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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26668

FusionGeneSummary for PENK_PLAT

check button Fusion gene summary
Fusion gene informationFusion gene name: PENK_PLAT
Fusion gene ID: 26668
HgeneTgene
Gene symbol

PENK

PLAT

Gene ID

5179

5327

Gene nameproenkephalinplasminogen activator, tissue type
SynonymsPE|PENK-AT-PA|TPA
Cytomap

8q12.1

8p11.21

Type of geneprotein-codingprotein-coding
Descriptionproenkephalin-Aenkephalin Apeptide Fpreproenkephalintissue-type plasminogen activatoralteplaseplasminogen/activator kringlereteplaset-plasminogen activator
Modification date2018052320180523
UniProtAcc

P01210

P00750

Ensembl transtripts involved in fusion geneENST00000314922, ENST00000451791, 
ENST00000523274, ENST00000523051, 
ENST00000518770, 
ENST00000270189, 
ENST00000429089, ENST00000220809, 
ENST00000352041, ENST00000519510, 
ENST00000429710, ENST00000524009, 
Fusion gene scores* DoF score1 X 1 X 1=127 X 5 X 11=1485
# samples 126
** MAII scorelog2(1/1*10)=3.32192809488736log2(26/1485*10)=-2.51387940265967
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PENK [Title/Abstract] AND PLAT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLAT

GO:0031639

plasminogen activation

12694198|17849409|24196407

TgenePLAT

GO:0045861

negative regulation of proteolysis

1695900


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPCPGTCGA-WB-A819-01APENKchr8

57353513

-PLATchr8

42051245

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000314922ENST00000270189PENKchr8

57353513

-PLATchr8

42051245

-
5CDS-intronENST00000314922ENST00000429089PENKchr8

57353513

-PLATchr8

42051245

-
5CDS-intronENST00000314922ENST00000220809PENKchr8

57353513

-PLATchr8

42051245

-
5CDS-intronENST00000314922ENST00000352041PENKchr8

57353513

-PLATchr8

42051245

-
5CDS-intronENST00000314922ENST00000519510PENKchr8

57353513

-PLATchr8

42051245

-
5CDS-intronENST00000314922ENST00000429710PENKchr8

57353513

-PLATchr8

42051245

-
5CDS-intronENST00000314922ENST00000524009PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000451791ENST00000270189PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000451791ENST00000429089PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000451791ENST00000220809PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000451791ENST00000352041PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000451791ENST00000519510PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000451791ENST00000429710PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000451791ENST00000524009PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000523274ENST00000270189PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000523274ENST00000429089PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000523274ENST00000220809PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000523274ENST00000352041PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000523274ENST00000519510PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000523274ENST00000429710PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000523274ENST00000524009PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000523051ENST00000270189PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000523051ENST00000429089PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000523051ENST00000220809PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000523051ENST00000352041PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000523051ENST00000519510PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000523051ENST00000429710PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000523051ENST00000524009PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000518770ENST00000270189PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000518770ENST00000429089PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000518770ENST00000220809PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000518770ENST00000352041PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000518770ENST00000519510PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000518770ENST00000429710PENKchr8

57353513

-PLATchr8

42051245

-
intron-intronENST00000518770ENST00000524009PENKchr8

57353513

-PLATchr8

42051245

-

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FusionProtFeatures for PENK_PLAT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PENK

P01210

PLAT

P00750

Met- and Leu-enkephalins compete with and mimic theeffects of opiate drugs. They play a role in a number ofphysiologic functions, including pain perception and responses tostress. PENK(114-133) and PENK(237-258) increase glutamate releasein the striatum. PENK(114-133) decreases GABA concentration in thestriatum.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PENK_PLAT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PENK_PLAT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PENKCDC27, CDC23, ANAPC5, ANAPC1, ANAPC4, ANAPC16, CDC26, PDYNPLATCLEC3B, CALR, PLAU, KRT8, ANXA2, SERPINI1, SERPINA5, F2, SERPINE1, FGA, LRP1, HMGB1, F10, FN1, LAMA1, TERF2, POT1, PDGFC, FGL1, DCN, TMEM25, PTPRK, IFNA14, LAMA3, SERPINB2, SERPING1, SERPINA10, PLA2G10, SERPINB6, SERPINE2, IGFBP1, DEFA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PENK_PLAT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePLATP00750DB01050IbuprofenTissue-type plasminogen activatorsmall moleculeapproved
TgenePLATP00750DB06404Human C1-esterase inhibitorTissue-type plasminogen activatorbiotechapproved
TgenePLATP00750DB00513Aminocaproic AcidTissue-type plasminogen activatorsmall moleculeapproved|investigational
TgenePLATP00750DB01088IloprostTissue-type plasminogen activatorsmall moleculeapproved|investigational
TgenePLATP00750DB09213DexibuprofenTissue-type plasminogen activatorsmall moleculeapproved|investigational
TgenePLATP00750DB09228Conestat alfaTissue-type plasminogen activatorbiotechapproved|investigational
TgenePLATP00750DB00013UrokinaseTissue-type plasminogen activatorbiotechapproved|investigational|withdrawn

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RelatedDiseases for PENK_PLAT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePENKC0011570Mental Depression4PSYGENET
HgenePENKC0011581Depressive disorder4PSYGENET
HgenePENKC0024809Marijuana Abuse3PSYGENET
HgenePENKC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgenePENKC0006870Cannabis Dependence1PSYGENET
HgenePENKC0013386Dyskinesia, Drug-Induced1CTD_human
HgenePENKC0027404Narcolepsy1CTD_human
HgenePENKC0027412Opioid-Related Disorders1CTD_human
HgenePENKC0027765nervous system disorder1CTD_human
HgenePENKC0030193Pain1CTD_human
HgenePENKC0033578Prostatic Neoplasms1CTD_human
HgenePENKC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgenePLATC0038454Cerebrovascular accident59CTD_human
TgenePLATC0027051Myocardial Infarction35CTD_human
TgenePLATC0007786Brain Ischemia25CTD_human
TgenePLATC2937358Cerebral Hemorrhage21CTD_human
TgenePLATC0151699Intracranial Hemorrhages14CTD_human
TgenePLATC0034065Pulmonary Embolism9CTD_human
TgenePLATC0019080Hemorrhage8CTD_human
TgenePLATC0007785Cerebral Infarction6CTD_human
TgenePLATC0040053Thrombosis4CTD_human
TgenePLATC0740392Infarction, Middle Cerebral Artery4CTD_human
TgenePLATC0002994Angioedema3CTD_human
TgenePLATC0010072Coronary Thrombosis3CTD_human
TgenePLATC0042487Venous Thrombosis3CTD_human
TgenePLATC0007781Intracranial Embolism and Thrombosis2CTD_human
TgenePLATC0877172Hematoma, Epidural, Spinal2CTD_human
TgenePLATC0001125Acidosis, Lactic1CTD_human
TgenePLATC0001883Airway Obstruction1CTD_human
TgenePLATC0003537Aphasia1CTD_human
TgenePLATC0003838Arterial Occlusive Diseases1CTD_human
TgenePLATC0004153Atherosclerosis1CTD_human
TgenePLATC0004604Back Pain1CTD_human
TgenePLATC0004610Bacteremia1CTD_human
TgenePLATC0007177Cardiac Tamponade1CTD_human
TgenePLATC0013922Embolism1CTD_human
TgenePLATC0018801Heart failure1CTD_human
TgenePLATC0018946Hematoma, Subdural1CTD_human
TgenePLATC0020538Hypertensive disease1CTD_human
TgenePLATC0020649Hypotension1CTD_human
TgenePLATC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePLATC0024031Low Back Pain1CTD_human
TgenePLATC0025309Meningoencephalitis1CTD_human
TgenePLATC0027746Nerve Degeneration1CTD_human
TgenePLATC0030552Paresis1CTD_human
TgenePLATC0031039Pericardial effusion1CTD_human
TgenePLATC0033975Psychotic Disorders1PSYGENET
TgenePLATC0035126Reperfusion Injury1CTD_human
TgenePLATC0035229Respiratory Insufficiency1CTD_human
TgenePLATC0036341Schizophrenia1PSYGENET
TgenePLATC0036980Shock, Cardiogenic1CTD_human
TgenePLATC0037926Compression of spinal cord1CTD_human
TgenePLATC0040038Thromboembolism1CTD_human
TgenePLATC0085307Embolism and Thrombosis1CTD_human
TgenePLATC0149649Cholesterol Embolism1CTD_human
TgenePLATC0162820Dermatitis, Allergic Contact1CTD_human
TgenePLATC0235032Neurotoxicity Syndromes1CTD_human
TgenePLATC0236733Amphetamine-Related Disorders1CTD_human
TgenePLATC0242184Hypoxia1CTD_human
TgenePLATC0242698Ventricular Dysfunction, Left1CTD_human
TgenePLATC0349204Nonorganic psychosis1PSYGENET
TgenePLATC0740858Substance abuse problem1PSYGENET
TgenePLATC0751895Vasospasm, Intracranial1CTD_human
TgenePLATC0751955Brain Infarction1CTD_human
TgenePLATC0752143Intracranial Thrombosis1CTD_human
TgenePLATC1861172Venous Thromboembolism1CTD_human
TgenePLATC4277682Chemical and Drug Induced Liver Injury1CTD_human