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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26447

FusionGeneSummary for PDE9A_TMPRSS2

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE9A_TMPRSS2
Fusion gene ID: 26447
HgeneTgene
Gene symbol

PDE9A

TMPRSS2

Gene ID

5152

7113

Gene namephosphodiesterase 9Atransmembrane serine protease 2
SynonymsHSPDE9A2PP9284|PRSS10
Cytomap

21q22.3

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionhigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9ACGMP-specific 3',5'-cyclic phosphodiesterase type 9phosphodiesterase PDE9A21transmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2
Modification date2018051920180523
UniProtAcc

O76083

O15393

Ensembl transtripts involved in fusion geneENST00000335512, ENST00000539837, 
ENST00000470987, ENST00000291539, 
ENST00000398236, ENST00000398229, 
ENST00000398234, ENST00000398232, 
ENST00000398227, ENST00000398225, 
ENST00000380328, ENST00000328862, 
ENST00000335440, ENST00000398224, 
ENST00000349112, 
ENST00000332149, 
ENST00000398585, ENST00000458356, 
ENST00000497881, 
Fusion gene scores* DoF score6 X 4 X 4=9616 X 12 X 3=576
# samples 620
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(20/576*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDE9A [Title/Abstract] AND TMPRSS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTissue-specifically expressed gene involved fusion gene, inframe and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDE9A

GO:0046068

cGMP metabolic process

9624146

HgenePDE9A

GO:0046069

cGMP catabolic process

25799991

TgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

TgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-ZG-A9L2-01APDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000335512ENST00000332149PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000335512ENST00000398585PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000335512ENST00000458356PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000335512ENST00000497881PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000539837ENST00000332149PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000539837ENST00000398585PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000539837ENST00000458356PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000539837ENST00000497881PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
3UTR-5UTRENST00000470987ENST00000332149PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
3UTR-5UTRENST00000470987ENST00000398585PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
3UTR-5UTRENST00000470987ENST00000458356PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
3UTR-5UTRENST00000470987ENST00000497881PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000291539ENST00000332149PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000291539ENST00000398585PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000291539ENST00000458356PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000291539ENST00000497881PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398236ENST00000332149PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398236ENST00000398585PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398236ENST00000458356PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398236ENST00000497881PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398229ENST00000332149PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398229ENST00000398585PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398229ENST00000458356PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398229ENST00000497881PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398234ENST00000332149PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398234ENST00000398585PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398234ENST00000458356PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398234ENST00000497881PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398232ENST00000332149PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398232ENST00000398585PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398232ENST00000458356PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398232ENST00000497881PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398227ENST00000332149PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398227ENST00000398585PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398227ENST00000458356PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398227ENST00000497881PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398225ENST00000332149PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398225ENST00000398585PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398225ENST00000458356PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398225ENST00000497881PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000380328ENST00000332149PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000380328ENST00000398585PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000380328ENST00000458356PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000380328ENST00000497881PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000328862ENST00000332149PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000328862ENST00000398585PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000328862ENST00000458356PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000328862ENST00000497881PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000335440ENST00000332149PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000335440ENST00000398585PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000335440ENST00000458356PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000335440ENST00000497881PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398224ENST00000332149PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398224ENST00000398585PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398224ENST00000458356PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000398224ENST00000497881PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000349112ENST00000332149PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000349112ENST00000398585PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000349112ENST00000458356PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000349112ENST00000497881PDE9Achr21

44153536

+TMPRSS2chr21

42870116

-

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FusionProtFeatures for PDE9A_TMPRSS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDE9A

O76083

TMPRSS2

O15393

Serine protease that proteolytically cleaves andactivates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized andmaintained in precursor intermediate folding states andproteolysis permits the refolding and energy release required tocreate stable virus-cell linkages and membrane coalescence.Facilitates human SARS coronavirus (SARS-CoV) infection via twoindependent mechanisms, proteolytic cleavage of ACE2, which mightpromote viral uptake, and cleavage of coronavirus spikeglycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activatesthe spike glycoproteins of human coronavirus 229E (HCoV-229E) andhuman coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0of Sendai virus (SeV), human metapneumovirus (HMPV), humanparainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential forspread and pathogenesis of influenza A virus (strains H1N1, H3N2and H7N9); involved in proteolytic cleavage and activation ofhemagglutinin (HA) protein which is essential for viralinfectivity. {ECO:0000269|PubMed:21068237,ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651,ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332,ECO:0000269|PubMed:24227843}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDE9A_TMPRSS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDE9A_TMPRSS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDE9ATRIM32, PHYHIPL, PDE9A, CLK1, CRY2, LMO2, SULT1E1, LAGE3, BAG3, GORASP2, TRPV6, KRTAP9-2, UTP23, NAA38, KRTAP4-2, KRTAP10-8, KRTAP10-3, NOTCH2NL, C9orf106, UNC119, TFAP4, C12orf75, PRKG2, RSPRY1, NPHP3TMPRSS2CLK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDE9A_TMPRSS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDE9A_TMPRSS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDE9AC0005586Bipolar Disorder1PSYGENET
TgeneTMPRSS2C0033578Prostatic Neoplasms2CTD_human