FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 26835

FusionGeneSummary for PGPEP1_FKBP8

check button Fusion gene summary
Fusion gene informationFusion gene name: PGPEP1_FKBP8
Fusion gene ID: 26835
HgeneTgene
Gene symbol

PGPEP1

FKBP8

Gene ID

54858

23770

Gene namepyroglutamyl-peptidase IFK506 binding protein 8
SynonymsPAP-I|PGI|PGP|PGP-I|PGPI|PcpFKBP38|FKBPr38
Cytomap

19p13.11

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionpyroglutamyl-peptidase 15-oxoprolyl-peptidasepGlu-peptidase Ipyroglutamyl aminopeptidase Ipyrrolidone-carboxylate peptidasepeptidyl-prolyl cis-trans isomerase FKBP838 kDa FK506-binding protein38 kDa FKBPFK506 binding protein 8, 38kDaFKBP-38FKBP-8PPIase FKBP8hFKBP38rotamase
Modification date2018052320180522
UniProtAcc

Q9NXJ5

Q14318

Ensembl transtripts involved in fusion geneENST00000269919, ENST00000604499, 
ENST00000595066, ENST00000252813, 
ENST00000597431, 
ENST00000597960, 
ENST00000610101, ENST00000596558, 
ENST00000222308, ENST00000608443, 
ENST00000453489, 
Fusion gene scores* DoF score4 X 4 X 4=6411 X 11 X 5=605
# samples 513
** MAII scorelog2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/605*10)=-2.2184235191335
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PGPEP1 [Title/Abstract] AND FKBP8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK026952PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
ChiTaRS3.1AK222838PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000269919ENST00000597960PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
3UTR-3CDSENST00000269919ENST00000610101PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
3UTR-3CDSENST00000269919ENST00000596558PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
3UTR-3CDSENST00000269919ENST00000222308PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
3UTR-3CDSENST00000269919ENST00000608443PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
3UTR-3CDSENST00000269919ENST00000453489PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000604499ENST00000597960PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000604499ENST00000610101PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000604499ENST00000596558PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000604499ENST00000222308PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000604499ENST00000608443PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000604499ENST00000453489PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000595066ENST00000597960PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000595066ENST00000610101PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000595066ENST00000596558PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000595066ENST00000222308PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000595066ENST00000608443PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000595066ENST00000453489PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
3UTR-3CDSENST00000252813ENST00000597960PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
3UTR-3CDSENST00000252813ENST00000610101PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
3UTR-3CDSENST00000252813ENST00000596558PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
3UTR-3CDSENST00000252813ENST00000222308PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
3UTR-3CDSENST00000252813ENST00000608443PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
3UTR-3CDSENST00000252813ENST00000453489PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000597431ENST00000597960PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000597431ENST00000610101PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000597431ENST00000596558PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000597431ENST00000222308PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000597431ENST00000608443PGPEP1chr19

18474512

+FKBP8chr19

18652658

-
intron-3CDSENST00000597431ENST00000453489PGPEP1chr19

18474512

+FKBP8chr19

18652658

-

Top

FusionProtFeatures for PGPEP1_FKBP8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PGPEP1

Q9NXJ5

FKBP8

Q14318

Removes 5-oxoproline from various penultimate amino acidresidues except L-proline. {ECO:0000269|PubMed:12651114}. Constitutively inactive PPiase, which becomes activewhen bound to calmodulin and calcium. Seems to act as a chaperonefor BCL2, targets it to the mitochondria and modulates itsphosphorylation state. The BCL2/FKBP8/calmodulin/calcium complexprobably interferes with the binding of BCL2 to its targets. Theactive form of FKBP8 may therefore play a role in the regulationof apoptosis. {ECO:0000269|PubMed:12510191,ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PGPEP1_FKBP8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PGPEP1_FKBP8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PGPEP1_FKBP8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PGPEP1_FKBP8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource