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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26800

FusionGeneSummary for PGC_CHGB

check button Fusion gene summary
Fusion gene informationFusion gene name: PGC_CHGB
Fusion gene ID: 26800
HgeneTgene
Gene symbol

PGC

CHGB

Gene ID

5225

1114

Gene nameprogastricsinchromogranin B
SynonymsPEPC|PGIISCG1
Cytomap

6p21.1

20p12.3

Type of geneprotein-codingprotein-coding
Descriptiongastricsinpepsin Cpepsinogen Cpepsinogen group IIpreprogastricsinsecretogranin-1cgBsecretogranin Bsecretogranin IsgI
Modification date2018052320180523
UniProtAcc

P20142

P05060

Ensembl transtripts involved in fusion geneENST00000373025, ENST00000425343, 
ENST00000378961, ENST00000488832, 
Fusion gene scores* DoF score4 X 5 X 3=602 X 2 X 2=8
# samples 52
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: PGC [Title/Abstract] AND CHGB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPAADTCGA-HZ-A49H-01APGCchr6

41704450

-CHGBchr20

5905618

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000373025ENST00000378961PGCchr6

41704450

-CHGBchr20

5905618

+
5CDS-intronENST00000373025ENST00000488832PGCchr6

41704450

-CHGBchr20

5905618

+
intron-3CDSENST00000425343ENST00000378961PGCchr6

41704450

-CHGBchr20

5905618

+
intron-intronENST00000425343ENST00000488832PGCchr6

41704450

-CHGBchr20

5905618

+

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FusionProtFeatures for PGC_CHGB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PGC

P20142

CHGB

P05060

Hydrolyzes a variety of proteins. Secretogranin-1 is a neuroendocrine secretory granuleprotein, which may be the precursor for other biologically activepeptides.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGCchr6:41704450chr20:5905618ENST00000373025-9973_385436389DomainPeptidase A1

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGCchr6:41704450chr20:5905618ENST00000425343-1773_385-23316DomainPeptidase A1
TgeneCHGBchr6:41704450chr20:5905618ENST00000378961+35163_171652678Compositional biasNote=Poly-Glu
TgeneCHGBchr6:41704450chr20:5905618ENST00000378961+35116_120652678RegionNote=O-glycosylated at one site


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FusionGeneSequence for PGC_CHGB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PGC_ENST00000373025_chr6_41704450_-_CHGB_ENST00000378961_chr20_5905618_+_26aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PGC_ENST00000373025_chr6_41704450_-_CHGB_ENST00000378961_chr20_5905618_+_78nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_PGC_ENST00000373025_chr6_41704450_-_CHGB_ENST00000378961_chr20_5905618_+_1761nt
ACTCCACTGCGACTGCAGAACTCAGAGCTGCTCTTCCTCTGTGGCCAGTTGGGGACCAGCATCATGAAGTGGATGGTGGTGGTCTTGGTC
TGCCTCCAGCTCTTGGAGGCAGCAGTGGTCAAAGTGCCCCTGAAGAAATTTAAGTCTATCCGTGAGACCATGAAGGAGAAGGGCTTGCTG
GGGGAGTTCCTGAGGACCCACAAGTATGATCCTGCTTGGAAGTACCGCTTTGGTGACCTCAGCGTGACCTACGAGCCCATGGCCTACATG
GATGCTGCCTACTTTGGTGAGATCAGCATCGGGACTCCACCCCAGAACTTCCTGGTCCTTTTTGACACCGGCTCCTCCAACTTGTGGGTG
CCCTCTGTCTACTGCCAGAGCCAGGCCTGCACCAGTCACTCCCGCTTCAACCCCAGCGAGTCGTCCACCTACTCCACCAATGGGCAGACC
TTCTCCCTGCAGTATGGCAGTGGCAGCCTCACCGGCTTCTTTGGCTATGACACCCTGACTGTCCAGAGCATCCAGGTCCCCAACCAGGAG
TTCGGCTTGAGTGAGAATGAGCCTGGTACCAACTTCGTCTATGCGCAGTTTGATGGCATCATGGGCCTGGCCTACCCTGCTCTGTCCGTG
GATGAGGCCACCACAGCTATGCAGGGCATGGTGCAGGAGGGCGCCCTCACCAGCCCCGTCTTCAGCGTCTACCTCAGCAACCAGCAGGGC
TCCAGCGGGGGAGCGGTTGTCTTTGGGGGTGTGGATAGCAGCCTGTACACGGGGCAGATCTACTGGGCGCCTGTCACCCAGGAACTCTAC
TGGCAGATTGGCATTGAAGAGTTCCTCATCGGCGGCCAGGCCTCCGGCTGGTGTTCTGAGGGTTGCCAGGCCATCGTGGACACAGGCACC
TCTCTGCTCACTGTGCCCCAGCAGTACATGAGTGCTCTTCTGCAGGCCACAGGGGCCCAGGAGGATGAGTATGGACAGTTTCTCGTGAAC
TGTAACAGCATTCAGAATCTGCCCAGCTTGACCTTCATCATCAATGGTGTGGAGTTCCCTCTGCCACCTTCCTCCTATATCCTCAGTAAC
AACGGCTACTGCACCGTGGGAGTCGAGCCCACCTACCTGTCCTCCCAGAACGGCCAGCCCCTGTGGATCCTCGGGGATGTCTTCCTCAGG
TCCTACTATTCCGTCTACGACTTGGGCAACAACAGAGTAGGCTTTGCCACTGCCGCCTAGACTTGCTGCCTCGACACGTGGGCTCCCCTC
TTCCTCTTGACCCTGCACCCTCCTAGGGCATTGTATCTGTCTTTCCACTCTGGATTCAGCCTTCTTTTTCTGGACTCTGGACTTTCTCTA
ATAATAAATAGTTCTTCTTTAAAAAAAGAACTCGAAAACTTGGCTGCAATGGATTTGGAACTACAGAAGATAGCTGAGAAATTCAGCCAA
AGGGGCTGACTGTCATTGGAGCGGTGGGCACTGTTAAGAAGCAGCCATCACATGATCTGTTTTTCACCACTTCACTGAAAGACACCATTT
ATCTACCCAAGGGCAGAAAGTAGAACTTACTATTCATTAAATGTTTGACACAATTGGAATTGTCTTTAATTTCTGTCAGAATGCTATTGA
AAATGTGAATTGCATGACTTGTAGCATATTCTTTTCTGCAAAATAGACATATTAACATGCTTATGACAATGACTGTGCTACTGTCTTTGG


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FusionGenePPI for PGC_CHGB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PGCCCNT1, CDK9, ESR1, ATP4ACHGBACACA, CBFB, SGK223, CCDC92, MOGS, MARK3, MGLL, OGG1, TWF2, SAFB2, ATXN2, TAZ, FGFR3, POLD1, PTEN, S100A8, SLC25A6, YLPM1, TUBB2A, RAC2, RAP1B, TK1, CDKN1A, RCC1, PKN2, ANXA7, UBQLN1, APP, PARK2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PGC_CHGB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PGC_CHGB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCHGBC0036341Schizophrenia3PSYGENET
TgeneCHGBC0221765Chronic schizophrenia1PSYGENET