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Fusion gene ID: 26609 |
FusionGeneSummary for PDZD8_ENO4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDZD8_ENO4 | Fusion gene ID: 26609 | Hgene | Tgene | Gene symbol | PDZD8 | ENO4 | Gene ID | 118987 | 387712 |
| Gene name | PDZ domain containing 8 | enolase 4 | |
| Synonyms | PDZK8 | C10orf134 | |
| Cytomap | 10q25.3-q26.11 | 10q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PDZ domain-containing protein 8sarcoma antigen NY-SAR-84/NY-SAR-104 | enolase 42-phospho-D-glycerate hydro-lyaseenolase family member 4enolase-like protein ENO4 | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | Q8NEN9 | A6NNW6 | |
| Ensembl transtripts involved in fusion gene | ENST00000334464, ENST00000482496, | ENST00000341276, ENST00000409522, ENST00000369207, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PDZD8 [Title/Abstract] AND ENO4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PDZD8 | GO:0051560 | mitochondrial calcium ion homeostasis | 29097544 |
| Hgene | PDZD8 | GO:1990456 | mitochondrion-endoplasmic reticulum membrane tethering | 29097544 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-DA-A1I8-06A | PDZD8 | chr10 | 119078383 | - | ENO4 | chr10 | 118615134 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000334464 | ENST00000341276 | PDZD8 | chr10 | 119078383 | - | ENO4 | chr10 | 118615134 | + |
| 5CDS-intron | ENST00000334464 | ENST00000409522 | PDZD8 | chr10 | 119078383 | - | ENO4 | chr10 | 118615134 | + |
| 5CDS-intron | ENST00000334464 | ENST00000369207 | PDZD8 | chr10 | 119078383 | - | ENO4 | chr10 | 118615134 | + |
| intron-3CDS | ENST00000482496 | ENST00000341276 | PDZD8 | chr10 | 119078383 | - | ENO4 | chr10 | 118615134 | + |
| intron-intron | ENST00000482496 | ENST00000409522 | PDZD8 | chr10 | 119078383 | - | ENO4 | chr10 | 118615134 | + |
| intron-intron | ENST00000482496 | ENST00000369207 | PDZD8 | chr10 | 119078383 | - | ENO4 | chr10 | 118615134 | + |
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FusionProtFeatures for PDZD8_ENO4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDZD8 | ENO4 |
| Molecular tethering protein that connects endoplasmicreticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering isessential for endoplasmic reticulum-mitochondria Ca(2+) transfer(PubMed:29097544). In neurons, involved in the regulation ofdendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+)uptake in neurons (PubMed:29097544). Plays an indirect role in theregulation of cell morphology and cytoskeletal organization(PubMed:21834987). May inhibit herpes simplex virus 1 infection atan early stage (PubMed:21549406). {ECO:0000269|PubMed:21549406,ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29097544}. | May be required for sperm motility and function.{ECO:0000250|UniProtKB:Q8C042}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PDZD8 | chr10:119078383 | chr10:118615134 | ENST00000334464 | - | 3 | 5 | 91_294 | 366 | 1155 | Domain | SMP-LTD |
| Hgene | PDZD8 | chr10:119078383 | chr10:118615134 | ENST00000334464 | - | 3 | 5 | 2_24 | 366 | 1155 | Transmembrane | Helical |
| Tgene | >ENO4 | chr10:119078383 | chr10:118615134 | ENST00000409522 | + | 0 | 7 | 189_231 | -19 | 309 | Compositional bias | Note=Pro-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PDZD8 | chr10:119078383 | chr10:118615134 | ENST00000334464 | - | 3 | 5 | 1028_1063 | 366 | 1155 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PDZD8 | chr10:119078383 | chr10:118615134 | ENST00000334464 | - | 3 | 5 | 551_626 | 366 | 1155 | Compositional bias | Note=Pro-rich |
| Hgene | >PDZD8 | chr10:119078383 | chr10:118615134 | ENST00000334464 | - | 3 | 5 | 366_449 | 366 | 1155 | Domain | PDZ |
| Hgene | >PDZD8 | chr10:119078383 | chr10:118615134 | ENST00000334464 | - | 3 | 5 | 840_891 | 366 | 1155 | Zinc finger | Phorbol-ester/DAG-type |
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FusionGeneSequence for PDZD8_ENO4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PDZD8_ENST00000334464_chr10_119078383_-_ENO4_ENST00000341276_chr10_118615134_+_939aa MGLLLMILASAVLGSFLTLLAQFFLLYRRQPEPPADEAARAGEGFRYIKPVPGLLLREYLYGGGRDEEPSGAAPEGGATPTAAPETPAPP TRETCYFLNATILFLFRELRDTALTRRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLVRPVVPSATGEPDGPEGE ALPAACPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRLVFTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSI IVNQLKKIIKRKHTLPNYKIRFKPFFPYQTLQGFEEDEEHIHIQQWALTEGRLKVTLLECSRLLIFGSYDREANVHCTLELSSSVWEEKQ RSSIKTANCFSKLAKPPTICKIVGKDVLDGLGLPTLQVDIFCTIQNFPKNVCSVVISTHFEVHENALPELAKAEEAERASAVSTAVQWVN STITHELQGMAPSDQAEVDHLLRIFFASKVQEDKGRKELEKSLEYSTVPTPLPPVPPPPPPPPPTKKKGQKPGRKDTITEKPIAPAEPVE PVLSGSMAIGAVSLAVAKACAMLLNKPLYLNIALLKHNQEQPTTLSMPLLMVSLVSCGKSSSGKLNLMKEVICIPHPELTTKQGVEMLME MQKHINKIIEMVSPSPPKAETKKGHDGSKRGQQQITGKMSHLGCLTINCDSIEQPLLLIQEICANLGLELGTNLHLAINCAGHELMDYNK GKYEVIMGTYKNAAEMVDLYVDLINKYPSIIALIDPFRKEDSEQWDSIYHALGSRCYIIAGTASKSISKLLEQGNISIPKSNGLIIKHTN QTTMSDLVEITNLIDSKKHITVFGSTEGESSDDSLVDLAVGLGVRFIKLGGLSRGERVTKYNRLLTIEEELVQNGTLGFKEEHTFFYFNE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PDZD8_ENST00000334464_chr10_119078383_-_ENO4_ENST00000341276_chr10_118615134_+_2817nt ATGGGGCTGCTGCTCATGATCCTGGCGTCGGCCGTGCTGGGTTCCTTCCTCACGCTCCTCGCCCAGTTCTTCCTGCTGTACCGCAGACAG CCCGAGCCGCCGGCGGACGAGGCCGCCCGCGCGGGCGAGGGCTTCCGCTACATCAAGCCAGTGCCGGGCCTGCTCCTAAGGGAGTACCTT TATGGCGGCGGCCGGGATGAGGAGCCCTCCGGAGCGGCCCCTGAGGGCGGCGCGACCCCCACCGCGGCCCCCGAGACCCCCGCCCCGCCG ACGCGGGAGACTTGCTACTTCCTCAACGCCACCATCCTATTCCTGTTCCGGGAGTTGCGGGACACCGCGCTGACCCGCCGCTGGGTCACC AAGAAGATCAAGGTGGAGTTCGAGGAGCTGCTGCAGACCAAGACGGCCGGGCGCCTGCTGGAGGGGCTGAGCCTGCGGGACGTGTTCCTG GGCGAGACGGTGCCCTTCATCAAGACCATCCGGCTCGTGCGGCCAGTCGTGCCCTCGGCCACCGGGGAGCCCGATGGCCCTGAAGGGGAG GCGCTGCCCGCCGCCTGCCCCGAGGAGCTGGCCTTCGAGGCGGAGGTGGAGTACAACGGGGGCTTCCACCTGGCCATCGACGTGGACCTG GTCTTCGGCAAGTCCGCCTACTTGTTTGTCAAGCTGTCCCGCGTGGTGGGAAGGCTGCGCTTGGTCTTTACGCGCGTGCCCTTCACCCAC TGGTTCTTCTCCTTCGTGGAAGACCCGCTGATCGACTTCGAGGTGCGCTCCCAGTTTGAAGGGCGGCCCATGCCCCAGCTCACCTCCATC ATCGTCAACCAGCTCAAGAAGATCATCAAGCGCAAGCACACCCTACCGAATTACAAGATCAGGTTTAAGCCGTTTTTTCCATACCAGACC TTGCAAGGATTTGAAGAAGATGAAGAGCATATCCATATACAACAATGGGCACTTACTGAAGGCCGTCTTAAAGTTACGTTGTTAGAATGT AGCAGGTTACTCATTTTTGGATCCTATGACAGAGAGGCAAATGTTCATTGCACACTTGAGTTAAGCAGTAGTGTTTGGGAAGAAAAACAG AGGAGTTCTATTAAGACGGCAAACTGCTTTTCTAAACTTGCAAAGCCTCCCACCATATGCAAAATAGTGGGGAAAGACGTACTAGATGGA CTGGGGCTTCCAACCCTGCAAGTGGACATATTCTGCACCATTCAAAACTTTCCCAAGAACGTATGTTCTGTGGTGATCTCGACTCATTTT GAAGTCCATGAGAATGCTCTGCCCGAGCTGGCCAAGGCGGAGGAGGCAGAGAGGGCCAGCGCGGTGAGCACCGCCGTGCAGTGGGTCAAC AGCACCATCACGCACGAGCTCCAGGGGATGGCACCCTCTGACCAGGCAGAGGTGGATCACCTACTCAGGATATTCTTCGCAAGTAAAGTA CAAGAAGATAAGGGGAGAAAAGAATTGGAAAAGAGCCTGGAATACTCAACAGTGCCTACACCTCTACCTCCAGTACCACCACCACCACCC CCTCCACCTCCTACCAAAAAAAAGGGGCAAAAGCCAGGGAGGAAGGATACTATTACAGAGAAACCTATTGCGCCTGCAGAGCCTGTTGAG CCTGTACTCAGTGGCAGTATGGCCATAGGGGCCGTGTCACTAGCTGTTGCCAAAGCCTGTGCCATGCTGCTTAATAAACCTCTGTACTTA AATATCGCTCTACTGAAGCACAATCAGGAACAGCCAACAACGCTATCTATGCCTTTGCTGATGGTATCGCTGGTCAGCTGTGGGAAGTCA TCATCTGGGAAGCTAAATTTAATGAAAGAAGTGATTTGTATACCCCATCCTGAATTAACAACCAAACAAGGTGTCGAGATGCTTATGGAA ATGCAGAAACATATCAACAAAATAATTGAAATGGTATCACCCTCTCCTCCAAAAGCAGAGACAAAAAAAGGGCACGATGGAAGCAAAAGA GGTCAACAGCAGATCACTGGCAAGATGTCTCATCTTGGCTGTTTAACCATTAACTGTGACTCCATAGAACAGCCACTGCTTCTAATACAG GAAATCTGTGCCAACCTGGGGCTAGAACTGGGAACAAATCTGCATCTAGCTATCAACTGTGCTGGACATGAGCTGATGGACTACAATAAA GGAAAGTATGAAGTGATCATGGGCACATACAAAAATGCAGCGGAGATGGTTGACCTGTATGTGGATCTGATCAACAAGTACCCTTCAATT ATTGCCTTAATTGATCCTTTCAGGAAGGAGGACTCTGAACAGTGGGACAGCATCTATCACGCACTTGGTTCCAGGTGTTACATAATTGCA GGAACTGCTTCCAAAAGCATTTCTAAACTTCTAGAGCAAGGAAACATCAGCATCCCCAAATCCAATGGGCTGATCATAAAACACACAAAC CAAACTACAATGTCTGACTTGGTGGAAATAACCAATCTGATTGACAGTAAGAAGCACATCACTGTCTTTGGAAGTACAGAAGGAGAATCA TCTGATGACAGCCTTGTCGATTTGGCTGTTGGGCTTGGTGTCCGGTTCATCAAGTTGGGGGGTCTTTCCCGTGGTGAACGAGTGACTAAA TACAACCGCCTTCTCACTATAGAGGAAGAACTTGTCCAGAATGGAACACTGGGTTTCAAAGAAGAACACACTTTTTTTTACTTTAATGAG GAAGCTGAAAAGGCTGCGGAGGCACTTGAGGCTGCTGCGGCTAGGGAGCCGCTGGTGCCCACCTTCCCCACACAAGGTGTAGAGGAATCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PDZD8_ENST00000334464_chr10_119078383_-_ENO4_ENST00000341276_chr10_118615134_+_3894nt GGTCCCGGCCCCGCTGCCGCCGCCGCCACACCGGCCCTTCGGGAGCGTCTGAGGAGGCGCGGGCCGCTGCGGGCTCGGGCGCCGCAGCGC GCCGGCCCGAGCCCCTGGACGAGGCCCACGGAGCCGCTCGCCCCGACCCAGCCGCCCGATGTCCTCAAAATGGAGGCAGCGGGGGCGGCG GCGTGAAGAAAGCGGCGCTGTGGGCGCGGGAGTAGGGGCCCGGGCGGAGGCGGTGGCGGGATGGGGCTGCTGCTCATGATCCTGGCGTCG GCCGTGCTGGGTTCCTTCCTCACGCTCCTCGCCCAGTTCTTCCTGCTGTACCGCAGACAGCCCGAGCCGCCGGCGGACGAGGCCGCCCGC GCGGGCGAGGGCTTCCGCTACATCAAGCCAGTGCCGGGCCTGCTCCTAAGGGAGTACCTTTATGGCGGCGGCCGGGATGAGGAGCCCTCC GGAGCGGCCCCTGAGGGCGGCGCGACCCCCACCGCGGCCCCCGAGACCCCCGCCCCGCCGACGCGGGAGACTTGCTACTTCCTCAACGCC ACCATCCTATTCCTGTTCCGGGAGTTGCGGGACACCGCGCTGACCCGCCGCTGGGTCACCAAGAAGATCAAGGTGGAGTTCGAGGAGCTG CTGCAGACCAAGACGGCCGGGCGCCTGCTGGAGGGGCTGAGCCTGCGGGACGTGTTCCTGGGCGAGACGGTGCCCTTCATCAAGACCATC CGGCTCGTGCGGCCAGTCGTGCCCTCGGCCACCGGGGAGCCCGATGGCCCTGAAGGGGAGGCGCTGCCCGCCGCCTGCCCCGAGGAGCTG GCCTTCGAGGCGGAGGTGGAGTACAACGGGGGCTTCCACCTGGCCATCGACGTGGACCTGGTCTTCGGCAAGTCCGCCTACTTGTTTGTC AAGCTGTCCCGCGTGGTGGGAAGGCTGCGCTTGGTCTTTACGCGCGTGCCCTTCACCCACTGGTTCTTCTCCTTCGTGGAAGACCCGCTG ATCGACTTCGAGGTGCGCTCCCAGTTTGAAGGGCGGCCCATGCCCCAGCTCACCTCCATCATCGTCAACCAGCTCAAGAAGATCATCAAG CGCAAGCACACCCTACCGAATTACAAGATCAGGTTTAAGCCGTTTTTTCCATACCAGACCTTGCAAGGATTTGAAGAAGATGAAGAGCAT ATCCATATACAACAATGGGCACTTACTGAAGGCCGTCTTAAAGTTACGTTGTTAGAATGTAGCAGGTTACTCATTTTTGGATCCTATGAC AGAGAGGCAAATGTTCATTGCACACTTGAGTTAAGCAGTAGTGTTTGGGAAGAAAAACAGAGGAGTTCTATTAAGACGGCAAACTGCTTT TCTAAACTTGCAAAGCCTCCCACCATATGCAAAATAGTGGGGAAAGACGTACTAGATGGACTGGGGCTTCCAACCCTGCAAGTGGACATA TTCTGCACCATTCAAAACTTTCCCAAGAACGTATGTTCTGTGGTGATCTCGACTCATTTTGAAGTCCATGAGAATGCTCTGCCCGAGCTG GCCAAGGCGGAGGAGGCAGAGAGGGCCAGCGCGGTGAGCACCGCCGTGCAGTGGGTCAACAGCACCATCACGCACGAGCTCCAGGGGATG GCACCCTCTGACCAGGCAGAGGTGGATCACCTACTCAGGATATTCTTCGCAAGTAAAGTACAAGAAGATAAGGGGAGAAAAGAATTGGAA AAGAGCCTGGAATACTCAACAGTGCCTACACCTCTACCTCCAGTACCACCACCACCACCCCCTCCACCTCCTACCAAAAAAAAGGGGCAA AAGCCAGGGAGGAAGGATACTATTACAGAGAAACCTATTGCGCCTGCAGAGCCTGTTGAGCCTGTACTCAGTGGCAGTATGGCCATAGGG GCCGTGTCACTAGCTGTTGCCAAAGCCTGTGCCATGCTGCTTAATAAACCTCTGTACTTAAATATCGCTCTACTGAAGCACAATCAGGAA CAGCCAACAACGCTATCTATGCCTTTGCTGATGGTATCGCTGGTCAGCTGTGGGAAGTCATCATCTGGGAAGCTAAATTTAATGAAAGAA GTGATTTGTATACCCCATCCTGAATTAACAACCAAACAAGGTGTCGAGATGCTTATGGAAATGCAGAAACATATCAACAAAATAATTGAA ATGGTATCACCCTCTCCTCCAAAAGCAGAGACAAAAAAAGGGCACGATGGAAGCAAAAGAGGTCAACAGCAGATCACTGGCAAGATGTCT CATCTTGGCTGTTTAACCATTAACTGTGACTCCATAGAACAGCCACTGCTTCTAATACAGGAAATCTGTGCCAACCTGGGGCTAGAACTG GGAACAAATCTGCATCTAGCTATCAACTGTGCTGGACATGAGCTGATGGACTACAATAAAGGAAAGTATGAAGTGATCATGGGCACATAC AAAAATGCAGCGGAGATGGTTGACCTGTATGTGGATCTGATCAACAAGTACCCTTCAATTATTGCCTTAATTGATCCTTTCAGGAAGGAG GACTCTGAACAGTGGGACAGCATCTATCACGCACTTGGTTCCAGGTGTTACATAATTGCAGGAACTGCTTCCAAAAGCATTTCTAAACTT CTAGAGCAAGGAAACATCAGCATCCCCAAATCCAATGGGCTGATCATAAAACACACAAACCAAACTACAATGTCTGACTTGGTGGAAATA ACCAATCTGATTGACAGTAAGAAGCACATCACTGTCTTTGGAAGTACAGAAGGAGAATCATCTGATGACAGCCTTGTCGATTTGGCTGTT GGGCTTGGTGTCCGGTTCATCAAGTTGGGGGGTCTTTCCCGTGGTGAACGAGTGACTAAATACAACCGCCTTCTCACTATAGAGGAAGAA CTTGTCCAGAATGGAACACTGGGTTTCAAAGAAGAACACACTTTTTTTTACTTTAATGAGGAAGCTGAAAAGGCTGCGGAGGCACTTGAG GCTGCTGCGGCTAGGGAGCCGCTGGTGCCCACCTTCCCCACACAAGGTGTAGAGGAATCAGCCGAAACAGGAGCATCCTCTGGATAGGGC TGTACACACCCCAGGTTCCAGCCACACCATCAGTATTAGTAGACCGGGAGGTCTGAAGTACGGCGCCGTGTCTCCACATGGAGTTTCCTC TTCAACTTCACCAACTCTTGTGGTTTTTATTCTTCTAATTCCACTGTTTGGTAAATTACATATATGATGTTTTTGCCTGAAATTCTGTGA ACTTCGTTTTGCAGCCACCACACTTCCATGTGGATTTTGTTTGTCTATTAGCTCTCCTGTCCATTTTTCAGGGACACGCTCCAGTAAAAG AGGCCAATATTTTTGTTGCCAACTCCACACTCAGTCAAACACCCCATCCTTTACCAATCAGAATATCTCTGAGAACAAAAACCTAATGAC CCTAGAAGCTCTCTGTGCTGGGAACAGATGTCCATCTTCTGTGTTTATTCTACATGTCTGTGCTGAAAAGCACTGACACATTTTTGTAAC CAACCTCACGTAGAAGTGTGAGAGCATCACCATTTTTTGTAAGAGCCAATTTCATCTCACTTTCCTACCCTTGATTCCTTTTTTCCTAAT TCCCTCTCCTTTTTAAATTTTAGTTTTTCTTGTATTATTTTTATCTTTGCGAGTCTTCTTAGATCCTTTTTGGAGTAAGAATGAGTATAA ATGAATAAGCACATCAGTAAATGAATTAATATTCTCAAGGTTATTAAATGCCCAGTTATTCATACCACAGCATTTAAAAAGCAATCCGCA AGTGATAAAAAAAAAAAAAAAAAATGATGTGACATATCCATTGCCTGAATTGCTCTTTTGTAAGCCAGTGTTGGGATTATAGCAGAGGAG |
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FusionGenePPI for PDZD8_ENO4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PDZD8 | ELAVL1, BARD1, SRPRB, TEX264, BTN2A1, TREML2, FAM189A2, EVA1C, CHRNA9, TMEM17, TMEM216, CTDNEP1, ZNRF4, PCDHB16, PCDHGA5, CNGA3, KCNS3, PCDHGB4, LRRTM1, GABRA6, CHRND, TMEM9B, PCDHB7, TMPRSS3, KCNC4, ENTPD4, FSHR, PCDHB11, PCDHAC2, IL17RC, NMUR2, FAM189B, CDH5, ASIC4 | ENO4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDZD8_ENO4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PDZD8_ENO4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ENO4 | C0021364 | Male infertility | 1 | CTD_human |
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