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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2674

FusionGeneSummary for ARID4B_PCNXL2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID4B_PCNXL2
Fusion gene ID: 2674
HgeneTgene
Gene symbol

ARID4B

PCNXL2

Gene ID

51742

80003

Gene nameAT-rich interaction domain 4Bpecanex homolog 2
SynonymsBCAA|BRCAA1|RBBP1L1|RBP1L1|SAP180PCNXL2
Cytomap

1q42.3

1q42.2

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 4B180 kDa Sin3-associated polypeptideARID domain-containing protein 4BAT rich interactive domain 4B (RBP1-like)Rb-binding protein homologSIN3A-associated protein 180breast cancer-associated antigen 1brepecanex-like protein 2
Modification date2018052320180519
UniProtAcc

Q4LE39

Ensembl transtripts involved in fusion geneENST00000366603, ENST00000264183, 
ENST00000349213, ENST00000494543, 
ENST00000258229, ENST00000344698, 
ENST00000488780, ENST00000520463, 
ENST00000430153, 
Fusion gene scores* DoF score15 X 13 X 7=13654 X 3 X 3=36
# samples 164
** MAII scorelog2(16/1365*10)=-3.09275714091985
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARID4B [Title/Abstract] AND PCNXL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-OL-A5D8-01AARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000366603ENST00000258229ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
5CDS-intronENST00000366603ENST00000344698ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
5CDS-intronENST00000366603ENST00000488780ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
5CDS-intronENST00000366603ENST00000520463ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
5CDS-intronENST00000366603ENST00000430153ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
Frame-shiftENST00000264183ENST00000258229ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
5CDS-intronENST00000264183ENST00000344698ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
5CDS-intronENST00000264183ENST00000488780ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
5CDS-intronENST00000264183ENST00000520463ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
5CDS-intronENST00000264183ENST00000430153ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
Frame-shiftENST00000349213ENST00000258229ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
5CDS-intronENST00000349213ENST00000344698ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
5CDS-intronENST00000349213ENST00000488780ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
5CDS-intronENST00000349213ENST00000520463ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
5CDS-intronENST00000349213ENST00000430153ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
intron-3CDSENST00000494543ENST00000258229ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
intron-intronENST00000494543ENST00000344698ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
intron-intronENST00000494543ENST00000488780ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
intron-intronENST00000494543ENST00000520463ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-
intron-intronENST00000494543ENST00000430153ARID4Bchr1

235420475

-PCNXL2chr1

233314921

-

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FusionProtFeatures for ARID4B_PCNXL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARID4B

Q4LE39

PCNXL2

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARID4B_PCNXL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARID4B_PCNXL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARID4BSIN3A, HDAC1, HDAC2, SUDS3, SAP130, ING2, RANBP2, ARID4A, SIRT1, ETS1, DDB1, CUL4B, MXD1, CASP1, CTSK, RBBP7, LACC1, LOC101929876, RPS26, SAP30, NTRK1, HIST1H2BG, KIF11, FOXK1, FOXK2, FBXW7, GATAD1, FAM60A, MXD3, ZNF704, PHF23, YAF2, TRIM25PCNXL2MUS81, PTTG1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARID4B_PCNXL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARID4B_PCNXL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARID4BC0010606Adenoid Cystic Carcinoma1CTD_human