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Fusion gene ID: 26668 |
FusionGeneSummary for PENK_PLAT |
Fusion gene summary |
Fusion gene information | Fusion gene name: PENK_PLAT | Fusion gene ID: 26668 | Hgene | Tgene | Gene symbol | PENK | PLAT | Gene ID | 5179 | 5327 |
Gene name | proenkephalin | plasminogen activator, tissue type | |
Synonyms | PE|PENK-A | T-PA|TPA | |
Cytomap | 8q12.1 | 8p11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | proenkephalin-Aenkephalin Apeptide Fpreproenkephalin | tissue-type plasminogen activatoralteplaseplasminogen/activator kringlereteplaset-plasminogen activator | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P01210 | P00750 | |
Ensembl transtripts involved in fusion gene | ENST00000314922, ENST00000451791, ENST00000523274, ENST00000523051, ENST00000518770, | ENST00000270189, ENST00000429089, ENST00000220809, ENST00000352041, ENST00000519510, ENST00000429710, ENST00000524009, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 27 X 5 X 11=1485 |
# samples | 1 | 26 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(26/1485*10)=-2.51387940265967 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PENK [Title/Abstract] AND PLAT [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PLAT | GO:0031639 | plasminogen activation | 12694198|17849409|24196407 |
Tgene | PLAT | GO:0045861 | negative regulation of proteolysis | 1695900 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PCPG | TCGA-WB-A819-01A | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000314922 | ENST00000270189 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000314922 | ENST00000429089 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000314922 | ENST00000220809 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000314922 | ENST00000352041 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000314922 | ENST00000519510 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000314922 | ENST00000429710 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
5CDS-intron | ENST00000314922 | ENST00000524009 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000451791 | ENST00000270189 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000451791 | ENST00000429089 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000451791 | ENST00000220809 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000451791 | ENST00000352041 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000451791 | ENST00000519510 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000451791 | ENST00000429710 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000451791 | ENST00000524009 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000523274 | ENST00000270189 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000523274 | ENST00000429089 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000523274 | ENST00000220809 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000523274 | ENST00000352041 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000523274 | ENST00000519510 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000523274 | ENST00000429710 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000523274 | ENST00000524009 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000523051 | ENST00000270189 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000523051 | ENST00000429089 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000523051 | ENST00000220809 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000523051 | ENST00000352041 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000523051 | ENST00000519510 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000523051 | ENST00000429710 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000523051 | ENST00000524009 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000518770 | ENST00000270189 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000518770 | ENST00000429089 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000518770 | ENST00000220809 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000518770 | ENST00000352041 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000518770 | ENST00000519510 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000518770 | ENST00000429710 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
intron-intron | ENST00000518770 | ENST00000524009 | PENK | chr8 | 57353513 | - | PLAT | chr8 | 42051245 | - |
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FusionProtFeatures for PENK_PLAT |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PENK | PLAT |
Met- and Leu-enkephalins compete with and mimic theeffects of opiate drugs. They play a role in a number ofphysiologic functions, including pain perception and responses tostress. PENK(114-133) and PENK(237-258) increase glutamate releasein the striatum. PENK(114-133) decreases GABA concentration in thestriatum. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PENK_PLAT |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PENK_PLAT |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PENK | CDC27, CDC23, ANAPC5, ANAPC1, ANAPC4, ANAPC16, CDC26, PDYN | PLAT | CLEC3B, CALR, PLAU, KRT8, ANXA2, SERPINI1, SERPINA5, F2, SERPINE1, FGA, LRP1, HMGB1, F10, FN1, LAMA1, TERF2, POT1, PDGFC, FGL1, DCN, TMEM25, PTPRK, IFNA14, LAMA3, SERPINB2, SERPING1, SERPINA10, PLA2G10, SERPINB6, SERPINE2, IGFBP1, DEFA1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PENK_PLAT |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PLAT | P00750 | DB01050 | Ibuprofen | Tissue-type plasminogen activator | small molecule | approved |
Tgene | PLAT | P00750 | DB06404 | Human C1-esterase inhibitor | Tissue-type plasminogen activator | biotech | approved |
Tgene | PLAT | P00750 | DB00513 | Aminocaproic Acid | Tissue-type plasminogen activator | small molecule | approved|investigational |
Tgene | PLAT | P00750 | DB01088 | Iloprost | Tissue-type plasminogen activator | small molecule | approved|investigational |
Tgene | PLAT | P00750 | DB09213 | Dexibuprofen | Tissue-type plasminogen activator | small molecule | approved|investigational |
Tgene | PLAT | P00750 | DB09228 | Conestat alfa | Tissue-type plasminogen activator | biotech | approved|investigational |
Tgene | PLAT | P00750 | DB00013 | Urokinase | Tissue-type plasminogen activator | biotech | approved|investigational|withdrawn |
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RelatedDiseases for PENK_PLAT |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PENK | C0011570 | Mental Depression | 4 | PSYGENET |
Hgene | PENK | C0011581 | Depressive disorder | 4 | PSYGENET |
Hgene | PENK | C0024809 | Marijuana Abuse | 3 | PSYGENET |
Hgene | PENK | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | PENK | C0006870 | Cannabis Dependence | 1 | PSYGENET |
Hgene | PENK | C0013386 | Dyskinesia, Drug-Induced | 1 | CTD_human |
Hgene | PENK | C0027404 | Narcolepsy | 1 | CTD_human |
Hgene | PENK | C0027412 | Opioid-Related Disorders | 1 | CTD_human |
Hgene | PENK | C0027765 | nervous system disorder | 1 | CTD_human |
Hgene | PENK | C0030193 | Pain | 1 | CTD_human |
Hgene | PENK | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | PENK | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
Tgene | PLAT | C0038454 | Cerebrovascular accident | 59 | CTD_human |
Tgene | PLAT | C0027051 | Myocardial Infarction | 35 | CTD_human |
Tgene | PLAT | C0007786 | Brain Ischemia | 25 | CTD_human |
Tgene | PLAT | C2937358 | Cerebral Hemorrhage | 21 | CTD_human |
Tgene | PLAT | C0151699 | Intracranial Hemorrhages | 14 | CTD_human |
Tgene | PLAT | C0034065 | Pulmonary Embolism | 9 | CTD_human |
Tgene | PLAT | C0019080 | Hemorrhage | 8 | CTD_human |
Tgene | PLAT | C0007785 | Cerebral Infarction | 6 | CTD_human |
Tgene | PLAT | C0040053 | Thrombosis | 4 | CTD_human |
Tgene | PLAT | C0740392 | Infarction, Middle Cerebral Artery | 4 | CTD_human |
Tgene | PLAT | C0002994 | Angioedema | 3 | CTD_human |
Tgene | PLAT | C0010072 | Coronary Thrombosis | 3 | CTD_human |
Tgene | PLAT | C0042487 | Venous Thrombosis | 3 | CTD_human |
Tgene | PLAT | C0007781 | Intracranial Embolism and Thrombosis | 2 | CTD_human |
Tgene | PLAT | C0877172 | Hematoma, Epidural, Spinal | 2 | CTD_human |
Tgene | PLAT | C0001125 | Acidosis, Lactic | 1 | CTD_human |
Tgene | PLAT | C0001883 | Airway Obstruction | 1 | CTD_human |
Tgene | PLAT | C0003537 | Aphasia | 1 | CTD_human |
Tgene | PLAT | C0003838 | Arterial Occlusive Diseases | 1 | CTD_human |
Tgene | PLAT | C0004153 | Atherosclerosis | 1 | CTD_human |
Tgene | PLAT | C0004604 | Back Pain | 1 | CTD_human |
Tgene | PLAT | C0004610 | Bacteremia | 1 | CTD_human |
Tgene | PLAT | C0007177 | Cardiac Tamponade | 1 | CTD_human |
Tgene | PLAT | C0013922 | Embolism | 1 | CTD_human |
Tgene | PLAT | C0018801 | Heart failure | 1 | CTD_human |
Tgene | PLAT | C0018946 | Hematoma, Subdural | 1 | CTD_human |
Tgene | PLAT | C0020538 | Hypertensive disease | 1 | CTD_human |
Tgene | PLAT | C0020649 | Hypotension | 1 | CTD_human |
Tgene | PLAT | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | PLAT | C0024031 | Low Back Pain | 1 | CTD_human |
Tgene | PLAT | C0025309 | Meningoencephalitis | 1 | CTD_human |
Tgene | PLAT | C0027746 | Nerve Degeneration | 1 | CTD_human |
Tgene | PLAT | C0030552 | Paresis | 1 | CTD_human |
Tgene | PLAT | C0031039 | Pericardial effusion | 1 | CTD_human |
Tgene | PLAT | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Tgene | PLAT | C0035126 | Reperfusion Injury | 1 | CTD_human |
Tgene | PLAT | C0035229 | Respiratory Insufficiency | 1 | CTD_human |
Tgene | PLAT | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | PLAT | C0036980 | Shock, Cardiogenic | 1 | CTD_human |
Tgene | PLAT | C0037926 | Compression of spinal cord | 1 | CTD_human |
Tgene | PLAT | C0040038 | Thromboembolism | 1 | CTD_human |
Tgene | PLAT | C0085307 | Embolism and Thrombosis | 1 | CTD_human |
Tgene | PLAT | C0149649 | Cholesterol Embolism | 1 | CTD_human |
Tgene | PLAT | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
Tgene | PLAT | C0235032 | Neurotoxicity Syndromes | 1 | CTD_human |
Tgene | PLAT | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Tgene | PLAT | C0242184 | Hypoxia | 1 | CTD_human |
Tgene | PLAT | C0242698 | Ventricular Dysfunction, Left | 1 | CTD_human |
Tgene | PLAT | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Tgene | PLAT | C0740858 | Substance abuse problem | 1 | PSYGENET |
Tgene | PLAT | C0751895 | Vasospasm, Intracranial | 1 | CTD_human |
Tgene | PLAT | C0751955 | Brain Infarction | 1 | CTD_human |
Tgene | PLAT | C0752143 | Intracranial Thrombosis | 1 | CTD_human |
Tgene | PLAT | C1861172 | Venous Thromboembolism | 1 | CTD_human |
Tgene | PLAT | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |