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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 26666

FusionGeneSummary for PEMT_SCUBE1

check button Fusion gene summary
Fusion gene informationFusion gene name: PEMT_SCUBE1
Fusion gene ID: 26666
HgeneTgene
Gene symbol

PEMT

SCUBE1

Gene ID

10400

80274

Gene namephosphatidylethanolamine N-methyltransferasesignal peptide, CUB domain and EGF like domain containing 1
SynonymsPEAMT|PEMPT|PEMT2|PLMT|PNMT-
Cytomap

17p11.2

22q13.2

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylethanolamine N-methyltransferasephospholipid methyltransferasesignal peptide, CUB and EGF-like domain-containing protein 1signal peptide, CUB domain, EGF-like 1signal peptide-CUB domain-EGF-related 1
Modification date2018052320180523
UniProtAcc

Q9UBM1

Q8IWY4

Ensembl transtripts involved in fusion geneENST00000395782, ENST00000395783, 
ENST00000435340, ENST00000255389, 
ENST00000395781, ENST00000484838, 
ENST00000360835, ENST00000290460, 
ENST00000470433, 
Fusion gene scores* DoF score9 X 4 X 6=2167 X 6 X 7=294
# samples 87
** MAII scorelog2(8/216*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PEMT [Title/Abstract] AND SCUBE1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-ER-A197-06APEMTchr17

17480234

-SCUBE1chr22

43654341

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000395782ENST00000360835PEMTchr17

17480234

-SCUBE1chr22

43654341

-
In-frameENST00000395782ENST00000290460PEMTchr17

17480234

-SCUBE1chr22

43654341

-
5CDS-intronENST00000395782ENST00000470433PEMTchr17

17480234

-SCUBE1chr22

43654341

-
Frame-shiftENST00000395783ENST00000360835PEMTchr17

17480234

-SCUBE1chr22

43654341

-
Frame-shiftENST00000395783ENST00000290460PEMTchr17

17480234

-SCUBE1chr22

43654341

-
5CDS-intronENST00000395783ENST00000470433PEMTchr17

17480234

-SCUBE1chr22

43654341

-
Frame-shiftENST00000435340ENST00000360835PEMTchr17

17480234

-SCUBE1chr22

43654341

-
Frame-shiftENST00000435340ENST00000290460PEMTchr17

17480234

-SCUBE1chr22

43654341

-
5CDS-intronENST00000435340ENST00000470433PEMTchr17

17480234

-SCUBE1chr22

43654341

-
Frame-shiftENST00000255389ENST00000360835PEMTchr17

17480234

-SCUBE1chr22

43654341

-
Frame-shiftENST00000255389ENST00000290460PEMTchr17

17480234

-SCUBE1chr22

43654341

-
5CDS-intronENST00000255389ENST00000470433PEMTchr17

17480234

-SCUBE1chr22

43654341

-
Frame-shiftENST00000395781ENST00000360835PEMTchr17

17480234

-SCUBE1chr22

43654341

-
Frame-shiftENST00000395781ENST00000290460PEMTchr17

17480234

-SCUBE1chr22

43654341

-
5CDS-intronENST00000395781ENST00000470433PEMTchr17

17480234

-SCUBE1chr22

43654341

-
intron-3CDSENST00000484838ENST00000360835PEMTchr17

17480234

-SCUBE1chr22

43654341

-
intron-3CDSENST00000484838ENST00000290460PEMTchr17

17480234

-SCUBE1chr22

43654341

-
intron-intronENST00000484838ENST00000470433PEMTchr17

17480234

-SCUBE1chr22

43654341

-

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FusionProtFeatures for PEMT_SCUBE1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PEMT

Q9UBM1

SCUBE1

Q8IWY4

Could function as an adhesive molecule and its matrixbound and soluble fragments may play a critical role in vascularbiology. {ECO:0000269|PubMed:16753137}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePEMTchr17:17480234chr22:43654341ENST00000255389-2713_3368237IntramembraneHelical
HgenePEMTchr17:17480234chr22:43654341ENST00000395781-2813_3368233IntramembraneHelical
HgenePEMTchr17:17480234chr22:43654341ENST00000395782-2713_3331200IntramembraneHelical
HgenePEMTchr17:17480234chr22:43654341ENST00000395783-2713_3331200IntramembraneHelical
HgenePEMTchr17:17480234chr22:43654341ENST00000255389-271_1268237Topological domainLumenal
HgenePEMTchr17:17480234chr22:43654341ENST00000255389-2734_4568237Topological domainLumenal
HgenePEMTchr17:17480234chr22:43654341ENST00000395781-281_1268233Topological domainLumenal
HgenePEMTchr17:17480234chr22:43654341ENST00000395781-2834_4568233Topological domainLumenal
HgenePEMTchr17:17480234chr22:43654341ENST00000395782-271_1231200Topological domainLumenal
HgenePEMTchr17:17480234chr22:43654341ENST00000395783-271_1231200Topological domainLumenal
HgenePEMTchr17:17480234chr22:43654341ENST00000255389-2746_6668237TransmembraneHelical
HgenePEMTchr17:17480234chr22:43654341ENST00000395781-2846_6668233TransmembraneHelical
TgeneSCUBE1chr17:17480234chr22:43654341ENST00000360835-422206_241203989DomainEGF-like 5
TgeneSCUBE1chr17:17480234chr22:43654341ENST00000360835-422245_280203989DomainEGF-like 6
TgeneSCUBE1chr17:17480234chr22:43654341ENST00000360835-422282_322203989DomainEGF-like 7%3B calcium-binding
TgeneSCUBE1chr17:17480234chr22:43654341ENST00000360835-422323_361203989DomainEGF-like 8%3B calcium-binding
TgeneSCUBE1chr17:17480234chr22:43654341ENST00000360835-422362_402203989DomainEGF-like 9%3B calcium-binding
TgeneSCUBE1chr17:17480234chr22:43654341ENST00000360835-422798_910203989DomainCUB

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePEMTchr17:17480234chr22:43654341ENST00000255389-27180_18168237RegionS-adenosyl-L-methionine binding
HgenePEMTchr17:17480234chr22:43654341ENST00000255389-2798_10068237RegionS-adenosyl-L-methionine binding
HgenePEMTchr17:17480234chr22:43654341ENST00000395781-28180_18168233RegionS-adenosyl-L-methionine binding
HgenePEMTchr17:17480234chr22:43654341ENST00000395781-2898_10068233RegionS-adenosyl-L-methionine binding
HgenePEMTchr17:17480234chr22:43654341ENST00000395782-27180_18131200RegionS-adenosyl-L-methionine binding
HgenePEMTchr17:17480234chr22:43654341ENST00000395782-2798_10031200RegionS-adenosyl-L-methionine binding
HgenePEMTchr17:17480234chr22:43654341ENST00000395783-27180_18131200RegionS-adenosyl-L-methionine binding
HgenePEMTchr17:17480234chr22:43654341ENST00000395783-2798_10031200RegionS-adenosyl-L-methionine binding
HgenePEMTchr17:17480234chr22:43654341ENST00000255389-27115_15768237Topological domainLumenal
HgenePEMTchr17:17480234chr22:43654341ENST00000255389-27179_19968237Topological domainCytoplasmic
HgenePEMTchr17:17480234chr22:43654341ENST00000255389-2767_9368237Topological domainCytoplasmic
HgenePEMTchr17:17480234chr22:43654341ENST00000395781-28115_15768233Topological domainLumenal
HgenePEMTchr17:17480234chr22:43654341ENST00000395781-28179_19968233Topological domainCytoplasmic
HgenePEMTchr17:17480234chr22:43654341ENST00000395781-2867_9368233Topological domainCytoplasmic
HgenePEMTchr17:17480234chr22:43654341ENST00000395782-27115_15731200Topological domainLumenal
HgenePEMTchr17:17480234chr22:43654341ENST00000395782-27179_19931200Topological domainCytoplasmic
HgenePEMTchr17:17480234chr22:43654341ENST00000395782-2734_4531200Topological domainLumenal
HgenePEMTchr17:17480234chr22:43654341ENST00000395782-2767_9331200Topological domainCytoplasmic
HgenePEMTchr17:17480234chr22:43654341ENST00000395783-27115_15731200Topological domainLumenal
HgenePEMTchr17:17480234chr22:43654341ENST00000395783-27179_19931200Topological domainCytoplasmic
HgenePEMTchr17:17480234chr22:43654341ENST00000395783-2734_4531200Topological domainLumenal
HgenePEMTchr17:17480234chr22:43654341ENST00000395783-2767_9331200Topological domainCytoplasmic
HgenePEMTchr17:17480234chr22:43654341ENST00000255389-27158_17868237TransmembraneHelical
HgenePEMTchr17:17480234chr22:43654341ENST00000255389-2794_11468237TransmembraneHelical
HgenePEMTchr17:17480234chr22:43654341ENST00000395781-28158_17868233TransmembraneHelical
HgenePEMTchr17:17480234chr22:43654341ENST00000395781-2894_11468233TransmembraneHelical
HgenePEMTchr17:17480234chr22:43654341ENST00000395782-27158_17831200TransmembraneHelical
HgenePEMTchr17:17480234chr22:43654341ENST00000395782-2746_6631200TransmembraneHelical
HgenePEMTchr17:17480234chr22:43654341ENST00000395782-2794_11431200TransmembraneHelical
HgenePEMTchr17:17480234chr22:43654341ENST00000395783-27158_17831200TransmembraneHelical
HgenePEMTchr17:17480234chr22:43654341ENST00000395783-2746_6631200TransmembraneHelical
HgenePEMTchr17:17480234chr22:43654341ENST00000395783-2794_11431200TransmembraneHelical
TgeneSCUBE1chr17:17480234chr22:43654341ENST00000360835-422117_153203989DomainEGF-like 3%3B calcium-binding
TgeneSCUBE1chr17:17480234chr22:43654341ENST00000360835-422166_202203989DomainEGF-like 4
TgeneSCUBE1chr17:17480234chr22:43654341ENST00000360835-42233_73203989DomainEGF-like 1%3B calcium-binding
TgeneSCUBE1chr17:17480234chr22:43654341ENST00000360835-42274_116203989DomainEGF-like 2%3B calcium-binding


