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Fusion gene ID: 26657 |
FusionGeneSummary for PELP1_CHRNE |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PELP1_CHRNE | Fusion gene ID: 26657 | Hgene | Tgene | Gene symbol | PELP1 | CHRNE | Gene ID | 27043 | 1145 |
| Gene name | proline, glutamate and leucine rich protein 1 | cholinergic receptor nicotinic epsilon subunit | |
| Synonyms | MNAR|P160 | ACHRE|CMS1D|CMS1E|CMS2A|CMS4A|CMS4B|CMS4C|FCCMS|SCCMS | |
| Cytomap | 17p13.2 | 17p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | proline-, glutamic acid- and leucine-rich protein 1modulator of non-genomic activity of estrogen receptorproline and glutamic acid rich nuclear proteintranscription factor HMX3 | acetylcholine receptor subunit epsilonAchR epsilon subunitacetylcholine receptor, nicotinic, epsilon (muscle)cholinergic receptor, nicotinic epsiloncholinergic receptor, nicotinic, epsilon (muscle)cholinergic receptor, nicotinic, epsilon polypeptide | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IZL8 | Q04844 | |
| Ensembl transtripts involved in fusion gene | ENST00000574876, ENST00000572293, ENST00000269230, ENST00000301396, ENST00000436683, ENST00000570823, | ENST00000293780, ENST00000575637, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 1 X 1=1 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/1*10)=4.32192809488736 | |
| Context | PubMed: PELP1 [Title/Abstract] AND CHRNE [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PELP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17505058 |
| Hgene | PELP1 | GO:0071391 | cellular response to estrogen stimulus | 17505058 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-18-4083-01A | PELP1 | chr17 | 4607158 | - | CHRNE | chr17 | 4806058 | - |
| TCGA | LD | LUSC | TCGA-60-2719-01A | PELP1 | chr17 | 4579652 | - | CHRNE | chr17 | 4806058 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000574876 | ENST00000293780 | PELP1 | chr17 | 4607158 | - | CHRNE | chr17 | 4806058 | - |
| 5CDS-intron | ENST00000574876 | ENST00000575637 | PELP1 | chr17 | 4607158 | - | CHRNE | chr17 | 4806058 | - |
| Frame-shift | ENST00000572293 | ENST00000293780 | PELP1 | chr17 | 4607158 | - | CHRNE | chr17 | 4806058 | - |
| 5CDS-intron | ENST00000572293 | ENST00000575637 | PELP1 | chr17 | 4607158 | - | CHRNE | chr17 | 4806058 | - |
| Frame-shift | ENST00000269230 | ENST00000293780 | PELP1 | chr17 | 4607158 | - | CHRNE | chr17 | 4806058 | - |
| 5CDS-intron | ENST00000269230 | ENST00000575637 | PELP1 | chr17 | 4607158 | - | CHRNE | chr17 | 4806058 | - |
| Frame-shift | ENST00000301396 | ENST00000293780 | PELP1 | chr17 | 4607158 | - | CHRNE | chr17 | 4806058 | - |
| 5CDS-intron | ENST00000301396 | ENST00000575637 | PELP1 | chr17 | 4607158 | - | CHRNE | chr17 | 4806058 | - |
| 5UTR-3CDS | ENST00000436683 | ENST00000293780 | PELP1 | chr17 | 4607158 | - | CHRNE | chr17 | 4806058 | - |
| 5UTR-intron | ENST00000436683 | ENST00000575637 | PELP1 | chr17 | 4607158 | - | CHRNE | chr17 | 4806058 | - |
| 5UTR-3CDS | ENST00000570823 | ENST00000293780 | PELP1 | chr17 | 4607158 | - | CHRNE | chr17 | 4806058 | - |
| 5UTR-intron | ENST00000570823 | ENST00000575637 | PELP1 | chr17 | 4607158 | - | CHRNE | chr17 | 4806058 | - |
| In-frame | ENST00000574876 | ENST00000293780 | PELP1 | chr17 | 4579652 | - | CHRNE | chr17 | 4806058 | - |
| 5CDS-intron | ENST00000574876 | ENST00000575637 | PELP1 | chr17 | 4579652 | - | CHRNE | chr17 | 4806058 | - |
| In-frame | ENST00000572293 | ENST00000293780 | PELP1 | chr17 | 4579652 | - | CHRNE | chr17 | 4806058 | - |
| 5CDS-intron | ENST00000572293 | ENST00000575637 | PELP1 | chr17 | 4579652 | - | CHRNE | chr17 | 4806058 | - |
| In-frame | ENST00000269230 | ENST00000293780 | PELP1 | chr17 | 4579652 | - | CHRNE | chr17 | 4806058 | - |
| 5CDS-intron | ENST00000269230 | ENST00000575637 | PELP1 | chr17 | 4579652 | - | CHRNE | chr17 | 4806058 | - |
| In-frame | ENST00000301396 | ENST00000293780 | PELP1 | chr17 | 4579652 | - | CHRNE | chr17 | 4806058 | - |
| 5CDS-intron | ENST00000301396 | ENST00000575637 | PELP1 | chr17 | 4579652 | - | CHRNE | chr17 | 4806058 | - |
| Frame-shift | ENST00000436683 | ENST00000293780 | PELP1 | chr17 | 4579652 | - | CHRNE | chr17 | 4806058 | - |
| 5CDS-intron | ENST00000436683 | ENST00000575637 | PELP1 | chr17 | 4579652 | - | CHRNE | chr17 | 4806058 | - |
| intron-3CDS | ENST00000570823 | ENST00000293780 | PELP1 | chr17 | 4579652 | - | CHRNE | chr17 | 4806058 | - |
| intron-intron | ENST00000570823 | ENST00000575637 | PELP1 | chr17 | 4579652 | - | CHRNE | chr17 | 4806058 | - |
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FusionProtFeatures for PELP1_CHRNE |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PELP1 | CHRNE |
