	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 26849

FusionGeneSummary for PGS1_SYNGR2

Fusion gene summary

Fusion gene information	Fusion gene name: PGS1_SYNGR2
	Fusion gene ID: 26849
		Hgene	Tgene
	Gene symbol	PGS1	SYNGR2
	Gene ID	9489	9144
	Gene name	phosphatidylglycerophosphate synthase 1	synaptogyrin 2
	Synonyms	-	-
	Cytomap	17q25.3	17q25.3
	Type of gene	protein-coding	protein-coding
	Description	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrialPGP synthase 1	synaptogyrin-2cellugyrin
	Modification date	20180519	20180523
	UniProtAcc	Q32NB8	O43760
	Ensembl transtripts involved in fusion gene	ENST00000262764, ENST00000329897, ENST00000588281,	ENST00000225777, ENST00000585591, ENST00000589711, ENST00000588282, ENST00000590201, ENST00000592456,
Fusion gene scores	* DoF score	9 X 7 X 6=378	1 X 1 X 1=1
	# samples	9	1
	** MAII score	log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: PGS1 [Title/Abstract] AND SYNGR2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	OV	TCGA-24-1427-01A	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000262764	ENST00000225777	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
Frame-shift	ENST00000262764	ENST00000585591	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
5CDS-3UTR	ENST00000262764	ENST00000589711	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
5CDS-3UTR	ENST00000262764	ENST00000588282	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
5CDS-3UTR	ENST00000262764	ENST00000590201	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
5CDS-3UTR	ENST00000262764	ENST00000592456	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
5UTR-3CDS	ENST00000329897	ENST00000225777	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
5UTR-3CDS	ENST00000329897	ENST00000585591	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
5UTR-3UTR	ENST00000329897	ENST00000589711	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
5UTR-3UTR	ENST00000329897	ENST00000588282	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
5UTR-3UTR	ENST00000329897	ENST00000590201	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
5UTR-3UTR	ENST00000329897	ENST00000592456	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
intron-3CDS	ENST00000588281	ENST00000225777	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
intron-3CDS	ENST00000588281	ENST00000585591	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
intron-3UTR	ENST00000588281	ENST00000589711	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
intron-3UTR	ENST00000588281	ENST00000588282	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
intron-3UTR	ENST00000588281	ENST00000590201	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+
intron-3UTR	ENST00000588281	ENST00000592456	PGS1	chr17	76374889	+	SYNGR2	chr17	76167820	+

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FusionProtFeatures for PGS1_SYNGR2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PGS1 Q32NB8	SYNGR2 O43760
Functions in the biosynthesis of the anionicphospholipids phosphatidylglycerol and cardiolipin. {ECO:0000250}.	May play a role in regulated exocytosis. In neuronalcells, modulates the localization of synaptophysin/SYP intosynaptic-like microvesicles and may therefore play a role in theformation and/or the maturation of this vesicles. May also play arole in GLUT4 storage and transport to the plasma membrane.{ECO:0000250\|UniProtKB:O54980}. (Microbial infection) May play a role in the assembly ofcytoplasmic inclusion bodies required for SFTS phlebovirusreplication. {ECO:0000269\|PubMed:27226560}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PGS1

