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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26574

FusionGeneSummary for PDSS2_SOBP

check button Fusion gene summary
Fusion gene informationFusion gene name: PDSS2_SOBP
Fusion gene ID: 26574
HgeneTgene
Gene symbol

PDSS2

SOBP

Gene ID

57107

55084

Gene namedecaprenyl diphosphate synthase subunit 2sine oculis binding protein homolog
SynonymsC6orf210|COQ10D3|DLP1|bA59I9.3|hDLP1JXC1|MRAMS
Cytomap

6q21

6q21

Type of geneprotein-codingprotein-coding
Descriptiondecaprenyl-diphosphate synthase subunit 2all-trans-decaprenyl-diphosphate synthase subunit 2decaprenyl pyrophosphate synthase subunit 2decaprenyl pyrophosphate synthetase subunit 2prenyl (decaprenyl) diphosphate synthase, subunit 2subunit 2 of decaprsine oculis-binding protein homologjackson circler protein 1
Modification date2018052720180519
UniProtAcc

Q86YH6

A7XYQ1

Ensembl transtripts involved in fusion geneENST00000369037, ENST00000453874, 
ENST00000369031, 
ENST00000317357, 
ENST00000494935, 
Fusion gene scores* DoF score5 X 5 X 3=754 X 4 X 3=48
# samples 64
** MAII scorelog2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDSS2 [Title/Abstract] AND SOBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDSS2

GO:0006744

ubiquinone biosynthetic process

16262699

HgenePDSS2

GO:0008299

isoprenoid biosynthetic process

16262699


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A1RF-01APDSS2chr6

107655402

-SOBPchr6

107979411

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000369037ENST00000317357PDSS2chr6

107655402

-SOBPchr6

107979411

+
5CDS-intronENST00000369037ENST00000494935PDSS2chr6

107655402

-SOBPchr6

107979411

+
5CDS-3UTRENST00000453874ENST00000317357PDSS2chr6

107655402

-SOBPchr6

107979411

+
5CDS-intronENST00000453874ENST00000494935PDSS2chr6

107655402

-SOBPchr6

107979411

+
5CDS-3UTRENST00000369031ENST00000317357PDSS2chr6

107655402

-SOBPchr6

107979411

+
5CDS-intronENST00000369031ENST00000494935PDSS2chr6

107655402

-SOBPchr6

107979411

+

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FusionProtFeatures for PDSS2_SOBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDSS2

Q86YH6

SOBP

A7XYQ1

Supplies decaprenyl diphosphate, the precursor for theside chain of the isoprenoid quinones ubiquinone-10.{ECO:0000269|PubMed:16262699}. Implicated in development of the cochlea.{ECO:0000250|UniProtKB:Q0P5V2}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDSS2_SOBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDSS2_SOBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDSS2ELAVL1, APP, OXLD1, ACAD9, SDHA, THEM4, FDPSSOBPCELF3, CTBP1, SUMO2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDSS2_SOBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDSS2_SOBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDSS2C3553358COENZYME Q10 DEFICIENCY, PRIMARY, 31UNIPROT
TgeneSOBPC0033975Psychotic Disorders1PSYGENET
TgeneSOBPC0349204Nonorganic psychosis1PSYGENET