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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 26784

FusionGeneSummary for PGAP3_ERBB2

check button Fusion gene summary
Fusion gene informationFusion gene name: PGAP3_ERBB2
Fusion gene ID: 26784
HgeneTgene
Gene symbol

PGAP3

ERBB2

Gene ID

93210

2064

Gene namepost-GPI attachment to proteins 3erb-b2 receptor tyrosine kinase 2
SynonymsAGLA546|CAB2|PERLD1|PP1498|hCOS16CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1
Cytomap

17q12

17q12

Type of geneprotein-codingprotein-coding
Descriptionpost-GPI attachment to proteins factor 3COS16 homologgene coamplified with ERBB2 proteinper1-like domain containing 1receptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2
Modification date2018052320180527
UniProtAcc

Q96FM1

P04626

Ensembl transtripts involved in fusion geneENST00000579146, ENST00000300658, 
ENST00000378011, ENST00000429199, 
ENST00000584601, ENST00000406381, 
ENST00000541774, ENST00000445658, 
ENST00000540147, ENST00000584450, 
ENST00000269571, ENST00000578199, 
ENST00000540042, ENST00000584888, 
Fusion gene scores* DoF score13 X 4 X 6=31217 X 14 X 7=1666
# samples 1218
** MAII scorelog2(12/312*10)=-1.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/1666*10)=-3.21031958903587
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PGAP3 [Title/Abstract] AND ERBB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneERBB2

GO:0007165

signal transduction

10572067

TgeneERBB2

GO:0007166

cell surface receptor signaling pathway

9685399

TgeneERBB2

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

7514177

TgeneERBB2

GO:0014065

phosphatidylinositol 3-kinase signaling

7556068

TgeneERBB2

GO:0032886

regulation of microtubule-based process

20937854

TgeneERBB2

GO:0042060

wound healing

12646923

TgeneERBB2

GO:0043406

positive regulation of MAP kinase activity

10572067

TgeneERBB2

GO:0045785

positive regulation of cell adhesion

7556068

TgeneERBB2

GO:0045945

positive regulation of transcription by RNA polymerase III

19372587

TgeneERBB2

GO:0046777

protein autophosphorylation

7556068

TgeneERBB2

GO:0050679

positive regulation of epithelial cell proliferation

10572067

TgeneERBB2

GO:0071363

cellular response to growth factor stimulus

20010870

TgeneERBB2

GO:0090314

positive regulation of protein targeting to membrane

20010870


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-VS-A9U5-01APGAP3chr17

37842175

-ERBB2chr17

37844949

+
TCGARVCESCTCGA-VS-A9V0-01APGAP3chr17

37840850

-ERBB2chr17

37880979

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000579146ENST00000584601PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000579146ENST00000406381PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000579146ENST00000541774PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000579146ENST00000445658PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000579146ENST00000540147PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000579146ENST00000584450PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000579146ENST00000269571PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000579146ENST00000578199PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000579146ENST00000540042PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000579146ENST00000584888PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000300658ENST00000584601PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000300658ENST00000406381PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000300658ENST00000541774PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000300658ENST00000445658PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000300658ENST00000540147PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000300658ENST00000584450PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000300658ENST00000269571PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000300658ENST00000578199PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000300658ENST00000540042PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000300658ENST00000584888PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000378011ENST00000584601PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000378011ENST00000406381PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000378011ENST00000541774PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000378011ENST00000445658PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000378011ENST00000540147PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000378011ENST00000584450PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000378011ENST00000269571PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000378011ENST00000578199PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000378011ENST00000540042PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000378011ENST00000584888PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000429199ENST00000584601PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000429199ENST00000406381PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000429199ENST00000541774PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000429199ENST00000445658PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000429199ENST00000540147PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000429199ENST00000584450PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000429199ENST00000269571PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000429199ENST00000578199PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000429199ENST00000540042PGAP3chr17

37842175

-ERBB2chr17

37844949

+
5CDS-intronENST00000429199ENST00000584888PGAP3chr17

37842175

-ERBB2chr17

37844949

+
In-frameENST00000579146ENST00000584601PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000579146ENST00000406381PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000579146ENST00000541774PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000579146ENST00000445658PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000579146ENST00000540147PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000579146ENST00000584450PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000579146ENST00000269571PGAP3chr17

37840850

-ERBB2chr17

37880979

+
5CDS-intronENST00000579146ENST00000578199PGAP3chr17

37840850

-ERBB2chr17

37880979

+
5CDS-intronENST00000579146ENST00000540042PGAP3chr17

37840850

-ERBB2chr17

37880979

+
5CDS-intronENST00000579146ENST00000584888PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000300658ENST00000584601PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000300658ENST00000406381PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000300658ENST00000541774PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000300658ENST00000445658PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000300658ENST00000540147PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000300658ENST00000584450PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000300658ENST00000269571PGAP3chr17

37840850

-ERBB2chr17

37880979

+
5CDS-intronENST00000300658ENST00000578199PGAP3chr17

37840850

-ERBB2chr17

37880979

+
5CDS-intronENST00000300658ENST00000540042PGAP3chr17

37840850

-ERBB2chr17

37880979

+
5CDS-intronENST00000300658ENST00000584888PGAP3chr17

37840850

-ERBB2chr17

37880979

+
intron-3CDSENST00000378011ENST00000584601PGAP3chr17

37840850

-ERBB2chr17

37880979

+
intron-3CDSENST00000378011ENST00000406381PGAP3chr17

37840850

-ERBB2chr17

37880979

+
intron-3CDSENST00000378011ENST00000541774PGAP3chr17

37840850

-ERBB2chr17

37880979

+
intron-3CDSENST00000378011ENST00000445658PGAP3chr17

37840850

-ERBB2chr17

37880979

+
intron-3CDSENST00000378011ENST00000540147PGAP3chr17

37840850

-ERBB2chr17

37880979

+
intron-3CDSENST00000378011ENST00000584450PGAP3chr17

37840850

-ERBB2chr17

37880979

+
intron-3CDSENST00000378011ENST00000269571PGAP3chr17

37840850

-ERBB2chr17

37880979

+
intron-intronENST00000378011ENST00000578199PGAP3chr17

37840850

-ERBB2chr17

37880979

+
intron-intronENST00000378011ENST00000540042PGAP3chr17

37840850

-ERBB2chr17

37880979

+
intron-intronENST00000378011ENST00000584888PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000429199ENST00000584601PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000429199ENST00000406381PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000429199ENST00000541774PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000429199ENST00000445658PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000429199ENST00000540147PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000429199ENST00000584450PGAP3chr17

37840850

-ERBB2chr17

37880979

+
In-frameENST00000429199ENST00000269571PGAP3chr17

37840850

-ERBB2chr17

37880979

+
5CDS-intronENST00000429199ENST00000578199PGAP3chr17

37840850

-ERBB2chr17

37880979

+
5CDS-intronENST00000429199ENST00000540042PGAP3chr17

37840850

-ERBB2chr17

37880979

+
5CDS-intronENST00000429199ENST00000584888PGAP3chr17

37840850

-ERBB2chr17

37880979

+

Top

FusionProtFeatures for PGAP3_ERBB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PGAP3

Q96FM1

ERBB2

P04626

Involved in the lipid remodeling steps of GPI-anchormaturation. Lipid remodeling steps consist in the generation of 2saturated fatty chains at the sn-2 position of GPI-anchorsproteins. Required for phospholipase A2 activity that removes anacyl-chain at the sn-2 position of GPI-anchors during theremodeling of GPI (Probable). {ECO:0000305|PubMed:17021251}. Protein tyrosine kinase that is part of several cellsurface receptor complexes, but that apparently needs a coreceptorfor ligand binding. Essential component of a neuregulin-receptorcomplex, although neuregulins do not interact with it alone. GP30is a potential ligand for this receptor. Regulates outgrowth andstabilization of peripheral microtubules (MTs). Upon ERBB2activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits thephosphorylation and thus the inhibition of GSK3B at cell membrane.This prevents the phosphorylation of APC and CLASP2, allowing itsassociation with the cell membrane. In turn, membrane-bound APCallows the localization of MACF1 to the cell membrane, which isrequired for microtubule capture and stabilization. {ECO:0000305}. In the nucleus is involved in transcriptionalregulation. Associates with the 5'-TCAAATTC-3' sequence in thePTGS2/COX-2 promoter and activates its transcription. Implicatedin transcriptional activation of CDKN1A; the function involvesSTAT3 and SRC. Involved in the transcription of rRNA genes by RNAPol I and enhances protein synthesis and cell growth.{ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516,ECO:0000269|PubMed:21555369}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGAP3chr17:37840850chr17:37880979ENST00000300658-38120_135144321Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr17:37880979ENST00000300658-3821_98144321Topological domainLumenal
HgenePGAP3chr17:37840850chr17:37880979ENST00000300658-3899_119144321TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePGAP3chr17:37840850chr17:37880979ENST00000300658-38157_169144321Topological domainLumenal
HgenePGAP3chr17:37840850chr17:37880979ENST00000300658-38191_193144321Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr17:37880979ENST00000300658-38215_224144321Topological domainLumenal
HgenePGAP3chr17:37840850chr17:37880979ENST00000300658-38246_257144321Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr17:37880979ENST00000300658-38279_279144321Topological domainLumenal
HgenePGAP3chr17:37840850chr17:37880979ENST00000300658-38300_320144321Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr17:37880979ENST00000378011-17120_135-15270Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr17:37880979ENST00000378011-17157_169-15270Topological domainLumenal
HgenePGAP3chr17:37840850chr17:37880979ENST00000378011-17191_193-15270Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr17:37880979ENST00000378011-17215_224-15270Topological domainLumenal
HgenePGAP3chr17:37840850chr17:37880979ENST00000378011-1721_98-15270Topological domainLumenal
HgenePGAP3chr17:37840850chr17:37880979ENST00000378011-17246_257-15270Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr17:37880979ENST00000378011-17279_279-15270Topological domainLumenal
HgenePGAP3chr17:37840850chr17:37880979ENST00000378011-17300_320-15270Topological domainCytoplasmic
HgenePGAP3chr17:37840850chr17:37880979ENST00000300658-38136_156144321TransmembraneHelical
HgenePGAP3chr17:37840850chr17:37880979ENST00000300658-38170_190144321TransmembraneHelical
HgenePGAP3chr17:37840850chr17:37880979ENST00000300658-38194_214144321TransmembraneHelical
HgenePGAP3chr17:37840850chr17:37880979ENST00000300658-38225_245144321TransmembraneHelical
HgenePGAP3chr17:37840850chr17:37880979ENST00000300658-38258_278144321TransmembraneHelical
HgenePGAP3chr17:37840850chr17:37880979ENST00000300658-38280_299144321TransmembraneHelical
HgenePGAP3chr17:37840850chr17:37880979ENST00000378011-17136_156-15270TransmembraneHelical
HgenePGAP3chr17:37840850chr17:37880979ENST00000378011-17170_190-15270TransmembraneHelical
HgenePGAP3chr17:37840850chr17:37880979ENST00000378011-17194_214-15270TransmembraneHelical
HgenePGAP3chr17:37840850chr17:37880979ENST00000378011-17225_245-15270TransmembraneHelical
HgenePGAP3chr17:37840850chr17:37880979ENST00000378011-17258_278-15270TransmembraneHelical
HgenePGAP3chr17:37840850chr17:37880979ENST00000378011-17280_299-15270TransmembraneHelical
HgenePGAP3chr17:37840850chr17:37880979ENST00000378011-1799_119-15270TransmembraneHelical
TgeneERBB2chr17:37840850chr17:37880979ENST00000269571+1827720_9877691256DomainProtein kinase
TgeneERBB2chr17:37840850chr17:37880979ENST00000541774+1827720_9877541241DomainProtein kinase
TgeneERBB2chr17:37840850chr17:37880979ENST00000269571+1827676_6897691256MotifNote=Nuclear localization signal
TgeneERBB2chr17:37840850chr17:37880979ENST00000541774+1827676_6897541241MotifNote=Nuclear localization signal
TgeneERBB2chr17:37840850chr17:37880979ENST00000269571+1827726_7347691256Nucleotide bindingATP
TgeneERBB2chr17:37840850chr17:37880979ENST00000541774+1827726_7347541241Nucleotide bindingATP
TgeneERBB2chr17:37840850chr17:37880979ENST00000269571+182723_6527691256Topological domainExtracellular
TgeneERBB2chr17:37840850chr17:37880979ENST00000269571+1827676_12557691256Topological domainCytoplasmic
TgeneERBB2chr17:37840850chr17:37880979ENST00000541774+182723_6527541241Topological domainExtracellular
TgeneERBB2chr17:37840850chr17:37880979ENST00000541774+1827676_12557541241Topological domainCytoplasmic
TgeneERBB2chr17:37840850chr17:37880979ENST00000269571+1827653_6757691256TransmembraneHelical
TgeneERBB2chr17:37840850chr17:37880979ENST00000541774+1827653_6757541241TransmembraneHelical


