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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26485

FusionGeneSummary for PDIA3_EFCAB5

check button Fusion gene summary
Fusion gene informationFusion gene name: PDIA3_EFCAB5
Fusion gene ID: 26485
HgeneTgene
Gene symbol

PDIA3

EFCAB5

Gene ID

2923

374786

Gene nameprotein disulfide isomerase family A member 3EF-hand calcium binding domain 5
SynonymsER60|ERp57|ERp60|ERp61|GRP57|GRP58|HEL-S-269|HEL-S-93n|HsT17083|P58|PI-PLC-
Cytomap

15q15.3

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionprotein disulfide-isomerase A358 kDa glucose-regulated protein58 kDa microsomal proteinER protein 57ER protein 60disulfide isomerase ER-60endoplasmic reticulum P58endoplasmic reticulum resident protein 57endoplasmic reticulum resident protein 60eEF-hand calcium-binding domain-containing protein 5
Modification date2018052320180522
UniProtAcc

P30101

A4FU69

Ensembl transtripts involved in fusion geneENST00000300289, ENST00000469684, 
ENST00000538521, 
ENST00000534836, 
ENST00000541045, ENST00000536908, 
ENST00000378738, ENST00000394832, 
ENST00000320856, ENST00000394835, 
Fusion gene scores* DoF score9 X 8 X 4=2889 X 7 X 5=315
# samples 99
** MAII scorelog2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/315*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDIA3 [Title/Abstract] AND EFCAB5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-FX-A3TO-01APDIA3chr15

44038904

+EFCAB5chr17

28418889

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000300289ENST00000534836PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
5CDS-intronENST00000300289ENST00000541045PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
5CDS-intronENST00000300289ENST00000536908PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
5CDS-intronENST00000300289ENST00000378738PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
5CDS-intronENST00000300289ENST00000394832PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
5CDS-intronENST00000300289ENST00000320856PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
5CDS-intronENST00000300289ENST00000394835PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
3UTR-intronENST00000469684ENST00000534836PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
3UTR-intronENST00000469684ENST00000541045PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
3UTR-intronENST00000469684ENST00000536908PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
3UTR-intronENST00000469684ENST00000378738PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
3UTR-intronENST00000469684ENST00000394832PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
3UTR-intronENST00000469684ENST00000320856PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
3UTR-intronENST00000469684ENST00000394835PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
5UTR-intronENST00000538521ENST00000534836PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
5UTR-intronENST00000538521ENST00000541045PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
5UTR-intronENST00000538521ENST00000536908PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
5UTR-intronENST00000538521ENST00000378738PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
5UTR-intronENST00000538521ENST00000394832PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
5UTR-intronENST00000538521ENST00000320856PDIA3chr15

44038904

+EFCAB5chr17

28418889

+
5UTR-intronENST00000538521ENST00000394835PDIA3chr15

44038904

+EFCAB5chr17

28418889

+

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FusionProtFeatures for PDIA3_EFCAB5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDIA3

P30101

EFCAB5

A4FU69


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDIA3_EFCAB5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDIA3_EFCAB5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDIA3CALR, GYPC, SLC2A1, SLC12A3, TAP1, STAT3, HMGB1, PLAA, CAV1, CDK2, SEC61A1, APP, HSPA8, HSPA5, VIM, PPIB, GARS, RPN2, ITGA2, ITGA3, ITGA6, ITGB1, ITGB5, COL6A1, LAMB1, LAMB3, LAMC1, LAMC2, PLXNA1, AGRN, EFEMP1, LDLR, DCBLD1, CLU, LOXL2, ADAM17, ADAM10, MFI2, PLOD1, TAPBP, PDIA4, ERO1L, ERO1LB, ATF2, MTOR, RPTOR, RICTOR, CANX, HDAC10, EGFR, BCCIP, CNDP2, CSE1L, LDHA, MTPN, NANS, NPEPPS, ABCE1, ACOT7, ADSS, ATP6V1A, DAK, HSPD1, MTAP, RAB1A, RBBP4, PGD, RPL23, SLC9A3R1, SMS, FUS, CUL7, OBSL1, CCDC8, SUZ12, ESR1, INHA, LGALS9, UNK, ATP5O, DDX17, FLNA, HMBS, NMD3, P4HB, AARS, ANXA5, ARHGDIA, ATP5H, CORO1C, HNRNPK, PAK2, TARDBP, TXLNA, PSMB5, RAD23B, TAGLN2, XRCC6, NTRK1, MDM2, OFD1, TCTN3, CNTRL, FBF1, TCTN1, PPME1, ATP6AP2, GOLT1B, KBTBD7, UBE3A, MCM2, PES1, U2AF2, PTPRN, ACP5, DUSP13, JMJD8, PTPRO, PA2G4, TRAP1, SND1, SNRPB2, EIF5B, GPI, IDH2, UBE2N, MRPL12, CRNN, ZNF207, MTNR1B, DLST, PDHA1, SDHA, SOAT1, SOD1, EDEM3, HLA-B, YAP1EFCAB5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDIA3_EFCAB5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePDIA3P30101DB01593ZincProtein disulfide-isomerase A3small moleculeapproved|investigational

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RelatedDiseases for PDIA3_EFCAB5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDIA3C0033578Prostatic Neoplasms1CTD_human
HgenePDIA3C0948089Acute Coronary Syndrome1CTD_human
HgenePDIA3C1846707SPINOCEREBELLAR ATAXIA 171CTD_human
HgenePDIA3C2239176Liver carcinoma1CTD_human