, KIF11, FBXO7, CCDC88A, TUBA1C, WDR62, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PHKB_PDE3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePDE3AQ14432DB00235MilrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Asmall moleculeapproved
TgenePDE3AQ14432DB00261AnagrelidecGMP-inhibited 3',5'-cyclic phosphodiesterase Asmall moleculeapproved
TgenePDE3AQ14432DB00277TheophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Asmall moleculeapproved
TgenePDE3AQ14432DB01223AminophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Asmall moleculeapproved
TgenePDE3AQ14432DB01303OxtriphyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Asmall moleculeapproved
TgenePDE3AQ14432DB01427AmrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Asmall moleculeapproved
TgenePDE3AQ14432DB08811TofisopamcGMP-inhibited 3',5'-cyclic phosphodiesterase Asmall moleculeapproved
TgenePDE3AQ14432DB00922LevosimendancGMP-inhibited 3',5'-cyclic phosphodiesterase Asmall moleculeapproved|investigational
TgenePDE3AQ14432DB01166CilostazolcGMP-inhibited 3',5'-cyclic phosphodiesterase Asmall moleculeapproved|investigational
TgenePDE3AQ14432DB04880EnoximonecGMP-inhibited 3',5'-cyclic phosphodiesterase Asmall moleculeapproved|investigational
TgenePDE3AQ14432DB05266IbudilastcGMP-inhibited 3',5'-cyclic phosphodiesterase Asmall moleculeapproved|investigational

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RelatedDiseases for PHKB_PDE3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePHKBC0543514Glycogen Storage Disease IXB1CTD_human;ORPHANET;UNIPROT
TgenePDE3AC0027051Myocardial Infarction1CTD_human
TgenePDE3AC0040053Thrombosis1CTD_human
TgenePDE3AC1862170Brachydactyly with hypertension1CTD_human;ORPHANET;UNIPROT