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FusionGeneSequence for PGAP3_ERBB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PGAP3_ERBB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PGAP3TBRG4, VKORC1L1ERBB2SHC1, SH3BGRL, PTPN11, GRB2, MUC1, CTNNB1, ERBB2, CD82, EGF, PAK1, ERBB2IP, PICK1, PIK3R2, DLG4, ERBB4, NRG1, JUP, STAT3, SRC, JAK2, HSP90B1, CD44, GRB7, PLCG1, IL6ST, OSMR, PTK2B, HSP90AA1, ELF3, EGFR, ERBB3, HDAC6, LRIG1, STUB1, HSPA4, IGF1R, CUL5, ESR1, PPP1R13B, H2AFY, PIK3R1, PIN1, PTK6, ACTB, POLR1B, KPNB1, XPO1, CLTC, AP2B1, EEA1, APBB1, SH2B2, IRS4, SH2D1B, SOCS1, NCK2, DAB1, GRAP2, APBB3, ABL1, FGR, CHN1, FER, PLCG2, RASA1, JAK1, IRS1, STAT1, MATK, TEC, TXK, ABL2, SYK, CRK, CRKL, BLK, BMX, VAV2, SH3BP2, SHC2, ITK, SLA, MAPK8IP2, RIN1, BCAR3, TENC1, TNS3, DOK6, SH2D5, SUPT6H, ANKS1B, CLNK, DOK4, BLNK, RIN2, SHC3, PIK3R3, ANKS1A, VAV1, DOK1, SH2D3A, SLA2, SH2D2A, CISH, VAV3, MAPK8IP1, SH2B3, TLN1, SRPK1, CBL, ERRFI1, FRS3, USP2, NXF1, DTWD2, TGFBR2, NAALADL2, LPAR6, VSIG4, PTGER3, CYP17A1, GLCE, IL13RA2, KLK5, LYPD3, NAT2, PRDM14, PSMC3IP, RHOBTB2, THRSP, ANXA6, BAI1, CLCN6, GMPR2, HDLBP, IARS, MTCH1, MUCL1, PHF23, POLD2, PSAP, STK24, TCEAL2, ATP6AP1, TTC9B, UTP18, ATP1A1, EEF1G, TNPO1, PC, SURF4, TFRC, VAPB, PTDSS1, HPSE, ZNF280C, CCDC88A, ZNF622, BTC, PTK2, TGFA, BCAR1, ESRRB, CDC37, EZR, RDX, ITGAV, L1CAM, ITGB1, CHEK2, TOP1, RRM2, CDK4, CDH2, CDH1, PTPN6, PTPRR, PTPRT, PTPRU, PTPRA, PTPRH, MPZL2, SSH1, CD79B, MAS1, HAVCR2, IL4R, PPM1A, PPM1F, ILKAP, DUSP14, DUSP18, DUSP19, STYX, GAB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneERBB2chr17:37840850chr17:37880979ENST00000269571+18271195_11977691256PIK3C2B
TgeneERBB2chr17:37840850chr17:37880979ENST00000541774+18271195_11977541241PIK3C2B


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PGAP3_ERBB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneERBB2P04626DB06366PertuzumabReceptor tyrosine-protein kinase erbB-2biotechapproved
TgeneERBB2P04626DB08916AfatinibReceptor tyrosine-protein kinase erbB-2small moleculeapproved
TgeneERBB2P04626DB00072TrastuzumabReceptor tyrosine-protein kinase erbB-2biotechapproved|investigational
TgeneERBB2P04626DB01259LapatinibReceptor tyrosine-protein kinase erbB-2small moleculeapproved|investigational
TgeneERBB2P04626DB05773Trastuzumab emtansineReceptor tyrosine-protein kinase erbB-2biotechapproved|investigational

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RelatedDiseases for PGAP3_ERBB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePGAP3C3810354HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 41UNIPROT
TgeneERBB2C1458155Mammary Neoplasms40CTD_human
TgeneERBB2C0033578Prostatic Neoplasms3CTD_human
TgeneERBB2C0038356Stomach Neoplasms3CTD_human
TgeneERBB2C0001418Adenocarcinoma2CTD_human
TgeneERBB2C0024668Mammary Neoplasms, Experimental2CTD_human
TgeneERBB2C0919267ovarian neoplasm2CTD_human
TgeneERBB2C0007117Basal cell carcinoma1CTD_human
TgeneERBB2C0007134Renal Cell Carcinoma1CTD_human
TgeneERBB2C0009375Colonic Neoplasms1CTD_human
TgeneERBB2C0014859Esophageal Neoplasms1CTD_human
TgeneERBB2C0016978gallbladder neoplasm1CTD_human
TgeneERBB2C0017185Gastrointestinal Neoplasms1CTD_human
TgeneERBB2C0024121Lung Neoplasms1CTD_human
TgeneERBB2C0024232Lymphatic Metastasis1CTD_human
TgeneERBB2C0024667Animal Mammary Neoplasms1CTD_human
TgeneERBB2C0025149Medulloblastoma1CTD_human
TgeneERBB2C0027627Neoplasm Metastasis1CTD_human
TgeneERBB2C0027643Neoplasm Recurrence, Local1CTD_human
TgeneERBB2C0027659Neoplasms, Experimental1CTD_human
TgeneERBB2C0030354Papilloma1CTD_human
TgeneERBB2C0206698Cholangiocarcinoma1CTD_human
TgeneERBB2C0596263Carcinogenesis1CTD_human
TgeneERBB2C2931822Nasopharyngeal carcinoma1CTD_human