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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26788

FusionGeneSummary for PGAP3_LRRC6

check button Fusion gene summary
Fusion gene informationFusion gene name: PGAP3_LRRC6
Fusion gene ID: 26788
HgeneTgene
Gene symbol

PGAP3

LRRC6

Gene ID

93210

23639

Gene namepost-GPI attachment to proteins 3leucine rich repeat containing 6
SynonymsAGLA546|CAB2|PERLD1|PP1498|hCOS16CILD19|LRTP|TSLRP
Cytomap

17q12

8q24.22

Type of geneprotein-codingprotein-coding
Descriptionpost-GPI attachment to proteins factor 3COS16 homologgene coamplified with ERBB2 proteinper1-like domain containing 1protein tilB homologprotein TILB homologtestis-specific leucine-rich repeat protein
Modification date2018052320180523
UniProtAcc

Q96FM1

Q86X45

Ensembl transtripts involved in fusion geneENST00000579146, ENST00000300658, 
ENST00000378011, ENST00000429199, 
ENST00000519595, ENST00000518642, 
ENST00000250173, ENST00000520446, 
Fusion gene scores* DoF score13 X 4 X 6=3126 X 4 X 6=144
# samples 126
** MAII scorelog2(12/312*10)=-1.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PGAP3 [Title/Abstract] AND LRRC6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-4Z-AA7S-01APGAP3chr17

37840850

-LRRC6chr8

133622507

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000579146ENST00000519595PGAP3chr17

37840850

-LRRC6chr8

133622507

-
5CDS-intronENST00000579146ENST00000518642PGAP3chr17

37840850

-LRRC6chr8

133622507

-
5CDS-intronENST00000579146ENST00000250173PGAP3chr17

37840850

-LRRC6chr8

133622507

-
5CDS-intronENST00000579146ENST00000520446PGAP3chr17

37840850

-LRRC6chr8

133622507

-
In-frameENST00000300658ENST00000519595PGAP3chr17

37840850

-LRRC6chr8

133622507

-
5CDS-intronENST00000300658ENST00000518642PGAP3chr17

37840850

-LRRC6chr8

133622507

-
5CDS-intronENST00000300658ENST00000250173PGAP3chr17

37840850

-LRRC6chr8

133622507

-
5CDS-intronENST00000300658ENST00000520446PGAP3chr17

37840850

-LRRC6chr8

133622507

-
intron-3CDSENST00000378011ENST00000519595PGAP3chr17

37840850

-LRRC6chr8

133622507

-
intron-intronENST00000378011ENST00000518642PGAP3chr17

37840850

-LRRC6chr8

133622507

-
intron-intronENST00000378011ENST00000250173PGAP3chr17

37840850

-LRRC6chr8

133622507

-
intron-intronENST00000378011ENST00000520446PGAP3chr17

37840850

-LRRC6chr8

133622507

-
In-frameENST00000429199ENST00000519595PGAP3chr17

37840850

-LRRC6chr8

133622507

-
5CDS-intronENST00000429199ENST00000518642PGAP3chr17

37840850

-LRRC6chr8

133622507

-
5CDS-intronENST00000429199ENST00000250173PGAP3chr17

37840850

-LRRC6chr8

133622507

-
5CDS-intronENST00000429199ENST00000520446PGAP3chr17

37840850

-LRRC6chr8

133622507

-

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FusionProtFeatures for PGAP3_LRRC6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PGAP3

Q96FM1

LRRC6

Q86X45

Involved in the lipid remodeling steps of GPI-anchormaturation. Lipid remodeling steps consist in the generation of 2saturated fatty chains at the sn-2 position of GPI-anchorsproteins. Required for phospholipase A2 activity that removes anacyl-chain at the sn-2 position of GPI-anchors during theremodeling of GPI (Probable). {ECO:0000305|PubMed:17021251}. May play a role in dynein arm assembly, hence essentialfor proper axoneme building for cilia motility.{ECO:0000269|PubMed:23122589}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGAP3chr17:37840850chr8:133622507ENST00000300658-38120_135144321Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr8:133622507ENST00000300658-3821_98144321Topological domainLumenal
HgenePGAP3chr17:37840850chr8:133622507ENST00000300658-3899_119144321TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGAP3chr17:37840850chr8:133622507ENST00000300658-38157_169144321Topological domainLumenal
HgenePGAP3chr17:37840850chr8:133622507ENST00000300658-38191_193144321Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr8:133622507ENST00000300658-38215_224144321Topological domainLumenal
HgenePGAP3chr17:37840850chr8:133622507ENST00000300658-38246_257144321Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr8:133622507ENST00000300658-38279_279144321Topological domainLumenal
HgenePGAP3chr17:37840850chr8:133622507ENST00000300658-38300_320144321Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr8:133622507ENST00000378011-17120_135-15270Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr8:133622507ENST00000378011-17157_169-15270Topological domainLumenal
HgenePGAP3chr17:37840850chr8:133622507ENST00000378011-17191_193-15270Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr8:133622507ENST00000378011-17215_224-15270Topological domainLumenal
HgenePGAP3chr17:37840850chr8:133622507ENST00000378011-1721_98-15270Topological domainLumenal
HgenePGAP3chr17:37840850chr8:133622507ENST00000378011-17246_257-15270Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr8:133622507ENST00000378011-17279_279-15270Topological domainLumenal
HgenePGAP3chr17:37840850chr8:133622507ENST00000378011-17300_320-15270Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr8:133622507ENST00000300658-38136_156144321TransmembraneHelical
HgenePGAP3chr17:37840850chr8:133622507ENST00000300658-38170_190144321TransmembraneHelical
HgenePGAP3chr17:37840850chr8:133622507ENST00000300658-38194_214144321TransmembraneHelical
HgenePGAP3chr17:37840850chr8:133622507ENST00000300658-38225_245144321TransmembraneHelical
HgenePGAP3chr17:37840850chr8:133622507ENST00000300658-38258_278144321TransmembraneHelical
HgenePGAP3chr17:37840850chr8:133622507ENST00000300658-38280_299144321TransmembraneHelical
HgenePGAP3chr17:37840850chr8:133622507ENST00000378011-17136_156-15270TransmembraneHelical
HgenePGAP3chr17:37840850chr8:133622507ENST00000378011-17170_190-15270TransmembraneHelical
HgenePGAP3chr17:37840850chr8:133622507ENST00000378011-17194_214-15270TransmembraneHelical
HgenePGAP3chr17:37840850chr8:133622507ENST00000378011-17225_245-15270TransmembraneHelical
HgenePGAP3chr17:37840850chr8:133622507ENST00000378011-17258_278-15270TransmembraneHelical
HgenePGAP3chr17:37840850chr8:133622507ENST00000378011-17280_299-15270TransmembraneHelical
HgenePGAP3chr17:37840850chr8:133622507ENST00000378011-1799_119-15270TransmembraneHelical
TgeneLRRC6chr17:37840850chr8:133622507ENST00000250173-812178_204348467Coiled coilOntology_term=ECO:0000255
TgeneLRRC6chr17:37840850chr8:133622507ENST00000519595-812178_204348467Coiled coilOntology_term=ECO:0000255
TgeneLRRC6chr17:37840850chr8:133622507ENST00000250173-812281_286348467Compositional biasNote=Poly-Lys
TgeneLRRC6chr17:37840850chr8:133622507ENST00000519595-812281_286348467Compositional biasNote=Poly-Lys
TgeneLRRC6chr17:37840850chr8:133622507ENST00000250173-812123_161348467DomainNote=LRRCT
TgeneLRRC6chr17:37840850chr8:133622507ENST00000250173-812301_396348467DomainCS
TgeneLRRC6chr17:37840850chr8:133622507ENST00000519595-812123_161348467DomainNote=LRRCT
TgeneLRRC6chr17:37840850chr8:133622507ENST00000519595-812301_396348467DomainCS
TgeneLRRC6chr17:37840850chr8:133622507ENST00000250173-81222_43348467RepeatNote=LRR 1
TgeneLRRC6chr17:37840850chr8:133622507ENST00000250173-81245_66348467RepeatNote=LRR 2
TgeneLRRC6chr17:37840850chr8:133622507ENST00000250173-81267_88348467RepeatNote=LRR 3
TgeneLRRC6chr17:37840850chr8:133622507ENST00000250173-81289_110348467RepeatNote=LRR 4
TgeneLRRC6chr17:37840850chr8:133622507ENST00000519595-81222_43348467RepeatNote=LRR 1
TgeneLRRC6chr17:37840850chr8:133622507ENST00000519595-81245_66348467RepeatNote=LRR 2
TgeneLRRC6chr17:37840850chr8:133622507ENST00000519595-81267_88348467RepeatNote=LRR 3
TgeneLRRC6chr17:37840850chr8:133622507ENST00000519595-81289_110348467RepeatNote=LRR 4


