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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26711

FusionGeneSummary for PEX16_PEX16

check button Fusion gene summary
Fusion gene informationFusion gene name: PEX16_PEX16
Fusion gene ID: 26711
HgeneTgene
Gene symbol

PEX16

PEX16

Gene ID

9409

9409

Gene nameperoxisomal biogenesis factor 16peroxisomal biogenesis factor 16
SynonymsPBD8A|PBD8BPBD8A|PBD8B
Cytomap

11p11.2

11p11.2

Type of geneprotein-codingprotein-coding
Descriptionperoxisomal biogenesis factor 16peroxin 16peroxisomal membrane protein PEX16peroxisome biogenesis factor 16peroxisomal biogenesis factor 16peroxin 16peroxisomal membrane protein PEX16peroxisome biogenesis factor 16
Modification date2018052320180523
UniProtAcc

Q9Y5Y5

Q9Y5Y5

Ensembl transtripts involved in fusion geneENST00000241041, ENST00000378750, 
ENST00000532681, ENST00000532554, 
ENST00000241041, ENST00000378750, 
ENST00000532681, ENST00000532554, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: PEX16 [Title/Abstract] AND PEX16 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePEX16

GO:0022615

protein to membrane docking

19114594

HgenePEX16

GO:0032581

ER-dependent peroxisome organization

16717127

HgenePEX16

GO:0106101

ER-dependent peroxisome localization

19479899

TgenePEX16

GO:0022615

protein to membrane docking

19114594

TgenePEX16

GO:0032581

ER-dependent peroxisome organization

16717127

TgenePEX16

GO:0106101

ER-dependent peroxisome localization

19479899


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA357684PEX16chr11

45939367

+PEX16chr11

45937838

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000241041ENST00000241041PEX16chr11

45939367

+PEX16chr11

45937838

-
intron-3CDSENST00000241041ENST00000378750PEX16chr11

45939367

+PEX16chr11

45937838

-
intron-5UTRENST00000241041ENST00000532681PEX16chr11

45939367

+PEX16chr11

45937838

-
intron-intronENST00000241041ENST00000532554PEX16chr11

45939367

+PEX16chr11

45937838

-
intron-3CDSENST00000378750ENST00000241041PEX16chr11

45939367

+PEX16chr11

45937838

-
intron-3CDSENST00000378750ENST00000378750PEX16chr11

45939367

+PEX16chr11

45937838

-
intron-5UTRENST00000378750ENST00000532681PEX16chr11

45939367

+PEX16chr11

45937838

-
intron-intronENST00000378750ENST00000532554PEX16chr11

45939367

+PEX16chr11

45937838

-
intron-3CDSENST00000532681ENST00000241041PEX16chr11

45939367

+PEX16chr11

45937838

-
intron-3CDSENST00000532681ENST00000378750PEX16chr11

45939367

+PEX16chr11

45937838

-
intron-5UTRENST00000532681ENST00000532681PEX16chr11

45939367

+PEX16chr11

45937838

-
intron-intronENST00000532681ENST00000532554PEX16chr11

45939367

+PEX16chr11

45937838

-
intron-3CDSENST00000532554ENST00000241041PEX16chr11

45939367

+PEX16chr11

45937838

-
intron-3CDSENST00000532554ENST00000378750PEX16chr11

45939367

+PEX16chr11

45937838

-
intron-5UTRENST00000532554ENST00000532681PEX16chr11

45939367

+PEX16chr11

45937838

-
intron-intronENST00000532554ENST00000532554PEX16chr11

45939367

+PEX16chr11

45937838

-

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FusionProtFeatures for PEX16_PEX16


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PEX16

Q9Y5Y5

PEX16

Q9Y5Y5

Required for peroxisome membrane biogenesis. May play arole in early stages of peroxisome assembly. Can recruit otherperoxisomal proteins, such as PEX3 and PMP34, to de novoperoxisomes derived from the endoplasmic reticulum (ER). Mayfunction as receptor for PEX3. {ECO:0000269|PubMed:10704444,ECO:0000269|PubMed:12223482, ECO:0000269|PubMed:16717127}. Required for peroxisome membrane biogenesis. May play arole in early stages of peroxisome assembly. Can recruit otherperoxisomal proteins, such as PEX3 and PMP34, to de novoperoxisomes derived from the endoplasmic reticulum (ER). Mayfunction as receptor for PEX3. {ECO:0000269|PubMed:10704444,ECO:0000269|PubMed:12223482, ECO:0000269|PubMed:16717127}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PEX16_PEX16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PEX16_PEX16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PEX16_PEX16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PEX16_PEX16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePEX16C1832200Peroxisome biogenesis disorders2CTD_human
HgenePEX16C0043459Zellweger Syndrome1CTD_human;ORPHANET
HgenePEX16C3553960PEROXISOME BIOGENESIS DISORDER 8B1UNIPROT
TgenePEX16C1832200Peroxisome biogenesis disorders2CTD_human
TgenePEX16C0043459Zellweger Syndrome1CTD_human;ORPHANET
TgenePEX16C3553960PEROXISOME BIOGENESIS DISORDER 8B1UNIPROT