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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26570

FusionGeneSummary for PDSS2_CCDC178

check button Fusion gene summary
Fusion gene informationFusion gene name: PDSS2_CCDC178
Fusion gene ID: 26570
HgeneTgene
Gene symbol

PDSS2

CCDC178

Gene ID

57107

374864

Gene namedecaprenyl diphosphate synthase subunit 2coiled-coil domain containing 178
SynonymsC6orf210|COQ10D3|DLP1|bA59I9.3|hDLP1C18orf34
Cytomap

6q21

18q12.1

Type of geneprotein-codingprotein-coding
Descriptiondecaprenyl-diphosphate synthase subunit 2all-trans-decaprenyl-diphosphate synthase subunit 2decaprenyl pyrophosphate synthase subunit 2decaprenyl pyrophosphate synthetase subunit 2prenyl (decaprenyl) diphosphate synthase, subunit 2subunit 2 of decaprcoiled-coil domain-containing protein 178
Modification date2018052720180329
UniProtAcc

Q86YH6

Q5BJE1

Ensembl transtripts involved in fusion geneENST00000369037, ENST00000453874, 
ENST00000369031, 
ENST00000581852, 
ENST00000403303, ENST00000383096, 
ENST00000300227, ENST00000579916, 
ENST00000406524, ENST00000583930, 
ENST00000402325, ENST00000579947, 
ENST00000583550, 
Fusion gene scores* DoF score5 X 5 X 3=757 X 5 X 6=210
# samples 69
** MAII scorelog2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDSS2 [Title/Abstract] AND CCDC178 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDSS2

GO:0006744

ubiquinone biosynthetic process

16262699

HgenePDSS2

GO:0008299

isoprenoid biosynthetic process

16262699


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPAADTCGA-IB-7652-01APDSS2chr6

107655402

-CCDC178chr18

30554645

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000369037ENST00000581852PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369037ENST00000403303PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369037ENST00000383096PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369037ENST00000300227PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369037ENST00000579916PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369037ENST00000406524PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369037ENST00000583930PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369037ENST00000402325PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369037ENST00000579947PDSS2chr6

107655402

-CCDC178chr18

30554645

-
5CDS-intronENST00000369037ENST00000583550PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000453874ENST00000581852PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000453874ENST00000403303PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000453874ENST00000383096PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000453874ENST00000300227PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000453874ENST00000579916PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000453874ENST00000406524PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000453874ENST00000583930PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000453874ENST00000402325PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000453874ENST00000579947PDSS2chr6

107655402

-CCDC178chr18

30554645

-
5CDS-intronENST00000453874ENST00000583550PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369031ENST00000581852PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369031ENST00000403303PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369031ENST00000383096PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369031ENST00000300227PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369031ENST00000579916PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369031ENST00000406524PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369031ENST00000583930PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369031ENST00000402325PDSS2chr6

107655402

-CCDC178chr18

30554645

-
Frame-shitENST00000369031ENST00000579947PDSS2chr6

107655402

-CCDC178chr18

30554645

-
5CDS-intronENST00000369031ENST00000583550PDSS2chr6

107655402

-CCDC178chr18

30554645

-

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FusionProtFeatures for PDSS2_CCDC178


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDSS2

Q86YH6

CCDC178

Q5BJE1

Supplies decaprenyl diphosphate, the precursor for theside chain of the isoprenoid quinones ubiquinone-10.{ECO:0000269|PubMed:16262699}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDSS2_CCDC178


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDSS2_CCDC178


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDSS2ELAVL1, APP, OXLD1, ACAD9, SDHA, THEM4, FDPSCCDC178


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDSS2_CCDC178


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDSS2_CCDC178


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDSS2C3553358COENZYME Q10 DEFICIENCY, PRIMARY, 31UNIPROT