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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 2653

FusionGeneSummary for ARID3A_PMEPA1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID3A_PMEPA1
Fusion gene ID: 2653
HgeneTgene
Gene symbol

ARID3A

PMEPA1

Gene ID

1820

56937

Gene nameAT-rich interaction domain 3Aprostate transmembrane protein, androgen induced 1
SynonymsBRIGHT|DRIL1|DRIL3|E2FBP1STAG1|TMEPAI
Cytomap

19p13.3

20q13.31

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 3AARID domain-containing 3AARID domain-containing protein 3AAT rich interactive domain 3A (BRIGHT- like) proteinAT rich interactive domain 3A (BRIGHT-like)B-cell regulator of IgH transcriptionE2F-bindingprotein TMEPAIsolid tumor-associated 1 proteintransmembrane, prostate androgen induced RNA
Modification date2018052320180519
UniProtAcc

Q99856

Q969W9

Ensembl transtripts involved in fusion geneENST00000263620, ENST00000592216, 
ENST00000341744, ENST00000395816, 
ENST00000347215, ENST00000265626, 
ENST00000395814, ENST00000472841, 
Fusion gene scores* DoF score5 X 5 X 5=1253 X 2 X 3=18
# samples 53
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARID3A [Title/Abstract] AND PMEPA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePMEPA1

GO:0010991

negative regulation of SMAD protein complex assembly

20129061

TgenePMEPA1

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

24627487

TgenePMEPA1

GO:0060394

negative regulation of pathway-restricted SMAD protein phosphorylation

24627487


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A0AU-01AARID3Achr19

968503

+PMEPA1chr20

56234753

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000263620ENST00000341744ARID3Achr19

968503

+PMEPA1chr20

56234753

-
5CDS-5UTRENST00000263620ENST00000395816ARID3Achr19

968503

+PMEPA1chr20

56234753

-
5CDS-5UTRENST00000263620ENST00000347215ARID3Achr19

968503

+PMEPA1chr20

56234753

-
5CDS-5UTRENST00000263620ENST00000265626ARID3Achr19

968503

+PMEPA1chr20

56234753

-
5CDS-5UTRENST00000263620ENST00000395814ARID3Achr19

968503

+PMEPA1chr20

56234753

-
5CDS-5UTRENST00000263620ENST00000472841ARID3Achr19

968503

+PMEPA1chr20

56234753

-
intron-3CDSENST00000592216ENST00000341744ARID3Achr19

968503

+PMEPA1chr20

56234753

-
intron-5UTRENST00000592216ENST00000395816ARID3Achr19

968503

+PMEPA1chr20

56234753

-
intron-5UTRENST00000592216ENST00000347215ARID3Achr19

968503

+PMEPA1chr20

56234753

-
intron-5UTRENST00000592216ENST00000265626ARID3Achr19

968503

+PMEPA1chr20

56234753

-
intron-5UTRENST00000592216ENST00000395814ARID3Achr19

968503

+PMEPA1chr20

56234753

-
intron-5UTRENST00000592216ENST00000472841ARID3Achr19

968503

+PMEPA1chr20

56234753

-

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FusionProtFeatures for ARID3A_PMEPA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARID3A

Q99856

PMEPA1

Q969W9

Transcription factor which may be involved in thecontrol of cell cycle progression by the RB1/E2F1 pathway and inB-cell differentiation. {ECO:0000269|PubMed:11812999,ECO:0000269|PubMed:12692263}. Functions as a negative regulator of TGF-beta signalingand thereby probably plays a role in cell proliferation,differentiation, apoptosis, motility, extracellular matrixproduction and immunosuppression. In the canonical TGF-betapathway, ZFYVE9/SARA recruits the intracellular signal transducerand transcriptional modulators SMAD2 and SMAD3 to the TGF-betareceptor. Phosphorylated by the receptor, SMAD2 and SMAD3 thenform a heteromeric complex with SMAD4 that translocates to thenucleus to regulate transcription. Through interaction with SMAD2and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and preventpropagation of the intracellular signal (PubMed:20129061,PubMed:24627487). Also involved in down-regulation of the androgenreceptor (AR), enhancing ubiquitination and proteasome-mediateddegradation of AR, probably by recruiting NEDD4 (PubMed:18703514).{ECO:0000269|PubMed:18703514, ECO:0000269|PubMed:20129061,ECO:0000269|PubMed:24627487}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+89424_445531594Compositional biasNote=Ala-rich
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+8967_70531594Compositional biasNote=Poly-Ala
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+8989_157531594Compositional biasNote=Glu-rich
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+89238_330531594DomainARID
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+89119_156531594RegionNote=Acidic
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+89445_488531594RegionImportant for nuclear localization
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+89490_513531594RegionNote=Homodimerization
TgenePMEPA1chr19:968503chr20:56234753ENST00000265626-04158_161-14238MotifNote=PPxY motif 1
TgenePMEPA1chr19:968503chr20:56234753ENST00000265626-04229_232-14238MotifNote=PPxY motif 2
TgenePMEPA1chr19:968503chr20:56234753ENST00000341744-04158_16136288MotifNote=PPxY motif 1
TgenePMEPA1chr19:968503chr20:56234753ENST00000341744-04229_23236288MotifNote=PPxY motif 2
TgenePMEPA1chr19:968503chr20:56234753ENST00000347215-04158_1611253MotifNote=PPxY motif 1
TgenePMEPA1chr19:968503chr20:56234753ENST00000347215-04229_2321253MotifNote=PPxY motif 2
TgenePMEPA1chr19:968503chr20:56234753ENST00000395814-04158_161-14238MotifNote=PPxY motif 1
TgenePMEPA1chr19:968503chr20:56234753ENST00000395814-04229_232-14238MotifNote=PPxY motif 2
TgenePMEPA1chr19:968503chr20:56234753ENST00000395816-04158_161-14238MotifNote=PPxY motif 1
TgenePMEPA1chr19:968503chr20:56234753ENST00000395816-04229_232-14238MotifNote=PPxY motif 2
TgenePMEPA1chr19:968503chr20:56234753ENST00000265626-041_40-14238Topological domainLumenal
TgenePMEPA1chr19:968503chr20:56234753ENST00000265626-0464_287-14238Topological domainCytoplasmic
TgenePMEPA1chr19:968503chr20:56234753ENST00000341744-0464_28736288Topological domainCytoplasmic
TgenePMEPA1chr19:968503chr20:56234753ENST00000347215-041_401253Topological domainLumenal
TgenePMEPA1chr19:968503chr20:56234753ENST00000347215-0464_2871253Topological domainCytoplasmic
TgenePMEPA1chr19:968503chr20:56234753ENST00000395814-041_40-14238Topological domainLumenal
TgenePMEPA1chr19:968503chr20:56234753ENST00000395814-0464_287-14238Topological domainCytoplasmic
TgenePMEPA1chr19:968503chr20:56234753ENST00000395816-041_40-14238Topological domainLumenal
TgenePMEPA1chr19:968503chr20:56234753ENST00000395816-0464_287-14238Topological domainCytoplasmic
TgenePMEPA1chr19:968503chr20:56234753ENST00000265626-0441_63-14238TransmembraneHelical
TgenePMEPA1chr19:968503chr20:56234753ENST00000341744-0441_6336288TransmembraneHelical
TgenePMEPA1chr19:968503chr20:56234753ENST00000347215-0441_631253TransmembraneHelical
TgenePMEPA1chr19:968503chr20:56234753ENST00000395814-0441_63-14238TransmembraneHelical
TgenePMEPA1chr19:968503chr20:56234753ENST00000395816-0441_63-14238TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+89550_579531594Compositional biasNote=Gly-rich
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+89444_541531594DomainREKLES
HgeneARID3Achr19:968503chr20:56234753ENST00000263620+89537_557531594RegionImportant for cytoplasmic localization
TgenePMEPA1chr19:968503chr20:56234753ENST00000341744-041_4036288Topological domainLumenal


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FusionGeneSequence for ARID3A_PMEPA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ARID3A_ENST00000263620_chr19_968503_+_PMEPA1_ENST00000341744_chr20_56234753_-_783aa
MKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAPDEDREPESARMQRAQMAALAAMRAAAAGLGHPASPGGSEDGPPGSEE
EDAAREGTPGSPGRGREGPGEEHFEDMASDEDMKPKWEEEEMEEDLGEDEEEEEEDYEDEEEEEDEEGLGPPGPASLGTTALFPRKAQPP
QAFRGDGVPRVLGGQERPGPGPAHPGGAAHVAPQLQPPDHGDWTYEEQFKQLYELDGDPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVL
DLFMLYVLVTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECEKRGLSNPNELQAAIDSNRREGRRQSFGGSLFA
YSPGGAHGMLSSPKLPVSSLGLAASTNGSSITPAPKIKKEEDSAIPITVPGRLPVSLAGHPVVAAQAAAVQAAAAQAAVAAQAAALEQLR
EKLESAEPPEKKMALVADEQQRLMQRALQQNFLAMAAQLPMSIRINSQASESRQDSAVNLTGTNGSNSISMSVEINGIMYTAELEFVQII
IIVVVMMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQP
TYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRM


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ARID3A_ENST00000263620_chr19_968503_+_PMEPA1_ENST00000341744_chr20_56234753_-_2349nt
ATGAAACTACAGGCCGTGATGGAGACGCTGTTGCAGCGGCAGCAGCGGGCGCGCCAGGAGCTGGAGGCCCGGCAGCAGCTGCCCCCCGAT
CCCCCTGCTGCACCCCCCGGCCGGGCCCGGGCTGCCCCCGACGAGGACAGAGAGCCCGAGAGTGCCCGGATGCAGCGGGCTCAGATGGCC
GCACTGGCAGCCATGCGGGCTGCAGCTGCGGGCCTGGGACACCCAGCCAGCCCCGGCGGCTCTGAGGATGGGCCCCCAGGCTCGGAGGAG
GAGGACGCGGCCCGGGAGGGGACACCGGGCTCACCCGGGCGAGGCAGAGAAGGGCCAGGAGAGGAGCACTTTGAGGACATGGCCTCCGAC
GAGGACATGAAGCCCAAATGGGAGGAGGAGGAGATGGAGGAAGACCTCGGGGAGGATGAGGAGGAGGAGGAGGAGGATTACGAGGATGAG
GAGGAGGAGGAGGACGAGGAGGGGCTGGGCCCCCCAGGCCCTGCCAGCTTGGGCACCACGGCACTGTTCCCCCGAAAGGCCCAGCCACCC
CAGGCCTTCCGCGGCGATGGCGTTCCCAGGGTGCTGGGGGGCCAGGAGCGGCCGGGGCCTGGCCCTGCCCACCCCGGAGGGGCCGCCCAC
GTAGCCCCGCAGCTGCAGCCGCCTGACCACGGCGACTGGACTTACGAGGAGCAGTTTAAGCAGCTCTACGAACTCGACGGGGACCCCAAG
AGGAAGGAATTCCTGGATGACTTGTTCAGCTTCATGCAGAAGCGAGGGACACCTGTGAACCGCATCCCCATCATGGCCAAACAGGTCCTT
GACCTGTTCATGCTGTACGTGCTGGTGACGGAGAAGGGCGGCCTCGTGGAGGTCATCAACAAGAAGCTGTGGCGTGAGATCACCAAGGGC
CTCAACCTGCCCACGTCCATCACCAGTGCAGCCTTCACCCTGCGGACCCAATACATGAAGTACCTGTACCCCTACGAGTGTGAGAAGCGG
GGCCTCAGTAACCCCAATGAGCTCCAGGCAGCCATAGACAGCAACCGACGGGAGGGCCGGCGCCAGAGCTTTGGTGGCTCCCTCTTTGCC
TACTCGCCAGGCGGGGCACACGGCATGCTCTCCTCACCCAAGCTACCCGTGTCCTCCCTGGGCCTGGCCGCAAGCACCAATGGCAGCTCC
ATCACCCCCGCCCCTAAGATCAAGAAAGAGGAGGACTCAGCCATCCCCATCACAGTCCCTGGCCGCCTGCCTGTGTCCCTGGCGGGCCAC
CCTGTGGTGGCAGCCCAGGCAGCAGCTGTGCAAGCAGCAGCCGCCCAAGCAGCTGTGGCCGCACAGGCAGCTGCCCTGGAACAGCTGCGG
GAGAAGCTGGAGTCTGCAGAGCCTCCGGAGAAGAAGATGGCCCTGGTGGCCGATGAGCAGCAACGGCTGATGCAACGTGCACTCCAGCAG
AACTTCCTGGCCATGGCGGCCCAGCTGCCCATGAGCATTCGGATCAACAGCCAAGCCTCCGAAAGCCGCCAGGACTCTGCTGTGAACCTG
ACGGGCACCAACGGCAGCAACAGCATCAGCATGTCGGTGGAGATCAACGGCATCATGTACACAGCGGAGCTGGAGTTTGTTCAGATCATC
ATCATCGTGGTGGTGATGATGGTGATGGTGGTGGTGATCACGTGCCTGCTGAGCCACTACAAGCTGTCTGCACGGTCCTTCATCAGCCGG
CACAGCCAGGGGCGGAGGAGAGAAGATGCCCTGTCCTCAGAAGGATGCCTGTGGCCCTCGGAGAGCACAGTGTCAGGCAACGGAATCCCA
GAGCCGCAGGTCTACGCCCCGCCTCGGCCCACCGACCGCCTGGCCGTGCCGCCCTTCGCCCAGCGGGAGCGCTTCCACCGCTTCCAGCCC
ACCTATCCGTACCTGCAGCACGAGATCGACCTGCCACCCACCATCTCGCTGTCAGACGGGGAGGAGCCCCCACCCTACCAGGGCCCCTGC
ACCCTCCAGCTTCGGGACCCCGAGCAGCAGCTGGAACTGAACCGGGAGTCGGTGCGCGCACCCCCAAACAGAACCATCTTCGACAGTGAC
CTGATGGATAGTGCCAGGCTGGGCGGCCCCTGCCCCCCCAGCAGTAACTCGGGCATCAGCGCCACGTGCTACGGCAGCGGCGGGCGCATG
GAGGGGCCGCCGCCCACCTACAGCGAGGTCATCGGCCACTACCCGGGGTCCTCCTTCCAGCACCAGCAGAGCAGTGGGCCGCCCTCCTTG
CTGGAGGGGACCCGGCTCCACCACACACACATCGCGCCCCTAGAGAGCGCAGCCATCTGGAGCAAAGAGAAGGATAAACAGAAAGGACAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_ARID3A_ENST00000263620_chr19_968503_+_PMEPA1_ENST00000341744_chr20_56234753_-_6337nt
GCGGGGCGCCTCTTACCAATCGGGCGGAGGGGTGTAGACGCGGACGCGGCTGGCGGCTCGGTTTCTGCAAATGCGTGAATGAGCCGGATG
CCAGCCTCTGTCCCCTGGAGCCCAGCGTGAGGAAGAGGCATGCCCCATCAGCCTTCAGCTTGAGCCCGGCGGCCCCCGCCCCCGCCCCCT
GCCACCCTGCACTGCCCCGGCTCCCCCGCGGCCCCCACGCTGCAGTGCGGCCGGGCCCCCTCCCCGCAGGGGCCGCCCCCGCCGCCCACC
CCTAGCGCCCGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGCCCGGGCCGCAGGGCCATGAAACTACAGGCCGTGATGGAGACGCTGTTG
CAGCGGCAGCAGCGGGCGCGCCAGGAGCTGGAGGCCCGGCAGCAGCTGCCCCCCGATCCCCCTGCTGCACCCCCCGGCCGGGCCCGGGCT
GCCCCCGACGAGGACAGAGAGCCCGAGAGTGCCCGGATGCAGCGGGCTCAGATGGCCGCACTGGCAGCCATGCGGGCTGCAGCTGCGGGC
CTGGGACACCCAGCCAGCCCCGGCGGCTCTGAGGATGGGCCCCCAGGCTCGGAGGAGGAGGACGCGGCCCGGGAGGGGACACCGGGCTCA
CCCGGGCGAGGCAGAGAAGGGCCAGGAGAGGAGCACTTTGAGGACATGGCCTCCGACGAGGACATGAAGCCCAAATGGGAGGAGGAGGAG
ATGGAGGAAGACCTCGGGGAGGATGAGGAGGAGGAGGAGGAGGATTACGAGGATGAGGAGGAGGAGGAGGACGAGGAGGGGCTGGGCCCC
CCAGGCCCTGCCAGCTTGGGCACCACGGCACTGTTCCCCCGAAAGGCCCAGCCACCCCAGGCCTTCCGCGGCGATGGCGTTCCCAGGGTG
CTGGGGGGCCAGGAGCGGCCGGGGCCTGGCCCTGCCCACCCCGGAGGGGCCGCCCACGTAGCCCCGCAGCTGCAGCCGCCTGACCACGGC
GACTGGACTTACGAGGAGCAGTTTAAGCAGCTCTACGAACTCGACGGGGACCCCAAGAGGAAGGAATTCCTGGATGACTTGTTCAGCTTC
ATGCAGAAGCGAGGGACACCTGTGAACCGCATCCCCATCATGGCCAAACAGGTCCTTGACCTGTTCATGCTGTACGTGCTGGTGACGGAG
AAGGGCGGCCTCGTGGAGGTCATCAACAAGAAGCTGTGGCGTGAGATCACCAAGGGCCTCAACCTGCCCACGTCCATCACCAGTGCAGCC
TTCACCCTGCGGACCCAATACATGAAGTACCTGTACCCCTACGAGTGTGAGAAGCGGGGCCTCAGTAACCCCAATGAGCTCCAGGCAGCC
ATAGACAGCAACCGACGGGAGGGCCGGCGCCAGAGCTTTGGTGGCTCCCTCTTTGCCTACTCGCCAGGCGGGGCACACGGCATGCTCTCC
TCACCCAAGCTACCCGTGTCCTCCCTGGGCCTGGCCGCAAGCACCAATGGCAGCTCCATCACCCCCGCCCCTAAGATCAAGAAAGAGGAG
GACTCAGCCATCCCCATCACAGTCCCTGGCCGCCTGCCTGTGTCCCTGGCGGGCCACCCTGTGGTGGCAGCCCAGGCAGCAGCTGTGCAA
GCAGCAGCCGCCCAAGCAGCTGTGGCCGCACAGGCAGCTGCCCTGGAACAGCTGCGGGAGAAGCTGGAGTCTGCAGAGCCTCCGGAGAAG
AAGATGGCCCTGGTGGCCGATGAGCAGCAACGGCTGATGCAACGTGCACTCCAGCAGAACTTCCTGGCCATGGCGGCCCAGCTGCCCATG
AGCATTCGGATCAACAGCCAAGCCTCCGAAAGCCGCCAGGACTCTGCTGTGAACCTGACGGGCACCAACGGCAGCAACAGCATCAGCATG
TCGGTGGAGATCAACGGCATCATGTACACAGCGGAGCTGGAGTTTGTTCAGATCATCATCATCGTGGTGGTGATGATGGTGATGGTGGTG
GTGATCACGTGCCTGCTGAGCCACTACAAGCTGTCTGCACGGTCCTTCATCAGCCGGCACAGCCAGGGGCGGAGGAGAGAAGATGCCCTG
TCCTCAGAAGGATGCCTGTGGCCCTCGGAGAGCACAGTGTCAGGCAACGGAATCCCAGAGCCGCAGGTCTACGCCCCGCCTCGGCCCACC
GACCGCCTGGCCGTGCCGCCCTTCGCCCAGCGGGAGCGCTTCCACCGCTTCCAGCCCACCTATCCGTACCTGCAGCACGAGATCGACCTG
CCACCCACCATCTCGCTGTCAGACGGGGAGGAGCCCCCACCCTACCAGGGCCCCTGCACCCTCCAGCTTCGGGACCCCGAGCAGCAGCTG
GAACTGAACCGGGAGTCGGTGCGCGCACCCCCAAACAGAACCATCTTCGACAGTGACCTGATGGATAGTGCCAGGCTGGGCGGCCCCTGC
CCCCCCAGCAGTAACTCGGGCATCAGCGCCACGTGCTACGGCAGCGGCGGGCGCATGGAGGGGCCGCCGCCCACCTACAGCGAGGTCATC
GGCCACTACCCGGGGTCCTCCTTCCAGCACCAGCAGAGCAGTGGGCCGCCCTCCTTGCTGGAGGGGACCCGGCTCCACCACACACACATC
GCGCCCCTAGAGAGCGCAGCCATCTGGAGCAAAGAGAAGGATAAACAGAAAGGACACCCTCTCTAGGGTCCCCAGGGGGGCCGGGCTGGG
GCTGCGTAGGTGAAAAGGCAGAACACTCCGCGCTTCTTAGAAGAGGAGTGAGAGGAAGGCGGGGGGCGCAGCAACGCATCGTGTGGCCCT
CCCCTCCCACCTCCCTGTGTATAAATATTTACATGTGATGTCTGGTCTGAATGCACAAGCTAAGAGAGCTTGCAAAAAAAAAAAGAAAAA
AGAAAAAAAAAAACCACGTTTCTTTGTTGAGCTGTGTCTTGAAGGCAAAAGAAAAAAAATTTCTACAGTAGTCTTTCTTGTTTCTAGTTG
AGCTGCGTGCGTGAATGCTTATTTTCTTTTGTTTATGATAATTTCACTTAACTTTAAAGACATATTTGCACAAAACCTTTGTTTAAAGAT
CTGCAATATTATATATATAAATATATATAAGATAAGAGAAACTGTATGTGCGAGGGCAGGAGTATTTTTGTATTAGAAGAGGCCTATTAA
