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Fusion gene ID: 2662 |
FusionGeneSummary for ARID4A_NAA30 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARID4A_NAA30 | Fusion gene ID: 2662 | Hgene | Tgene | Gene symbol | ARID4A | NAA30 | Gene ID | 5926 | 122830 |
| Gene name | AT-rich interaction domain 4A | N(alpha)-acetyltransferase 30, NatC catalytic subunit | |
| Synonyms | RBBP-1|RBBP1|RBP-1|RBP1 | C14orf35|MAK3|Mak3p|NAT12|NAT12P | |
| Cytomap | 14q23.1 | 14q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AT-rich interactive domain-containing protein 4AARID domain-containing protein 4AAT rich interactive domain 4A (RBP1-like)retinoblastoma-binding protein 1 | N-alpha-acetyltransferase 30N-acetyltransferase 12 (GCN5-related, putative)N-acetyltransferase MAK3 homolognatC catalytic subunitputative N-acetyltransferase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P29374 | Q147X3 | |
| Ensembl transtripts involved in fusion gene | ENST00000355431, ENST00000348476, ENST00000395168, ENST00000431317, ENST00000553355, | ENST00000555166, ENST00000556492, ENST00000554703, | |
| Fusion gene scores | * DoF score | 6 X 6 X 5=180 | 2 X 1 X 2=4 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: ARID4A [Title/Abstract] AND NAA30 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARID4A | GO:0045892 | negative regulation of transcription, DNA-templated | 12724404 |
| Tgene | NAA30 | GO:0017196 | N-terminal peptidyl-methionine acetylation | 19398576 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-BD-A3ER-01A | ARID4A | chr14 | 58766578 | + | NAA30 | chr14 | 57863470 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000355431 | ENST00000555166 | ARID4A | chr14 | 58766578 | + | NAA30 | chr14 | 57863470 | + |
| 5CDS-5UTR | ENST00000355431 | ENST00000556492 | ARID4A | chr14 | 58766578 | + | NAA30 | chr14 | 57863470 | + |
| 5CDS-5UTR | ENST00000355431 | ENST00000554703 | ARID4A | chr14 | 58766578 | + | NAA30 | chr14 | 57863470 | + |
| 5CDS-5UTR | ENST00000348476 | ENST00000555166 | ARID4A | chr14 | 58766578 | + | NAA30 | chr14 | 57863470 | + |
| 5CDS-5UTR | ENST00000348476 | ENST00000556492 | ARID4A | chr14 | 58766578 | + | NAA30 | chr14 | 57863470 | + |
| 5CDS-5UTR | ENST00000348476 | ENST00000554703 | ARID4A | chr14 | 58766578 | + | NAA30 | chr14 | 57863470 | + |
| 5CDS-5UTR | ENST00000395168 | ENST00000555166 | ARID4A | chr14 | 58766578 | + | NAA30 | chr14 | 57863470 | + |
| 5CDS-5UTR | ENST00000395168 | ENST00000556492 | ARID4A | chr14 | 58766578 | + | NAA30 | chr14 | 57863470 | + |
| 5CDS-5UTR | ENST00000395168 | ENST00000554703 | ARID4A | chr14 | 58766578 | + | NAA30 | chr14 | 57863470 | + |
| 5CDS-5UTR | ENST00000431317 | ENST00000555166 | ARID4A | chr14 | 58766578 | + | NAA30 | chr14 | 57863470 | + |
| 5CDS-5UTR | ENST00000431317 | ENST00000556492 | ARID4A | chr14 | 58766578 | + | NAA30 | chr14 | 57863470 | + |
| 5CDS-5UTR | ENST00000431317 | ENST00000554703 | ARID4A | chr14 | 58766578 | + | NAA30 | chr14 | 57863470 | + |
| intron-5UTR | ENST00000553355 | ENST00000555166 | ARID4A | chr14 | 58766578 | + | NAA30 | chr14 | 57863470 | + |
| intron-5UTR | ENST00000553355 | ENST00000556492 | ARID4A | chr14 | 58766578 | + | NAA30 | chr14 | 57863470 | + |
| intron-5UTR | ENST00000553355 | ENST00000554703 | ARID4A | chr14 | 58766578 | + | NAA30 | chr14 | 57863470 | + |
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FusionProtFeatures for ARID4A_NAA30 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARID4A | NAA30 |
| Interacts with the viral protein-binding domain of theretinoblastoma protein. | Catalytic subunit of the N-terminal acetyltransferase C(NatC) complex. Catalyzes acetylation of the N-terminal methionineresidues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly.Necessary for the lysosomal localization and function of ARL8Bsugeesting that ARL8B is a NatC substrate.{ECO:0000269|PubMed:19398576}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ARID4A_NAA30 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ARID4A_NAA30 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ARID4A | RB1, RBL1, ING2, ARID4B, BRMS1, SAP30, SIN3A, SIN3B, HDAC1, RBBP7, RBBP4, CCND1, CDK4, CCNE1, CDK2, CCNA2, CDK1, CCNB1, HIST4H4, HIST2H3C, MXD1, HIST1H2BG, FOXK1, FOXK2, GATAD1, FAM60A, ZNF704 | NAA30 | PTAR1, DUSP19, CD2BP2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARID4A_NAA30 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARID4A_NAA30 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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