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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26869

FusionGeneSummary for PHB2_BTN3A2

check button Fusion gene summary
Fusion gene informationFusion gene name: PHB2_BTN3A2
Fusion gene ID: 26869
HgeneTgene
Gene symbol

PHB2

BTN3A2

Gene ID

11331

11118

Gene nameprohibitin 2butyrophilin subfamily 3 member A2
SynonymsBAP|BCAP37|Bap37|PNAS-141|REA|hBAP|p22BT3.2|BTF4|BTN3.2|CD277
Cytomap

12p13.31

6p22.2

Type of geneprotein-codingprotein-coding
Descriptionprohibitin-2B-cell associated proteinB-cell receptor-associated protein BAP37D-prohibitinrepressor of estrogen receptor activitybutyrophilin subfamily 3 member A2butyrophilin protein
Modification date2018051920180523
UniProtAcc

Q99623

P78410

Ensembl transtripts involved in fusion geneENST00000546111, ENST00000535923, 
ENST00000542912, ENST00000440277, 
ENST00000399433, ENST00000544134, 
ENST00000527422, ENST00000356386, 
ENST00000396934, ENST00000377708, 
ENST00000396948, ENST00000532994, 
ENST00000508906, 
Fusion gene scores* DoF score7 X 7 X 2=981 X 1 X 1=1
# samples 71
** MAII scorelog2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: PHB2 [Title/Abstract] AND BTN3A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePHB2

GO:0000060

protein import into nucleus, translocation

17008324|19116139

HgenePHB2

GO:0007062

sister chromatid cohesion

23548868

HgenePHB2

GO:0030449

regulation of complement activation

17070910

HgenePHB2

GO:0045892

negative regulation of transcription, DNA-templated

10359819

HgenePHB2

GO:0051091

positive regulation of DNA binding transcription factor activity

18629613


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA995792PHB2chr12

7074772

+BTN3A2chr6

26368495

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000546111ENST00000527422PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000546111ENST00000356386PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000546111ENST00000396934PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000546111ENST00000377708PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000546111ENST00000396948PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000546111ENST00000532994PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000546111ENST00000508906PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000535923ENST00000527422PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000535923ENST00000356386PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000535923ENST00000396934PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000535923ENST00000377708PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000535923ENST00000396948PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000535923ENST00000532994PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000535923ENST00000508906PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000542912ENST00000527422PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000542912ENST00000356386PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000542912ENST00000396934PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000542912ENST00000377708PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000542912ENST00000396948PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000542912ENST00000532994PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000542912ENST00000508906PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000440277ENST00000527422PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000440277ENST00000356386PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000440277ENST00000396934PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000440277ENST00000377708PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000440277ENST00000396948PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000440277ENST00000532994PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000440277ENST00000508906PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000399433ENST00000527422PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000399433ENST00000356386PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000399433ENST00000396934PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000399433ENST00000377708PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000399433ENST00000396948PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000399433ENST00000532994PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000399433ENST00000508906PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000544134ENST00000527422PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000544134ENST00000356386PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000544134ENST00000396934PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000544134ENST00000377708PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000544134ENST00000396948PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000544134ENST00000532994PHB2chr12

7074772

+BTN3A2chr6

26368495

-
intron-intronENST00000544134ENST00000508906PHB2chr12

7074772

+BTN3A2chr6

26368495

-

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FusionProtFeatures for PHB2_BTN3A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHB2

Q99623

BTN3A2

P78410

Acts as a mediator of transcriptional repression bynuclear hormone receptors via recruitment of histone deacetylases(By similarity). Functions as an estrogen receptor (ER)-selectivecoregulator that potentiates the inhibitory activities ofantiestrogens and represses the activity of estrogens. Competeswith NCOA1 for modulation of ER transcriptional activity. Probablyinvolved in regulating mitochondrial respiration activity and inaging. {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:10359819,ECO:0000303|PubMed:11302691}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PHB2_BTN3A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PHB2_BTN3A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PHB2CTNNB1, TFE3, SIRT2, CDC25B, SERINC3, JUP, NUP205, USP15, MMS19, PDXDC1, RIPK2, DDX20, NUP93, NELFCD, RUNX3, TIMM50, EPPK1, COPG1, LGALS3BP, ESR1, PTMA, ATG2A, HDAC1, HDAC2, HDAC3, HDAC5, NR2F1, NR2F2, EZH2, PHB, RNF185, ICT1, AGO3, CDK2, RNF2, KIAA1244, ILF3, UQCRC1, TUFM, AKT1, MYOD1, MEF2A, FHL2, BRCA1, ECT2, MDC1, PAXIP1, FMNL1, EPAS1, FN1, VCAM1, C1QBP, ATF2, UBL4A, ITGA4, ADRB2, TEAD3, AFP, UPF2, ASB14, ASB17, STAU1, NCOR1, IGF1R, HUWE1, PPARG, SUZ12, EED, BLK, RIC3, XIAP, NMRAL1, HNRNPA1, UNK, NTRK1, ATP6V1C1, CCDC47, COX4I1, GOSR1, LGALS1, MRPL17, NDUFB8, AFG3L2, ATAD3A, ATAD3B, ATL3, ATP5L, CLTC, CYB5B, CYC1, HNRNPA3, IDH1, LDHB, LMAN1, MRPL2, MRPL40, MTCH2, NDUFA2, NDUFB7, NDUFS8, NDUFV1, PSMC3, RAB11B, STOML2, TOMM40, TUBB, TUBB4B, VAPA, VDAC1, VDAC2, VDAC3, PTBP1, SSR1, FAP, ANKRA2, RFXANK, MED20, PTPN1, RAB2A, RAB5C, TMPO, XRCC3, RAB7A, AKAP1, RAB11A, EMC2, MTX2, FGFR1OP2, GOLT1B, TMEM63B, YIPF5, MMGT1, TRIM29, MCM2, MCM5, GLI1, ESRRB, U2AF2, KPNA1, KPNA2, KPNA5, KPNA6, ARMC7, ZNF746, TPTE, STOM, ALDH2, TUBA1A, CYLD, LMNA, YAP1, MTF1, BRD1BTN3A2BTN3A3, BTN3A1, ATP5G1, PEX13, TMEM245, CCDC68


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PHB2_BTN3A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePHB2Q99623DB06774CapsaicinProhibitin-2small moleculeapproved

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RelatedDiseases for PHB2_BTN3A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource