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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2682

FusionGeneSummary for ARID5B_ARID5B

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID5B_ARID5B
Fusion gene ID: 2682
HgeneTgene
Gene symbol

ARID5B

ARID5B

Gene ID

84159

84159

Gene nameAT-rich interaction domain 5BAT-rich interaction domain 5B
SynonymsDESRT|MRF-2|MRF2DESRT|MRF-2|MRF2
Cytomap

10q21.2

10q21.2

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 5BARID domain-containing protein 5BAT-rich interactive domain 5B (MRF1-like)MRF1-like proteinmodulator recognition factor 2 (MRF2)AT-rich interactive domain-containing protein 5BARID domain-containing protein 5BAT-rich interactive domain 5B (MRF1-like)MRF1-like proteinmodulator recognition factor 2 (MRF2)
Modification date2018052320180523
UniProtAcc

Q14865

Q14865

Ensembl transtripts involved in fusion geneENST00000279873, ENST00000309334, 
ENST00000279873, ENST00000309334, 
Fusion gene scores* DoF score8 X 8 X 3=1924 X 4 X 1=16
# samples 84
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARID5B [Title/Abstract] AND ARID5B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARID5B

GO:0000122

negative regulation of transcription by RNA polymerase II

8649988

HgeneARID5B

GO:0051091

positive regulation of DNA binding transcription factor activity

21532585

TgeneARID5B

GO:0000122

negative regulation of transcription by RNA polymerase II

8649988

TgeneARID5B

GO:0051091

positive regulation of DNA binding transcription factor activity

21532585


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW337747ARID5Bchr10

63856469

-ARID5Bchr10

63856380

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000279873ENST00000279873ARID5Bchr10

63856469

-ARID5Bchr10

63856380

+
3UTR-intronENST00000279873ENST00000309334ARID5Bchr10

63856469

-ARID5Bchr10

63856380

+
intron-3UTRENST00000309334ENST00000279873ARID5Bchr10

63856469

-ARID5Bchr10

63856380

+
intron-intronENST00000309334ENST00000309334ARID5Bchr10

63856469

-ARID5Bchr10

63856380

+

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FusionProtFeatures for ARID5B_ARID5B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARID5B

Q14865

ARID5B

Q14865


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARID5B_ARID5B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARID5B_ARID5B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARID5B_ARID5B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARID5B_ARID5B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARID5BC0003873Rheumatoid Arthritis2CTD_human
HgeneARID5BC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human
HgeneARID5BC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneARID5BC0018213Graves Disease1CTD_human
HgeneARID5BC0041755Adverse reaction to drug1CTD_human
TgeneARID5BC0003873Rheumatoid Arthritis2CTD_human
TgeneARID5BC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human
TgeneARID5BC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneARID5BC0018213Graves Disease1CTD_human
TgeneARID5BC0041755Adverse reaction to drug1CTD_human