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FusionGeneSequence for PEMT_SCUBE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PEMT_ENST00000395782_chr17_17480234_-_SCUBE1_ENST00000360835_chr22_43654341_-_816aa
MTRLLGYVDPLDPSFVAAVITITFNPLYWNVXPVIMETEAASTAVRTQTQAPRVVATRSTPSTQTVARASRRAQSITEAATGHARTQPLA
CDAAAPLDSHCSRTGRHAKTSTSAWSTTEAATTSAATPWAASSAAAGRATSCSPTSAPARTSTSAPSSGPVTTSASTPRAASSACVTAAT
SSTGQPTAEMWTSAAXATGAVTRAASTPRAATSASVPRGGGSTGTGRIAWRQASVFLAPRPPPGPSCPAARQAVWRAASFPARLTHSSCQ
TRKIATSXAAEFQGRRARRCRNATAPALASGPAAQMPPPPPSNRRPASRSEMPSATSGPTARHEQRRPPGSRCWTTAMXLSXPSSVTPPR
RGAVAASPHPRRCPTSQQSLRSRQRWKRPQTHAKRTACGSEQNRACRPPSRPCASPSAGSSSMSRSQALSTRXPRGQPRRWRGRGHVAQA
RCYRTANALPVGLAPTSVVSSASVCHVCQEHTRTWKASSVAHRAPAATGLVCLVPATCRNVEASVLQASSRPMASSPARPAPWARTSLSP
GAPAASPVEGVCSPNTKAPPPSRTARLKCTAPPATTTTPPPTAASAAPSAPTSPSLARTTASPVRATPAQTSMAPPTSHTAKTSTAAASL
VTTPATSSPPTTLATTQPTLNASGTSRLPQSAGSSSWSLRSSCPSRMSAAMFWSXGRVPLPRPSPPMRPARPTRGPSPSPPAPASSGSSS
NPMKATAAKASKCPMSPTMRTTSNSXRTSCAMGACTPRRTTRKFXKTRSXSRPSSTCWRIPRTTSSTQPRNPRRCSHGPSSNCCAPKCLG

>In-frame_PEMT_ENST00000395782_chr17_17480234_-_SCUBE1_ENST00000290460_chr22_43654341_-_175aa
MTRLLGYVDPLDPSFVAAVITITFNPLYWNVXPVIMETEAASTAVRTQTQAPRVVATRSTPSTQTVARASRRMRLQLSALSSMPRQXLMW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PEMT_ENST00000395782_chr17_17480234_-_SCUBE1_ENST00000360835_chr22_43654341_-_2450nt
ATGACCCGGCTGCTGGGCTACGTGGACCCCCTGGATCCCAGCTTTGTGGCTGCCGTCATCACCATCACCTTCAATCCGCTCTACTGGAAT
GTGTAACCTGTAATTATGGAAACGGAGGCTGCCAGCACAGCTGTGAGGACACAGACACAGGCCCCACGTGTGGTTGCCACCAGAAGTACG
CCCTCCACTCAGACGGTCGCACGTGCATCGAGACGTGCGCAGTCAATAACGGAGGCTGCGACCGGACATGCAAGGACACAGCCACTGGCG
TGCGATGCAGCTGCCCCGTTGGATTCACACTGCAGCCGGACGGGAAGACATGCAAAGACATCAACGAGTGCCTGGTCAACAACGGAGGCT
GCGACCACTTCTGCCGCAACACCGTGGGCAGCTTCGAGTGCGGCTGCCGGAAGGGCTACAAGCTGCTCACCGACGAGCGCACCTGCCAGG
ACATCGACGAGTGCTCCTTCGAGCGGACCTGTGACCACATCTGCATCAACTCCCCGGGCAGCTTCCAGTGCCTGTGTCACCGCGGCTACA
TCCTCTACGGGACAACCCACTGCGGAGATGTGGACGAGTGCAGCATGAGCAACGGGAGCTGTGACCAGGGCTGCGTCAACACCAAGGGCA
GCTACGAGTGCGTCTGTCCCCCGGGGAGGCGGCTCCACTGGAACGGGAAGGATTGCGTGGAGACAGGCAAGTGTCTTTCTCGCGCCAAGA
CCTCCCCCCGGGCCCAGCTGTCCTGCAGCAAGGCAGGCGGTGTGGAGAGCTGCTTCCTTTCCTGCCCGGCTCACACACTCTTCGTGCCAG
ACTCGGAAAATAGCTACGTCCTGAGCTGCGGAGTTCCAGGGCCGCAGGGCAAGGCGCTGCAGAAACGCAACGGCACCAGCTCTGGCCTCG
GGCCCAGCTGCTCAGATGCCCCCACCACCCCCATCAAACAGAAGGCCCGCTTCAAGATCCGAGATGCCAAGTGCCACCTCCGGCCCCACA
GCCAGGCACGAGCAAAGGAGACCGCCAGGCAGCCGCTGCTGGACCACTGCCATGTGACTTTCGTGACCCTCAAGTGTGACTCCTCCAAGA
AGAGGCGCCGTGGCCGCAAGTCCCCATCCAAGGAGGTGTCCCACATCACAGCAGAGTTTGAGATCGAGACAAAGATGGAAGAGGCCTCAG
ACACATGCGAAGCGGACTGCTTGCGGAAGCGAGCAGAACAGAGCCTGCAGGCCGCCATCAAGACCCTGCGCAAGTCCATCGGCCGGCAGC
AGTTCTATGTCCAGGTCTCAGGCACTGAGTACGAGGTAGCCCAGAGGCCAGCCAAGGCGCTGGAGGGGCAGGGGGCATGTGGCGCAGGCC
AGGTGCTACAGGACAGCAAATGCGTTGCCTGTGGGCCTGGCACCCACTTCGGTGGTGAGCTCGGCCAGTGTGTGTCATGTATGCCAGGAA
CATACCAGGACATGGAAGGCCAGCTCAGTTGCACACCGTGCCCCAGCAGCGACGGGCTTGGTCTGCCTGGTGCCCGCAACGTGTCGGAAT
GTGGAGGCCAGTGTTCTCCAGGCTTCTTCTCGGCCGATGGCTTCAAGCCCTGCCAGGCCTGCCCCGTGGGCACGTACCAGCCTGAGCCCG
GGCGCACCGGCTGCTTCCCCTGTGGAGGGGGTTTGCTCACCAAACACGAAGGCACCACCTCCTTCCAGGACTGCGAGGCTAAAGTGCACT
GCTCCCCCGGCCACCACTACAACACCACCACCCACCGCTGCATCCGCTGCCCCGTCGGCACCTACCAGCCCGAGTTTGGCCAGAACCACT
GCATCACCTGTCCGGGCAACACCAGCACAGACTTCGATGGCTCCACCAACGTCACACACTGCAAAAACCAGCACTGCGGCGGCGAGCTTG
GTGACTACACCGGCTACATCGAGTCCCCCAACTACCCTGGCGACTACCCAGCCAACGCTGAATGCGTCTGGCACATCGCGCCTCCCCCAA
AGCGCAGGATCCTCATCGTGGTCCCTGAGATCTTCCTGCCCATCGAGGATGAGTGCGGCGATGTTCTGGTCATGAGGAAGAGTGCCTCTC
CCACGTCCATCACCACCTATGAGACCTGCCAGACCTACGAGAGGCCCATCGCCTTCACCTCCCGCTCCCGCAAGCTCTGGATCCAGTTCA
AATCCAATGAAGGCAACAGCGGCAAAGGCTTCCAAGTGCCCTATGTCACCTACGATGAGGACTACCAGCAACTCATAGAGGACATCGTGC
GCGATGGGCGCCTGTACGCCTCGGAGAACCACCAGGAAATTTTGAAAGACAAGAAGCTGATCAAGGCCCTCTTCGACGTGCTGGCGCATC
CCCAGAACTACTTCAAGTACACAGCCCAGGAATCCAAGGAGATGTTCCCACGGTCCTTCATCAAACTGCTGCGCTCCAAAGTGTCTCGGT

>In-frame_PEMT_ENST00000395782_chr17_17480234_-_SCUBE1_ENST00000290460_chr22_43654341_-_527nt
ATGACCCGGCTGCTGGGCTACGTGGACCCCCTGGATCCCAGCTTTGTGGCTGCCGTCATCACCATCACCTTCAATCCGCTCTACTGGAAT
GTGTAACCTGTAATTATGGAAACGGAGGCTGCCAGCACAGCTGTGAGGACACAGACACAGGCCCCACGTGTGGTTGCCACCAGAAGTACG
CCCTCCACTCAGACGGTCGCACGTGCATCGAGAAGGATGAGGCTGCAATTGAGCGCTCTCAGTTCAATGCCACGTCAGTAGCTGATGTGG
ACAAGCGGGTGAAACGGCGGCTACTCATGGAGACGTGCGCAGTCAATAACGGAGGCTGCGACCGGACATGCAAGGACACAGCCACTGGCG
TGCGATGCAGCTGCCCCGTTGGATTCACACTGCAGCCGGACGGGAAGACATGCAAAGGTCAGCATGTGGAGCTGTGTGGGTGCCCCTGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_PEMT_ENST00000395782_chr17_17480234_-_SCUBE1_ENST00000360835_chr22_43654341_-_9231nt
GGCGAGGAGAGGCACACCACTATTGTTTTAATTTGCTTTTACCTGATTCCTGGCAGACTTCTGCGTTATGACCCGGCTGCTGGGCTACGT
GGACCCCCTGGATCCCAGCTTTGTGGCTGCCGTCATCACCATCACCTTCAATCCGCTCTACTGGAATGTGTAACCTGTAATTATGGAAAC
GGAGGCTGCCAGCACAGCTGTGAGGACACAGACACAGGCCCCACGTGTGGTTGCCACCAGAAGTACGCCCTCCACTCAGACGGTCGCACG
TGCATCGAGACGTGCGCAGTCAATAACGGAGGCTGCGACCGGACATGCAAGGACACAGCCACTGGCGTGCGATGCAGCTGCCCCGTTGGA
TTCACACTGCAGCCGGACGGGAAGACATGCAAAGACATCAACGAGTGCCTGGTCAACAACGGAGGCTGCGACCACTTCTGCCGCAACACC
GTGGGCAGCTTCGAGTGCGGCTGCCGGAAGGGCTACAAGCTGCTCACCGACGAGCGCACCTGCCAGGACATCGACGAGTGCTCCTTCGAG
CGGACCTGTGACCACATCTGCATCAACTCCCCGGGCAGCTTCCAGTGCCTGTGTCACCGCGGCTACATCCTCTACGGGACAACCCACTGC
GGAGATGTGGACGAGTGCAGCATGAGCAACGGGAGCTGTGACCAGGGCTGCGTCAACACCAAGGGCAGCTACGAGTGCGTCTGTCCCCCG
GGGAGGCGGCTCCACTGGAACGGGAAGGATTGCGTGGAGACAGGCAAGTGTCTTTCTCGCGCCAAGACCTCCCCCCGGGCCCAGCTGTCC
TGCAGCAAGGCAGGCGGTGTGGAGAGCTGCTTCCTTTCCTGCCCGGCTCACACACTCTTCGTGCCAGACTCGGAAAATAGCTACGTCCTG
AGCTGCGGAGTTCCAGGGCCGCAGGGCAAGGCGCTGCAGAAACGCAACGGCACCAGCTCTGGCCTCGGGCCCAGCTGCTCAGATGCCCCC
ACCACCCCCATCAAACAGAAGGCCCGCTTCAAGATCCGAGATGCCAAGTGCCACCTCCGGCCCCACAGCCAGGCACGAGCAAAGGAGACC
GCCAGGCAGCCGCTGCTGGACCACTGCCATGTGACTTTCGTGACCCTCAAGTGTGACTCCTCCAAGAAGAGGCGCCGTGGCCGCAAGTCC
CCATCCAAGGAGGTGTCCCACATCACAGCAGAGTTTGAGATCGAGACAAAGATGGAAGAGGCCTCAGACACATGCGAAGCGGACTGCTTG
CGGAAGCGAGCAGAACAGAGCCTGCAGGCCGCCATCAAGACCCTGCGCAAGTCCATCGGCCGGCAGCAGTTCTATGTCCAGGTCTCAGGC
ACTGAGTACGAGGTAGCCCAGAGGCCAGCCAAGGCGCTGGAGGGGCAGGGGGCATGTGGCGCAGGCCAGGTGCTACAGGACAGCAAATGC
GTTGCCTGTGGGCCTGGCACCCACTTCGGTGGTGAGCTCGGCCAGTGTGTGTCATGTATGCCAGGAACATACCAGGACATGGAAGGCCAG
CTCAGTTGCACACCGTGCCCCAGCAGCGACGGGCTTGGTCTGCCTGGTGCCCGCAACGTGTCGGAATGTGGAGGCCAGTGTTCTCCAGGC
TTCTTCTCGGCCGATGGCTTCAAGCCCTGCCAGGCCTGCCCCGTGGGCACGTACCAGCCTGAGCCCGGGCGCACCGGCTGCTTCCCCTGT
GGAGGGGGTTTGCTCACCAAACACGAAGGCACCACCTCCTTCCAGGACTGCGAGGCTAAAGTGCACTGCTCCCCCGGCCACCACTACAAC
ACCACCACCCACCGCTGCATCCGCTGCCCCGTCGGCACCTACCAGCCCGAGTTTGGCCAGAACCACTGCATCACCTGTCCGGGCAACACC
AGCACAGACTTCGATGGCTCCACCAACGTCACACACTGCAAAAACCAGCACTGCGGCGGCGAGCTTGGTGACTACACCGGCTACATCGAG
TCCCCCAACTACCCTGGCGACTACCCAGCCAACGCTGAATGCGTCTGGCACATCGCGCCTCCCCCAAAGCGCAGGATCCTCATCGTGGTC
CCTGAGATCTTCCTGCCCATCGAGGATGAGTGCGGCGATGTTCTGGTCATGAGGAAGAGTGCCTCTCCCACGTCCATCACCACCTATGAG
ACCTGCCAGACCTACGAGAGGCCCATCGCCTTCACCTCCCGCTCCCGCAAGCTCTGGATCCAGTTCAAATCCAATGAAGGCAACAGCGGC
AAAGGCTTCCAAGTGCCCTATGTCACCTACGATGAGGACTACCAGCAACTCATAGAGGACATCGTGCGCGATGGGCGCCTGTACGCCTCG
GAGAACCACCAGGAAATTTTGAAAGACAAGAAGCTGATCAAGGCCCTCTTCGACGTGCTGGCGCATCCCCAGAACTACTTCAAGTACACA
GCCCAGGAATCCAAGGAGATGTTCCCACGGTCCTTCATCAAACTGCTGCGCTCCAAAGTGTCTCGGTTCCTGCGGCCCTACAAATAACCG
GGGGGAGCGGCCCTGCCTGGGGGTGGCCTGGTCCGCGGAGGGTGCACCTGCCCTCCACAGTGGGAGCTGCATGGGCCTCCACACCACCTT
GGGAACCCCATGGCACTGCCCTTCAGGGAAGCCGACCAGCCCATGGAGACCGAGCCCAGGCACCCTTCGGACCCGCTGCCCCTGTGGGAG
CACCCTGCTTCAGGAAGCCTCCCTCCCTCCCTCTGCCTCCCTTCCCCAGGACACCAAGAGCGCCCTCTCCTGAGCCCTGGCAGACCGACT
GCAGGTAGCAGGATTGCAGGACCCTCTGCCTGGCCTGGCGTTTCAGGAGAGAGGGGAAGTGGGGCCTGTGCTCTGGGAGGCGTGGTCATC
CGAGACAGGAGTCCAGGGGAGAGAGGAGGGGACAAAGGCGCCGTCTGGGGGAGGTCGATGAGCCTGTGCTGGCATCCGCGGGCCCCACGC
TTTGCCAACTCCTCCAGCCACAGGCAAGGCCACGGCTCCGGGCTGTTGCGCTCTAAGGGTTCTGTGATTGGATGGAACAGAGCTGCTGGG
GAGGAGACTGGAAGTTTCTGCATTCCTTCAACAGAACATTTAATGAAGTACTCTATATATATATATAAATATATATATAAATATATATAT
ATACTTCTATTTGTGGGTACTTTAGGAAAATGCCCTTTGGTCACTGTAAATATGAATTGTGACCCCATCCCTTCCCGCATGAGCCCAGTG
AGTCCCAGCAGCTATCAGCCTCCCTGAACGATTAAACAGCTCCTCCCAGCATTTGCATTTGCCCTTCTGTTTCTGTGAGGCCGGCAGCCC
TTGGGGCTGGGGAGAGCACAGCTTGCCTTGGACTTGCTTCTGAACACGAATTCTTCGAGAACTAGGCTCAGATGCTCTGCTGGAGTGTTG
GCCTCACCCCAGTCCCCTTGCCAGCAACATCACTGCCCTTGGACGAGACTCAGTGGAAGACACTTCCCCTCGGACCCGTTCCCAGGAGGT
GCAGGGGCCCAGCAATAAACGGCGAAAGGGGCCTTGGCTCTTGCCCTGTGGCAGTGACCTTGGGGTCCGTACTATGCCCAGGTGTCAGCA
GGAAACAAGGCCTTGCTCACAGGAGCACAGGCTGTACCACCACAAGGAGCCTCAGAGCGGCCAGTGAGGAAAGGGGAGAGAGCAGAGCTT
GCTGTCAGAGGCCAGGCTCCCAGTGCAGCCTCCTCTTGCTACGCCATGCCACCCCCATTCACAGGGAAACCTCTTTCCTTCCTATAAAGG
AAAGAGGTTGAATTGACTCACATTTCCACATGGCTTGGGAGGCCTCAGGAAACTTACAATCATGGCGGAGGGTGAAGGGGAAGCAAGCGC
CTTCTTCACAAGGCAGCAGGAGAGAGAAGCAAGCAGGGAAATGTCGGGAGAAAGAGAGTCTGGGCTGTGACCGAGTGCATGTGTCCCACC
CAGCCGGAAGGCCAGCGCCTGGGATGGAGCCAGCAGAACCCCATGCCGAGGTCCAGGAGGCCTTGCCTGCTCTTCATCTGCCTGCGAGCT
GTAGGACCTGCATGGGAAATGGTCTGTGTGTTTCAGGTTAACAAATACTGAAAATCCCAAGGAACCTGGGAGAATCTGAAAATGAACTCC
AGTCTTCAGCTCGAAGTTGCCTCTAGGGTTCCTCCTGGTCACCCCCGGGCCCAGCCTGGCTGGCGAGAAACAAACACGGTTTGAGAGGCT
GTGGCACACTGAGGACCACACAGATGGAGGCAGCCAAGTGAGGTCCCTGGAGGTTCAGGGCTTGGTGACGAGGTAGGCCGTGATCACATA
TTCTACAGTCCAAAAGAGGGCCCGGAGCTCAGCAATTACTCACGCCGTCACATGTGCCCACAGTAGCGGGCTCCGCGGCGTGGCTCCTGC
TGCCATCAGCTGCCTTCTCTGCTGAAGTCCAACTCAAGTCGGAGAGAGAGTGGAGCCTCTGCACTTGGGGAGTAGGTCAGTGTCAACTAA
CAAGCCCTGCCAGGGGCCACTGCCGCTCCTCTGGTCACAGTCCACGCAGGCCAGCCCTGGTTTCTGGAAAGAGGCCTCCCTCCCTCCCTT
TGTGGAGCCGTCAGTCATCCCCAAGATGAGAGGCGAGCATCCTGCCGAGTGAGCCTGCAGCAACAGCTCCTGAGGAAGGTGCCGGGAGGG
GTGTCGCCTCTTCACGAGTGTTCTCCAGAGAATCAGAACCCAGAGGATACAGACGTAGATGTGTGAGGGGCTGCATTATGGGAACTGGCT
CACAGATTCTGGAGGCCAACAAGTCCCACGATCGGCTGTCTGCGATTGGGAGACCAGGAGAAGCCACACCGTAACTCAGTCTGAGTCCAA
AGCCCGAGAAGCCAGGGGCCACCCTGTGAGTCCCAGCATCCAAAGCCCCGAGAACGAGGAAGATGGATGTCCCAGCTCCCAAAGGGAGGA
TTCTCCCTTCCTCCTCCTTCTTTTCTATTGGGGCCCTCAACAGATTGGATGGAGTGGATGTCTTCACTCAGTCTGCCAATTCCCATCCTA
ACCTCTTCTGGAAACACCCTAGCATGTTTTCCCAGCTAGCTGGGTATCCGTTCACCCAACCAAGACGACCATGCAATCAACCATCACACT
TAAATGTTTTTGTTTTGTTTTTTTTGTTTTGTTTTTTGTTTTCTTTTTTTGTTTTCTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGT
CTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCGATCTTGGTTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCA
GCCTCCCGAGTAGCTGGGACTACAGGCACCCACCACCTTGCCCGGCTAATTTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATATTA
GCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCAG
CCAGGGTTTTCTTTTTTAATCCTTTCCAGAAACAGAAAGAGCTCTTAACCTCTCTGAGCTCTTTCTGCAATTCCTTTGGGCGATTTCTGA
AAGTTGCCACCCACGTACTCACAGATCCACTGCCCGCCTCTCCTCCCCTCATGTTCCAGGACTCACCACCGTGGTCAGACCATGCCCAGT
GTGCCCAGGGCAAAGTTGGATGGGCAGGTGCAGACGAGGCCCAGCCTTCATCCTGCTTTCCCTCGCAAGCCCTTCTATAGCTCCCAGCCC
ACGGGAGAGGCCATGAGGAGCGCGAGGTCGCCAGCAGCCCCACTGGGCCTCCCACACCATCTGAGTGACTTGAATTCCAGGGTTGGGCTC
TGTCTTGAGTCTCCACATCAGTCTCACACCAGGGAACTTGGGGGTCCCCCGTTAAACTACAGCTGACCCTGGGCCTCAGGGCGGGATGGT
CCCAAGGTGAGCTCCGTGGACAGCAAAGCGCATTTCTTCCAGTTGGCATGTTGTCGAAGCCAATGGCAGCTTGACTGATGTGAGGTGGCT
ATTCCACCTGGTTCAAGATGGAGGTGTAGAGAAAAGGGAAGTGGGGAACAAGGACTGGGCCAGGTAGGACGGATCCACGTAACGAGGCCC
AAGAAAAAATGGAAGCTGGGGGCAGAGAGTCCAGGAGGCCCCCATGCTGTCTGAGGGGAGGCCGGCATAGCCCCTCCTCGACTGTCGCCT
GAGCAGCTGATGAGGTCCCCAGCGCCGCACGCTGTGCTCCAGGGAGAGGAGCCAAGAAGCAAGCGGGCTGCTGGGAGTCCCTGCACTGCC
ATCTGGCCGGGACGGAGGCGCCTGCCCGGTCTCCAGGCTCCTCTGAGCTTGGGTCAGCTCCTAATGGAGCATGGCACCCCAGGGAACCAG
AGGAACTCTGTGAAGAAAGGCATGGAAAACCGGGGTGTCTCCCGCACAGCTTCCCAGGAGTCAGGTGGGACCCAGGCGTGGGGGGACCTT
TCTGCCCCACATTCCTGGCATTCCCCCCAAGTTTATTTCTACTTTCCAGAAACAAGCCACGGGAAGGGAAGGAACCTGCAGCAGGGTTTC
GAAGACAGCCAGGCCCTCCGTGATTGAGGGCTCATATAGCCGCTGAGGGCAGCCTGCAGCCAGGTGGCCTCACCTGCTGCCCAGAATTAG
GCTGTGCCTTTTCCCAGTCCTTCCCCATGCCAGAGCCTCTCCCCATCTTTCCCCGCGCCAGAGCCTCACAGCCACAGCCACACCAACCTC
CCTCCTCTCAAGCAGCAGAATCAGCCTACGCTCCCCAGCCTCAGTGCCCCTGCCCCACACAGGTCACGCTGGCAAGGCGATGACCAGTTT
CCGAAACGCTGGATCCCCAAGGGTACAGTGTGGCCCAGTCCTCCCCCACCTCCATGGTGGCCCAGGCTGCAGGGCTCACGGTGGGCCCAC
GGTGGAGGCCTCAGGCAGCTTTCTCTCCAGCTACCCATTGGCTTAGGACACACAGATAAAGTAGAGCTGAAACACGGGCCAAAACATCCC
CAGACAAGGATGGCACAAGAGGCCAAATTTGAAGGCCTTGGGAGAGAAGCCATTTCCCCTACCTCTAACGAGCGTAGTTTTCTGTCTGAA
TGGCCCCCCTTTTCATGCACGCTCGTTCTTAAGAGACGCACCATCCGCAGGCAGCGTCTCAGTGAAGCCTGTCCCCTGGGCTTGTCCACG
GCAGGAGGCCCCTGGCCTGTTTAAGCCATACCGATGCTTAATTTACATTTTTGGAGTTGAATATTATTCCGGTGCCTCCACCACCCCCAG
CAGAAAAAATAAGATACTGAAATAAGTTGAGTCATTTCGCAAACATTTACTGAGCACCTCCTGTGTGCCAGGCTCCTAGAAAGACAGGGA
GTTGGTGCCCTGCACAGATGACAAACTGCCCCAGACAGCAGACAGACAAACAAACTGCCCCGGACAGCAGACAGACAAACAGACACATTG
CCCTGGACAGCAGAGAGACAAACAGACACACTGCCCCGGACAGCAGACAGACAGACACGTTGCCCCGGACAGCAGACAGAAAAACTGCCC
CGGACAGCAGACAGACAGACAAACTGCCCCAGACAGCAGACAGACAAACTGCCCCGGAAAGCAGACAGCAAACTGCCCCAGACAGCAGAC
AGACAGACACACTTCCCCAGACAGCAGATAGACAGACACCCTGCCCCAGACAGCAGACAAGCTGCCCTGGACAGCCTGCTCACCTTGCCT
GCCACAGTGCATGCCCCACAGGGAGAAGCCTTCCTTCTCACCCAGGGAGTCCAGCCATTTTCACCTCCCCTGGTCCATGCTCAGGAAGTC
TGGTCACCCTGGCAAACTGCACCTGACATTGAGGTCCCTTTTCACCAAAGATGCACAAGGTGTCCATGCCGAGCCGACATCATTCAGGCC
AAGGGCAGAGGATGTAATGAGGGGTGGAGTGAGGATGTGGAGAGAGAGCAGAGAGCGCCTCCTATTCTACCGCGGCTGCCTCTGCCCCCA
CAGCACCCACAGATCCCTGGCCCTTCCAGGAGTAAGTCCTGGGCAGGCAGAGCTGGGGTTGGCCTGATCCCACCTGCCTTGCTCTTGGAA
AGGACATCAGGTGTGGGCAAAGCATCCTTGAAGCCCAGACAACACAGGCATGGCCTGCGTGCCCTCCCAGCATCTGCTGCGATGGCCTCA
AGGCCTCTCCAGTCCCCTGCTGCACCATGCCACTCAGAGCCCCTGAGTGAGCCCCCTGGAATTGTCTGCACCCCCCAAGCCCCAACAGGA
AGAAGGGAAAGGTGGGGAAGCTGACGCTCACTCAGTGCCCACTGGGTGCCAGGCTCTGGGCTCAACCCTCTAATATCCACACATTCCATC
CCCCCAGCCCCATGTAGATGGTGGGGTTAAGACCATTCTTCAGATGTGGAAATGAAGGCTCTGGGAGACCACAGGACATGCCCAAGGCAA
AGAGTTGGTAGTCCCTGGATTTGGGAATCAAACTCAAGCCCATCTAATCCAAGGGTAGGAAATGTCTCTAAAACGTTGATCAATCTGAAG
CTTACAGATTGGAAACTGGGCCAGGTCAGCCCTGGCGGTGGAGTCCAGAGACAGAGAGAAGGCTGCAGGGAGGGGAGAGAACAGGAGGAT
CCCGGGCCAGGGTGACTTCAGTGACATTCCTTCCCTCCTTCACAAGCACGAAAAACTCGTTCGGAGAAAAGACAGCTTCTGCCTTCCCTA
CCAGGCGGACAGGGTACTCACTGTGCCGACGTGAGCAGACACAGCCAGAGGCTCAAGTGCCCTTGCCGAGTGTCCCCACTGCTCTTGGGG
AGGCCCCGGCACAGCCCTGCAGAGATGCAAGTAAGAGAGTGCCCAGTGCCCTCGGCAGATGGGTGGCAGAAAGCAGGAGGAGGAAGAGGG
AGCTGACCGATGCCGGGTGTCTTACTCCGCTGAGATCAGAACCTCCAACATGCCGAGCAGACGCAGGCCACATTGCTCGGGGAACAGGAC
ACCAGGGCGCTGTGCTAGCGGCCCGCAGACTTCACTTCTGGCTCCTGTGAGGGCACTGTATTGTCCAGACGCTTGGCAACGACTCTGCCT
GCAAGTGGCAAATACCAACATAACCACATCTTCCTTTTAGTTGCCACAAATATTCAGTTTTGTTTTATCCATCATGTCCCCCATATGCAT

>In-frame_PEMT_ENST00000395782_chr17_17480234_-_SCUBE1_ENST00000290460_chr22_43654341_-_1746nt
GGCGAGGAGAGGCACACCACTATTGTTTTAATTTGCTTTTACCTGATTCCTGGCAGACTTCTGCGTTATGACCCGGCTGCTGGGCTACGT
GGACCCCCTGGATCCCAGCTTTGTGGCTGCCGTCATCACCATCACCTTCAATCCGCTCTACTGGAATGTGTAACCTGTAATTATGGAAAC
GGAGGCTGCCAGCACAGCTGTGAGGACACAGACACAGGCCCCACGTGTGGTTGCCACCAGAAGTACGCCCTCCACTCAGACGGTCGCACG
TGCATCGAGAAGGATGAGGCTGCAATTGAGCGCTCTCAGTTCAATGCCACGTCAGTAGCTGATGTGGACAAGCGGGTGAAACGGCGGCTA
CTCATGGAGACGTGCGCAGTCAATAACGGAGGCTGCGACCGGACATGCAAGGACACAGCCACTGGCGTGCGATGCAGCTGCCCCGTTGGA
TTCACACTGCAGCCGGACGGGAAGACATGCAAAGGTCAGCATGTGGAGCTGTGTGGGTGCCCCTGCCTGTACTGGCCTGGCCAAGAGCCT
CCGTGTGCTTGCATAGCCGGGCCCAGGGCTGGGCTGAACGGGGGCCACGTGTAGCTGTGGGAAAGGACACGTGGCAATCATTTGCTTTGC
TGTTGGAGAGGCCAGGAAGAGGGAGGGCTGGCCAGCAGCAGGGTCCCCAGCAGAGTTCGAGAGAACACAGGTCCCACGGCACATCAGCAG
GTTCCTGGGCCAAAAAGGCACTGATGTCAGAGAATTTGGCTGCACGCTGGGTTAAACAGTTAAGCCAGCGTCTCTACTGTGGGACTTCCT
GGGCCCTCAGTGATAGTGTGGCTTCCCAAGGCGCGTAGAATGTAGCGCGTTTCCGAACCCCTTGACCTTTGGTTGCAGTGGGTCTTGCAG
AGCTGATGGGGACAGTCTGGTGTTGGGCCATCTGGGACACACAGGTCTACTCATGCCAGGAAAAATAAGGACAGTGTGTCACTACTAGGG
GGGCGAGGCTAGGGGGATCCCATCTGAAAAGATAAGGACTCAGGACTTCTGCTTGCCATCAGAAAATGAGGAGTCAGGAAGACCTGAGAG
TGACTGGTTGAAGGAAGGAGGGACAGGGCTGGCCTGCTGGTGGCTGGCAGTGAGGGAAGGCAGAGGTGTATCCTCCCACTTGTCCCCTGA
GTCACCCCACAAAGACTTACTGAGTACCTCCTGGGTTGAGGGGACCCTCAGGAAACAGGAAGCCCAGGGAGCTGGGAGAGGAGAGCTGGG
TGGGCTCTCGAGACAGCCCTGCAGATGAGGAGGTCCAGCTACCCCCAAAGGACAGACGGAGCCCCAAGAAGCTGTGGGCCCTGGGGCAGG
GTGTTAGGCCTGAGTGCCGGAGCCCTCTGTGCAGAAGGGTGAGGGGCAGTGCTCAGTGCCCCCAGCATCACTCCAGACCACCCTCCAAAC
GCCCCCACCCCAGCGCTGGGCAGTACCCCCACACTCTGCCAGGAAGGGAGAGCCTAGAGAGCAGGGCGTGGAGGGGAGAGGAACTGGAAC
TTCCAAAGTCCCATCGGGGAAAATATTGAAAGTGGAGGTTAGGGTGACTTAAAATAGCTTGAGGTGGACTTTTTTTAAGCCTGTAAAAAT
AAATGTATTTTTGTACAGTGTATGACTTCTTCCTTGCCAACTTGCTGGGAAGAACCGAGTGATTATTGACAGAAATAACAGTGCTTCCGC


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FusionGenePPI for PEMT_SCUBE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PEMTSPP1SCUBE1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PEMT_SCUBE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PEMT_SCUBE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePEMTC0036341Schizophrenia2PSYGENET