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Fusion gene ID: 26951 |
FusionGeneSummary for PHF2_WNK2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PHF2_WNK2 | Fusion gene ID: 26951 | Hgene | Tgene | Gene symbol | PHF2 | WNK2 | Gene ID | 5253 | 65268 |
Gene name | PHD finger protein 2 | WNK lysine deficient protein kinase 2 | |
Synonyms | CENP-35|GRC5|JHDM1E|KDM7C | NY-CO-43|P/OKcl.13|PRKWNK2|SDCCAG43 | |
Cytomap | 9q22.31 | 9q22.31 | |
Type of gene | protein-coding | protein-coding | |
Description | lysine-specific demethylase PHF2centromere protein 35jumonji C domain-containing histone demethylase 1E | serine/threonine-protein kinase WNK2antigen NY-CO-43mitogen-activated protein kinase kinase kinaseprotein kinase lysine-deficient 2protein kinase with no lysine 2serologically defined colon cancer antigen 43 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O75151 | Q9Y3S1 | |
Ensembl transtripts involved in fusion gene | ENST00000359246, ENST00000375376, | ENST00000427277, ENST00000297954, ENST00000395475, ENST00000356055, ENST00000349097, ENST00000395477, ENST00000471076, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 7 X 7 X 7=343 |
# samples | 2 | 7 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(7/343*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PHF2 [Title/Abstract] AND WNK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PHF2 | GO:0006482 | protein demethylation | 21532585 |
Tgene | WNK2 | GO:0006468 | protein phosphorylation | 21733846 |
Tgene | WNK2 | GO:0046777 | protein autophosphorylation | 17667937 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ESCA | TCGA-R6-A8W5-01B | PHF2 | chr9 | 96339153 | + | WNK2 | chr9 | 96000515 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000359246 | ENST00000427277 | PHF2 | chr9 | 96339153 | + | WNK2 | chr9 | 96000515 | + |
Frame-shift | ENST00000359246 | ENST00000297954 | PHF2 | chr9 | 96339153 | + | WNK2 | chr9 | 96000515 | + |
Frame-shift | ENST00000359246 | ENST00000395475 | PHF2 | chr9 | 96339153 | + | WNK2 | chr9 | 96000515 | + |
5CDS-5UTR | ENST00000359246 | ENST00000356055 | PHF2 | chr9 | 96339153 | + | WNK2 | chr9 | 96000515 | + |
5CDS-5UTR | ENST00000359246 | ENST00000349097 | PHF2 | chr9 | 96339153 | + | WNK2 | chr9 | 96000515 | + |
5CDS-5UTR | ENST00000359246 | ENST00000395477 | PHF2 | chr9 | 96339153 | + | WNK2 | chr9 | 96000515 | + |
5CDS-intron | ENST00000359246 | ENST00000471076 | PHF2 | chr9 | 96339153 | + | WNK2 | chr9 | 96000515 | + |
Frame-shift | ENST00000375376 | ENST00000427277 | PHF2 | chr9 | 96339153 | + | WNK2 | chr9 | 96000515 | + |
Frame-shift | ENST00000375376 | ENST00000297954 | PHF2 | chr9 | 96339153 | + | WNK2 | chr9 | 96000515 | + |
Frame-shift | ENST00000375376 | ENST00000395475 | PHF2 | chr9 | 96339153 | + | WNK2 | chr9 | 96000515 | + |
5CDS-5UTR | ENST00000375376 | ENST00000356055 | PHF2 | chr9 | 96339153 | + | WNK2 | chr9 | 96000515 | + |
5CDS-5UTR | ENST00000375376 | ENST00000349097 | PHF2 | chr9 | 96339153 | + | WNK2 | chr9 | 96000515 | + |
5CDS-5UTR | ENST00000375376 | ENST00000395477 | PHF2 | chr9 | 96339153 | + | WNK2 | chr9 | 96000515 | + |
5CDS-intron | ENST00000375376 | ENST00000471076 | PHF2 | chr9 | 96339153 | + | WNK2 | chr9 | 96000515 | + |
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FusionProtFeatures for PHF2_WNK2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PHF2 | WNK2 |
Lysine demethylase that demethylates both histones andnon-histone proteins. Enzymatically inactive by itself, andbecomes active following phosphorylation by PKA: forms a complexwith ARID5B and mediates demethylation of methylated ARID5B.Demethylation of ARID5B leads to target the PHF2-ARID5B complex totarget promoters, where PHF2 mediates demethylation ofdimethylated 'Lys-9' of histone H3 (H3K9me2), followed bytranscription activation of target genes. The PHF2-ARID5B complexacts as a coactivator of HNF4A in liver. PHF2 is recruited totrimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promotersand promotes expression of rDNA. {ECO:0000269|PubMed:20129925,ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}. | Serine/threonine kinase which plays an important role inthe regulation of electrolyte homeostasis, cell signaling,survival, and proliferation. Acts as an activator and inhibitor ofsodium-coupled chloride cotransporters and potassium-coupledchloride cotransporters respectively. Activates SLC12A2, SCNN1A,SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulatesthe EGF-induced activation of the ERK/MAPK-pathway and thedownstream cell cycle progression. Affects MAPK3/MAPK1 activity bymodulating the activity of MAP2K1 and this modulation depends onphosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering withthe activity of PAK1 by controlling the balance of the activity ofupstream regulators of PAK1 activity, RHOA and RAC1, which displayreciprocal activity. {ECO:0000269|PubMed:17667937,ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PHF2_WNK2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PHF2_WNK2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PHF2 | HIST2H3C, HIST3H3, HIST1H2BG, USP37, CDC14B, FOXA1 | WNK2 | YWHAZ, WNK1, SGK1, ATXN1, KLHL3, KLHL2, DGCR14, TSC22D4, PSMC3, SPATA1, TRIM25 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PHF2_WNK2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PHF2_WNK2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |