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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26613

FusionGeneSummary for PDZRN3_EIF4E3

check button Fusion gene summary
Fusion gene informationFusion gene name: PDZRN3_EIF4E3
Fusion gene ID: 26613
HgeneTgene
Gene symbol

PDZRN3

EIF4E3

Gene ID

23024

317649

Gene namePDZ domain containing ring finger 3eukaryotic translation initiation factor 4E family member 3
SynonymsLNX3|SEMACAP3|SEMCAP3eIF-4E3|eIF4E-3
Cytomap

3p13

3p13

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase PDZRN3RING-type E3 ubiquitin transferase PDZRN3ligand of Numb protein X 3likely ortholog of mouse semaF cytoplasmic domain associated protein 3semaphorin cytoplasmic domain-associated protein 3eukaryotic translation initiation factor 4E type 3
Modification date2018052320180519
UniProtAcc

Q9UPQ7

Q8N5X7

Ensembl transtripts involved in fusion geneENST00000263666, ENST00000466780, 
ENST00000308537, ENST00000462146, 
ENST00000535920, ENST00000479530, 
ENST00000466348, 
ENST00000425534, 
ENST00000389826, ENST00000448225, 
ENST00000295612, ENST00000468147, 
ENST00000421769, 
Fusion gene scores* DoF score8 X 4 X 6=1923 X 2 X 4=24
# samples 106
** MAII scorelog2(10/192*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/24*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PDZRN3 [Title/Abstract] AND EIF4E3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-VP-A87K-01APDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263666ENST00000425534PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
5CDS-5UTRENST00000263666ENST00000389826PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
5CDS-5UTRENST00000263666ENST00000448225PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
5CDS-5UTRENST00000263666ENST00000295612PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
5CDS-5UTRENST00000263666ENST00000468147PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
5CDS-5UTRENST00000263666ENST00000421769PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-intronENST00000466780ENST00000425534PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000466780ENST00000389826PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000466780ENST00000448225PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000466780ENST00000295612PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000466780ENST00000468147PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000466780ENST00000421769PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
5CDS-intronENST00000308537ENST00000425534PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
5CDS-5UTRENST00000308537ENST00000389826PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
5CDS-5UTRENST00000308537ENST00000448225PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
5CDS-5UTRENST00000308537ENST00000295612PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
5CDS-5UTRENST00000308537ENST00000468147PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
5CDS-5UTRENST00000308537ENST00000421769PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-intronENST00000462146ENST00000425534PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000462146ENST00000389826PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000462146ENST00000448225PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000462146ENST00000295612PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000462146ENST00000468147PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000462146ENST00000421769PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-intronENST00000535920ENST00000425534PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000535920ENST00000389826PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000535920ENST00000448225PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000535920ENST00000295612PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000535920ENST00000468147PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000535920ENST00000421769PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-intronENST00000479530ENST00000425534PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000479530ENST00000389826PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000479530ENST00000448225PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000479530ENST00000295612PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000479530ENST00000468147PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000479530ENST00000421769PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-intronENST00000466348ENST00000425534PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000466348ENST00000389826PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000466348ENST00000448225PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000466348ENST00000295612PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000466348ENST00000468147PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-
intron-5UTRENST00000466348ENST00000421769PDZRN3chr3

73651505

-EIF4E3chr3

71777774

-

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FusionProtFeatures for PDZRN3_EIF4E3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDZRN3

Q9UPQ7

EIF4E3

Q8N5X7

E3 ubiquitin-protein ligase. Plays an important role inregulating the surface level of MUSK on myotubes. Mediates theubiquitination of MUSK, promoting its endocytosis and lysosomaldegradation. Might contribute to terminal myogenicdifferentiation. {ECO:0000250|UniProtKB:Q69ZS0}. Recognizes and binds the 7-methylguanosine-containingmRNA cap during an early step in the initiation of proteinsynthesis. May act as an inhibitor of EIF4E1 activity (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDZRN3_EIF4E3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDZRN3_EIF4E3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDZRN3MUSK, UBE2D2, LNX1, LNX2, OIP5, FAM13C, OFD1, SDHA, ZNF785, STX11, POTEB3, FZD4EIF4E3DCC, ELAVL1, TBC1D4, THEMIS2, FBXW7, EIF4A1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDZRN3_EIF4E3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDZRN3_EIF4E3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDZRN3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneEIF4E3C0023893Liver Cirrhosis, Experimental1CTD_human