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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26390

FusionGeneSummary for PDE4B_GADD45A

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE4B_GADD45A
Fusion gene ID: 26390
HgeneTgene
Gene symbol

PDE4B

GADD45A

Gene ID

5142

1647

Gene namephosphodiesterase 4Bgrowth arrest and DNA damage inducible alpha
SynonymsDPDE4|PDEIVBDDIT1|GADD45
Cytomap

1p31.3

1p31.3

Type of geneprotein-codingprotein-coding
DescriptioncAMP-specific 3',5'-cyclic phosphodiesterase 4Bdunce-like phosphodiesterase E4phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)growth arrest and DNA damage-inducible protein GADD45 alphaDDIT-1DNA damage-inducible transcript 1 proteinDNA damage-inducible transcript-1growth arrest and DNA-damage-inducible 45 alpha
Modification date2018051920180523
UniProtAcc

Q07343

P24522

Ensembl transtripts involved in fusion geneENST00000329654, ENST00000371049, 
ENST00000423207, ENST00000371048, 
ENST00000371045, ENST00000480109, 
ENST00000370986, ENST00000370985, 
ENST00000460575, 
Fusion gene scores* DoF score4 X 5 X 2=401 X 1 X 1=1
# samples 51
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: PDE4B [Title/Abstract] AND GADD45A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationDDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDE4B

GO:0006198

cAMP catabolic process

17404263

TgeneGADD45A

GO:0000185

activation of MAPKKK activity

9827804

TgeneGADD45A

GO:0043065

positive regulation of apoptotic process

9827804

TgeneGADD45A

GO:0046330

positive regulation of JNK cascade

9827804

TgeneGADD45A

GO:0071850

mitotic cell cycle arrest

10097101

TgeneGADD45A

GO:1900745

positive regulation of p38MAPK cascade

9827804


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A18T-01APDE4Bchr1

66834652

+GADD45Achr1

68151708

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000329654ENST00000370986PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
5CDS-intronENST00000329654ENST00000370985PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
5CDS-3UTRENST00000329654ENST00000460575PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
Frame-shitENST00000371049ENST00000370986PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
5CDS-intronENST00000371049ENST00000370985PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
5CDS-3UTRENST00000371049ENST00000460575PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
Frame-shitENST00000423207ENST00000370986PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
5CDS-intronENST00000423207ENST00000370985PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
5CDS-3UTRENST00000423207ENST00000460575PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
intron-3CDSENST00000371048ENST00000370986PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
intron-intronENST00000371048ENST00000370985PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
intron-3UTRENST00000371048ENST00000460575PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
Frame-shitENST00000371045ENST00000370986PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
5CDS-intronENST00000371045ENST00000370985PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
5CDS-3UTRENST00000371045ENST00000460575PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
Frame-shitENST00000480109ENST00000370986PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
5CDS-intronENST00000480109ENST00000370985PDE4Bchr1

66834652

+GADD45Achr1

68151708

+
5CDS-3UTRENST00000480109ENST00000460575PDE4Bchr1

66834652

+GADD45Achr1

68151708

+

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FusionProtFeatures for PDE4B_GADD45A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDE4B

Q07343

GADD45A

P24522

Hydrolyzes the second messenger cAMP, which is a keyregulator of many important physiological processes. May beinvolved in mediating central nervous system effects oftherapeutic agents ranging from antidepressants to antiasthmaticand anti-inflammatory agents. {ECO:0000269|PubMed:10846163,ECO:0000269|PubMed:15003452}. In T-cells, functions as a regulator of p38 MAPKs byinhibiting p88 phosphorylation and activity (By similarity). Mightaffect PCNA interaction with some CDK (cell division proteinkinase) complexes; stimulates DNA excision repair in vitro andinhibits entry of cells into S phase. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDE4B_GADD45A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDE4B_GADD45A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDE4BDISC1, PAFAH1B1, APOA1, ALB, MAGEA11, RCBTB2, MOV10, NXF1, NTRK1, XPO1, PDE4DGADD45APCNA, DCTN2, GADD45A, CDK1, CDKN1A, GADD45G, GADD45GIP1, ESR1, GADD45B, RARA, RXRA, MAP3K4, CCNB1, MIDN, RPS2, IGSF21, TP53, CENPB, RAI1, SYNE4, EEF1G, EEF1A1, GNB2, IGHM, FBN3, DNAJC13, C14orf1, ADAP1, UBR1, LMO4, GBP2, BAG6, UBE2D1, PFKFB4, GAPDH, MICAL1, MPP1, JMJD1C, VIM, SPTBN4, CHD3, ZHX1, QARS, FAM83D, ZNF135, KHSRP, TLE1, RBPJ, NRBP1, MASP1, CLEC3B, PTN, DNMT1, TIAL1, HNRNPA0, MAPK1, RPS7, MDM2, NUCB2, SH3GLB1, ASCC2, FAS, CDK11A, PTPRK, PSMC3, APEX1, ING4, MTOR, STAT3, AURKA, HNRNPA1, MAP2K6, BTRC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDE4B_GADD45A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePDE4BQ07343DB00201CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved
HgenePDE4BQ07343DB00277TheophyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved
HgenePDE4BQ07343DB00651DyphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved
HgenePDE4BQ07343DB01427AmrinonecAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved
HgenePDE4BQ07343DB01656RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved
HgenePDE4BQ07343DB00806PentoxifyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved|investigational
HgenePDE4BQ07343DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved|investigational
HgenePDE4BQ07343DB01113PapaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved|investigational
HgenePDE4BQ07343DB01412TheobrominecAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved|investigational
HgenePDE4BQ07343DB05266IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved|investigational
HgenePDE4BQ07343DB05676ApremilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Bsmall moleculeapproved|investigational

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RelatedDiseases for PDE4B_GADD45A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDE4BC0011570Mental Depression5PSYGENET
HgenePDE4BC0011581Depressive disorder5PSYGENET
HgenePDE4BC0005586Bipolar Disorder4CTD_human;PSYGENET
HgenePDE4BC0036341Schizophrenia2CTD_human
HgenePDE4BC0001973Alcoholic Intoxication, Chronic1CTD_human
HgenePDE4BC0004096Asthma1CTD_human
HgenePDE4BC0004352Autistic Disorder1CTD_human
HgenePDE4BC0023467Leukemia, Myelocytic, Acute1CTD_human
HgenePDE4BC0037274Dermatologic disorders1CTD_human
HgenePDE4BC0151744Myocardial Ischemia1CTD_human
HgenePDE4BC0236733Amphetamine-Related Disorders1CTD_human
HgenePDE4BC0311375Arsenic Poisoning1CTD_human
TgeneGADD45AC0019693HIV Infections1CTD_human
TgeneGADD45AC0030297Pancreatic Neoplasm1CTD_human
TgeneGADD45AC0033578Prostatic Neoplasms1CTD_human
TgeneGADD45AC0038356Stomach Neoplasms1CTD_human
TgeneGADD45AC0263454Chloracne1CTD_human
TgeneGADD45AC0919267ovarian neoplasm1CTD_human
TgeneGADD45AC3495559Juvenile arthritis1CTD_human
TgeneGADD45AC4277682Chemical and Drug Induced Liver Injury1CTD_human