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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26941

FusionGeneSummary for PHF21A_PHF21A

check button Fusion gene summary
Fusion gene informationFusion gene name: PHF21A_PHF21A
Fusion gene ID: 26941
HgeneTgene
Gene symbol

PHF21A

PHF21A

Gene ID

51317

51317

Gene namePHD finger protein 21APHD finger protein 21A
SynonymsBHC80|BM-006BHC80|BM-006
Cytomap

11p11.2

11p11.2

Type of geneprotein-codingprotein-coding
DescriptionPHD finger protein 21ABHC80aBRAF35-HDAC complex protein BHC80BRAF35/HDAC2 complex (80 kDa)PHD finger protein 21ABHC80aBRAF35-HDAC complex protein BHC80BRAF35/HDAC2 complex (80 kDa)
Modification date2018052320180523
UniProtAcc

Q96BD5

Q96BD5

Ensembl transtripts involved in fusion geneENST00000257821, ENST00000323180, 
ENST00000418153, ENST00000527753, 
ENST00000257821, ENST00000323180, 
ENST00000418153, ENST00000527753, 
Fusion gene scores* DoF score15 X 7 X 13=13657 X 7 X 4=196
# samples 199
** MAII scorelog2(19/1365*10)=-2.84482962747627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/196*10)=-1.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHF21A [Title/Abstract] AND PHF21A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA442046PHF21Achr11

45951570

-PHF21Achr11

45953262

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000257821ENST00000257821PHF21Achr11

45951570

-PHF21Achr11

45953262

-
intron-intronENST00000257821ENST00000323180PHF21Achr11

45951570

-PHF21Achr11

45953262

-
intron-intronENST00000257821ENST00000418153PHF21Achr11

45951570

-PHF21Achr11

45953262

-
intron-intronENST00000257821ENST00000527753PHF21Achr11

45951570

-PHF21Achr11

45953262

-
intron-3UTRENST00000323180ENST00000257821PHF21Achr11

45951570

-PHF21Achr11

45953262

-
intron-intronENST00000323180ENST00000323180PHF21Achr11

45951570

-PHF21Achr11

45953262

-
intron-intronENST00000323180ENST00000418153PHF21Achr11

45951570

-PHF21Achr11

45953262

-
intron-intronENST00000323180ENST00000527753PHF21Achr11

45951570

-PHF21Achr11

45953262

-
intron-3UTRENST00000418153ENST00000257821PHF21Achr11

45951570

-PHF21Achr11

45953262

-
intron-intronENST00000418153ENST00000323180PHF21Achr11

45951570

-PHF21Achr11

45953262

-
intron-intronENST00000418153ENST00000418153PHF21Achr11

45951570

-PHF21Achr11

45953262

-
intron-intronENST00000418153ENST00000527753PHF21Achr11

45951570

-PHF21Achr11

45953262

-
intron-3UTRENST00000527753ENST00000257821PHF21Achr11

45951570

-PHF21Achr11

45953262

-
intron-intronENST00000527753ENST00000323180PHF21Achr11

45951570

-PHF21Achr11

45953262

-
intron-intronENST00000527753ENST00000418153PHF21Achr11

45951570

-PHF21Achr11

45953262

-
intron-intronENST00000527753ENST00000527753PHF21Achr11

45951570

-PHF21Achr11

45953262

-

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FusionProtFeatures for PHF21A_PHF21A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHF21A

Q96BD5

PHF21A

Q96BD5

Component of the BHC complex, a corepressor complex thatrepresses transcription of neuron-specific genes in non-neuronalcells. The BHC complex is recruited at RE1/NRSE sites by REST andacts by deacetylating and demethylating specific sites onhistones, thereby acting as a chromatin modifier. In the BHCcomplex, it may act as a scaffold. Inhibits KDM1A-mediateddemethylation of 'Lys-4' of histone H3 in vitro, suggesting a rolein demethylation regulation. {ECO:0000269|PubMed:16140033}. Component of the BHC complex, a corepressor complex thatrepresses transcription of neuron-specific genes in non-neuronalcells. The BHC complex is recruited at RE1/NRSE sites by REST andacts by deacetylating and demethylating specific sites onhistones, thereby acting as a chromatin modifier. In the BHCcomplex, it may act as a scaffold. Inhibits KDM1A-mediateddemethylation of 'Lys-4' of histone H3 in vitro, suggesting a rolein demethylation regulation. {ECO:0000269|PubMed:16140033}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PHF21A_PHF21A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PHF21A_PHF21A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PHF21A_PHF21A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PHF21A_PHF21A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource