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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26787

FusionGeneSummary for PGAP3_IKZF3

check button Fusion gene summary
Fusion gene informationFusion gene name: PGAP3_IKZF3
Fusion gene ID: 26787
HgeneTgene
Gene symbol

PGAP3

IKZF3

Gene ID

93210

22806

Gene namepost-GPI attachment to proteins 3IKAROS family zinc finger 3
SynonymsAGLA546|CAB2|PERLD1|PP1498|hCOS16AIO|AIOLOS|ZNFN1A3
Cytomap

17q12

17q12-q21.1

Type of geneprotein-codingprotein-coding
Descriptionpost-GPI attachment to proteins factor 3COS16 homologgene coamplified with ERBB2 proteinper1-like domain containing 1zinc finger protein Aioloszinc finger DNA binding protein Aioloszinc finger protein, subfamily 1A, 3 (Aiolos)
Modification date2018052320180523
UniProtAcc

Q96FM1

Q9UKT9

Ensembl transtripts involved in fusion geneENST00000579146, ENST00000300658, 
ENST00000378011, ENST00000429199, 
ENST00000346872, ENST00000394189, 
ENST00000439167, ENST00000535189, 
ENST00000377944, ENST00000377945, 
ENST00000377952, ENST00000377958, 
ENST00000346243, ENST00000350532, 
ENST00000351680, ENST00000467757, 
ENST00000439016, ENST00000583368, 
Fusion gene scores* DoF score13 X 4 X 6=31227 X 9 X 12=2916
# samples 1234
** MAII scorelog2(12/312*10)=-1.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(34/2916*10)=-3.10038406818924
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PGAP3 [Title/Abstract] AND IKZF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0B7-01APGAP3chr17

37840850

-IKZF3chr17

37988404

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000579146ENST00000346872PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000579146ENST00000394189PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000579146ENST00000439167PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000579146ENST00000535189PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000579146ENST00000377944PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000579146ENST00000377945PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000579146ENST00000377952PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000579146ENST00000377958PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000579146ENST00000346243PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000579146ENST00000350532PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000579146ENST00000351680PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000579146ENST00000467757PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000579146ENST00000439016PGAP3chr17

37840850

-IKZF3chr17

37988404

-
5CDS-intronENST00000579146ENST00000583368PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000300658ENST00000346872PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000300658ENST00000394189PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000300658ENST00000439167PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000300658ENST00000535189PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000300658ENST00000377944PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000300658ENST00000377945PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000300658ENST00000377952PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000300658ENST00000377958PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000300658ENST00000346243PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000300658ENST00000350532PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000300658ENST00000351680PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000300658ENST00000467757PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000300658ENST00000439016PGAP3chr17

37840850

-IKZF3chr17

37988404

-
5CDS-intronENST00000300658ENST00000583368PGAP3chr17

37840850

-IKZF3chr17

37988404

-
intron-3CDSENST00000378011ENST00000346872PGAP3chr17

37840850

-IKZF3chr17

37988404

-
intron-3CDSENST00000378011ENST00000394189PGAP3chr17

37840850

-IKZF3chr17

37988404

-
intron-3CDSENST00000378011ENST00000439167PGAP3chr17

37840850

-IKZF3chr17

37988404

-
intron-3CDSENST00000378011ENST00000535189PGAP3chr17

37840850

-IKZF3chr17

37988404

-
intron-3CDSENST00000378011ENST00000377944PGAP3chr17

37840850

-IKZF3chr17

37988404

-
intron-3CDSENST00000378011ENST00000377945PGAP3chr17

37840850

-IKZF3chr17

37988404

-
intron-3CDSENST00000378011ENST00000377952PGAP3chr17

37840850

-IKZF3chr17

37988404

-
intron-3CDSENST00000378011ENST00000377958PGAP3chr17

37840850

-IKZF3chr17

37988404

-
intron-3CDSENST00000378011ENST00000346243PGAP3chr17

37840850

-IKZF3chr17

37988404

-
intron-3CDSENST00000378011ENST00000350532PGAP3chr17

37840850

-IKZF3chr17

37988404

-
intron-3CDSENST00000378011ENST00000351680PGAP3chr17

37840850

-IKZF3chr17

37988404

-
intron-3CDSENST00000378011ENST00000467757PGAP3chr17

37840850

-IKZF3chr17

37988404

-
intron-3CDSENST00000378011ENST00000439016PGAP3chr17

37840850

-IKZF3chr17

37988404

-
intron-intronENST00000378011ENST00000583368PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000429199ENST00000346872PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000429199ENST00000394189PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000429199ENST00000439167PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000429199ENST00000535189PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000429199ENST00000377944PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000429199ENST00000377945PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000429199ENST00000377952PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000429199ENST00000377958PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000429199ENST00000346243PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000429199ENST00000350532PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000429199ENST00000351680PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000429199ENST00000467757PGAP3chr17

37840850

-IKZF3chr17

37988404

-
Frame-shiftENST00000429199ENST00000439016PGAP3chr17

37840850

-IKZF3chr17

37988404

-
5CDS-intronENST00000429199ENST00000583368PGAP3chr17

37840850

-IKZF3chr17

37988404

-

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FusionProtFeatures for PGAP3_IKZF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PGAP3

Q96FM1

IKZF3

Q9UKT9

Involved in the lipid remodeling steps of GPI-anchormaturation. Lipid remodeling steps consist in the generation of 2saturated fatty chains at the sn-2 position of GPI-anchorsproteins. Required for phospholipase A2 activity that removes anacyl-chain at the sn-2 position of GPI-anchors during theremodeling of GPI (Probable). {ECO:0000305|PubMed:17021251}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PGAP3_IKZF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PGAP3_IKZF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PGAP3TBRG4, VKORC1L1IKZF3UBE2I, SIN3A, SIN3B, HDAC2, HDAC4, HDAC5, HDAC7, CHD4, IKZF4, IKZF5, IKZF2, HRAS, BCL2L1, IKZF1, NOTCH1, FOXP3, CRBN, UBC, ARNT2, DGCR6, PRKAB2, AES, AQP1, RHOA, CDKN1A, CDKN2D, GEM, GRB2, HNRNPF, KRT19, LMO1, LMO2, PFDN5, PIK3R2, PIN1, PRKAA1, PSMA1, RAD51D, STK16, STX11, POLR1C, EMC2, FAM115A, AKAP9, BCAS2, KAT5, MRPL28, FARS2, NEK6, IKZF3, ABLIM3, PPP1R16B, POLM, OSGIN1, CHCHD2, SPG21, OAZ3, C1orf109, MAGOHB, FANCL, TBC1D22B, RCOR3, PCID2, CABP5, LGALS14, EXOSC5, STAMBPL1, TRAPPC6A, ARMC7, TSSK3, ING5, ZGPAT, FBF1, ATPAF2, EFHC1, MRPL53, EXOC8, TEKT4, TSTD2, NATD1, MORN3, TRIM42, ARMC8, SETMAR, DGCR14, GID4, MAD1L1, LDOC1, STK26, SUMO1, PRDM1, CUL4A, GATAD2B, TRIM25, SMARCB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PGAP3_IKZF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PGAP3_IKZF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePGAP3C3810354HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 41UNIPROT
TgeneIKZF3C0003873Rheumatoid Arthritis1CTD_human
TgeneIKZF3C0004096Asthma1CTD_human
TgeneIKZF3C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human