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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26674

FusionGeneSummary for PEPD_ZNF829

check button Fusion gene summary
Fusion gene informationFusion gene name: PEPD_ZNF829
Fusion gene ID: 26674
HgeneTgene
Gene symbol

PEPD

ZNF829

Gene ID

5184

374899

Gene namepeptidase Dzinc finger protein 829
SynonymsPROLIDASE-
Cytomap

19q13.11

19q13.12

Type of geneprotein-codingprotein-coding
Descriptionxaa-Pro dipeptidaseX-Pro dipeptidaseaminoacyl-L-proline hydrolaseimidodipeptidaseproline dipeptidasetesticular tissue protein Li 138zinc finger protein 829
Modification date2018051920180519
UniProtAcc

P12955

Q3KNS6

Ensembl transtripts involved in fusion geneENST00000244137, ENST00000397032, 
ENST00000436370, ENST00000591968, 
ENST00000520965, ENST00000391711, 
Fusion gene scores* DoF score6 X 4 X 6=1442 X 2 X 2=8
# samples 62
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: PEPD [Title/Abstract] AND ZNF829 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1842-01APEPDchr19

34003499

-ZNF829chr19

37383373

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000244137ENST00000520965PEPDchr19

34003499

-ZNF829chr19

37383373

-
Frame-shiftENST00000244137ENST00000391711PEPDchr19

34003499

-ZNF829chr19

37383373

-
Frame-shiftENST00000397032ENST00000520965PEPDchr19

34003499

-ZNF829chr19

37383373

-
Frame-shiftENST00000397032ENST00000391711PEPDchr19

34003499

-ZNF829chr19

37383373

-
Frame-shiftENST00000436370ENST00000520965PEPDchr19

34003499

-ZNF829chr19

37383373

-
Frame-shiftENST00000436370ENST00000391711PEPDchr19

34003499

-ZNF829chr19

37383373

-
intron-3CDSENST00000591968ENST00000520965PEPDchr19

34003499

-ZNF829chr19

37383373

-
intron-3CDSENST00000591968ENST00000391711PEPDchr19

34003499

-ZNF829chr19

37383373

-

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FusionProtFeatures for PEPD_ZNF829


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PEPD

P12955

ZNF829

Q3KNS6

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PEPD_ZNF829


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PEPD_ZNF829


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PEPDTERF1, CUL2, ATXN1, SPP1, ASS1, BCCIP, CAPN1, CASP7, DLD, DPP3, EIF5A, FTO, GBP2, GDA, GINS2, GLS, GNS, LDHAL6B, MVD, NDRG1, CNDP2, EIF4E, EIF6, GSR, KYNU, NAMPT, NHLRC2, CTSA, RPS6KA1, USP7, MOV10, NXF1, GOT1, HSPE1, LDHA, LDHB, RPIA, SOD2, PSMG4, TANGO2ZNF829SMARCAD1, CBX5, KDM1A, SUV39H1, TRIM28, AIM1, APPL1, STAT3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PEPD_ZNF829


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PEPD_ZNF829


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePEPDC0268532Deficiency of prolidase5CTD_human;ORPHANET;UNIPROT
HgenePEPDC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgenePEPDC0019209Hepatomegaly1CTD_human;HPO
HgenePEPDC0035242Respiratory Tract Diseases1CTD_human
HgenePEPDC0037299Skin Ulcer1CTD_human;HPO
HgenePEPDC0038002Splenomegaly1CTD_human;HPO
HgenePEPDC0700359Organophosphate poisoning1CTD_human
HgenePEPDC3714514Infection1CTD_human