chr17:76374889

chr17:76167820

ENST00000262764

215_241

665

Domain

PLD phosphodiesterase 1

Hgene

PGS1

chr17:76374889

chr17:76167820

ENST00000262764

460_493

665

Domain

PLD phosphodiesterase 2

Hgene

PGS1

chr17:76374889

chr17:76167820

ENST00000262764

124_131

665

Nucleotide binding

ATP

Tgene

SYNGR2

chr17:76374889

chr17:76167820

ENST00000225777

20_171

159

225

Domain

MARVEL

Tgene

SYNGR2

chr17:76374889

chr17:76167820

ENST00000585591

20_171

159

266

Domain

MARVEL

Tgene

SYNGR2

chr17:76374889

chr17:76167820

ENST00000225777

105_125

159

225

Transmembrane

Helical

Tgene

SYNGR2

chr17:76374889

chr17:76167820

ENST00000225777

147_167

159

225

Transmembrane

Helical

Tgene

SYNGR2

chr17:76374889

chr17:76167820

ENST00000225777

26_46

159

225

Transmembrane

Helical

Tgene

SYNGR2

chr17:76374889

chr17:76167820

ENST00000225777

73_93

159

225

Transmembrane

Helical

Tgene

SYNGR2

chr17:76374889

chr17:76167820

ENST00000585591

105_125

159

266

Transmembrane

Helical

Tgene

SYNGR2

chr17:76374889

chr17:76167820

ENST00000585591

147_167

159

266

Transmembrane

Helical

Tgene

SYNGR2

chr17:76374889

chr17:76167820

ENST00000585591

26_46

159

266

Transmembrane

Helical

Tgene

SYNGR2

chr17:76374889

chr17:76167820

ENST00000585591

73_93

159

266

Transmembrane

Helical

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FusionGeneSequence for PGS1_SYNGR2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

>In-frame_PGS1_ENST00000262764_chr17_76374889_+_SYNGR2_ENST00000225777_chr17_76167820_+_113aa
MAVAAAAAAGPVFWRRLLGLLPGRPGLAALLGRLSDRLGRNRDRQRRRVCWPPWPTSATRLAWTTSSRITLTPLRTPTLPTPPTQVHLWT

* Fusion transcript sequences (only coding sequence (CDS) region).

>In-frame_PGS1_ENST00000262764_chr17_76374889_+_SYNGR2_ENST00000225777_chr17_76167820_+_341nt
ATGGCGGTGGCGGCGGCAGCTGCGGCGGGACCCGTGTTCTGGAGGCGACTGCTGGGCCTCCTGCCTGGCCGCCCAGGGCTGGCCGCGCTC
CTGGGACGCCTGTCCGACCGCCTCGGCAGGAACCGGGACCGCCAGCGCAGGAGGGTGTGCTGGCCTCCCTGGCCTACCAGCGCTACAAGG
CTGGCGTGGACGACTTCATCCAGAATTACGTTGACCCCACTCCGGACCCCAACACTGCCTACGCCTCCTACCCAGGTGCATCTGTGGACA

* Fusion transcript sequences (Full-length transcript).

