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Fusion gene ID: 26368 |
FusionGeneSummary for PDE10A_PSMB1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PDE10A_PSMB1 | Fusion gene ID: 26368 | Hgene | Tgene | Gene symbol | PDE10A | PSMB1 | Gene ID | 10846 | 5689 |
Gene name | phosphodiesterase 10A | proteasome subunit beta 1 | |
Synonyms | ADSD2|HSPDE10A|IOLOD|LINC00473|PDE10A19 | HC5|PMSB1|PSC5 | |
Cytomap | 6q27 | 6q27 | |
Type of gene | protein-coding | protein-coding | |
Description | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3',5' cAMP/cGMP phosphodiesterasedJ416F21.1 (phosphodiesterase 10A)phosphodiesterase 10A1 (PDE10A1)phosphodiesterase 10A7 (PDE10A7) | proteasome subunit beta type-1macropain subunit C5multicatalytic endopeptidase complex subunit C5proteasome (prosome, macropain) subunit, beta type, 1proteasome beta 1 subunitproteasome component C5proteasome gamma chainproteasome subunit HC5testi | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9Y233 | P20618 | |
Ensembl transtripts involved in fusion gene | ENST00000366882, ENST00000354448, ENST00000539869, ENST00000535229, | ENST00000262193, ENST00000462957, | |
Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 8 X 6 X 4=192 |
# samples | 5 | 8 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PDE10A [Title/Abstract] AND PSMB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-E2-A1LE-01A | PDE10A | chr6 | 165956928 | - | PSMB1 | chr6 | 170846428 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000366882 | ENST00000262193 | PDE10A | chr6 | 165956928 | - | PSMB1 | chr6 | 170846428 | - |
5CDS-5UTR | ENST00000366882 | ENST00000462957 | PDE10A | chr6 | 165956928 | - | PSMB1 | chr6 | 170846428 | - |
In-frame | ENST00000354448 | ENST00000262193 | PDE10A | chr6 | 165956928 | - | PSMB1 | chr6 | 170846428 | - |
5CDS-5UTR | ENST00000354448 | ENST00000462957 | PDE10A | chr6 | 165956928 | - | PSMB1 | chr6 | 170846428 | - |
In-frame | ENST00000539869 | ENST00000262193 | PDE10A | chr6 | 165956928 | - | PSMB1 | chr6 | 170846428 | - |
5CDS-5UTR | ENST00000539869 | ENST00000462957 | PDE10A | chr6 | 165956928 | - | PSMB1 | chr6 | 170846428 | - |
intron-3CDS | ENST00000535229 | ENST00000262193 | PDE10A | chr6 | 165956928 | - | PSMB1 | chr6 | 170846428 | - |
intron-5UTR | ENST00000535229 | ENST00000462957 | PDE10A | chr6 | 165956928 | - | PSMB1 | chr6 | 170846428 | - |
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FusionProtFeatures for PDE10A_PSMB1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PDE10A | PSMB1 |
Plays a role in signal transduction by regulating theintracellular concentration of cyclic nucleotides. Can hydrolyzeboth cAMP and cGMP, but has higher affinity for cAMP and is moreefficient with cAMP as substrate. May play a critical role inregulating cAMP and cGMP levels in the striatum, a region of thebrain that contributes to the control of movement and cognition.{ECO:0000250|UniProtKB:Q8CA95, ECO:0000269|PubMed:17389385}. | Component of the 20S core proteasome complex involved inthe proteolytic degradation of most intracellular proteins. Thiscomplex plays numerous essential roles within the cell byassociating with different regulatory particles. Associated withtwo 19S regulatory particles, forms the 26S proteasome and thusparticipates in the ATP-dependent degradation of ubiquitinatedproteins. The 26S proteasome plays a key role in the maintenanceof protein homeostasis by removing misfolded or damaged proteinsthat could impair cellular functions, and by removing proteinswhose functions are no longer required. Associated with the PA200or PA28, the 20S proteasome mediates ubiquitin-independent proteindegradation. This type of proteolysis is required in severalpathways including spermatogenesis (20S-PA200 complex) orgeneration of a subset of MHC class I-presented antigenic peptides(20S-PA28 complex). {ECO:0000269|PubMed:15244466,ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >PDE10A | chr6:165956928 | chr6:170846428 | ENST00000354448 | - | 2 | 22 | 266_412 | 55 | 780 | Domain | Note=GAF 2 |
