FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 26498

FusionGeneSummary for PDIA4_SCHIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: PDIA4_SCHIP1
Fusion gene ID: 26498
HgeneTgene
Gene symbol

PDIA4

SCHIP1

Gene ID

9601

29970

Gene nameprotein disulfide isomerase family A member 4schwannomin interacting protein 1
SynonymsERP70|ERP72|ERp-72SCHIP-1
Cytomap

7q36.1

3q25.32-q25.33

Type of geneprotein-codingprotein-coding
Descriptionprotein disulfide-isomerase A4ER protein 70ER protein 72endoplasmic reticulum resident protein 70endoplasmic reticulum resident protein 72protein disulfide isomerase related protein (calcium-binding protein, intestinal-related)protein disulfide isomschwannomin-interacting protein 1
Modification date2018052320180519
UniProtAcc

P13667

Ensembl transtripts involved in fusion geneENST00000286091, ENST00000445224, 
ENST00000483730, ENST00000482804, 
Fusion gene scores* DoF score11 X 8 X 6=5281 X 1 X 1=1
# samples 111
** MAII scorelog2(11/528*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: PDIA4 [Title/Abstract] AND SCHIP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-66-2756-01APDIA4chr7

148725413

-SCHIP1chr3

159583952

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000286091ENST00000445224PDIA4chr7

148725413

-SCHIP1chr3

159583952

+
5CDS-intronENST00000286091ENST00000483730PDIA4chr7

148725413

-SCHIP1chr3

159583952

+
5CDS-intronENST00000286091ENST00000482804PDIA4chr7

148725413

-SCHIP1chr3

159583952

+

Top

FusionProtFeatures for PDIA4_SCHIP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDIA4

P13667

SCHIP1

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDIA4chr7:148725413chr3:159583952ENST00000286091-11039_5529646Compositional biasNote=Asp/Glu-rich (acidic)
HgenePDIA4chr7:148725413chr3:159583952ENST00000286091-110158_30129646DomainThioredoxin 2
HgenePDIA4chr7:148725413chr3:159583952ENST00000286091-11021_16929646DomainThioredoxin 1
HgenePDIA4chr7:148725413chr3:159583952ENST00000286091-110505_63629646DomainThioredoxin 3
HgenePDIA4chr7:148725413chr3:159583952ENST00000286091-110642_64529646MotifNote=Prevents secretion from ER


Top

FusionGeneSequence for PDIA4_SCHIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PDIA4_ENST00000286091_chr7_148725413_-_SCHIP1_ENST00000445224_chr3_159583952_+_264aa
MRPRKAFLLLLLLGLVQLLAVAGAEGPDEGTEKXERVYQTEVGTWKLLXXWPRNLYQLXQKWEAKPFLPTAEWDELADMLCQRQWQXXGQ
XCXXQXDXNQLGHPLVSHEQTEFFLFXXRHYXRGVXILGXHGLPYKAKEIASXSQNGPCHGQTNGQNASRSGETEQEKVSRRXSSATHAS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PDIA4_ENST00000286091_chr7_148725413_-_SCHIP1_ENST00000445224_chr3_159583952_+_793nt
ATGAGGCCCCGGAAAGCCTTCCTGCTCCTGCTGCTCTTGGGGCTGGTGCAGCTGCTGGCCGTGGCGGGTGCCGAGGGCCCGGACGAGGGC
ACAGAAAAATGAGAGAGAGTCTATCAGACAGAAGTTGGCACTTGGAAGCTTCTTTGATGATGGCCCAGGAATTTATACCAGCTGTAGCAA
AAGTGGGAAGCCAAGCCTTTCCTCCCGACTGCAGAGTGGGATGAACTTGCAGATATGCTTTGTCAACGACAGTGGCAGTGATAAGGACAG
TGATGCTGATGACAGTAAGACTGAAACCAGCTTGGACACCCCCTTGTCTCCCATGAGCAAACAGAGTTCTTCCTATTCTGATAGAGACAC
TACTGAAGAGGAGTCTGAATCCTTGGATGACATGGACTTCCTTACAAGGCAAAAGAAATTGCAAGCTGAAGCCAAAATGGCCCTTGCCAT
GGCCAAACCAATGGCCAAAATGCAAGTAGAAGTGGAGAAACAGAACAGGAAAAAGTCTCCCGTCGCTGATCTTCTGCCACACATGCCTCA
TATAAGTGAATGCTTGATGAAAAGAAGTTTAAAACCCACCGACCTGAGAGACATGACTATTGGGCAGCTACAAGTGATAGTCAATGATCT
CCATTCCCAGATAGAAAGCTTGAATGAAGAGTTGGTCCAGCTGCTTCTCATCCGAGATGAGCTGCACACAGAGCAGGATGCCATGCTGGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_PDIA4_ENST00000286091_chr7_148725413_-_SCHIP1_ENST00000445224_chr3_159583952_+_1612nt
GGCGGCGGAGCCGACTCGTCGCGGCCGAGGCGCGCGCGGTCCGTGCCGGCGTCAGTCTGGGATTGGCCGGCCCGCGACTTCCTCCGCCCC
CTGCCAATCGCCGGGGACGACTTCCGTGGGTTTTTCCGGCTCCCCCGCGTCGCTAAGGAGCGACGGGCTGTCGGCCAGACCCCGAGTTCT
CGGTGCGCTCAGCGGCCGCCGACGCTAGGAGGCCGCGCTCCGCCCCCGCTACCATGAGGCCCCGGAAAGCCTTCCTGCTCCTGCTGCTCT
TGGGGCTGGTGCAGCTGCTGGCCGTGGCGGGTGCCGAGGGCCCGGACGAGGGCACAGAAAAATGAGAGAGAGTCTATCAGACAGAAGTTG
GCACTTGGAAGCTTCTTTGATGATGGCCCAGGAATTTATACCAGCTGTAGCAAAAGTGGGAAGCCAAGCCTTTCCTCCCGACTGCAGAGT
GGGATGAACTTGCAGATATGCTTTGTCAACGACAGTGGCAGTGATAAGGACAGTGATGCTGATGACAGTAAGACTGAAACCAGCTTGGAC
ACCCCCTTGTCTCCCATGAGCAAACAGAGTTCTTCCTATTCTGATAGAGACACTACTGAAGAGGAGTCTGAATCCTTGGATGACATGGAC
TTCCTTACAAGGCAAAAGAAATTGCAAGCTGAAGCCAAAATGGCCCTTGCCATGGCCAAACCAATGGCCAAAATGCAAGTAGAAGTGGAG
AAACAGAACAGGAAAAAGTCTCCCGTCGCTGATCTTCTGCCACACATGCCTCATATAAGTGAATGCTTGATGAAAAGAAGTTTAAAACCC
ACCGACCTGAGAGACATGACTATTGGGCAGCTACAAGTGATAGTCAATGATCTCCATTCCCAGATAGAAAGCTTGAATGAAGAGTTGGTC
CAGCTGCTTCTCATCCGAGATGAGCTGCACACAGAGCAGGATGCCATGCTGGTGGACATTGAAGACTTGACCAGACATGCTGAAAGTCAG
CAGAAGCACATGGCAGAGAAAATGCCTGCAAAGTGAAAAGAAGCCATTCAACCAGAGAACAAGCTAGAATTTATTTTGCTTCTGTGGTTG
TAAAAATGCTGTTGCTAAAGGTGGCGCAGAAACAAATATCAGTGTTAGTCATTGATAATGTCTGAAGCTTAATGTCCAGTGATTGGCCTT
TGCTTCTTAATTTATTTTAATTTTTTACTTGTGCCACTTAATATCAGGCATTTTAATAAAATATTGTTACAAAAAATGTACAGTACTGAC
ACCACCACAAATCATGGTTAATAAAAGAGAGTAGTTTTAACTTTATTTTTATTTGTTTAGAGATTTTAAGTTGGAACAGTATTTTCCCAT
TGACTACTTTTCATTCTTCACTGTAGTTTTAAAGAAGAACTGTAAATGACGGTGCTATACAAGTCAAAAAATACATGCCTGCCTCGTAGT
GAAGTTGTAGCTCTCCGTAATATGTATATTTTACTCAGTTTTCAACATTTTGTGAATGTTGACTACCTGAAGTTCCTTTTTAGATGTGCT


Top

FusionGenePPI for PDIA4_SCHIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDIA4EIF2B1, VWF, APOB, H2AFX, GADD45G, BCL2L1, ELAVL1, SIRT7, CDK2, P4HB, NENF, ILF3, CDH2, LDLR, PDIA3, ERO1L, ERO1LB, ATF2, PARK2, ASNS, CAPN2, MSN, NAE1, PAFAH1B1, PAFAH1B2, ALDH7A1, CAPNS1, GSS, HMGB3, ISOC1, STK26, MYO1E, OGFOD1, PRCP, PTMA, STK24, TBCB, TWF2, VCL, PPP1R2, PROSC, RAP1GDS1, TATDN1, TUFM, YWHAE, YWHAH, GPX7, PCSK9, CUL7, OBSL1, CCDC8, PSMD4, NTRK1, EWSR1, TCTN2, TCTN3, CNTRL, TCTN1, PPME1, PTPRN, EMC3, EMC7, PTPRO, SOD1, EDEM3, TRIM25, BRCA1SCHIP1SCHIP1, NF2, SCOC, PSMD4, ZC3H13, PTMS, TMSB4X, XPO1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PDIA4_SCHIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PDIA4_SCHIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource