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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26928

FusionGeneSummary for PHF20_ZFAS1

check button Fusion gene summary
Fusion gene informationFusion gene name: PHF20_ZFAS1
Fusion gene ID: 26928
HgeneTgene
Gene symbol

PHF20

ZFAS1

Gene ID

51230

441951

Gene namePHD finger protein 20ZNFX1 antisense RNA 1
SynonymsC20orf104|GLEA2|HCA58|NZF|TDRD20A|TZPC20orf199|HSUP1|HSUP2|NCRNA00275|ZNFX1-AS1
Cytomap

20q11.22-q11.23

20q13.13

Type of geneprotein-codingncRNA
DescriptionPHD finger protein 20glioma-expressed antigen 2hepatocellular carcinoma-associated antigen 58novel zinc finger proteintranscription factor TZPtudor domain containing 20AZNFX1 antisense RNA 1 (non-protein coding)ZNFX1 antisense gene protein 1
Modification date2018052320180519
UniProtAcc

Q9BVI0

Ensembl transtripts involved in fusion geneENST00000374012, ENST00000439301, 
ENST00000481202, 
ENST00000371743, 
ENST00000450535, ENST00000441722, 
ENST00000417721, ENST00000458653, 
ENST00000326677, ENST00000428008, 
Fusion gene scores* DoF score11 X 9 X 9=8914 X 4 X 3=48
# samples 134
** MAII scorelog2(13/891*10)=-2.77691380849347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PHF20 [Title/Abstract] AND ZFAS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePHF20

GO:0043981

histone H4-K5 acetylation

20018852

HgenePHF20

GO:0043982

histone H4-K8 acetylation

20018852

HgenePHF20

GO:0043984

histone H4-K16 acetylation

20018852


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-55-8206-01APHF20chr20

34389527

+ZFAS1chr20

47905582

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000374012ENST00000371743PHF20chr20

34389527

+ZFAS1chr20

47905582

+
5CDS-3UTRENST00000374012ENST00000450535PHF20chr20

34389527

+ZFAS1chr20

47905582

+
5CDS-3UTRENST00000374012ENST00000441722PHF20chr20

34389527

+ZFAS1chr20

47905582

+
5CDS-3UTRENST00000374012ENST00000417721PHF20chr20

34389527

+ZFAS1chr20

47905582

+
5CDS-3UTRENST00000374012ENST00000458653PHF20chr20

34389527

+ZFAS1chr20

47905582

+
5CDS-3UTRENST00000374012ENST00000326677PHF20chr20

34389527

+ZFAS1chr20

47905582

+
5CDS-3UTRENST00000374012ENST00000428008PHF20chr20

34389527

+ZFAS1chr20

47905582

+
5CDS-3UTRENST00000439301ENST00000371743PHF20chr20

34389527

+ZFAS1chr20

47905582

+
5CDS-3UTRENST00000439301ENST00000450535PHF20chr20

34389527

+ZFAS1chr20

47905582

+
5CDS-3UTRENST00000439301ENST00000441722PHF20chr20

34389527

+ZFAS1chr20

47905582

+
5CDS-3UTRENST00000439301ENST00000417721PHF20chr20

34389527

+ZFAS1chr20

47905582

+
5CDS-3UTRENST00000439301ENST00000458653PHF20chr20

34389527

+ZFAS1chr20

47905582

+
5CDS-3UTRENST00000439301ENST00000326677PHF20chr20

34389527

+ZFAS1chr20

47905582

+
5CDS-3UTRENST00000439301ENST00000428008PHF20chr20

34389527

+ZFAS1chr20

47905582

+
3UTR-3UTRENST00000481202ENST00000371743PHF20chr20

34389527

+ZFAS1chr20

47905582

+
3UTR-3UTRENST00000481202ENST00000450535PHF20chr20

34389527

+ZFAS1chr20

47905582

+
3UTR-3UTRENST00000481202ENST00000441722PHF20chr20

34389527

+ZFAS1chr20

47905582

+
3UTR-3UTRENST00000481202ENST00000417721PHF20chr20

34389527

+ZFAS1chr20

47905582

+
3UTR-3UTRENST00000481202ENST00000458653PHF20chr20

34389527

+ZFAS1chr20

47905582

+
3UTR-3UTRENST00000481202ENST00000326677PHF20chr20

34389527

+ZFAS1chr20

47905582

+
3UTR-3UTRENST00000481202ENST00000428008PHF20chr20

34389527

+ZFAS1chr20

47905582

+

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FusionProtFeatures for PHF20_ZFAS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHF20

Q9BVI0

ZFAS1

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PHF20_ZFAS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PHF20_ZFAS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PHF20KAT8, HIST1H3A, HIST1H4A, DDX42, PATL1, TP53, MOV10, NXF1, POLE3, TFG, KANSL1, KANSL3, KANSL2, MCRS1, PTPN14, TRIM25ZFAS1TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PHF20_ZFAS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PHF20_ZFAS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource