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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26690

FusionGeneSummary for PER3_TP53I11

check button Fusion gene summary
Fusion gene informationFusion gene name: PER3_TP53I11
Fusion gene ID: 26690
HgeneTgene
Gene symbol

PER3

TP53I11

Gene ID

8863

9537

Gene nameperiod circadian regulator 3tumor protein p53 inducible protein 11
SynonymsFASPS3|GIG13PIG11
Cytomap

1p36.23

11p11.2

Type of geneprotein-codingprotein-coding
Descriptionperiod circadian protein homolog 3cell growth-inhibiting gene 13 proteincircadian clock protein PERIOD 3hPER3period circadian clock 3period circadian protein 3tumor protein p53-inducible protein 11p53-induced gene 11 protein
Modification date2018052320180519
UniProtAcc

P56645

O14683

Ensembl transtripts involved in fusion geneENST00000377532, ENST00000361923, 
ENST00000377541, 
ENST00000395648, 
ENST00000308212, ENST00000533940, 
ENST00000525680, ENST00000531130, 
ENST00000531928, 
Fusion gene scores* DoF score9 X 8 X 5=3604 X 4 X 2=32
# samples 84
** MAII scorelog2(8/360*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PER3 [Title/Abstract] AND TP53I11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePER3

GO:0000122

negative regulation of transcription by RNA polymerase II

26903630


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM546204PER3chr1

7887697

+TP53I11chr11

44956035

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000377532ENST00000395648PER3chr1

7887697

+TP53I11chr11

44956035

-
5CDS-3UTRENST00000377532ENST00000308212PER3chr1

7887697

+TP53I11chr11

44956035

-
5CDS-3UTRENST00000377532ENST00000533940PER3chr1

7887697

+TP53I11chr11

44956035

-
5CDS-3UTRENST00000377532ENST00000525680PER3chr1

7887697

+TP53I11chr11

44956035

-
5CDS-intronENST00000377532ENST00000531130PER3chr1

7887697

+TP53I11chr11

44956035

-
5CDS-intronENST00000377532ENST00000531928PER3chr1

7887697

+TP53I11chr11

44956035

-
5CDS-3UTRENST00000361923ENST00000395648PER3chr1

7887697

+TP53I11chr11

44956035

-
5CDS-3UTRENST00000361923ENST00000308212PER3chr1

7887697

+TP53I11chr11

44956035

-
5CDS-3UTRENST00000361923ENST00000533940PER3chr1

7887697

+TP53I11chr11

44956035

-
5CDS-3UTRENST00000361923ENST00000525680PER3chr1

7887697

+TP53I11chr11

44956035

-
5CDS-intronENST00000361923ENST00000531130PER3chr1

7887697

+TP53I11chr11

44956035

-
5CDS-intronENST00000361923ENST00000531928PER3chr1

7887697

+TP53I11chr11

44956035

-
intron-3UTRENST00000377541ENST00000395648PER3chr1

7887697

+TP53I11chr11

44956035

-
intron-3UTRENST00000377541ENST00000308212PER3chr1

7887697

+TP53I11chr11

44956035

-
intron-3UTRENST00000377541ENST00000533940PER3chr1

7887697

+TP53I11chr11

44956035

-
intron-3UTRENST00000377541ENST00000525680PER3chr1

7887697

+TP53I11chr11

44956035

-
intron-intronENST00000377541ENST00000531130PER3chr1

7887697

+TP53I11chr11

44956035

-
intron-intronENST00000377541ENST00000531928PER3chr1

7887697

+TP53I11chr11

44956035

-

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FusionProtFeatures for PER3_TP53I11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PER3

P56645

TP53I11

O14683


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PER3_TP53I11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PER3_TP53I11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PER3_TP53I11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PER3_TP53I11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePER3C0005586Bipolar Disorder5PSYGENET
HgenePER3C0011570Mental Depression2PSYGENET
HgenePER3C0011581Depressive disorder2PSYGENET
HgenePER3C0085159Seasonal Affective Disorder2PSYGENET
HgenePER3C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgenePER3C0023473Myeloid Leukemia, Chronic1CTD_human
HgenePER3C0036341Schizophrenia1PSYGENET
HgenePER3C0038587Substance Withdrawal Syndrome1CTD_human
HgenePER3C1458155Mammary Neoplasms1CTD_human