AAAAAAAAGTTGTTTTCTGAACTAGAAGAGGAAAAAAATGGCAATTTTTGAGTGCCAAGTCAGAAAGTGTGTATTACCTTGTAAAGAAAA
AAATTACAAAGCAGGGGTTTAGAGTTATTTATATAAATGTTGAGATTTTGCACTATTTTTTAATATAAATATGTCAGTGCTTGCTTGATG
GAAACTTCTCTTGTGTCTGTTGAGACTTTAAGGGAGAAATGTCGGAATTTCAGAGTCGCCTGACGGCAGAGGGTGAGCCCCCGTGGAGTC
TGCAGAGAGGCCTTGGCCAGGAGCGGCGGGCTTTCCCGAGGGGCCACTGTCCCTGCAGAGTGGATGCTTCTGCCTAGTGACAGGTTATCA
CCACGTTATATATTCCCTACCGAAGGAGACACCTTTTCCCCCCTGACCCAGAACAGCCTTTAAATCACAAGCAAAATAGGAAAGTTAACC
ACGGAGGCACCGAGTTCCAGGTAGTGGTTTTGCCTTTCCCAAAAATGAAAATAAACTGTTACCGAAGGAATTAGTTTTTCCTCTTCTTTT
TTCCAACTGTGAAGGTCCCCGTGGGGTGGAGCATGGTGCCCCTCACAAGCCGCAGCGGCTGGTGCCCGGGCTACCAGGGACATGCCAGAG
GGCTCGATGACTTGTCTCTGCAGGGCGCTTTGGTGGTTGTTCAGCTGGCTAAAGGTTCACCGGTGAAGGCAGGTGCGGTAACTGCCGCAC
TGGACCCTAGGAAGCCCCAGGTATTCGCAATCTGACCTCCTCCTGTCTGTTTCCCTTCACGGATCAATTCTCACTTAAGAGGCCAATAAA
CAACCCAACATGAAAAGGTGACAAGCCTGGGTTTCTCCCAGGATAGGTGAAAGGGTTAAAATGAGTAAAGCAGTTGAGCAAACACCAACC
CGAGCTTCGGGCGCAGAATTCTTCACCTTCTCTTCCCCTTTCCATCTCCTTTCCCCGCGGAAACAACGCTTCCCTTCTGGTGTGTCTGTT
GATCTGTGTTTTCATTTACATCTCTCTTAGACTCCGCTCTTGTTCTCCAGGTTTTCACCAGATAGATTTGGGGTTGGCGGGACCTGCTGG
TGACGTGCAGGTGAAGGACAGGAAGGGGCATGTGAGCGTAAATAGAGGTGACCAGAGGAGAGCATGAGGGGTGGGGCTTTGGGACCCACC
GGGGCCAGTGGCTGGAGCTTGACGTCTTTCCTCCCCATGGGGGTGGGAGGGCCCCCAGCTGGAAGAGCAGACTCCCAGCTGCTACCCCCT
CCCTTCCCATGGGAGTGGCTTTCCATTTTGGGCAGAATGCTGACTAGTAGACTAACATAAAAGATATAAAAGGCAATAACTATTGTTTGT
GAGCAACTTTTTTATAACTTCCAAAACAAAAACCTGAGCACAGTTTTGAAGTTCTAGCCACTCGAGCTCATGCATGTGAAACGTGTGCTT
TACGAAGGTGGCAGCTGACAGACGTGGGCTCTGCATGCCGCCAGCCTAGTAGAAAGTTCTCGTTCATTGGCAACAGCAGAACCTGCCTCT
CCGTGAAGTCGTCAGCCTAAAATTTGTTTCTCTCTTGAAGAGGATTCTTTGAAAAGGTCCTGCAGAGAAATCAGTACAGGTTATCCCGAA
AGGTACAAGGACGCACTTGTAAAGATGATTAAAACGTATCTTTCCTTTATGTGACGCGTCTCTAGTGCCTTACTGAAGAAGCAGTGACAC
TCCCGTCGCTCGGTGAGGACGTTCCCGGACAGTGCCTCACTCACCTGGGACTGGTATCCCCTCCCAGGGTCCACCAAGGGCTCCTGCTTT
TCAGACACCCCATCATCCTCGCGCGTCCTCACCCTGTCTCTACCAGGGAGGTGCCTAGCTTGGTGAGGTTACTCCTGCTCCTCCAACCTT
TTTTTGCCAAGGTTTGTACACGACTCCCATCTAGGCTGAAAACCTAGAAGTGGACCTTGTGTGTGTGCATGGTGTCAGCCCAAAGCCAGG
CTGAGACAGTCCTCATATCCTCTTGAGCCAAACTGTTTGGGTCTCGTTGCTTCATGGTATGGTCTGGATTTGTGGGAATGGCTTTGCGTG
AGAAAGGGGAGGAGAGTGGTTGCTGCCCTCAGCCGGCTTGAGGACAGAGCCTGTCCCTCTCATGACAACTCAGTGTTGAAGCCCAGTGTC
CTCAGCTTCATGTCCAGTGGATGGCAGAAGTTCATGGGGTAGTGGCCTCTCAAAGGCTGGGCGCATCCCAAGACAGCCAGCAGGTTGTCT
CTGGAAACGACCAGAGTTAAGCTCTCGGCTTCTCTGCTGAGGGTGCACCCTTTCCTCTAGATGGTAGTTGTCACGTTATCTTTGAAAACT
CTTGGACTGCTCCTGAGGAGGCCCTCTTTTCCAGTAGGAAGTTAGATGGGGGTTCTCAGAAGTGGCTGATTGGAAGGGGACAAGCTTCGT
TTCAGGGGTCTGCCGTTCCATCCTGGTTCAGAGAAGGCCGAGCGTGGCTTTCTCTAGCCTTGTCACTGTCTCCCTGCCTGTCAATCACCA
CCTTTCCTCCAGAGGAGGAAAATTATCTCCCCTGCAAAGCCCGGTTCTACACAGATTTCACAAATTGTGCTAAGAACCGTCCGTGTTCTC
AGAAAGCCCAGTGTTTTTGCAAAGAATGAAAAGGGACCCCATATGTAGCAAAAATCAGGGCTGGGGGAGAGCCGGGTTCATTCCCTGTCC
TCATTGGTCGTCCCTATGAATTGTACGTTTCAGAGAAATTTTTTTTCCTATGTGCAACACGAAGCTTCCAGAACCATAAAATATCCCGTC
GATAAGGAAAGAAAATGTCGTTGTTGTTGTTTTTCTGGAAACTGCTTGAAATCTTGCTGTACTATAGAGCTCAGAAGGACACAGCCCGTC
CTCCCCTGCCTGCCTGATTCCATGGCTGTTGTGCTGATTCCAATGCTTTCACGTTGGTTCCTGGCGTGGGAACTGCTCTCCTTTGCAGCC
CCATTTCCCAAGCTCTGTTCAAGTTAAACTTATGTAAGCTTTCCGTGGCATGCGGGGCGCGCACCCACGTCCCCGCTGCGTAAGACTCTG
TATTTGGATGCCAATCCACAGGCCTGAAGAAACTGCTTGTTGTGTATCAGTAATCATTAGTGGCAATGATGACATTCTGAAAAGCTGCAA


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FusionGenePPI for ARID3A_PMEPA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARID3ABTK, E2F1, ELAVL1, UBC, SP100, UBE2E3, PML, TP53, E2F2, E2F4, APP, TP53BP1, SOX2, TTC32, NOTCH2NL, FOXB1, FOXH1, FOXL1, NANOG, ARID3C, ARID3B, ZBED8, HERC2, LCN15, KIAA0430, HELZ, SOWAHA, EIF4ENIF1, PAN2, PCGF3, NISCHPMEPA1NEDD4, AR, CAND1, UBQLN4, HGS, STAM, DCTN6, DCTN5, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARID3A_PMEPA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARID3A_PMEPA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePMEPA1C0023893Liver Cirrhosis, Experimental1CTD_human