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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26468

FusionGeneSummary for PDGFRL_PDGFRL

check button Fusion gene summary
Fusion gene informationFusion gene name: PDGFRL_PDGFRL
Fusion gene ID: 26468
HgeneTgene
Gene symbol

PDGFRL

PDGFRL

Gene ID

5157

5157

Gene nameplatelet derived growth factor receptor likeplatelet derived growth factor receptor like
SynonymsPDGRL|PRLTSPDGRL|PRLTS
Cytomap

8p22

8p22

Type of geneprotein-codingprotein-coding
Descriptionplatelet-derived growth factor receptor-like proteinPDGF receptor beta-like tumor suppressorPDGFR-like proteinplatelet-derived growth factor-beta-like tumor suppressorplatelet-derived growth factor receptor-like proteinPDGF receptor beta-like tumor suppressorPDGFR-like proteinplatelet-derived growth factor-beta-like tumor suppressor
Modification date2018032920180329
UniProtAcc

Q15198

Q15198

Ensembl transtripts involved in fusion geneENST00000541323, ENST00000251630, 
ENST00000398074, ENST00000523248, 
ENST00000541323, ENST00000251630, 
ENST00000398074, ENST00000523248, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: PDGFRL [Title/Abstract] AND PDGFRL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA455210PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000541323ENST00000541323PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+
In-frameENST00000541323ENST00000251630PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+
In-frameENST00000541323ENST00000398074PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+
5CDS-3UTRENST00000541323ENST00000523248PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+
In-frameENST00000251630ENST00000541323PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+
In-frameENST00000251630ENST00000251630PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+
In-frameENST00000251630ENST00000398074PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+
5CDS-3UTRENST00000251630ENST00000523248PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+
In-frameENST00000398074ENST00000541323PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+
In-frameENST00000398074ENST00000251630PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+
In-frameENST00000398074ENST00000398074PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+
5CDS-3UTRENST00000398074ENST00000523248PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+
intron-3CDSENST00000523248ENST00000541323PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+
intron-3CDSENST00000523248ENST00000251630PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+
intron-3CDSENST00000523248ENST00000398074PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+
intron-3UTRENST00000523248ENST00000523248PDGFRLchr8

17478679

-PDGFRLchr8

17491674

+

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FusionProtFeatures for PDGFRL_PDGFRL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDGFRL

Q15198

PDGFRL

Q15198


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDGFRL_PDGFRL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDGFRL_PDGFRL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDGFRL_PDGFRL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDGFRL_PDGFRL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDGFRLC1527249Colorectal Cancer1UNIPROT
TgenePDGFRLC1527249Colorectal Cancer1UNIPROT