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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2642

FusionGeneSummary for ARID1B_TIAM2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID1B_TIAM2
Fusion gene ID: 2642
HgeneTgene
Gene symbol

ARID1B

TIAM2

Gene ID

57492

26230

Gene nameAT-rich interaction domain 1BT cell lymphoma invasion and metastasis 2
Synonyms6A3-5|BAF250B|BRIGHT|CSS1|DAN15|ELD/OSA1|MRD12|OSA2|P250RSTEF|TIAM-2
Cytomap

6q25.3

6q25.2-q25.3

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 1BARID domain-containing protein 1BAT rich interactive domain 1B (SWI1-like)BRG1-associated factor 250bBRG1-binding protein ELD/OSA1ELD (eyelid)/OSA proteinT-lymphoma invasion and metastasis-inducing protein 2SIF and TIAM1-like exchange factor
Modification date2018052920180519
UniProtAcc

Q8NFD5

Q8IVF5

Ensembl transtripts involved in fusion geneENST00000350026, ENST00000346085, 
ENST00000367148, ENST00000275248, 
ENST00000478761, 		ENST00000461783, 
ENST00000449545, ENST00000367174, 
ENST00000456144, ENST00000318981, 
ENST00000360366, ENST00000529824, 
ENST00000456877, ENST00000528391, 
ENST00000275246, 
Fusion gene scores* DoF score20 X 12 X 11=26407 X 6 X 8=336
# samples 218
** MAII scorelog2(21/2640*10)=-3.65207669657969
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARID1B [Title/Abstract] AND TIAM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVGBMTCGA-19-5960-01AARID1Bchr6

157100605

+TIAM2chr6

155411423

+
TCGARVLUSCTCGA-85-7950-01AARID1Bchr6

157470085

+TIAM2chr6

155265250

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000350026ENST00000461783ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000350026ENST00000449545ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000350026ENST00000367174ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000350026ENST00000456144ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000350026ENST00000318981ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000350026ENST00000360366ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000350026ENST00000529824ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000350026ENST00000456877ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000350026ENST00000528391ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000350026ENST00000275246ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-5UTRENST00000346085ENST00000461783ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000346085ENST00000449545ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000346085ENST00000367174ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000346085ENST00000456144ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000346085ENST00000318981ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000346085ENST00000360366ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000346085ENST00000529824ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000346085ENST00000456877ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000346085ENST00000528391ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000346085ENST00000275246ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-5UTRENST00000367148ENST00000461783ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000367148ENST00000449545ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000367148ENST00000367174ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000367148ENST00000456144ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000367148ENST00000318981ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000367148ENST00000360366ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000367148ENST00000529824ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000367148ENST00000456877ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000367148ENST00000528391ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000367148ENST00000275246ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-5UTRENST00000275248ENST00000461783ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000275248ENST00000449545ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000275248ENST00000367174ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000275248ENST00000456144ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000275248ENST00000318981ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000275248ENST00000360366ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000275248ENST00000529824ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000275248ENST00000456877ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000275248ENST00000528391ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-intronENST00000275248ENST00000275246ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
intron-5UTRENST00000478761ENST00000461783ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
intron-intronENST00000478761ENST00000449545ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
intron-intronENST00000478761ENST00000367174ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
intron-intronENST00000478761ENST00000456144ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
intron-intronENST00000478761ENST00000318981ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
intron-intronENST00000478761ENST00000360366ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
intron-intronENST00000478761ENST00000529824ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
intron-intronENST00000478761ENST00000456877ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
intron-intronENST00000478761ENST00000528391ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
intron-intronENST00000478761ENST00000275246ARID1Bchr6

157100605

+TIAM2chr6

155411423

+
5CDS-5UTRENST00000350026ENST00000461783ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000350026ENST00000449545ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000350026ENST00000367174ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000350026ENST00000456144ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000350026ENST00000318981ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000350026ENST00000360366ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000350026ENST00000529824ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000350026ENST00000456877ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000350026ENST00000528391ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000350026ENST00000275246ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-5UTRENST00000346085ENST00000461783ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000346085ENST00000449545ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000346085ENST00000367174ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000346085ENST00000456144ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000346085ENST00000318981ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000346085ENST00000360366ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000346085ENST00000529824ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000346085ENST00000456877ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000346085ENST00000528391ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000346085ENST00000275246ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-5UTRENST00000367148ENST00000461783ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000367148ENST00000449545ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000367148ENST00000367174ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000367148ENST00000456144ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000367148ENST00000318981ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000367148ENST00000360366ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000367148ENST00000529824ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000367148ENST00000456877ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000367148ENST00000528391ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000367148ENST00000275246ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-5UTRENST00000275248ENST00000461783ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000275248ENST00000449545ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000275248ENST00000367174ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000275248ENST00000456144ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000275248ENST00000318981ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000275248ENST00000360366ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000275248ENST00000529824ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000275248ENST00000456877ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000275248ENST00000528391ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
5CDS-intronENST00000275248ENST00000275246ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
3UTR-5UTRENST00000478761ENST00000461783ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
3UTR-intronENST00000478761ENST00000449545ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
3UTR-intronENST00000478761ENST00000367174ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
3UTR-intronENST00000478761ENST00000456144ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
3UTR-intronENST00000478761ENST00000318981ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
3UTR-intronENST00000478761ENST00000360366ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
3UTR-intronENST00000478761ENST00000529824ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
3UTR-intronENST00000478761ENST00000456877ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
3UTR-intronENST00000478761ENST00000528391ARID1Bchr6

157470085

+TIAM2chr6

155265250

+
3UTR-intronENST00000478761ENST00000275246ARID1Bchr6

157470085

+TIAM2chr6

155265250

+

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FusionProtFeatures for ARID1B_TIAM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARID1B

Q8NFD5

TIAM2

Q8IVF5

Involved in transcriptional activation and repression ofselect genes by chromatin remodeling (alteration of DNA-nucleosometopology). Component of SWI/SNF chromatin remodeling complexesthat carry out key enzymatic activities, changing chromatinstructure by altering DNA-histone contacts within a nucleosome inan ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and theneuron-specific chromatin remodeling complex (nBAF complex).During neural development a switch from a stem/progenitor to apostmitotic chromatin remodeling mechanism occurs as neurons exitthe cell cycle and become committed to their adult state. Thetransition from proliferating neural stem/progenitor cells topostmitotic neurons requires a switch in subunit composition ofthe npBAF and nBAF complexes. As neural progenitors exit mitosisand differentiate into neurons, npBAF complexes which containACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologousalternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunitsin neuron-specific complexes (nBAF). The npBAF complex isessential for the self-renewal/proliferative capacity of themultipotent neural stem cells. The nBAF complex along with CRESTplays a role regulating the activity of genes essential fordendrite growth (By similarity). Binds DNA non-specifically(PubMed:14982958, PubMed:15170388). {ECO:0000250|UniProtKB:E9Q4N7,ECO:0000269|PubMed:14982958, ECO:0000269|PubMed:15170388,ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240,ECO:0000303|PubMed:26601204}. Modulates the activity of RHO-like proteins and connectsextracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTPexchange activity of RHO-like GTPases and activates them. Mediatesextracellular laminin signals to activate Rac1, contributing toneurite growth. Involved in lamellipodial formation andadvancement of the growth cone of embryonic hippocampal neurons.Promotes migration of neurons in the cerebral cortex. Whenoverexpressed, induces membrane ruffling accompanied by theaccumulation of actin filaments along the altered plasma membrane(By similarity). Activates specifically RAC1, but not CDC42 andRHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARID1B_TIAM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARID1B_TIAM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARID1BSMARCA4, SMARCB1, SMARCA2, KDM5B, CUL2, SMARCC2, SMARCC1, HIST2H2BE, TCEB1, RBX1, ARID1A, SMARCA1, SMARCD1, PRMT5, SMAD2, SMARCE1, CAND1, ACTL6A, EPAS1, SMAD9, YAP1, QPRT, DPF3, DPF2, SS18, SMARCD2, SMARCD3, BCL7A, BCL7B, BCL7C, KRAS, B9D2, SPICE1, STIL, PCGF1, NANOG, POU5F1, EYA2, NAGK, NR3C1, AR, TRIM25TIAM2DISC1, TNIK, DNM2, UFD1L, SH3GL2, H2AFX, TK1, ANXA7, RNF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARID1B_TIAM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARID1B_TIAM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARID1BC0265338Coffin-Siris syndrome2CTD_human;ORPHANET
HgeneARID1BC0027819Neuroblastoma1CTD_human
HgeneARID1BC2239176Liver carcinoma1CTD_human
TgeneTIAM2C0236969Substance-Related Disorders1CTD_human