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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26934

FusionGeneSummary for PHF21A_CCDC178

check button Fusion gene summary
Fusion gene informationFusion gene name: PHF21A_CCDC178
Fusion gene ID: 26934
HgeneTgene
Gene symbol

PHF21A

CCDC178

Gene ID

51317

374864

Gene namePHD finger protein 21Acoiled-coil domain containing 178
SynonymsBHC80|BM-006C18orf34
Cytomap

11p11.2

18q12.1

Type of geneprotein-codingprotein-coding
DescriptionPHD finger protein 21ABHC80aBRAF35-HDAC complex protein BHC80BRAF35/HDAC2 complex (80 kDa)coiled-coil domain-containing protein 178
Modification date2018052320180329
UniProtAcc

Q96BD5

Q5BJE1

Ensembl transtripts involved in fusion geneENST00000257821, ENST00000323180, 
ENST00000418153, ENST00000527753, 
ENST00000581852, ENST00000403303, 
ENST00000383096, ENST00000300227, 
ENST00000579916, ENST00000406524, 
ENST00000583930, ENST00000402325, 
ENST00000579947, ENST00000583550, 
Fusion gene scores* DoF score15 X 7 X 13=13657 X 5 X 6=210
# samples 199
** MAII scorelog2(19/1365*10)=-2.84482962747627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHF21A [Title/Abstract] AND CCDC178 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0BG-01APHF21Achr11

46098305

-CCDC178chr18

30847261

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000257821ENST00000581852PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000257821ENST00000403303PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000257821ENST00000383096PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000257821ENST00000300227PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000257821ENST00000579916PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000257821ENST00000406524PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000257821ENST00000583930PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000257821ENST00000402325PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000257821ENST00000579947PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000257821ENST00000583550PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000323180ENST00000581852PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000323180ENST00000403303PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000323180ENST00000383096PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000323180ENST00000300227PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000323180ENST00000579916PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000323180ENST00000406524PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000323180ENST00000583930PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000323180ENST00000402325PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000323180ENST00000579947PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000323180ENST00000583550PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000418153ENST00000581852PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000418153ENST00000403303PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000418153ENST00000383096PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000418153ENST00000300227PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000418153ENST00000579916PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000418153ENST00000406524PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000418153ENST00000583930PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000418153ENST00000402325PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000418153ENST00000579947PHF21Achr11

46098305

-CCDC178chr18

30847261

-
5CDS-intronENST00000418153ENST00000583550PHF21Achr11

46098305

-CCDC178chr18

30847261

-
intron-intronENST00000527753ENST00000581852PHF21Achr11

46098305

-CCDC178chr18

30847261

-
intron-intronENST00000527753ENST00000403303PHF21Achr11

46098305

-CCDC178chr18

30847261

-
intron-intronENST00000527753ENST00000383096PHF21Achr11

46098305

-CCDC178chr18

30847261

-
intron-intronENST00000527753ENST00000300227PHF21Achr11

46098305

-CCDC178chr18

30847261

-
intron-intronENST00000527753ENST00000579916PHF21Achr11

46098305

-CCDC178chr18

30847261

-
intron-intronENST00000527753ENST00000406524PHF21Achr11

46098305

-CCDC178chr18

30847261

-
intron-intronENST00000527753ENST00000583930PHF21Achr11

46098305

-CCDC178chr18

30847261

-
intron-intronENST00000527753ENST00000402325PHF21Achr11

46098305

-CCDC178chr18

30847261

-
intron-intronENST00000527753ENST00000579947PHF21Achr11

46098305

-CCDC178chr18

30847261

-
intron-intronENST00000527753ENST00000583550PHF21Achr11

46098305

-CCDC178chr18

30847261

-

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FusionProtFeatures for PHF21A_CCDC178


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHF21A

Q96BD5

CCDC178

Q5BJE1

Component of the BHC complex, a corepressor complex thatrepresses transcription of neuron-specific genes in non-neuronalcells. The BHC complex is recruited at RE1/NRSE sites by REST andacts by deacetylating and demethylating specific sites onhistones, thereby acting as a chromatin modifier. In the BHCcomplex, it may act as a scaffold. Inhibits KDM1A-mediateddemethylation of 'Lys-4' of histone H3 in vitro, suggesting a rolein demethylation regulation. {ECO:0000269|PubMed:16140033}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PHF21A_CCDC178


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PHF21A_CCDC178


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PHF21ALPXN, HDAC1, KDM1A, HMG20B, RCOR1, HDAC2, GTF2I, TAF10, ESCO2, HIST2H3C, ELAVL1, HIST3H3, FHL3, TRAF1, ZYX, NUP62, BANP, KRT40, SCLT1, CD14, KIF22, LLGL2, SOD1, MYH13, NUPL1, HMG20A, NAF1, IP6K3, RBPJ, EXOC1, MAX, ARNTL, RPRD1A, HAUS6, PHLDB3, PTRF, OIP5, CCDC93, CCDC132, DZIP3, GRIPAP1, VPS53, PSMD9, CLOCK, RABGAP1L, GOLGA5, TUFT1, YEATS4, CCHCR1, TFPT, NCKAP5L, PKN3, GIT2, RABGEF1, NUF2, THAP11, VPS51, JUN, TSSC1CCDC178


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PHF21A_CCDC178


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PHF21A_CCDC178


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource