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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26418

FusionGeneSummary for PDE4D_RNF180

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE4D_RNF180
Fusion gene ID: 26418
HgeneTgene
Gene symbol

PDE4D

RNF180

Gene ID

5144

285671

Gene namephosphodiesterase 4Dring finger protein 180
SynonymsACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1RINES
Cytomap

5q11.2-q12.1

5q12.3

Type of geneprotein-codingprotein-coding
DescriptioncAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136E3 ubiquitin-protein ligase RNF180RING-type E3 ubiquitin transferase RNF180
Modification date2018051920180523
UniProtAcc

Q08499

Q86T96

Ensembl transtripts involved in fusion geneENST00000340635, ENST00000360047, 
ENST00000507116, ENST00000502484, 
ENST00000546160, ENST00000502575, 
ENST00000358923, ENST00000503258, 
ENST00000405755, ENST00000317118, 
ENST00000503947, 		ENST00000389100, 
ENST00000296615, ENST00000381081, 
Fusion gene scores* DoF score23 X 14 X 10=32205 X 4 X 4=80
# samples 345
** MAII scorelog2(34/3220*10)=-3.24345403686428
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDE4D [Title/Abstract] AND RNF180 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDE4D

GO:0006198

cAMP catabolic process

9371713|17404263


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-P4-A5EB-01APDE4Dchr5

59064073

-RNF180chr5

63665442

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000340635ENST00000389100PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000340635ENST00000296615PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000340635ENST00000381081PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-3CDSENST00000360047ENST00000389100PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000360047ENST00000296615PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000360047ENST00000381081PDE4Dchr5

59064073

-RNF180chr5

63665442

+
Frame-shiftENST00000507116ENST00000389100PDE4Dchr5

59064073

-RNF180chr5

63665442

+
5CDS-intronENST00000507116ENST00000296615PDE4Dchr5

59064073

-RNF180chr5

63665442

+
5CDS-intronENST00000507116ENST00000381081PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-3CDSENST00000502484ENST00000389100PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000502484ENST00000296615PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000502484ENST00000381081PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-3CDSENST00000546160ENST00000389100PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000546160ENST00000296615PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000546160ENST00000381081PDE4Dchr5

59064073

-RNF180chr5

63665442

+
Frame-shiftENST00000502575ENST00000389100PDE4Dchr5

59064073

-RNF180chr5

63665442

+
5CDS-intronENST00000502575ENST00000296615PDE4Dchr5

59064073

-RNF180chr5

63665442

+
5CDS-intronENST00000502575ENST00000381081PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-3CDSENST00000358923ENST00000389100PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000358923ENST00000296615PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000358923ENST00000381081PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-3CDSENST00000503258ENST00000389100PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000503258ENST00000296615PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000503258ENST00000381081PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-3CDSENST00000405755ENST00000389100PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000405755ENST00000296615PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000405755ENST00000381081PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-3CDSENST00000317118ENST00000389100PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000317118ENST00000296615PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000317118ENST00000381081PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-3CDSENST00000503947ENST00000389100PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000503947ENST00000296615PDE4Dchr5

59064073

-RNF180chr5

63665442

+
intron-intronENST00000503947ENST00000381081PDE4Dchr5

59064073

-RNF180chr5

63665442

+

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FusionProtFeatures for PDE4D_RNF180


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDE4D

Q08499

RNF180

Q86T96

E3 ubiquitin-protein ligase which promotespolyubiquitination and degradation by the proteasome pathway ofZIC2. {ECO:0000250|UniProtKB:Q3U827}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDE4D_RNF180


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDE4D_RNF180


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDE4DPDE4DIP, PDE4D, AKAP6, GNB2L1, ARRB1, MDM2, ITSN1, ARRB2, PPP3CA, PPP3CB, PPP3R1, GSK3B, CSNK1A1, CDK2, PAFAH1B1, PRKACA, APP, LYN, SRC, FYN, ABL1, GRB2, PIAS4, MAPK1, BIN1, HDGFRP2, ZBTB1, MAGEA6, TRAF1, COIL, GOLGA8EP, GOLGA8F, ZDHHC17, SPTAN1, PIK3R1, TRIM23, ITPKB, PFKFB2, AKAP12, ATOH1, DUSP13, PDE4B, TRIM25RNF180ZIC2, LYN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDE4D_RNF180


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePDE4DQ08499DB00651DyphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved
HgenePDE4DQ08499DB01656RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved
HgenePDE4DQ08499DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved|investigational
HgenePDE4DQ08499DB05266IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved|investigational
HgenePDE4DQ08499DB05676ApremilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved|investigational

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RelatedDiseases for PDE4D_RNF180


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDE4DC3553250ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE4UNIPROT
HgenePDE4DC0011581Depressive disorder3PSYGENET
HgenePDE4DC0004096Asthma2CTD_human
HgenePDE4DC0011570Mental Depression2PSYGENET
HgenePDE4DC0033578Prostatic Neoplasms1CTD_human
HgenePDE4DC0036341Schizophrenia1PSYGENET
HgenePDE4DC0236733Amphetamine-Related Disorders1CTD_human