>In-frame_PGS1_ENST00000262764_chr17_76374889_+_SYNGR2_ENST00000225777_chr17_76167820_+_1958nt
AGCGGAAGCGGAAGCGGCGAGTCTCCATGGCGGTGGCGGCGGCAGCTGCGGCGGGACCCGTGTTCTGGAGGCGACTGCTGGGCCTCCTGC
CTGGCCGCCCAGGGCTGGCCGCGCTCCTGGGACGCCTGTCCGACCGCCTCGGCAGGAACCGGGACCGCCAGCGCAGGAGGGTGTGCTGGC
CTCCCTGGCCTACCAGCGCTACAAGGCTGGCGTGGACGACTTCATCCAGAATTACGTTGACCCCACTCCGGACCCCAACACTGCCTACGC
CTCCTACCCAGGTGCATCTGTGGACAACTACCAACAGCCACCCTTCACCCAGAACGCGGAGACCACCGAGGGCTACCAGCCGCCCCCTGT
GTACTGAGCGGCGGTTAGCGTGGGAAGGGGGACAGAGAGGGCCCTCCCCTCTGCCCTGGACTTTCCCATGAGCCTCCTGGAACTGCCAGC
CCCTCTCTTTCACCTGTTCCATCCTGTGCAGCTGACACACAGCTAAGGAGCCTCATAGCCTGGCGGGGGCTGGCAGAGCCACACCCCAAG
TGCCTGTGCCCAGAGGGCTTCAGTCAGCCGCTCACTCCTCCAGGGCACTTTTAGGAAAGGGTTTTTAGCTAGTGTTTTTCCTCGCTTTTA
ATGACCTCAGCCCCGCCTGCAGTGGCTAGAAGCCAGCAGGTGCCCATGTGCTACTGACAAGTGCCTCAGCTTCCCCCCGGCCCGGGTCAG
GCCGTGGGAGCCGCTATTATCTGCGTTCTCTGCCAAAGACTCGTGGGGGCCATCACACCTGCCCTGTGCAGCGGAGCCGGACCAGGCTCT
TGTGTCCTCACTCAGGTTTGCTTCCCCTGTGCCCACTGCTGTATGATCTGGGGGCCACCACCCTGTGCCGGTGGCCTCTGGGCTGCCTCC
CGTGGTGTGAGGGCGGGGCTGGTGCTCATGGCACTTCCTCCTTGCTCCCACCCCTGGCAGCAGGGAAGGGCTTTGCCTGACAACACCCAG
CTTTATGTAAATATTCTGCAGTTGTTACTTAGGAAGCCTGGGGAGGGCAGGGGTGCCCCATGGCTCCCAGACTCTGTCTGTGCCGAGTGT
ATTATAAAATCGTGGGGGAGATGCCCGGCCTGGGATGCTGTTTGGAGACGGAATAAATGTTTTCTCATTCAGTCTCCAGTCATTGGTTGA
GCCACAGCCTAGGGGTTGGAGGAAGACTCCACTCTGGGTACACCCTTAGGGGCTGGCTTTATGGAACTTGTAGTTTGAACAAGGCAGTGG
CAATCCGCCCCCTCCAGCCTGCCTGGCTGGCCCCCTTCCCTCTGTCTGGGGTCGCATTCCGCACAAGCCTTTCATCAACATCTTAAAATA
GTAACTGTGCTCAGCTTGTAAACAAGATGATTTTTCTGGCCTGCAGTGCCAGGGTCCTGCTGCTCCCTTCCTAGAGTGGGGGTGGGGGTA
CCTGGGAGTTGTCGGTGAATGCCCCTTTCTTGCACTGAATAGGGGTACCATAGGTAAGACCAGGTTTCTACCTTCCTCCAGGGTCAGCAC
CTCTGGAGCCTTCCTGGGACACGGCCTTGGCCGTCCAGCCCACCCCTCGGAGATAAGGCCCATCTCTGGAAGAGGTCAAGGCCCTAAAGC
AACTTCTGGCTTCTTCTTTTGAGCAATGACAGAGGGAGCTGTCATCGGCAAGTCCCGATTGTTTAAAAATCCCCAGTACGAACTAACAGG
GCACTGCTCCCAGCCTCACCCGATGGCTTTGGCTTGGGACACATCACTAGCGAAGGGGAGAGGGAGGCTGGGGAGGCCCTGGGAGTGGTG
ACCCTGCCTGCACAGGACACACCTTACCCCAGCGATGCTTGCCCCCAAGTGAGCTGCCAACAGCCCATCTCTGAGGCACAGCTGAGAGAT

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FusionGenePPI for PGS1_SYNGR2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
PGS1		SYNGR2	ATP4A, SCARA3, SYNE4, GPR52, EDNRA, FATE1, VIPR2, PCDHAC2, SLC22A9, SLC34A2, CD97, SLCO1B1, TACR1, FPR2, SLC7A1, OPRM1, ZFYVE27, GPR114, SLC22A16, VIPR1, HTR2C, SYPL2

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for PGS1_SYNGR2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for PGS1_SYNGR2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 26849

FusionGeneSummary for PGS1_SYNGR2

FusionProtFeatures for PGS1_SYNGR2

FusionGeneSequence for PGS1_SYNGR2

FusionGenePPI for PGS1_SYNGR2

RelatedDrugs for PGS1_SYNGR2

RelatedDiseases for PGS1_SYNGR2