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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26439

FusionGeneSummary for PDE8A_PDE8A

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE8A_PDE8A
Fusion gene ID: 26439
HgeneTgene
Gene symbol

PDE8A

PDE8A

Gene ID

5151

5151

Gene namephosphodiesterase 8Aphosphodiesterase 8A
SynonymsHsT19550HsT19550
Cytomap

15q25.3

15q25.3

Type of geneprotein-codingprotein-coding
Descriptionhigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AcAMP-specific cyclic nucleotide phosphodiesterase 8Ahigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AcAMP-specific cyclic nucleotide phosphodiesterase 8A
Modification date2018051920180519
UniProtAcc

O60658

O60658

Ensembl transtripts involved in fusion geneENST00000310298, ENST00000557957, 
ENST00000394553, ENST00000339708, 
ENST00000557819, 		ENST00000310298, 
ENST00000557957, ENST00000394553, 
ENST00000339708, ENST00000557819, 
Fusion gene scores* DoF score6 X 4 X 4=963 X 3 X 1=9
# samples 64
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PDE8A [Title/Abstract] AND PDE8A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF951597PDE8Achr15

85666328

-PDE8Achr15

85660947

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000310298ENST00000310298PDE8Achr15

85666328

-PDE8Achr15

85660947

+
Frame-shiftENST00000310298ENST00000557957PDE8Achr15

85666328

-PDE8Achr15

85660947

+
Frame-shiftENST00000310298ENST00000394553PDE8Achr15

85666328

-PDE8Achr15

85660947

+
Frame-shiftENST00000310298ENST00000339708PDE8Achr15

85666328

-PDE8Achr15

85660947

+
5CDS-intronENST00000310298ENST00000557819PDE8Achr15

85666328

-PDE8Achr15

85660947

+
Frame-shiftENST00000557957ENST00000310298PDE8Achr15

85666328

-PDE8Achr15

85660947

+
Frame-shiftENST00000557957ENST00000557957PDE8Achr15

85666328

-PDE8Achr15

85660947

+
Frame-shiftENST00000557957ENST00000394553PDE8Achr15

85666328

-PDE8Achr15

85660947

+
Frame-shiftENST00000557957ENST00000339708PDE8Achr15

85666328

-PDE8Achr15

85660947

+
5CDS-intronENST00000557957ENST00000557819PDE8Achr15

85666328

-PDE8Achr15

85660947

+
Frame-shiftENST00000394553ENST00000310298PDE8Achr15

85666328

-PDE8Achr15

85660947

+
Frame-shiftENST00000394553ENST00000557957PDE8Achr15

85666328

-PDE8Achr15

85660947

+
Frame-shiftENST00000394553ENST00000394553PDE8Achr15

85666328

-PDE8Achr15

85660947

+
Frame-shiftENST00000394553ENST00000339708PDE8Achr15

85666328

-PDE8Achr15

85660947

+
5CDS-intronENST00000394553ENST00000557819PDE8Achr15

85666328

-PDE8Achr15

85660947

+
Frame-shiftENST00000339708ENST00000310298PDE8Achr15

85666328

-PDE8Achr15

85660947

+
Frame-shiftENST00000339708ENST00000557957PDE8Achr15

85666328

-PDE8Achr15

85660947

+
Frame-shiftENST00000339708ENST00000394553PDE8Achr15

85666328

-PDE8Achr15

85660947

+
Frame-shiftENST00000339708ENST00000339708PDE8Achr15

85666328

-PDE8Achr15

85660947

+
5CDS-intronENST00000339708ENST00000557819PDE8Achr15

85666328

-PDE8Achr15

85660947

+
intron-3CDSENST00000557819ENST00000310298PDE8Achr15

85666328

-PDE8Achr15

85660947

+
intron-3CDSENST00000557819ENST00000557957PDE8Achr15

85666328

-PDE8Achr15

85660947

+
intron-3CDSENST00000557819ENST00000394553PDE8Achr15

85666328

-PDE8Achr15

85660947

+
intron-3CDSENST00000557819ENST00000339708PDE8Achr15

85666328

-PDE8Achr15

85660947

+
intron-intronENST00000557819ENST00000557819PDE8Achr15

85666328

-PDE8Achr15

85660947

+

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FusionProtFeatures for PDE8A_PDE8A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDE8A

O60658

PDE8A

O60658


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDE8A_PDE8A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDE8A_PDE8A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDE8A_PDE8A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDE8A_PDE8A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource