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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2667

FusionGeneSummary for ARID4B_CARD10

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID4B_CARD10
Fusion gene ID: 2667
HgeneTgene
Gene symbol

ARID4B

CARD10

Gene ID

51742

29775

Gene nameAT-rich interaction domain 4Bcaspase recruitment domain family member 10
SynonymsBCAA|BRCAA1|RBBP1L1|RBP1L1|SAP180BIMP1|CARMA3
Cytomap

1q42.3

22q13.1

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 4B180 kDa Sin3-associated polypeptideARID domain-containing protein 4BAT rich interactive domain 4B (RBP1-like)Rb-binding protein homologSIN3A-associated protein 180breast cancer-associated antigen 1brecaspase recruitment domain-containing protein 10Bcl10 binding protein and activator of NFKBCARD-containing MAGUK 3 proteinCARD-containing MAGUK protein 3carma 3
Modification date2018052320180519
UniProtAcc

Q4LE39

Q9BWT7

Ensembl transtripts involved in fusion geneENST00000366603, ENST00000264183, 
ENST00000349213, ENST00000494543, 
ENST00000403299, ENST00000406271, 
ENST00000251973, ENST00000494166, 
Fusion gene scores* DoF score15 X 13 X 7=13653 X 3 X 2=18
# samples 162
** MAII scorelog2(16/1365*10)=-3.09275714091985
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/18*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARID4B [Title/Abstract] AND CARD10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCARD10

GO:0007250

activation of NF-kappaB-inducing kinase activity

11259443


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A12K-01AARID4Bchr1

235311719

-CARD10chr22

37900776

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000366603ENST00000403299ARID4Bchr1

235311719

-CARD10chr22

37900776

-
intron-3CDSENST00000366603ENST00000406271ARID4Bchr1

235311719

-CARD10chr22

37900776

-
intron-3CDSENST00000366603ENST00000251973ARID4Bchr1

235311719

-CARD10chr22

37900776

-
intron-intronENST00000366603ENST00000494166ARID4Bchr1

235311719

-CARD10chr22

37900776

-
intron-3CDSENST00000264183ENST00000403299ARID4Bchr1

235311719

-CARD10chr22

37900776

-
intron-3CDSENST00000264183ENST00000406271ARID4Bchr1

235311719

-CARD10chr22

37900776

-
intron-3CDSENST00000264183ENST00000251973ARID4Bchr1

235311719

-CARD10chr22

37900776

-
intron-intronENST00000264183ENST00000494166ARID4Bchr1

235311719

-CARD10chr22

37900776

-
intron-3CDSENST00000349213ENST00000403299ARID4Bchr1

235311719

-CARD10chr22

37900776

-
intron-3CDSENST00000349213ENST00000406271ARID4Bchr1

235311719

-CARD10chr22

37900776

-
intron-3CDSENST00000349213ENST00000251973ARID4Bchr1

235311719

-CARD10chr22

37900776

-
intron-intronENST00000349213ENST00000494166ARID4Bchr1

235311719

-CARD10chr22

37900776

-
intron-3CDSENST00000494543ENST00000403299ARID4Bchr1

235311719

-CARD10chr22

37900776

-
intron-3CDSENST00000494543ENST00000406271ARID4Bchr1

235311719

-CARD10chr22

37900776

-
intron-3CDSENST00000494543ENST00000251973ARID4Bchr1

235311719

-CARD10chr22

37900776

-
intron-intronENST00000494543ENST00000494166ARID4Bchr1

235311719

-CARD10chr22

37900776

-

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FusionProtFeatures for ARID4B_CARD10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARID4B

Q4LE39

CARD10

Q9BWT7

Activates NF-kappa-B via BCL10 and IKK.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARID4B_CARD10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARID4B_CARD10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARID4BSIN3A, HDAC1, HDAC2, SUDS3, SAP130, ING2, RANBP2, ARID4A, SIRT1, ETS1, DDB1, CUL4B, MXD1, CASP1, CTSK, RBBP7, LACC1, LOC101929876, RPS26, SAP30, NTRK1, HIST1H2BG, KIF11, FOXK1, FOXK2, FBXW7, GATAD1, FAM60A, MXD3, ZNF704, PHF23, YAF2, TRIM25CARD10BCL10, ATXN7, IKBKG, CARD10, KLHL12, GFOD1, CAPZA2, DBN1, MYO1C, KIF20A, MYO19, CDC5L, FAM167A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARID4B_CARD10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARID4B_CARD10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARID4BC0010606Adenoid Cystic Carcinoma1CTD_human