| Coactivator of estrogen receptor-mediated transcriptionand a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor(ER) genomic activity when present in the nuclear compartment byactivating the ER target genes in a hormonal stimulation dependentmanner. Can facilitate ER non-genomic signaling via SRC and PI3Kinteraction in the cytosol. Plays a role in E2-mediated cell cycleprogression by interacting with RB1. May have important functionalimplications in ER/growth factor cross-talk. Interacts withseveral growth factor signaling components including EGFR and HRS.Involved in nuclear receptor signaling via its interaction with ARand NR3C1. May promote tumorigenesis via its interaction with andmodulation of several oncogenes including SRC, PI3K, STAT3 andEGFR. Plays a role in cancer cell metastasis via its ability tomodulate E2-mediated cytoskeleton changes and cell migration viaits interaction with SRC and PI3K. Functions as the keystabilizing component of the Five Friends of Methylated CHTOP(5FMC) complex; the 5FMC complex is recruited to ZNF148 bymethylated CHTOP, leading to desumoylation of ZNF148 andsubsequent transactivation of ZNF148 target genes. Component ofthe PELP1 complex involved in the nucleolar steps of 28S rRNAmaturation and the subsequent nucleoplasmic transit of the pre-60Sribosomal subunit. Regulates pre-60S association of the criticalremodeling factor MDN1 (PubMed:21326211).{ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12415108,ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108,ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770,ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929,ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611,ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211,ECO:0000269|PubMed:22872859}. | After binding acetylcholine, the AChR responds by anextensive change in conformation that affects all subunits andleads to opening of an ion-conducting channel across the plasmamembrane. {ECO:0000269|PubMed:27375219}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PELP1 | chr17:4579652 | chr17:4806058 | ENST00000574876 | - | 7 | 17 | 111_115 | 284 | 1131 | Motif | Note=LXXLL motif 3 |
| Hgene | PELP1 | chr17:4579652 | chr17:4806058 | ENST00000574876 | - | 7 | 17 | 155_159 | 284 | 1131 | Motif | Note=LXXLL motif 4 |
| Hgene | PELP1 | chr17:4579652 | chr17:4806058 | ENST00000574876 | - | 7 | 17 | 177_181 | 284 | 1131 | Motif | Note=LXXLL motif 5 |
| Hgene | PELP1 | chr17:4579652 | chr17:4806058 | ENST00000574876 | - | 7 | 17 | 264_268 | 284 | 1131 | Motif | Note=LXXLL motif 6 |
| Hgene | PELP1 | chr17:4579652 | chr17:4806058 | ENST00000574876 | - | 7 | 17 | 271_275 | 284 | 1131 | Motif | Note=LXXLL motif 7 |
| Hgene | PELP1 | chr17:4579652 | chr17:4806058 | ENST00000574876 | - | 7 | 17 | 33_37 | 284 | 1131 | Motif | Note=LXXLL motif 1 |
| Hgene | PELP1 | chr17:4579652 | chr17:4806058 | ENST00000574876 | - | 7 | 17 | 69_73 | 284 | 1131 | Motif | Note=LXXLL motif 2 |
| Tgene | >CHRNE | chr17:4579652 | chr17:4806058 | ENST00000293780 | - | 0 | 12 | 21_239 | 15 | 494 | Topological domain | Extracellular |
| Tgene | >CHRNE | chr17:4579652 | chr17:4806058 | ENST00000293780 | - | 0 | 12 | 265_272 | 15 | 494 | Topological domain | Cytoplasmic |
| Tgene | >CHRNE | chr17:4579652 | chr17:4806058 | ENST00000293780 | - | 0 | 12 | 292_306 | 15 | 494 | Topological domain | Extracellular |
| Tgene | >CHRNE | chr17:4579652 | chr17:4806058 | ENST00000293780 | - | 0 | 12 | 329_456 | 15 | 494 | Topological domain | Cytoplasmic |
| Tgene | >CHRNE | chr17:4579652 | chr17:4806058 | ENST00000293780 | - | 0 | 12 | 481_493 | 15 | 494 | Topological domain | Extracellular |
| Tgene | >CHRNE | chr17:4579652 | chr17:4806058 | ENST00000293780 | - | 0 | 12 | 240_264 | 15 | 494 | Transmembrane | Helical |
| Tgene | >CHRNE | chr17:4579652 | chr17:4806058 | ENST00000293780 | - | 0 | 12 | 273_291 | 15 | 494 | Transmembrane | Helical |
| Tgene | >CHRNE | chr17:4579652 | chr17:4806058 | ENST00000293780 | - | 0 | 12 | 307_328 | 15 | 494 | Transmembrane | Helical |
| Tgene | >CHRNE | chr17:4579652 | chr17:4806058 | ENST00000293780 | - | 0 | 12 | 457_480 | 15 | 494 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PELP1 | chr17:4579652 | chr17:4806058 | ENST00000574876 | - | 7 | 17 | 633_872 | 284 | 1131 | Compositional bias | Note=Pro-rich |
| Hgene | >PELP1 | chr17:4579652 | chr17:4806058 | ENST00000574876 | - | 7 | 17 | 888_1101 | 284 | 1131 | Compositional bias | Note=Glu-rich |
| Hgene | >PELP1 | chr17:4579652 | chr17:4806058 | ENST00000574876 | - | 7 | 17 | 977_1083 | 284 | 1131 | Compositional bias | Note=Pro-rich |
| Hgene | >PELP1 | chr17:4579652 | chr17:4806058 | ENST00000574876 | - | 7 | 17 | 364_368 | 284 | 1131 | Motif | Note=LXXLL motif 8 |
| Hgene | >PELP1 | chr17:4579652 | chr17:4806058 | ENST00000574876 | - | 7 | 17 | 459_463 | 284 | 1131 | Motif | Note=LXXLL motif 9 |
| Hgene | >PELP1 | chr17:4579652 | chr17:4806058 | ENST00000574876 | - | 7 | 17 | 579_583 | 284 | 1131 | Motif | Note=LXXLL motif 10 |
| Hgene | >PELP1 | chr17:4579652 | chr17:4806058 | ENST00000574876 | - | 7 | 17 | 584_588 | 284 | 1131 | Motif | Note=LXXLL motif 11 |
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FusionGeneSequence for PELP1_CHRNE |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PELP1_ENST00000574876_chr17_4579652_-_CHRNE_ENST00000293780_chr17_4806058_-_763aa MAAAVLSGPSAGSAAGVPGGTGGLSAVSSGPRLRLLLLESVSGLLQPRTGSAVAPVHPPNRSAPHLPGLMCLLRLHGSVGGAQNLSALGA LVSLSNARLSSIKTRFEGLCLLSLLVGESPTELFQQHCVSWLRSIQQVLQTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGL LTSLLGLRPECEQSALEGMKACMTYFPRACGSLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLAS LHTLLGALYEGAETGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDD FGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFA VDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQ KCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPE APRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMG >In-frame_PELP1_ENST00000572293_chr17_4579652_-_CHRNE_ENST00000293780_chr17_4806058_-_813aa MLLPSLSPRVQPAFTQCARPQPPPHAPSPVGGRRGVFASSRHATTGTRGKMAAAVLSGPSAGSAAGVPGGTGGLSAVSSGPRLRLLLLES VSGLLQPRTGSAVAPVHPPNRSAPHLPGLMCLLRLHGSVGGAQNLSALGALVSLSNARLSSIKTRFEGLCLLSLLVGESPTELFQQHCVS WLRSIQQVLQTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACGSLKGKLASF FLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETGRGVGKNEELRLYHHLFNNYDPGSRP VREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVY EGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGA TDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFV MVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHR QGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGAYFNRVPDLPYAPCI >In-frame_PELP1_ENST00000269230_chr17_4579652_-_CHRNE_ENST00000293780_chr17_4806058_-_763aa MAAAVLSGPSAGSAAGVPGGTGGLSAVSSGPRLRLLLLESVSGLLQPRTGSAVAPVHPPNRSAPHLPGLMCLLRLHGSVGGAQNLSALGA LVSLSNARLSSIKTRFEGLCLLSLLVGESPTELFQQHCVSWLRSIQQVLQTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGL LTSLLGLRPECEQSALEGMKACMTYFPRACGSLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLAS LHTLLGALYEGAETGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDD FGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFA VDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQ KCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPE APRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMG >In-frame_PELP1_ENST00000301396_chr17_4579652_-_CHRNE_ENST00000293780_chr17_4806058_-_763aa MAAAVLSGPSAGSAAGVPGGTGGLSAVSSGPRLRLLLLESVSGLLQPRTGSAVAPVHPPNRSAPHLPGLMCLLRLHGSVGGAQNLSALGA LVSLSNARLSSIKTRFEGLCLLSLLVGESPTELFQQHCVSWLRSIQQVLQTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGL LTSLLGLRPECEQSALEGMKACMTYFPRACGSLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLAS LHTLLGALYEGAETGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDD FGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFA VDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQ KCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPE APRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PELP1_ENST00000574876_chr17_4579652_-_CHRNE_ENST00000293780_chr17_4806058_-_2289nt ATGGCGGCAGCCGTTCTGAGTGGGCCCTCTGCGGGCTCCGCGGCTGGGGTTCCTGGCGGGACCGGGGGTCTCTCGGCAGTGAGCTCGGGC CCGCGGCTCCGCCTGCTGCTGCTGGAGAGTGTTTCTGGTTTGCTGCAACCTCGAACGGGGTCTGCCGTTGCTCCGGTGCATCCCCCAAAC CGCTCGGCCCCACATTTGCCCGGGCTCATGTGCCTATTGCGGCTGCATGGGTCGGTGGGCGGGGCCCAGAACCTTTCAGCTCTTGGGGCA TTGGTGAGTCTCAGTAATGCACGTCTCAGTTCCATCAAAACTCGGTTTGAGGGCCTGTGTCTGCTGTCCCTGCTGGTAGGGGAGAGCCCC ACAGAGCTATTCCAGCAGCACTGTGTGTCTTGGCTTCGGAGCATTCAGCAGGTGTTACAGACCCAGGACCCGCCTGCCACAATGGAGCTG GCCGTGGCTGTCCTGAGGGACCTCCTCCGATATGCAGCCCAGCTGCCTGCACTGTTCCGGGACATCTCCATGAACCACCTCCCTGGCCTT CTCACCTCCCTGCTGGGCCTCAGGCCAGAGTGTGAGCAGTCAGCATTGGAAGGAATGAAGGCTTGTATGACCTATTTCCCTCGGGCTTGT GGTTCTCTCAAAGGCAAGCTGGCCTCATTTTTTCTGTCTAGGGTGGATGCCTTGAGCCCTCAGCTCCAACAGTTGGCCTGTGAGTGTTAT TCCCGGCTGCCCTCTTTAGGGGCTGGCTTTTCCCAAGGCCTGAAGCACACCGAGAGCTGGGAGCAGGAGCTACACAGTCTGCTGGCCTCA CTGCACACCCTGCTGGGGGCCCTGTACGAGGGAGCAGAGACTGGCAGGGGTGTGGGGAAGAACGAGGAACTGCGTCTTTATCACCATCTC TTCAACAACTATGACCCAGGAAGCCGGCCAGTGCGGGAGCCTGAGGATACTGTCACCATCAGCCTCAAGGTCACCCTGACGAATCTCATC TCACTGAATGAAAAAGAGGAGACTCTCACCACTAGCGTCTGGATTGGAATCGATTGGCAGGATTACCGACTCAACTACAGCAAGGACGAC TTTGGGGGTATAGAAACCCTGCGAGTCCCTTCAGAACTCGTGTGGCTGCCAGAGATTGTGCTGGAAAACAATATTGATGGCCAGTTCGGA GTGGCCTACGACGCCAACGTGCTCGTCTACGAGGGCGGCTCCGTGACGTGGCTGCCTCCGGCCATCTACCGCAGCGTCTGCGCAGTGGAG GTCACCTACTTCCCCTTCGATTGGCAGAACTGTTCGCTTATTTTCCGCTCTCAGACGTACAATGCCGAAGAGGTGGAGTTCACTTTTGCC GTAGACAACGACGGCAAGACCATCAACAAGATCGACATCGACACAGAGGCCTATACTGAGAACGGCGAGTGGGCCATCGACTTCTGCCCG GGGGTGATCCGCCGCCACCACGGTGGCGCCACCGACGGCCCAGGGGAGACTGACGTCATCTACTCGCTCATCATCCGCCGGAAGCCGCTC TTCTACGTCATTAACATCATCGTGCCCTGTGTGCTCATCTCGGGCCTGGTGCTGCTCGCCTACTTCCTGCCGGCGCAGGCCGGCGGCCAG AAATGCACGGTCTCCATCAACGTCCTGCTCGCCCAGACCGTCTTCTTGTTCCTCATTGCCCAGAAAATCCCAGAGACTTCTCTGAGCGTG CCGCTCCTGGGCAGGTTCCTTATTTTCGTCATGGTGGTCGCCACGCTCATTGTCATGAATTGCGTCATCGTGCTCAACGTGTCCCAGCGG ACGCCCACCACCCACGCCATGTCCCCGCGGCTGCGCCACGTTCTCCTGGAGCTGCTGCCGCGCCTCCTGGGCTCCCCGCCGCCGCCCGAG GCCCCCCGGGCCGCCTCGCCCCCAAGGCGGGCGTCGTCGGTGGGCTTATTGCTCCGCGCGGAGGAGCTGATACTGAAAAAGCCACGGAGC GAGCTCGTGTTTGAGGGGCAGAGGCACCGGCAGGGGACCTGGACGGCTGCCTTCTGCCAGAGCCTGGGCGCCGCCGCCCCCGAGGTCCGC TGCTGTGTGGATGCCGTGAACTTCGTGGCCGAGAGCACGAGAGATCAGGAGGCCACCGGCGAGGAAGTGTCCGACTGGGTGCGCATGGGG AATGCCCTTGACAACATCTGCTTCTGGGCCGCTCTGGTGCTCTTCAGCGTGGGCTCCAGCCTCATCTTCCTCGGGGCCTACTTCAACCGA >In-frame_PELP1_ENST00000572293_chr17_4579652_-_CHRNE_ENST00000293780_chr17_4806058_-_2439nt ATGCTCCTTCCCAGCTTGAGCCCGCGAGTCCAGCCTGCCTTCACTCAGTGCGCAAGACCGCAGCCCCCTCCCCACGCCCCCTCCCCAGTA GGCGGCCGTCGCGGTGTGTTTGCGTCATCGCGCCACGCCACCACTGGAACCCGGGGGAAGATGGCGGCAGCCGTTCTGAGTGGGCCCTCT GCGGGCTCCGCGGCTGGGGTTCCTGGCGGGACCGGGGGTCTCTCGGCAGTGAGCTCGGGCCCGCGGCTCCGCCTGCTGCTGCTGGAGAGT GTTTCTGGTTTGCTGCAACCTCGAACGGGGTCTGCCGTTGCTCCGGTGCATCCCCCAAACCGCTCGGCCCCACATTTGCCCGGGCTCATG TGCCTATTGCGGCTGCATGGGTCGGTGGGCGGGGCCCAGAACCTTTCAGCTCTTGGGGCATTGGTGAGTCTCAGTAATGCACGTCTCAGT TCCATCAAAACTCGGTTTGAGGGCCTGTGTCTGCTGTCCCTGCTGGTAGGGGAGAGCCCCACAGAGCTATTCCAGCAGCACTGTGTGTCT TGGCTTCGGAGCATTCAGCAGGTGTTACAGACCCAGGACCCGCCTGCCACAATGGAGCTGGCCGTGGCTGTCCTGAGGGACCTCCTCCGA TATGCAGCCCAGCTGCCTGCACTGTTCCGGGACATCTCCATGAACCACCTCCCTGGCCTTCTCACCTCCCTGCTGGGCCTCAGGCCAGAG TGTGAGCAGTCAGCATTGGAAGGAATGAAGGCTTGTATGACCTATTTCCCTCGGGCTTGTGGTTCTCTCAAAGGCAAGCTGGCCTCATTT TTTCTGTCTAGGGTGGATGCCTTGAGCCCTCAGCTCCAACAGTTGGCCTGTGAGTGTTATTCCCGGCTGCCCTCTTTAGGGGCTGGCTTT TCCCAAGGCCTGAAGCACACCGAGAGCTGGGAGCAGGAGCTACACAGTCTGCTGGCCTCACTGCACACCCTGCTGGGGGCCCTGTACGAG GGAGCAGAGACTGGCAGGGGTGTGGGGAAGAACGAGGAACTGCGTCTTTATCACCATCTCTTCAACAACTATGACCCAGGAAGCCGGCCA GTGCGGGAGCCTGAGGATACTGTCACCATCAGCCTCAAGGTCACCCTGACGAATCTCATCTCACTGAATGAAAAAGAGGAGACTCTCACC ACTAGCGTCTGGATTGGAATCGATTGGCAGGATTACCGACTCAACTACAGCAAGGACGACTTTGGGGGTATAGAAACCCTGCGAGTCCCT TCAGAACTCGTGTGGCTGCCAGAGATTGTGCTGGAAAACAATATTGATGGCCAGTTCGGAGTGGCCTACGACGCCAACGTGCTCGTCTAC GAGGGCGGCTCCGTGACGTGGCTGCCTCCGGCCATCTACCGCAGCGTCTGCGCAGTGGAGGTCACCTACTTCCCCTTCGATTGGCAGAAC TGTTCGCTTATTTTCCGCTCTCAGACGTACAATGCCGAAGAGGTGGAGTTCACTTTTGCCGTAGACAACGACGGCAAGACCATCAACAAG ATCGACATCGACACAGAGGCCTATACTGAGAACGGCGAGTGGGCCATCGACTTCTGCCCGGGGGTGATCCGCCGCCACCACGGTGGCGCC ACCGACGGCCCAGGGGAGACTGACGTCATCTACTCGCTCATCATCCGCCGGAAGCCGCTCTTCTACGTCATTAACATCATCGTGCCCTGT GTGCTCATCTCGGGCCTGGTGCTGCTCGCCTACTTCCTGCCGGCGCAGGCCGGCGGCCAGAAATGCACGGTCTCCATCAACGTCCTGCTC GCCCAGACCGTCTTCTTGTTCCTCATTGCCCAGAAAATCCCAGAGACTTCTCTGAGCGTGCCGCTCCTGGGCAGGTTCCTTATTTTCGTC ATGGTGGTCGCCACGCTCATTGTCATGAATTGCGTCATCGTGCTCAACGTGTCCCAGCGGACGCCCACCACCCACGCCATGTCCCCGCGG CTGCGCCACGTTCTCCTGGAGCTGCTGCCGCGCCTCCTGGGCTCCCCGCCGCCGCCCGAGGCCCCCCGGGCCGCCTCGCCCCCAAGGCGG GCGTCGTCGGTGGGCTTATTGCTCCGCGCGGAGGAGCTGATACTGAAAAAGCCACGGAGCGAGCTCGTGTTTGAGGGGCAGAGGCACCGG CAGGGGACCTGGACGGCTGCCTTCTGCCAGAGCCTGGGCGCCGCCGCCCCCGAGGTCCGCTGCTGTGTGGATGCCGTGAACTTCGTGGCC GAGAGCACGAGAGATCAGGAGGCCACCGGCGAGGAAGTGTCCGACTGGGTGCGCATGGGGAATGCCCTTGACAACATCTGCTTCTGGGCC GCTCTGGTGCTCTTCAGCGTGGGCTCCAGCCTCATCTTCCTCGGGGCCTACTTCAACCGAGTGCCTGATCTCCCCTACGCGCCGTGTATC >In-frame_PELP1_ENST00000269230_chr17_4579652_-_CHRNE_ENST00000293780_chr17_4806058_-_2289nt ATGGCGGCAGCCGTTCTGAGTGGGCCCTCTGCGGGCTCCGCGGCTGGGGTTCCTGGCGGGACCGGGGGTCTCTCGGCAGTGAGCTCGGGC CCGCGGCTCCGCCTGCTGCTGCTGGAGAGTGTTTCTGGTTTGCTGCAACCTCGAACGGGGTCTGCCGTTGCTCCGGTGCATCCCCCAAAC CGCTCGGCCCCACATTTGCCCGGGCTCATGTGCCTATTGCGGCTGCATGGGTCGGTGGGCGGGGCCCAGAACCTTTCAGCTCTTGGGGCA TTGGTGAGTCTCAGTAATGCACGTCTCAGTTCCATCAAAACTCGGTTTGAGGGCCTGTGTCTGCTGTCCCTGCTGGTAGGGGAGAGCCCC ACAGAGCTATTCCAGCAGCACTGTGTGTCTTGGCTTCGGAGCATTCAGCAGGTGTTACAGACCCAGGACCCGCCTGCCACAATGGAGCTG GCCGTGGCTGTCCTGAGGGACCTCCTCCGATATGCAGCCCAGCTGCCTGCACTGTTCCGGGACATCTCCATGAACCACCTCCCTGGCCTT CTCACCTCCCTGCTGGGCCTCAGGCCAGAGTGTGAGCAGTCAGCATTGGAAGGAATGAAGGCTTGTATGACCTATTTCCCTCGGGCTTGT GGTTCTCTCAAAGGCAAGCTGGCCTCATTTTTTCTGTCTAGGGTGGATGCCTTGAGCCCTCAGCTCCAACAGTTGGCCTGTGAGTGTTAT TCCCGGCTGCCCTCTTTAGGGGCTGGCTTTTCCCAAGGCCTGAAGCACACCGAGAGCTGGGAGCAGGAGCTACACAGTCTGCTGGCCTCA CTGCACACCCTGCTGGGGGCCCTGTACGAGGGAGCAGAGACTGGCAGGGGTGTGGGGAAGAACGAGGAACTGCGTCTTTATCACCATCTC TTCAACAACTATGACCCAGGAAGCCGGCCAGTGCGGGAGCCTGAGGATACTGTCACCATCAGCCTCAAGGTCACCCTGACGAATCTCATC TCACTGAATGAAAAAGAGGAGACTCTCACCACTAGCGTCTGGATTGGAATCGATTGGCAGGATTACCGACTCAACTACAGCAAGGACGAC TTTGGGGGTATAGAAACCCTGCGAGTCCCTTCAGAACTCGTGTGGCTGCCAGAGATTGTGCTGGAAAACAATATTGATGGCCAGTTCGGA GTGGCCTACGACGCCAACGTGCTCGTCTACGAGGGCGGCTCCGTGACGTGGCTGCCTCCGGCCATCTACCGCAGCGTCTGCGCAGTGGAG GTCACCTACTTCCCCTTCGATTGGCAGAACTGTTCGCTTATTTTCCGCTCTCAGACGTACAATGCCGAAGAGGTGGAGTTCACTTTTGCC GTAGACAACGACGGCAAGACCATCAACAAGATCGACATCGACACAGAGGCCTATACTGAGAACGGCGAGTGGGCCATCGACTTCTGCCCG GGGGTGATCCGCCGCCACCACGGTGGCGCCACCGACGGCCCAGGGGAGACTGACGTCATCTACTCGCTCATCATCCGCCGGAAGCCGCTC TTCTACGTCATTAACATCATCGTGCCCTGTGTGCTCATCTCGGGCCTGGTGCTGCTCGCCTACTTCCTGCCGGCGCAGGCCGGCGGCCAG AAATGCACGGTCTCCATCAACGTCCTGCTCGCCCAGACCGTCTTCTTGTTCCTCATTGCCCAGAAAATCCCAGAGACTTCTCTGAGCGTG CCGCTCCTGGGCAGGTTCCTTATTTTCGTCATGGTGGTCGCCACGCTCATTGTCATGAATTGCGTCATCGTGCTCAACGTGTCCCAGCGG ACGCCCACCACCCACGCCATGTCCCCGCGGCTGCGCCACGTTCTCCTGGAGCTGCTGCCGCGCCTCCTGGGCTCCCCGCCGCCGCCCGAG GCCCCCCGGGCCGCCTCGCCCCCAAGGCGGGCGTCGTCGGTGGGCTTATTGCTCCGCGCGGAGGAGCTGATACTGAAAAAGCCACGGAGC GAGCTCGTGTTTGAGGGGCAGAGGCACCGGCAGGGGACCTGGACGGCTGCCTTCTGCCAGAGCCTGGGCGCCGCCGCCCCCGAGGTCCGC TGCTGTGTGGATGCCGTGAACTTCGTGGCCGAGAGCACGAGAGATCAGGAGGCCACCGGCGAGGAAGTGTCCGACTGGGTGCGCATGGGG AATGCCCTTGACAACATCTGCTTCTGGGCCGCTCTGGTGCTCTTCAGCGTGGGCTCCAGCCTCATCTTCCTCGGGGCCTACTTCAACCGA >In-frame_PELP1_ENST00000301396_chr17_4579652_-_CHRNE_ENST00000293780_chr17_4806058_-_2289nt ATGGCGGCAGCCGTTCTGAGTGGGCCCTCTGCGGGCTCCGCGGCTGGGGTTCCTGGCGGGACCGGGGGTCTCTCGGCAGTGAGCTCGGGC CCGCGGCTCCGCCTGCTGCTGCTGGAGAGTGTTTCTGGTTTGCTGCAACCTCGAACGGGGTCTGCCGTTGCTCCGGTGCATCCCCCAAAC CGCTCGGCCCCACATTTGCCCGGGCTCATGTGCCTATTGCGGCTGCATGGGTCGGTGGGCGGGGCCCAGAACCTTTCAGCTCTTGGGGCA TTGGTGAGTCTCAGTAATGCACGTCTCAGTTCCATCAAAACTCGGTTTGAGGGCCTGTGTCTGCTGTCCCTGCTGGTAGGGGAGAGCCCC ACAGAGCTATTCCAGCAGCACTGTGTGTCTTGGCTTCGGAGCATTCAGCAGGTGTTACAGACCCAGGACCCGCCTGCCACAATGGAGCTG GCCGTGGCTGTCCTGAGGGACCTCCTCCGATATGCAGCCCAGCTGCCTGCACTGTTCCGGGACATCTCCATGAACCACCTCCCTGGCCTT CTCACCTCCCTGCTGGGCCTCAGGCCAGAGTGTGAGCAGTCAGCATTGGAAGGAATGAAGGCTTGTATGACCTATTTCCCTCGGGCTTGT GGTTCTCTCAAAGGCAAGCTGGCCTCATTTTTTCTGTCTAGGGTGGATGCCTTGAGCCCTCAGCTCCAACAGTTGGCCTGTGAGTGTTAT TCCCGGCTGCCCTCTTTAGGGGCTGGCTTTTCCCAAGGCCTGAAGCACACCGAGAGCTGGGAGCAGGAGCTACACAGTCTGCTGGCCTCA CTGCACACCCTGCTGGGGGCCCTGTACGAGGGAGCAGAGACTGGCAGGGGTGTGGGGAAGAACGAGGAACTGCGTCTTTATCACCATCTC TTCAACAACTATGACCCAGGAAGCCGGCCAGTGCGGGAGCCTGAGGATACTGTCACCATCAGCCTCAAGGTCACCCTGACGAATCTCATC TCACTGAATGAAAAAGAGGAGACTCTCACCACTAGCGTCTGGATTGGAATCGATTGGCAGGATTACCGACTCAACTACAGCAAGGACGAC TTTGGGGGTATAGAAACCCTGCGAGTCCCTTCAGAACTCGTGTGGCTGCCAGAGATTGTGCTGGAAAACAATATTGATGGCCAGTTCGGA GTGGCCTACGACGCCAACGTGCTCGTCTACGAGGGCGGCTCCGTGACGTGGCTGCCTCCGGCCATCTACCGCAGCGTCTGCGCAGTGGAG GTCACCTACTTCCCCTTCGATTGGCAGAACTGTTCGCTTATTTTCCGCTCTCAGACGTACAATGCCGAAGAGGTGGAGTTCACTTTTGCC GTAGACAACGACGGCAAGACCATCAACAAGATCGACATCGACACAGAGGCCTATACTGAGAACGGCGAGTGGGCCATCGACTTCTGCCCG GGGGTGATCCGCCGCCACCACGGTGGCGCCACCGACGGCCCAGGGGAGACTGACGTCATCTACTCGCTCATCATCCGCCGGAAGCCGCTC TTCTACGTCATTAACATCATCGTGCCCTGTGTGCTCATCTCGGGCCTGGTGCTGCTCGCCTACTTCCTGCCGGCGCAGGCCGGCGGCCAG AAATGCACGGTCTCCATCAACGTCCTGCTCGCCCAGACCGTCTTCTTGTTCCTCATTGCCCAGAAAATCCCAGAGACTTCTCTGAGCGTG CCGCTCCTGGGCAGGTTCCTTATTTTCGTCATGGTGGTCGCCACGCTCATTGTCATGAATTGCGTCATCGTGCTCAACGTGTCCCAGCGG ACGCCCACCACCCACGCCATGTCCCCGCGGCTGCGCCACGTTCTCCTGGAGCTGCTGCCGCGCCTCCTGGGCTCCCCGCCGCCGCCCGAG GCCCCCCGGGCCGCCTCGCCCCCAAGGCGGGCGTCGTCGGTGGGCTTATTGCTCCGCGCGGAGGAGCTGATACTGAAAAAGCCACGGAGC GAGCTCGTGTTTGAGGGGCAGAGGCACCGGCAGGGGACCTGGACGGCTGCCTTCTGCCAGAGCCTGGGCGCCGCCGCCCCCGAGGTCCGC TGCTGTGTGGATGCCGTGAACTTCGTGGCCGAGAGCACGAGAGATCAGGAGGCCACCGGCGAGGAAGTGTCCGACTGGGTGCGCATGGGG AATGCCCTTGACAACATCTGCTTCTGGGCCGCTCTGGTGCTCTTCAGCGTGGGCTCCAGCCTCATCTTCCTCGGGGCCTACTTCAACCGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PELP1_ENST00000574876_chr17_4579652_-_CHRNE_ENST00000293780_chr17_4806058_-_3269nt ACTGGAACCCGGGGGAAGATGGCGGCAGCCGTTCTGAGTGGGCCCTCTGCGGGCTCCGCGGCTGGGGTTCCTGGCGGGACCGGGGGTCTC TCGGCAGTGAGCTCGGGCCCGCGGCTCCGCCTGCTGCTGCTGGAGAGTGTTTCTGGTTTGCTGCAACCTCGAACGGGGTCTGCCGTTGCT CCGGTGCATCCCCCAAACCGCTCGGCCCCACATTTGCCCGGGCTCATGTGCCTATTGCGGCTGCATGGGTCGGTGGGCGGGGCCCAGAAC CTTTCAGCTCTTGGGGCATTGGTGAGTCTCAGTAATGCACGTCTCAGTTCCATCAAAACTCGGTTTGAGGGCCTGTGTCTGCTGTCCCTG CTGGTAGGGGAGAGCCCCACAGAGCTATTCCAGCAGCACTGTGTGTCTTGGCTTCGGAGCATTCAGCAGGTGTTACAGACCCAGGACCCG CCTGCCACAATGGAGCTGGCCGTGGCTGTCCTGAGGGACCTCCTCCGATATGCAGCCCAGCTGCCTGCACTGTTCCGGGACATCTCCATG AACCACCTCCCTGGCCTTCTCACCTCCCTGCTGGGCCTCAGGCCAGAGTGTGAGCAGTCAGCATTGGAAGGAATGAAGGCTTGTATGACC TATTTCCCTCGGGCTTGTGGTTCTCTCAAAGGCAAGCTGGCCTCATTTTTTCTGTCTAGGGTGGATGCCTTGAGCCCTCAGCTCCAACAG TTGGCCTGTGAGTGTTATTCCCGGCTGCCCTCTTTAGGGGCTGGCTTTTCCCAAGGCCTGAAGCACACCGAGAGCTGGGAGCAGGAGCTA CACAGTCTGCTGGCCTCACTGCACACCCTGCTGGGGGCCCTGTACGAGGGAGCAGAGACTGGCAGGGGTGTGGGGAAGAACGAGGAACTG CGTCTTTATCACCATCTCTTCAACAACTATGACCCAGGAAGCCGGCCAGTGCGGGAGCCTGAGGATACTGTCACCATCAGCCTCAAGGTC ACCCTGACGAATCTCATCTCACTGAATGAAAAAGAGGAGACTCTCACCACTAGCGTCTGGATTGGAATCGATTGGCAGGATTACCGACTC AACTACAGCAAGGACGACTTTGGGGGTATAGAAACCCTGCGAGTCCCTTCAGAACTCGTGTGGCTGCCAGAGATTGTGCTGGAAAACAAT ATTGATGGCCAGTTCGGAGTGGCCTACGACGCCAACGTGCTCGTCTACGAGGGCGGCTCCGTGACGTGGCTGCCTCCGGCCATCTACCGC AGCGTCTGCGCAGTGGAGGTCACCTACTTCCCCTTCGATTGGCAGAACTGTTCGCTTATTTTCCGCTCTCAGACGTACAATGCCGAAGAG GTGGAGTTCACTTTTGCCGTAGACAACGACGGCAAGACCATCAACAAGATCGACATCGACACAGAGGCCTATACTGAGAACGGCGAGTGG GCCATCGACTTCTGCCCGGGGGTGATCCGCCGCCACCACGGTGGCGCCACCGACGGCCCAGGGGAGACTGACGTCATCTACTCGCTCATC ATCCGCCGGAAGCCGCTCTTCTACGTCATTAACATCATCGTGCCCTGTGTGCTCATCTCGGGCCTGGTGCTGCTCGCCTACTTCCTGCCG GCGCAGGCCGGCGGCCAGAAATGCACGGTCTCCATCAACGTCCTGCTCGCCCAGACCGTCTTCTTGTTCCTCATTGCCCAGAAAATCCCA GAGACTTCTCTGAGCGTGCCGCTCCTGGGCAGGTTCCTTATTTTCGTCATGGTGGTCGCCACGCTCATTGTCATGAATTGCGTCATCGTG CTCAACGTGTCCCAGCGGACGCCCACCACCCACGCCATGTCCCCGCGGCTGCGCCACGTTCTCCTGGAGCTGCTGCCGCGCCTCCTGGGC TCCCCGCCGCCGCCCGAGGCCCCCCGGGCCGCCTCGCCCCCAAGGCGGGCGTCGTCGGTGGGCTTATTGCTCCGCGCGGAGGAGCTGATA CTGAAAAAGCCACGGAGCGAGCTCGTGTTTGAGGGGCAGAGGCACCGGCAGGGGACCTGGACGGCTGCCTTCTGCCAGAGCCTGGGCGCC GCCGCCCCCGAGGTCCGCTGCTGTGTGGATGCCGTGAACTTCGTGGCCGAGAGCACGAGAGATCAGGAGGCCACCGGCGAGGAAGTGTCC GACTGGGTGCGCATGGGGAATGCCCTTGACAACATCTGCTTCTGGGCCGCTCTGGTGCTCTTCAGCGTGGGCTCCAGCCTCATCTTCCTC GGGGCCTACTTCAACCGAGTGCCTGATCTCCCCTACGCGCCGTGTATCCAGCCTTAGCTCGCACCGACTTCAATTTCCCACCCATCTCCA GTAGGAAATTGATTTTGAAAAAGTAGGCTGCCGCCACCACGGCATTATGATCCCTTCCCCCTGCTGATCAATCTGCAGTTTGTGAACTTC ACAAGAATGGTGTGTGCCCGTTCCCTGGCGTGTGTAGGCCTGGCCGCAGTCCAGGGGTCAGCAGGAGGAAAGGGTTCACATAGGCTCTCA GGTGCCAGTCTTCCAGAAAGCAAGGACTGCCCTTCATTCAGCCTTGCTGACCTCCCAGCCTTTCTAAGGCTCAGCCCCACGGGACTCTGG TGGCTGCCAGCTTGTGAGCTATCTATCTATATTCATTTCATAGCCAAACAGGAGACCCCTTTGCAGGACTTGCACACAGGGAGGCTGTAG CCAGGAAACCCTCTTCTTCCCTGGTCTGGCTCTGCTGGAGCGGGTGGGAACCAAACACCTTCAGTGCTGGTGGCCCTCAGGCCCACAGGT TTAAGGCTGAGGCTGCCCTGACCCTTCCACAGTCATTTCTTCTAGGTTTTCTTGGCCCAGCACTGCCCATCCCACCCCATGAGGCTCACT CATTGCAGATCCCAGCCCACCCTGCCCCTTTCTTCCCCACCCTGGAGGCTCTCTCTGCCTAGTCTACAGTACTGACAGAAAGCAAGGACA TGCGGCCTGCATGGTGGGAGCTGGTTGAATTGTCTTTATTAACAAACAGGATATCCAAGGCCACTACATTGAGGAGGGGTGGGGGGGGAG GGAGAAGGGTTACTTGCTGCTCACACTATATACAGATGCAAGCAAGGGGCGTGGAGAGTGAGGGCTCCCTGCTCCCTCCCTCCACCGGGG AAGGGCATGGGCTAGAAGAGGAGAGGGGGGTCGGGAATGGGGGGAATGTTTTGGCTGGCGGGGTCCCCCCTCCATTCCCTGGAGTTTGGG >In-frame_PELP1_ENST00000572293_chr17_4579652_-_CHRNE_ENST00000293780_chr17_4806058_-_3465nt ATCCGCCATCACTCCGGGAACCGAGCACCCCGCTGCCTCGGCGCCCAGGCTGCTCTCTCCGCGCATGCTCCTTCCCAGCTTGAGCCCGCG AGTCCAGCCTGCCTTCACTCAGTGCGCAAGACCGCAGCCCCCTCCCCACGCCCCCTCCCCAGTAGGCGGCCGTCGCGGTGTGTTTGCGTC ATCGCGCCACGCCACCACTGGAACCCGGGGGAAGATGGCGGCAGCCGTTCTGAGTGGGCCCTCTGCGGGCTCCGCGGCTGGGGTTCCTGG CGGGACCGGGGGTCTCTCGGCAGTGAGCTCGGGCCCGCGGCTCCGCCTGCTGCTGCTGGAGAGTGTTTCTGGTTTGCTGCAACCTCGAAC GGGGTCTGCCGTTGCTCCGGTGCATCCCCCAAACCGCTCGGCCCCACATTTGCCCGGGCTCATGTGCCTATTGCGGCTGCATGGGTCGGT GGGCGGGGCCCAGAACCTTTCAGCTCTTGGGGCATTGGTGAGTCTCAGTAATGCACGTCTCAGTTCCATCAAAACTCGGTTTGAGGGCCT GTGTCTGCTGTCCCTGCTGGTAGGGGAGAGCCCCACAGAGCTATTCCAGCAGCACTGTGTGTCTTGGCTTCGGAGCATTCAGCAGGTGTT ACAGACCCAGGACCCGCCTGCCACAATGGAGCTGGCCGTGGCTGTCCTGAGGGACCTCCTCCGATATGCAGCCCAGCTGCCTGCACTGTT CCGGGACATCTCCATGAACCACCTCCCTGGCCTTCTCACCTCCCTGCTGGGCCTCAGGCCAGAGTGTGAGCAGTCAGCATTGGAAGGAAT GAAGGCTTGTATGACCTATTTCCCTCGGGCTTGTGGTTCTCTCAAAGGCAAGCTGGCCTCATTTTTTCTGTCTAGGGTGGATGCCTTGAG CCCTCAGCTCCAACAGTTGGCCTGTGAGTGTTATTCCCGGCTGCCCTCTTTAGGGGCTGGCTTTTCCCAAGGCCTGAAGCACACCGAGAG CTGGGAGCAGGAGCTACACAGTCTGCTGGCCTCACTGCACACCCTGCTGGGGGCCCTGTACGAGGGAGCAGAGACTGGCAGGGGTGTGGG GAAGAACGAGGAACTGCGTCTTTATCACCATCTCTTCAACAACTATGACCCAGGAAGCCGGCCAGTGCGGGAGCCTGAGGATACTGTCAC CATCAGCCTCAAGGTCACCCTGACGAATCTCATCTCACTGAATGAAAAAGAGGAGACTCTCACCACTAGCGTCTGGATTGGAATCGATTG GCAGGATTACCGACTCAACTACAGCAAGGACGACTTTGGGGGTATAGAAACCCTGCGAGTCCCTTCAGAACTCGTGTGGCTGCCAGAGAT TGTGCTGGAAAACAATATTGATGGCCAGTTCGGAGTGGCCTACGACGCCAACGTGCTCGTCTACGAGGGCGGCTCCGTGACGTGGCTGCC TCCGGCCATCTACCGCAGCGTCTGCGCAGTGGAGGTCACCTACTTCCCCTTCGATTGGCAGAACTGTTCGCTTATTTTCCGCTCTCAGAC GTACAATGCCGAAGAGGTGGAGTTCACTTTTGCCGTAGACAACGACGGCAAGACCATCAACAAGATCGACATCGACACAGAGGCCTATAC TGAGAACGGCGAGTGGGCCATCGACTTCTGCCCGGGGGTGATCCGCCGCCACCACGGTGGCGCCACCGACGGCCCAGGGGAGACTGACGT CATCTACTCGCTCATCATCCGCCGGAAGCCGCTCTTCTACGTCATTAACATCATCGTGCCCTGTGTGCTCATCTCGGGCCTGGTGCTGCT CGCCTACTTCCTGCCGGCGCAGGCCGGCGGCCAGAAATGCACGGTCTCCATCAACGTCCTGCTCGCCCAGACCGTCTTCTTGTTCCTCAT TGCCCAGAAAATCCCAGAGACTTCTCTGAGCGTGCCGCTCCTGGGCAGGTTCCTTATTTTCGTCATGGTGGTCGCCACGCTCATTGTCAT GAATTGCGTCATCGTGCTCAACGTGTCCCAGCGGACGCCCACCACCCACGCCATGTCCCCGCGGCTGCGCCACGTTCTCCTGGAGCTGCT GCCGCGCCTCCTGGGCTCCCCGCCGCCGCCCGAGGCCCCCCGGGCCGCCTCGCCCCCAAGGCGGGCGTCGTCGGTGGGCTTATTGCTCCG CGCGGAGGAGCTGATACTGAAAAAGCCACGGAGCGAGCTCGTGTTTGAGGGGCAGAGGCACCGGCAGGGGACCTGGACGGCTGCCTTCTG CCAGAGCCTGGGCGCCGCCGCCCCCGAGGTCCGCTGCTGTGTGGATGCCGTGAACTTCGTGGCCGAGAGCACGAGAGATCAGGAGGCCAC CGGCGAGGAAGTGTCCGACTGGGTGCGCATGGGGAATGCCCTTGACAACATCTGCTTCTGGGCCGCTCTGGTGCTCTTCAGCGTGGGCTC CAGCCTCATCTTCCTCGGGGCCTACTTCAACCGAGTGCCTGATCTCCCCTACGCGCCGTGTATCCAGCCTTAGCTCGCACCGACTTCAAT TTCCCACCCATCTCCAGTAGGAAATTGATTTTGAAAAAGTAGGCTGCCGCCACCACGGCATTATGATCCCTTCCCCCTGCTGATCAATCT GCAGTTTGTGAACTTCACAAGAATGGTGTGTGCCCGTTCCCTGGCGTGTGTAGGCCTGGCCGCAGTCCAGGGGTCAGCAGGAGGAAAGGG TTCACATAGGCTCTCAGGTGCCAGTCTTCCAGAAAGCAAGGACTGCCCTTCATTCAGCCTTGCTGACCTCCCAGCCTTTCTAAGGCTCAG CCCCACGGGACTCTGGTGGCTGCCAGCTTGTGAGCTATCTATCTATATTCATTTCATAGCCAAACAGGAGACCCCTTTGCAGGACTTGCA CACAGGGAGGCTGTAGCCAGGAAACCCTCTTCTTCCCTGGTCTGGCTCTGCTGGAGCGGGTGGGAACCAAACACCTTCAGTGCTGGTGGC CCTCAGGCCCACAGGTTTAAGGCTGAGGCTGCCCTGACCCTTCCACAGTCATTTCTTCTAGGTTTTCTTGGCCCAGCACTGCCCATCCCA CCCCATGAGGCTCACTCATTGCAGATCCCAGCCCACCCTGCCCCTTTCTTCCCCACCCTGGAGGCTCTCTCTGCCTAGTCTACAGTACTG ACAGAAAGCAAGGACATGCGGCCTGCATGGTGGGAGCTGGTTGAATTGTCTTTATTAACAAACAGGATATCCAAGGCCACTACATTGAGG AGGGGTGGGGGGGGAGGGAGAAGGGTTACTTGCTGCTCACACTATATACAGATGCAAGCAAGGGGCGTGGAGAGTGAGGGCTCCCTGCTC CCTCCCTCCACCGGGGAAGGGCATGGGCTAGAAGAGGAGAGGGGGGTCGGGAATGGGGGGAATGTTTTGGCTGGCGGGGTCCCCCCTCCA >In-frame_PELP1_ENST00000269230_chr17_4579652_-_CHRNE_ENST00000293780_chr17_4806058_-_3477nt ACAGGCAGCCTCATCCGCCATCACTCCGGGAACCGAGCACCCCGCTGCCTCGGCGCCCAGGCTGCTCTCTCCGCGCATGCTCCTTCCCAG CTTGAGCCCGCGAGTCCAGCCTGCCTTCACTCAGTGCGCAAGACCGCAGCCCCCTCCCCACGCCCCCTCCCCAGTAGGCGGCCGTCGCGG TGTGTTTGCGTCATCGCGCCACGCCACCACTGGAACCCGGGGGAAGATGGCGGCAGCCGTTCTGAGTGGGCCCTCTGCGGGCTCCGCGGC TGGGGTTCCTGGCGGGACCGGGGGTCTCTCGGCAGTGAGCTCGGGCCCGCGGCTCCGCCTGCTGCTGCTGGAGAGTGTTTCTGGTTTGCT GCAACCTCGAACGGGGTCTGCCGTTGCTCCGGTGCATCCCCCAAACCGCTCGGCCCCACATTTGCCCGGGCTCATGTGCCTATTGCGGCT GCATGGGTCGGTGGGCGGGGCCCAGAACCTTTCAGCTCTTGGGGCATTGGTGAGTCTCAGTAATGCACGTCTCAGTTCCATCAAAACTCG GTTTGAGGGCCTGTGTCTGCTGTCCCTGCTGGTAGGGGAGAGCCCCACAGAGCTATTCCAGCAGCACTGTGTGTCTTGGCTTCGGAGCAT TCAGCAGGTGTTACAGACCCAGGACCCGCCTGCCACAATGGAGCTGGCCGTGGCTGTCCTGAGGGACCTCCTCCGATATGCAGCCCAGCT GCCTGCACTGTTCCGGGACATCTCCATGAACCACCTCCCTGGCCTTCTCACCTCCCTGCTGGGCCTCAGGCCAGAGTGTGAGCAGTCAGC ATTGGAAGGAATGAAGGCTTGTATGACCTATTTCCCTCGGGCTTGTGGTTCTCTCAAAGGCAAGCTGGCCTCATTTTTTCTGTCTAGGGT GGATGCCTTGAGCCCTCAGCTCCAACAGTTGGCCTGTGAGTGTTATTCCCGGCTGCCCTCTTTAGGGGCTGGCTTTTCCCAAGGCCTGAA GCACACCGAGAGCTGGGAGCAGGAGCTACACAGTCTGCTGGCCTCACTGCACACCCTGCTGGGGGCCCTGTACGAGGGAGCAGAGACTGG CAGGGGTGTGGGGAAGAACGAGGAACTGCGTCTTTATCACCATCTCTTCAACAACTATGACCCAGGAAGCCGGCCAGTGCGGGAGCCTGA GGATACTGTCACCATCAGCCTCAAGGTCACCCTGACGAATCTCATCTCACTGAATGAAAAAGAGGAGACTCTCACCACTAGCGTCTGGAT TGGAATCGATTGGCAGGATTACCGACTCAACTACAGCAAGGACGACTTTGGGGGTATAGAAACCCTGCGAGTCCCTTCAGAACTCGTGTG GCTGCCAGAGATTGTGCTGGAAAACAATATTGATGGCCAGTTCGGAGTGGCCTACGACGCCAACGTGCTCGTCTACGAGGGCGGCTCCGT GACGTGGCTGCCTCCGGCCATCTACCGCAGCGTCTGCGCAGTGGAGGTCACCTACTTCCCCTTCGATTGGCAGAACTGTTCGCTTATTTT CCGCTCTCAGACGTACAATGCCGAAGAGGTGGAGTTCACTTTTGCCGTAGACAACGACGGCAAGACCATCAACAAGATCGACATCGACAC AGAGGCCTATACTGAGAACGGCGAGTGGGCCATCGACTTCTGCCCGGGGGTGATCCGCCGCCACCACGGTGGCGCCACCGACGGCCCAGG GGAGACTGACGTCATCTACTCGCTCATCATCCGCCGGAAGCCGCTCTTCTACGTCATTAACATCATCGTGCCCTGTGTGCTCATCTCGGG CCTGGTGCTGCTCGCCTACTTCCTGCCGGCGCAGGCCGGCGGCCAGAAATGCACGGTCTCCATCAACGTCCTGCTCGCCCAGACCGTCTT CTTGTTCCTCATTGCCCAGAAAATCCCAGAGACTTCTCTGAGCGTGCCGCTCCTGGGCAGGTTCCTTATTTTCGTCATGGTGGTCGCCAC GCTCATTGTCATGAATTGCGTCATCGTGCTCAACGTGTCCCAGCGGACGCCCACCACCCACGCCATGTCCCCGCGGCTGCGCCACGTTCT CCTGGAGCTGCTGCCGCGCCTCCTGGGCTCCCCGCCGCCGCCCGAGGCCCCCCGGGCCGCCTCGCCCCCAAGGCGGGCGTCGTCGGTGGG CTTATTGCTCCGCGCGGAGGAGCTGATACTGAAAAAGCCACGGAGCGAGCTCGTGTTTGAGGGGCAGAGGCACCGGCAGGGGACCTGGAC GGCTGCCTTCTGCCAGAGCCTGGGCGCCGCCGCCCCCGAGGTCCGCTGCTGTGTGGATGCCGTGAACTTCGTGGCCGAGAGCACGAGAGA TCAGGAGGCCACCGGCGAGGAAGTGTCCGACTGGGTGCGCATGGGGAATGCCCTTGACAACATCTGCTTCTGGGCCGCTCTGGTGCTCTT CAGCGTGGGCTCCAGCCTCATCTTCCTCGGGGCCTACTTCAACCGAGTGCCTGATCTCCCCTACGCGCCGTGTATCCAGCCTTAGCTCGC ACCGACTTCAATTTCCCACCCATCTCCAGTAGGAAATTGATTTTGAAAAAGTAGGCTGCCGCCACCACGGCATTATGATCCCTTCCCCCT GCTGATCAATCTGCAGTTTGTGAACTTCACAAGAATGGTGTGTGCCCGTTCCCTGGCGTGTGTAGGCCTGGCCGCAGTCCAGGGGTCAGC AGGAGGAAAGGGTTCACATAGGCTCTCAGGTGCCAGTCTTCCAGAAAGCAAGGACTGCCCTTCATTCAGCCTTGCTGACCTCCCAGCCTT TCTAAGGCTCAGCCCCACGGGACTCTGGTGGCTGCCAGCTTGTGAGCTATCTATCTATATTCATTTCATAGCCAAACAGGAGACCCCTTT GCAGGACTTGCACACAGGGAGGCTGTAGCCAGGAAACCCTCTTCTTCCCTGGTCTGGCTCTGCTGGAGCGGGTGGGAACCAAACACCTTC AGTGCTGGTGGCCCTCAGGCCCACAGGTTTAAGGCTGAGGCTGCCCTGACCCTTCCACAGTCATTTCTTCTAGGTTTTCTTGGCCCAGCA CTGCCCATCCCACCCCATGAGGCTCACTCATTGCAGATCCCAGCCCACCCTGCCCCTTTCTTCCCCACCCTGGAGGCTCTCTCTGCCTAG TCTACAGTACTGACAGAAAGCAAGGACATGCGGCCTGCATGGTGGGAGCTGGTTGAATTGTCTTTATTAACAAACAGGATATCCAAGGCC ACTACATTGAGGAGGGGTGGGGGGGGAGGGAGAAGGGTTACTTGCTGCTCACACTATATACAGATGCAAGCAAGGGGCGTGGAGAGTGAG GGCTCCCTGCTCCCTCCCTCCACCGGGGAAGGGCATGGGCTAGAAGAGGAGAGGGGGGTCGGGAATGGGGGGAATGTTTTGGCTGGCGGG >In-frame_PELP1_ENST00000301396_chr17_4579652_-_CHRNE_ENST00000293780_chr17_4806058_-_3477nt ACAGGCAGCCTCATCCGCCATCACTCCGGGAACCGAGCACCCCGCTGCCTCGGCGCCCAGGCTGCTCTCTCCGCGCATGCTCCTTCCCAG CTTGAGCCCGCGAGTCCAGCCTGCCTTCACTCAGTGCGCAAGACCGCAGCCCCCTCCCCACGCCCCCTCCCCAGTAGGCGGCCGTCGCGG TGTGTTTGCGTCATCGCGCCACGCCACCACTGGAACCCGGGGGAAGATGGCGGCAGCCGTTCTGAGTGGGCCCTCTGCGGGCTCCGCGGC TGGGGTTCCTGGCGGGACCGGGGGTCTCTCGGCAGTGAGCTCGGGCCCGCGGCTCCGCCTGCTGCTGCTGGAGAGTGTTTCTGGTTTGCT GCAACCTCGAACGGGGTCTGCCGTTGCTCCGGTGCATCCCCCAAACCGCTCGGCCCCACATTTGCCCGGGCTCATGTGCCTATTGCGGCT GCATGGGTCGGTGGGCGGGGCCCAGAACCTTTCAGCTCTTGGGGCATTGGTGAGTCTCAGTAATGCACGTCTCAGTTCCATCAAAACTCG GTTTGAGGGCCTGTGTCTGCTGTCCCTGCTGGTAGGGGAGAGCCCCACAGAGCTATTCCAGCAGCACTGTGTGTCTTGGCTTCGGAGCAT TCAGCAGGTGTTACAGACCCAGGACCCGCCTGCCACAATGGAGCTGGCCGTGGCTGTCCTGAGGGACCTCCTCCGATATGCAGCCCAGCT GCCTGCACTGTTCCGGGACATCTCCATGAACCACCTCCCTGGCCTTCTCACCTCCCTGCTGGGCCTCAGGCCAGAGTGTGAGCAGTCAGC ATTGGAAGGAATGAAGGCTTGTATGACCTATTTCCCTCGGGCTTGTGGTTCTCTCAAAGGCAAGCTGGCCTCATTTTTTCTGTCTAGGGT GGATGCCTTGAGCCCTCAGCTCCAACAGTTGGCCTGTGAGTGTTATTCCCGGCTGCCCTCTTTAGGGGCTGGCTTTTCCCAAGGCCTGAA GCACACCGAGAGCTGGGAGCAGGAGCTACACAGTCTGCTGGCCTCACTGCACACCCTGCTGGGGGCCCTGTACGAGGGAGCAGAGACTGG CAGGGGTGTGGGGAAGAACGAGGAACTGCGTCTTTATCACCATCTCTTCAACAACTATGACCCAGGAAGCCGGCCAGTGCGGGAGCCTGA GGATACTGTCACCATCAGCCTCAAGGTCACCCTGACGAATCTCATCTCACTGAATGAAAAAGAGGAGACTCTCACCACTAGCGTCTGGAT TGGAATCGATTGGCAGGATTACCGACTCAACTACAGCAAGGACGACTTTGGGGGTATAGAAACCCTGCGAGTCCCTTCAGAACTCGTGTG GCTGCCAGAGATTGTGCTGGAAAACAATATTGATGGCCAGTTCGGAGTGGCCTACGACGCCAACGTGCTCGTCTACGAGGGCGGCTCCGT GACGTGGCTGCCTCCGGCCATCTACCGCAGCGTCTGCGCAGTGGAGGTCACCTACTTCCCCTTCGATTGGCAGAACTGTTCGCTTATTTT CCGCTCTCAGACGTACAATGCCGAAGAGGTGGAGTTCACTTTTGCCGTAGACAACGACGGCAAGACCATCAACAAGATCGACATCGACAC AGAGGCCTATACTGAGAACGGCGAGTGGGCCATCGACTTCTGCCCGGGGGTGATCCGCCGCCACCACGGTGGCGCCACCGACGGCCCAGG GGAGACTGACGTCATCTACTCGCTCATCATCCGCCGGAAGCCGCTCTTCTACGTCATTAACATCATCGTGCCCTGTGTGCTCATCTCGGG CCTGGTGCTGCTCGCCTACTTCCTGCCGGCGCAGGCCGGCGGCCAGAAATGCACGGTCTCCATCAACGTCCTGCTCGCCCAGACCGTCTT CTTGTTCCTCATTGCCCAGAAAATCCCAGAGACTTCTCTGAGCGTGCCGCTCCTGGGCAGGTTCCTTATTTTCGTCATGGTGGTCGCCAC GCTCATTGTCATGAATTGCGTCATCGTGCTCAACGTGTCCCAGCGGACGCCCACCACCCACGCCATGTCCCCGCGGCTGCGCCACGTTCT CCTGGAGCTGCTGCCGCGCCTCCTGGGCTCCCCGCCGCCGCCCGAGGCCCCCCGGGCCGCCTCGCCCCCAAGGCGGGCGTCGTCGGTGGG CTTATTGCTCCGCGCGGAGGAGCTGATACTGAAAAAGCCACGGAGCGAGCTCGTGTTTGAGGGGCAGAGGCACCGGCAGGGGACCTGGAC GGCTGCCTTCTGCCAGAGCCTGGGCGCCGCCGCCCCCGAGGTCCGCTGCTGTGTGGATGCCGTGAACTTCGTGGCCGAGAGCACGAGAGA TCAGGAGGCCACCGGCGAGGAAGTGTCCGACTGGGTGCGCATGGGGAATGCCCTTGACAACATCTGCTTCTGGGCCGCTCTGGTGCTCTT CAGCGTGGGCTCCAGCCTCATCTTCCTCGGGGCCTACTTCAACCGAGTGCCTGATCTCCCCTACGCGCCGTGTATCCAGCCTTAGCTCGC ACCGACTTCAATTTCCCACCCATCTCCAGTAGGAAATTGATTTTGAAAAAGTAGGCTGCCGCCACCACGGCATTATGATCCCTTCCCCCT GCTGATCAATCTGCAGTTTGTGAACTTCACAAGAATGGTGTGTGCCCGTTCCCTGGCGTGTGTAGGCCTGGCCGCAGTCCAGGGGTCAGC AGGAGGAAAGGGTTCACATAGGCTCTCAGGTGCCAGTCTTCCAGAAAGCAAGGACTGCCCTTCATTCAGCCTTGCTGACCTCCCAGCCTT TCTAAGGCTCAGCCCCACGGGACTCTGGTGGCTGCCAGCTTGTGAGCTATCTATCTATATTCATTTCATAGCCAAACAGGAGACCCCTTT GCAGGACTTGCACACAGGGAGGCTGTAGCCAGGAAACCCTCTTCTTCCCTGGTCTGGCTCTGCTGGAGCGGGTGGGAACCAAACACCTTC AGTGCTGGTGGCCCTCAGGCCCACAGGTTTAAGGCTGAGGCTGCCCTGACCCTTCCACAGTCATTTCTTCTAGGTTTTCTTGGCCCAGCA CTGCCCATCCCACCCCATGAGGCTCACTCATTGCAGATCCCAGCCCACCCTGCCCCTTTCTTCCCCACCCTGGAGGCTCTCTCTGCCTAG TCTACAGTACTGACAGAAAGCAAGGACATGCGGCCTGCATGGTGGGAGCTGGTTGAATTGTCTTTATTAACAAACAGGATATCCAAGGCC ACTACATTGAGGAGGGGTGGGGGGGGAGGGAGAAGGGTTACTTGCTGCTCACACTATATACAGATGCAAGCAAGGGGCGTGGAGAGTGAG GGCTCCCTGCTCCCTCCCTCCACCGGGGAAGGGCATGGGCTAGAAGAGGAGAGGGGGGTCGGGAATGGGGGGAATGTTTTGGCTGGCGGG |
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FusionGenePPI for PELP1_CHRNE |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PELP1 | SRC, AR, RB1, ESR1, EP300, CREBBP, BAG6, TOM1L1, NR4A1, STAT3, SRF, HIST1H3A, HIST2H2AC, HIST2H2BE, HIST1H4A, HIST1H1A, HDAC2, KDM1A, LAS1L, SENP3, SMARCAD1, BLOC1S1, SIRT7, HGS, SNCA, MDN1, ECT2, FN1, SMAD9, MAP1LC3A, IPO5, TEX10, NOL9, WDR18, RPL26, RPL11, SOX2, NFKB1, RPA3, RPA2, RPA1, LGR4, CUL7, OBSL1, RNF2, SUMO2, BCAS3, RPL13, NPM1, RPS2, PIP5K1A, HIST1H2BA, NOLC1, AP3B1, CDK11A, HTATSF1, RUVBL1, NTRK1, IFI16, EWSR1, HERC2, RPL10, FOXQ1, MCM5, PHF19, TRIM25 | CHRNE | CHRNA1, RBM3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PELP1_CHRNE |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | CHRNE | Q04844 | DB00674 | Galantamine | Acetylcholine receptor subunit epsilon | small molecule | approved |
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RelatedDiseases for PELP1_CHRNE |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CHRNE | C4225413 | MYASTHENIC SYNDROME, CONGENITAL, 4A, SLOW-CHANNEL | 5 | UNIPROT |
| Tgene | CHRNE | C4225369 | MYASTHENIC SYNDROME, CONGENITAL, 4B, FAST-CHANNEL | 3 | UNIPROT |
| Tgene | CHRNE | C1837091 | MYASTHENIC SYNDROME, CONGENITAL, ASSOCIATED WITH ACETYLCHOLINE RECEPTOR DEFICIENCY | 1 | CTD_human;UNIPROT |
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