FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 2658

FusionGeneSummary for ARID4A_ARID4A

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID4A_ARID4A
Fusion gene ID: 2658
HgeneTgene
Gene symbol

ARID4A

ARID4A

Gene ID

5926

5926

Gene nameAT-rich interaction domain 4AAT-rich interaction domain 4A
SynonymsRBBP-1|RBBP1|RBP-1|RBP1RBBP-1|RBBP1|RBP-1|RBP1
Cytomap

14q23.1

14q23.1

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 4AARID domain-containing protein 4AAT rich interactive domain 4A (RBP1-like)retinoblastoma-binding protein 1AT-rich interactive domain-containing protein 4AARID domain-containing protein 4AAT rich interactive domain 4A (RBP1-like)retinoblastoma-binding protein 1
Modification date2018052320180523
UniProtAcc

P29374

P29374

Ensembl transtripts involved in fusion geneENST00000355431, ENST00000348476, 
ENST00000395168, ENST00000431317, 
ENST00000553355, 
ENST00000355431, 
ENST00000348476, ENST00000395168, 
ENST00000431317, ENST00000553355, 
Fusion gene scores* DoF score6 X 6 X 5=1802 X 2 X 1=4
# samples 73
** MAII scorelog2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/4*10)=2.90689059560852
Context

PubMed: ARID4A [Title/Abstract] AND ARID4A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARID4A

GO:0045892

negative regulation of transcription, DNA-templated

12724404

TgeneARID4A

GO:0045892

negative regulation of transcription, DNA-templated

12724404


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ575110ARID4Achr14

58813770

-ARID4Achr14

58811438

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000355431ENST00000355431ARID4Achr14

58813770

-ARID4Achr14

58811438

+
Frame-shitENST00000355431ENST00000348476ARID4Achr14

58813770

-ARID4Achr14

58811438

+
Frame-shitENST00000355431ENST00000395168ARID4Achr14

58813770

-ARID4Achr14

58811438

+
Frame-shitENST00000355431ENST00000431317ARID4Achr14

58813770

-ARID4Achr14

58811438

+
5CDS-intronENST00000355431ENST00000553355ARID4Achr14

58813770

-ARID4Achr14

58811438

+
Frame-shitENST00000348476ENST00000355431ARID4Achr14

58813770

-ARID4Achr14

58811438

+
Frame-shitENST00000348476ENST00000348476ARID4Achr14

58813770

-ARID4Achr14

58811438

+
Frame-shitENST00000348476ENST00000395168ARID4Achr14

58813770

-ARID4Achr14

58811438

+
Frame-shitENST00000348476ENST00000431317ARID4Achr14

58813770

-ARID4Achr14

58811438

+
5CDS-intronENST00000348476ENST00000553355ARID4Achr14

58813770

-ARID4Achr14

58811438

+
Frame-shitENST00000395168ENST00000355431ARID4Achr14

58813770

-ARID4Achr14

58811438

+
Frame-shitENST00000395168ENST00000348476ARID4Achr14

58813770

-ARID4Achr14

58811438

+
Frame-shitENST00000395168ENST00000395168ARID4Achr14

58813770

-ARID4Achr14

58811438

+
Frame-shitENST00000395168ENST00000431317ARID4Achr14

58813770

-ARID4Achr14

58811438

+
5CDS-intronENST00000395168ENST00000553355ARID4Achr14

58813770

-ARID4Achr14

58811438

+
Frame-shitENST00000431317ENST00000355431ARID4Achr14

58813770

-ARID4Achr14

58811438

+
Frame-shitENST00000431317ENST00000348476ARID4Achr14

58813770

-ARID4Achr14

58811438

+
Frame-shitENST00000431317ENST00000395168ARID4Achr14

58813770

-ARID4Achr14

58811438

+
Frame-shitENST00000431317ENST00000431317ARID4Achr14

58813770

-ARID4Achr14

58811438

+
5CDS-intronENST00000431317ENST00000553355ARID4Achr14

58813770

-ARID4Achr14

58811438

+
intron-3CDSENST00000553355ENST00000355431ARID4Achr14

58813770

-ARID4Achr14

58811438

+
intron-3CDSENST00000553355ENST00000348476ARID4Achr14

58813770

-ARID4Achr14

58811438

+
intron-3CDSENST00000553355ENST00000395168ARID4Achr14

58813770

-ARID4Achr14

58811438

+
intron-3CDSENST00000553355ENST00000431317ARID4Achr14

58813770

-ARID4Achr14

58811438

+
intron-intronENST00000553355ENST00000553355ARID4Achr14

58813770

-ARID4Achr14

58811438

+

Top

FusionProtFeatures for ARID4A_ARID4A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARID4A

P29374

ARID4A

P29374

Interacts with the viral protein-binding domain of theretinoblastoma protein. Interacts with the viral protein-binding domain of theretinoblastoma protein.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ARID4A_ARID4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ARID4A_ARID4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ARID4A_ARID4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ARID4A_ARID4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource