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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26751

FusionGeneSummary for PFKFB3_ECM1

check button Fusion gene summary
Fusion gene informationFusion gene name: PFKFB3_ECM1
Fusion gene ID: 26751
HgeneTgene
Gene symbol

PFKFB3

ECM1

Gene ID

5209

1893

Gene name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3extracellular matrix protein 1
SynonymsIPFK2|PFK2|iPFK-2URBWD
Cytomap

10p15.1

1q21.2

Type of geneprotein-codingprotein-coding
Description6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 36-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase6PF-2-K/Fru-2,6-P2ase 36PF-2-K/Fru-2,6-P2ase brain/placenta-type isozymePFK/FBPase 3fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphataseextracellular matrix protein 1secretory component p85testicular tissue protein Li 61
Modification date2018052420180522
UniProtAcc

Q16875

Q16610

Ensembl transtripts involved in fusion geneENST00000536985, ENST00000379789, 
ENST00000540253, ENST00000317350, 
ENST00000379785, ENST00000379782, 
ENST00000360521, ENST00000379775, 
ENST00000470432, ENST00000369049, 
ENST00000369047, ENST00000346569, 
Fusion gene scores* DoF score9 X 8 X 4=2881 X 1 X 1=1
# samples 91
** MAII scorelog2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: PFKFB3 [Title/Abstract] AND ECM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneECM1

GO:0001938

positive regulation of endothelial cell proliferation

11292659

TgeneECM1

GO:0010466

negative regulation of peptidase activity

16512877

TgeneECM1

GO:0030502

negative regulation of bone mineralization

11165938

TgeneECM1

GO:0045766

positive regulation of angiogenesis

11292659


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF826291PFKFB3chr10

6268297

+ECM1chr1

150484160

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000536985ENST00000470432PFKFB3chr10

6268297

+ECM1chr1

150484160

+
3UTR-3UTRENST00000536985ENST00000369049PFKFB3chr10

6268297

+ECM1chr1

150484160

+
3UTR-3UTRENST00000536985ENST00000369047PFKFB3chr10

6268297

+ECM1chr1

150484160

+
3UTR-intronENST00000536985ENST00000346569PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000379789ENST00000470432PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000379789ENST00000369049PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000379789ENST00000369047PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-intronENST00000379789ENST00000346569PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000540253ENST00000470432PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000540253ENST00000369049PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000540253ENST00000369047PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-intronENST00000540253ENST00000346569PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000317350ENST00000470432PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000317350ENST00000369049PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000317350ENST00000369047PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-intronENST00000317350ENST00000346569PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000379785ENST00000470432PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000379785ENST00000369049PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000379785ENST00000369047PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-intronENST00000379785ENST00000346569PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000379782ENST00000470432PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000379782ENST00000369049PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000379782ENST00000369047PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-intronENST00000379782ENST00000346569PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000360521ENST00000470432PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000360521ENST00000369049PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000360521ENST00000369047PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-intronENST00000360521ENST00000346569PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000379775ENST00000470432PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000379775ENST00000369049PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-3UTRENST00000379775ENST00000369047PFKFB3chr10

6268297

+ECM1chr1

150484160

+
5CDS-intronENST00000379775ENST00000346569PFKFB3chr10

6268297

+ECM1chr1

150484160

+

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FusionProtFeatures for PFKFB3_ECM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PFKFB3

Q16875

ECM1

Q16610

Synthesis and degradation of fructose 2,6-bisphosphate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PFKFB3_ECM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PFKFB3_ECM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PFKFB3_ECM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PFKFB3_ECM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePFKFB3C0005586Bipolar Disorder1PSYGENET
HgenePFKFB3C0011570Mental Depression1PSYGENET
HgenePFKFB3C0028754Obesity1CTD_human
HgenePFKFB3C0037274Dermatologic disorders1CTD_human
HgenePFKFB3C0041696Unipolar Depression1PSYGENET
HgenePFKFB3C0151744Myocardial Ischemia1CTD_human
HgenePFKFB3C0311375Arsenic Poisoning1CTD_human
HgenePFKFB3C0525045Mood Disorders1PSYGENET
HgenePFKFB3C1269683Major Depressive Disorder1PSYGENET
TgeneECM1C0000786Spontaneous abortion1CTD_human
TgeneECM1C0009324Ulcerative Colitis1CTD_human
TgeneECM1C0023795Lipoid Proteinosis of Urbach and Wiethe1CTD_human;ORPHANET;UNIPROT