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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26767

FusionGeneSummary for PFKP_CAMK2G

check button Fusion gene summary
Fusion gene informationFusion gene name: PFKP_CAMK2G
Fusion gene ID: 26767
HgeneTgene
Gene symbol

PFKP

CAMK2G

Gene ID

5214

818

Gene namephosphofructokinase, plateletcalcium/calmodulin dependent protein kinase II gamma
SynonymsATP-PFK|PFK-C|PFK-P|PFKFCAMK|CAMK-II|CAMKG
Cytomap

10p15.2

10q22.2

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent 6-phosphofructokinase, platelet type6-phosphofructokinase type C6-phosphofructokinase, platelet typephosphofructo-1-kinase isozyme Cphosphofructokinase 1phosphohexokinasecalcium/calmodulin-dependent protein kinase type II subunit gammacaMK-II subunit gammacalcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
Modification date2018052320180527
UniProtAcc

Q01813

Q13555

Ensembl transtripts involved in fusion geneENST00000381125, ENST00000381075, 
ENST00000421751, ENST00000381072, 
ENST00000351293, ENST00000322635, 
ENST00000394762, ENST00000423381, 
ENST00000322680, ENST00000305762, 
ENST00000372765, ENST00000472912, 
ENST00000444854, 
Fusion gene scores* DoF score4 X 4 X 2=326 X 6 X 4=144
# samples 47
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PFKP [Title/Abstract] AND CAMK2G [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCAMK2G

GO:0051259

protein complex oligomerization

20668654


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-4Z-AA84-01APFKPchr10

3159038

+CAMK2Gchr10

75620647

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000381125ENST00000351293PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
Frame-shiftENST00000381125ENST00000322635PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
Frame-shiftENST00000381125ENST00000394762PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
Frame-shiftENST00000381125ENST00000423381PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
Frame-shiftENST00000381125ENST00000322680PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
Frame-shiftENST00000381125ENST00000305762PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
Frame-shiftENST00000381125ENST00000372765PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
5CDS-5UTRENST00000381125ENST00000472912PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
5CDS-5UTRENST00000381125ENST00000444854PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
Frame-shiftENST00000381075ENST00000351293PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
Frame-shiftENST00000381075ENST00000322635PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
Frame-shiftENST00000381075ENST00000394762PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
Frame-shiftENST00000381075ENST00000423381PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
Frame-shiftENST00000381075ENST00000322680PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
Frame-shiftENST00000381075ENST00000305762PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
Frame-shiftENST00000381075ENST00000372765PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
5CDS-5UTRENST00000381075ENST00000472912PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
5CDS-5UTRENST00000381075ENST00000444854PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-3CDSENST00000421751ENST00000351293PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-3CDSENST00000421751ENST00000322635PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-3CDSENST00000421751ENST00000394762PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-3CDSENST00000421751ENST00000423381PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-3CDSENST00000421751ENST00000322680PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-3CDSENST00000421751ENST00000305762PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-3CDSENST00000421751ENST00000372765PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-5UTRENST00000421751ENST00000472912PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-5UTRENST00000421751ENST00000444854PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-3CDSENST00000381072ENST00000351293PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-3CDSENST00000381072ENST00000322635PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-3CDSENST00000381072ENST00000394762PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-3CDSENST00000381072ENST00000423381PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-3CDSENST00000381072ENST00000322680PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-3CDSENST00000381072ENST00000305762PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-3CDSENST00000381072ENST00000372765PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-5UTRENST00000381072ENST00000472912PFKPchr10

3159038

+CAMK2Gchr10

75620647

-
intron-5UTRENST00000381072ENST00000444854PFKPchr10

3159038

+CAMK2Gchr10

75620647

-

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FusionProtFeatures for PFKP_CAMK2G


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PFKP

Q01813

CAMK2G

Q13555

Catalyzes the phosphorylation of D-fructose 6-phosphateto fructose 1,6-bisphosphate by ATP, the first committing step ofglycolysis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PFKP_CAMK2G


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PFKP_CAMK2G


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PFKPMCC, DMWD, GBAS, WIPI2, SIRT7, PARD3, FBXO25, TERF1, TINF2, ACD, POT1, CUL3, COPS5, PFKL, PFKM, TMPO, EPRS, FN1, ITGA4, CD81, SOX2, HDAC6, EGFR, WNK1, AGO2, HIPK4, MAPK4, FBXO6, CRYZ, PCBP1, EEF1A1, PPIB, TUBB4B, VAT1, ILK, CUL7, CCDC8, FAF2, ALDH16A1, ARFIP1, ARHGAP1, CCDC22, DNAJC9, MCFD2, MCMBP, MTHFD1, NMD3, NPEPL1, OXSR1, ARHGDIA, CDA, COMMD4, ELAC2, FUS, METTL13, PYGL, RSU1, UBA6, PKM, PLCG1, PSMG1, PTPN6, SAMD9, SNW1, TXLNA, NTRK1, SKI, MCM2, CDC5L, EID1, RNF126, SENP3, CDH1, NELL1, IFT122, WDR19, TRIM25, BRCA1, YAP1, MCM9CAMK2GCALM1, RRAD, SMAD2, SMAD4, USP19, RCHY1, BCL10, MALT1, MYC, CUL3, HSP90AA1, GRIN1, GRIN2B, STMN1, SIVA1, CAMK2A, TIRAP, ECHS1, DACT2, ARHGAP25, NDUFA8, DDX11, PDLIM5, SBDS, CAPZA2, DBN1, IGBP1, TUBG1, IQGAP1, SYNPO, ANLN, THOC2, FLNA, SMAD3, CAMK2D, RBM42, ZNF488


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PFKP_CAMK2G


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCAMK2GQ13555DB06616BosutinibCalcium/calmodulin-dependent protein kinase type II subunit gammasmall moleculeapproved

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RelatedDiseases for PFKP_CAMK2G


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePFKPC0023893Liver Cirrhosis, Experimental1CTD_human