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FusionGeneSequence for PGAP3_LRRC6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PGAP3_ENST00000579146_chr17_37840850_-_LRRC6_ENST00000519595_chr8_133622507_-_263aa
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQF
HGKWPFSRFLFFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWPFQLVLPAEVKPDSSSAKRSQTTGHLVICMPKVGEV

>In-frame_PGAP3_ENST00000300658_chr17_37840850_-_LRRC6_ENST00000519595_chr8_133622507_-_263aa
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQF
HGKWPFSRFLFFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWPFQLVLPAEVKPDSSSAKRSQTTGHLVICMPKVGEV

>In-frame_PGAP3_ENST00000429199_chr17_37840850_-_LRRC6_ENST00000519595_chr8_133622507_-_263aa
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQF
HGKWPFSRFLFFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWPFQLVLPAEVKPDSSSAKRSQTTGHLVICMPKVGEV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PGAP3_ENST00000579146_chr17_37840850_-_LRRC6_ENST00000519595_chr8_133622507_-_789nt
ATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGCGCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTACCGC
GACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCTGAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTAGCA
GGCTGGACCTGTCGGGACGACTGTAAGTATGAGTGTATGTGGGTCACCGTTGGGCTCTACCTCCAGGAAGGTCACAAAGTGCCTCAGTTC
CATGGCAAGTGGCCCTTCTCCCGGTTCCTGTTCTTTCAAGAGCCGGCATCGGCCGTGGCCTCGTTTCTCAATGGCCTGGCCAGCCTGGTG
ATGCTCTGCCGCTACCGCACCTTCGTGCCAGCCTCCTCCCCCATGTACCACACCTGTGTGGCCTTCGCCTGGCCATTTCAGCTTGTCCTT
CCTGCAGAAGTGAAACCCGATAGTAGTTCTGCTAAAAGATCTCAGACAACGGGTCATTTGGTCATCTGCATGCCCAAGGTAGGAGAAGTA
ATCACAGGTGGTCAGCGAGCATTCAAATCTATGAAAACTACCTCGGACAGGAGCAGAGAACAAACAAATACAAGAAGCAAGCACATGGAG
AAACTAGAAGTAGACCCTAGCAAGCACTCATTCCCTGATGTGACTAACATAGTTCAAGAGAAAAAACACACACCCAGAAGACGACCTGAA

>In-frame_PGAP3_ENST00000300658_chr17_37840850_-_LRRC6_ENST00000519595_chr8_133622507_-_789nt
ATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGCGCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTACCGC
GACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCTGAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTAGCA
GGCTGGACCTGTCGGGACGACTGTAAGTATGAGTGTATGTGGGTCACCGTTGGGCTCTACCTCCAGGAAGGTCACAAAGTGCCTCAGTTC
CATGGCAAGTGGCCCTTCTCCCGGTTCCTGTTCTTTCAAGAGCCGGCATCGGCCGTGGCCTCGTTTCTCAATGGCCTGGCCAGCCTGGTG
ATGCTCTGCCGCTACCGCACCTTCGTGCCAGCCTCCTCCCCCATGTACCACACCTGTGTGGCCTTCGCCTGGCCATTTCAGCTTGTCCTT
CCTGCAGAAGTGAAACCCGATAGTAGTTCTGCTAAAAGATCTCAGACAACGGGTCATTTGGTCATCTGCATGCCCAAGGTAGGAGAAGTA
ATCACAGGTGGTCAGCGAGCATTCAAATCTATGAAAACTACCTCGGACAGGAGCAGAGAACAAACAAATACAAGAAGCAAGCACATGGAG
AAACTAGAAGTAGACCCTAGCAAGCACTCATTCCCTGATGTGACTAACATAGTTCAAGAGAAAAAACACACACCCAGAAGACGACCTGAA

>In-frame_PGAP3_ENST00000429199_chr17_37840850_-_LRRC6_ENST00000519595_chr8_133622507_-_789nt
ATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGCGCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTACCGC
GACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCTGAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTAGCA
GGCTGGACCTGTCGGGACGACTGTAAGTATGAGTGTATGTGGGTCACCGTTGGGCTCTACCTCCAGGAAGGTCACAAAGTGCCTCAGTTC
CATGGCAAGTGGCCCTTCTCCCGGTTCCTGTTCTTTCAAGAGCCGGCATCGGCCGTGGCCTCGTTTCTCAATGGCCTGGCCAGCCTGGTG
ATGCTCTGCCGCTACCGCACCTTCGTGCCAGCCTCCTCCCCCATGTACCACACCTGTGTGGCCTTCGCCTGGCCATTTCAGCTTGTCCTT
CCTGCAGAAGTGAAACCCGATAGTAGTTCTGCTAAAAGATCTCAGACAACGGGTCATTTGGTCATCTGCATGCCCAAGGTAGGAGAAGTA
ATCACAGGTGGTCAGCGAGCATTCAAATCTATGAAAACTACCTCGGACAGGAGCAGAGAACAAACAAATACAAGAAGCAAGCACATGGAG
AAACTAGAAGTAGACCCTAGCAAGCACTCATTCCCTGATGTGACTAACATAGTTCAAGAGAAAAAACACACACCCAGAAGACGACCTGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_PGAP3_ENST00000579146_chr17_37840850_-_LRRC6_ENST00000519595_chr8_133622507_-_1066nt
ATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAAAGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGC
GCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTACCGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCT
GAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTAGCAGGCTGGACCTGTCGGGACGACTGTAAGTATGAGTGTATGTGGGTCAC
CGTTGGGCTCTACCTCCAGGAAGGTCACAAAGTGCCTCAGTTCCATGGCAAGTGGCCCTTCTCCCGGTTCCTGTTCTTTCAAGAGCCGGC
ATCGGCCGTGGCCTCGTTTCTCAATGGCCTGGCCAGCCTGGTGATGCTCTGCCGCTACCGCACCTTCGTGCCAGCCTCCTCCCCCATGTA
CCACACCTGTGTGGCCTTCGCCTGGCCATTTCAGCTTGTCCTTCCTGCAGAAGTGAAACCCGATAGTAGTTCTGCTAAAAGATCTCAGAC
AACGGGTCATTTGGTCATCTGCATGCCCAAGGTAGGAGAAGTAATCACAGGTGGTCAGCGAGCATTCAAATCTATGAAAACTACCTCGGA
CAGGAGCAGAGAACAAACAAATACAAGAAGCAAGCACATGGAGAAACTAGAAGTAGACCCTAGCAAGCACTCATTCCCTGATGTGACTAA
CATAGTTCAAGAGAAAAAACACACACCCAGAAGACGACCTGAACCCAAAATTATACCAAGTGAGGAAGACCCAACCTTTGAAGACAACCC
TGAAGTGCCTCCGCTGATTTGAAACATCTGGCTGCGTTGCCATTGGCTGAGACCCACCAGGTCCAGTTTTGGTTGGTGTAGAGACCATAT
GCATATTATTCCTGGGATAAACACAGAGTTATTTGTCAATATCGCTGCTCCAGTGTTTTAACTCTTACTTTGCATAGTAATATCCTTAAG

>In-frame_PGAP3_ENST00000300658_chr17_37840850_-_LRRC6_ENST00000519595_chr8_133622507_-_1116nt
GTAGAATAAAGAACACAGGAACTTCCGGTTACTCCGGAAGTGGAAGCTTCATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAA
AGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGCGCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTAC
CGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCTGAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTA
GCAGGCTGGACCTGTCGGGACGACTGTAAGTATGAGTGTATGTGGGTCACCGTTGGGCTCTACCTCCAGGAAGGTCACAAAGTGCCTCAG
TTCCATGGCAAGTGGCCCTTCTCCCGGTTCCTGTTCTTTCAAGAGCCGGCATCGGCCGTGGCCTCGTTTCTCAATGGCCTGGCCAGCCTG
GTGATGCTCTGCCGCTACCGCACCTTCGTGCCAGCCTCCTCCCCCATGTACCACACCTGTGTGGCCTTCGCCTGGCCATTTCAGCTTGTC
CTTCCTGCAGAAGTGAAACCCGATAGTAGTTCTGCTAAAAGATCTCAGACAACGGGTCATTTGGTCATCTGCATGCCCAAGGTAGGAGAA
GTAATCACAGGTGGTCAGCGAGCATTCAAATCTATGAAAACTACCTCGGACAGGAGCAGAGAACAAACAAATACAAGAAGCAAGCACATG
GAGAAACTAGAAGTAGACCCTAGCAAGCACTCATTCCCTGATGTGACTAACATAGTTCAAGAGAAAAAACACACACCCAGAAGACGACCT
GAACCCAAAATTATACCAAGTGAGGAAGACCCAACCTTTGAAGACAACCCTGAAGTGCCTCCGCTGATTTGAAACATCTGGCTGCGTTGC
CATTGGCTGAGACCCACCAGGTCCAGTTTTGGTTGGTGTAGAGACCATATGCATATTATTCCTGGGATAAACACAGAGTTATTTGTCAAT
ATCGCTGCTCCAGTGTTTTAACTCTTACTTTGCATAGTAATATCCTTAAGATAGCTTAAAATTAAAATGTATGTCTTAAATGCTATAACT

>In-frame_PGAP3_ENST00000429199_chr17_37840850_-_LRRC6_ENST00000519595_chr8_133622507_-_1066nt
ATACTCCTAAGCTCCTCCCCCGGCGGCGAGCCAGGGAGAAAGGATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGC
GCTGGCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTACCGCGACTGCGTACTGCAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCT
GAATCACTTCCGCTCCCGCCAGCCAATCTACATGAGTCTAGCAGGCTGGACCTGTCGGGACGACTGTAAGTATGAGTGTATGTGGGTCAC
CGTTGGGCTCTACCTCCAGGAAGGTCACAAAGTGCCTCAGTTCCATGGCAAGTGGCCCTTCTCCCGGTTCCTGTTCTTTCAAGAGCCGGC
ATCGGCCGTGGCCTCGTTTCTCAATGGCCTGGCCAGCCTGGTGATGCTCTGCCGCTACCGCACCTTCGTGCCAGCCTCCTCCCCCATGTA
CCACACCTGTGTGGCCTTCGCCTGGCCATTTCAGCTTGTCCTTCCTGCAGAAGTGAAACCCGATAGTAGTTCTGCTAAAAGATCTCAGAC
AACGGGTCATTTGGTCATCTGCATGCCCAAGGTAGGAGAAGTAATCACAGGTGGTCAGCGAGCATTCAAATCTATGAAAACTACCTCGGA
CAGGAGCAGAGAACAAACAAATACAAGAAGCAAGCACATGGAGAAACTAGAAGTAGACCCTAGCAAGCACTCATTCCCTGATGTGACTAA
CATAGTTCAAGAGAAAAAACACACACCCAGAAGACGACCTGAACCCAAAATTATACCAAGTGAGGAAGACCCAACCTTTGAAGACAACCC
TGAAGTGCCTCCGCTGATTTGAAACATCTGGCTGCGTTGCCATTGGCTGAGACCCACCAGGTCCAGTTTTGGTTGGTGTAGAGACCATAT
GCATATTATTCCTGGGATAAACACAGAGTTATTTGTCAATATCGCTGCTCCAGTGTTTTAACTCTTACTTTGCATAGTAATATCCTTAAG


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FusionGenePPI for PGAP3_LRRC6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PGAP3TBRG4, VKORC1L1LRRC6SCRIB, CACYBP, TSC22D2, PHLPP2, CHEK1, DHPS, PPP1R7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PGAP3_LRRC6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PGAP3_LRRC6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePGAP3C3810354HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 41UNIPROT
TgeneLRRC6C3543826CILIARY DYSKINESIA, PRIMARY, 191UNIPROT