Hgene | >PDE10A | chr6:165956928 | chr6:170846428 | ENST00000354448 | - | 2 | 22 | 442_759 | 55 | 780 | Domain | PDEase |
Hgene | >PDE10A | chr6:165956928 | chr6:170846428 | ENST00000354448 | - | 2 | 22 | 91_234 | 55 | 780 | Domain | Note=GAF 1 |
Hgene | >PDE10A | chr6:165956928 | chr6:170846428 | ENST00000366882 | - | 3 | 23 | 266_412 | 55 | 780 | Domain | Note=GAF 2 |
Hgene | >PDE10A | chr6:165956928 | chr6:170846428 | ENST00000366882 | - | 3 | 23 | 442_759 | 55 | 780 | Domain | PDEase |
Hgene | >PDE10A | chr6:165956928 | chr6:170846428 | ENST00000366882 | - | 3 | 23 | 91_234 | 55 | 780 | Domain | Note=GAF 1 |
Hgene | >PDE10A | chr6:165956928 | chr6:170846428 | ENST00000539869 | - | 2 | 22 | 266_412 | 65 | 790 | Domain | Note=GAF 2 |
Hgene | >PDE10A | chr6:165956928 | chr6:170846428 | ENST00000539869 | - | 2 | 22 | 442_759 | 65 | 790 | Domain | PDEase |
Hgene | >PDE10A | chr6:165956928 | chr6:170846428 | ENST00000539869 | - | 2 | 22 | 91_234 | 65 | 790 | Domain | Note=GAF 1 |
Hgene | >PDE10A | chr6:165956928 | chr6:170846428 | ENST00000354448 | - | 2 | 22 | 286_287 | 55 | 780 | Region | Note=Allosteric effector binding |
Hgene | >PDE10A | chr6:165956928 | chr6:170846428 | ENST00000354448 | - | 2 | 22 | 330_331 | 55 | 780 | Region | Note=Allosteric effector binding |
Hgene | >PDE10A | chr6:165956928 | chr6:170846428 | ENST00000366882 | - | 3 | 23 | 286_287 | 55 | 780 | Region | Note=Allosteric effector binding |
Hgene | >PDE10A | chr6:165956928 | chr6:170846428 | ENST00000366882 | - | 3 | 23 | 330_331 | 55 | 780 | Region | Note=Allosteric effector binding |
Hgene | >PDE10A | chr6:165956928 | chr6:170846428 | ENST00000539869 | - | 2 | 22 | 286_287 | 65 | 790 | Region | Note=Allosteric effector binding |
Hgene | >PDE10A | chr6:165956928 | chr6:170846428 | ENST00000539869 | - | 2 | 22 | 330_331 | 65 | 790 | Region | Note=Allosteric effector binding |
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FusionGeneSequence for PDE10A_PSMB1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_PDE10A_ENST00000366882_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_153aa MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDN >In-frame_PDE10A_ENST00000354448_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_153aa MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDN >In-frame_PDE10A_ENST00000539869_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_163aa MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEGKGAVYSFDPVGSYQRDSFKAGGSA |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_PDE10A_ENST00000366882_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_459nt ATGAGGATAGAAGAGAGGAAATCCCAACATTTAACAGGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTA GATGAATTTGTATCTGAAAGTGTTAGTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGGAAAGGGGGCTGTA TACAGCTTTGATCCAGTAGGGTCTTACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAAC CAGGTTGGTTTTAAGAACATGCAGAATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATGCGGCTGGTGAAAGATGTCTTCATTTCT GCGGCTGAGAGAGATGTGTACACTGGGGACGCACTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGG >In-frame_PDE10A_ENST00000354448_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_459nt ATGAGGATAGAAGAGAGGAAATCCCAACATTTAACAGGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTA GATGAATTTGTATCTGAAAGTGTTAGTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGGAAAGGGGGCTGTA TACAGCTTTGATCCAGTAGGGTCTTACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAAC CAGGTTGGTTTTAAGAACATGCAGAATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATGCGGCTGGTGAAAGATGTCTTCATTTCT GCGGCTGAGAGAGATGTGTACACTGGGGACGCACTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGG >In-frame_PDE10A_ENST00000539869_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_489nt ATGGAAGATGGACCTTCTAATAATGCGAGCTGCTTCCGAAGGCTGACCGAGTGCTTCCTGAGCCCCAGTTTGACAGATGAAAAAGTGAAG GCATATCTTTCTCTTCACCCCCAGGTATTAGATGAATTTGTATCTGAAAGTGTTAGTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAG AACAACAAATCAGAAGGAAAGGGGGCTGTATACAGCTTTGATCCAGTAGGGTCTTACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCA AGTGCCATGCTACAGCCCCTGCTTGACAACCAGGTTGGTTTTAAGAACATGCAGAATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCC ATGCGGCTGGTGAAAGATGTCTTCATTTCTGCGGCTGAGAGAGATGTGTACACTGGGGACGCACTCCGGATCTGCATAGTGACCAAAGAG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_PDE10A_ENST00000366882_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_717nt CCAGGCGGCGGCGGCCAAACTCCGCGGCGTCCCCAGGGCGCCAGCTTCGCCCTCGCCGCCGCGGCCGCGCTGCTCTTCGGCTCCGACATG GAAGATGGACCTTCTAATAATGCGAGCTGCTTCCGAAGGCTGACCGAGTGCTTCCTGAGCCCCAAATGAGGATAGAAGAGAGGAAATCCC AACATTTAACAGGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTAGATGAATTTGTATCTGAAAGTGTTA GTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGGAAAGGGGGCTGTATACAGCTTTGATCCAGTAGGGTCTT ACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAACCAGGTTGGTTTTAAGAACATGCAGA ATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATGCGGCTGGTGAAAGATGTCTTCATTTCTGCGGCTGAGAGAGATGTGTACACTG GGGACGCACTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGGAAGGACTGATCTGTGTGCTCTTATC >In-frame_PDE10A_ENST00000354448_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_562nt ATGAGGATAGAAGAGAGGAAATCCCAACATTTAACAGGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTA GATGAATTTGTATCTGAAAGTGTTAGTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGGAAAGGGGGCTGTA TACAGCTTTGATCCAGTAGGGTCTTACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAAC CAGGTTGGTTTTAAGAACATGCAGAATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATGCGGCTGGTGAAAGATGTCTTCATTTCT GCGGCTGAGAGAGATGTGTACACTGGGGACGCACTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGG AAGGACTGATCTGTGTGCTCTTATCACCAATCAGTTCAGACCTGGTTGATTTTGTACTTTGGAACTGTACCTTGGATGGTTTTGTTTATT >In-frame_PDE10A_ENST00000539869_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_648nt CCCAGGGCGCCAGCTTCGCCCTCGCCGCCGCGGCCGCGCTGCTCTTCGGCTCCGACATGGAAGATGGACCTTCTAATAATGCGAGCTGCT TCCGAAGGCTGACCGAGTGCTTCCTGAGCCCCAGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTAGATG AATTTGTATCTGAAAGTGTTAGTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGGAAAGGGGGCTGTATACA GCTTTGATCCAGTAGGGTCTTACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAACCAGG TTGGTTTTAAGAACATGCAGAATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATGCGGCTGGTGAAAGATGTCTTCATTTCTGCGG CTGAGAGAGATGTGTACACTGGGGACGCACTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGGAAGG ACTGATCTGTGTGCTCTTATCACCAATCAGTTCAGACCTGGTTGATTTTGTACTTTGGAACTGTACCTTGGATGGTTTTGTTTATTAAAA |
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FusionGenePPI for PDE10A_PSMB1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PDE10A | TOP1, CSN1S1 | PSMB1 | EXOSC6, DCP2, VHL, DSTYK, RIOK3, CASP4, PASK, FANCG, PLK1, SLX1B, UBC, MYC, INSIG2, PSMA2, PCK1, BCL3, RAD23A, SHFM1, PSMB3, PSMB7, PSMB5, POMP, SERPINE1, PSMA4, SERPINB2, PSEN1, PSMB8, PSMA7, FKBP8, UCHL5, PSMB2, PSMA1, PSMA3, PSMA5, PSMA6, PSMB4, PSMB6, PSMC4, PSMD11, PSMD12, PSMD13, PSMD1, PSMD2, PSMD3, PSMD8, PSMD6, PSMC3, PSMC1, PSMD4, PSMC5, PSMC6, PSMC2, PSMD7, PSMD14, PSME1, PSME3, PSME2, PSMD5, PSMA8, PSMB10, UFM1, RBM8A, CCT5, UBE2A, UBE4B, SF3A1, NOTCH2, RPL5, RPL10A, UBE2V1, SNX3, RPL24, RPS23, RPL7A, FBXO28, SRSF2, SUGT1, RPS15A, EPAS1, FN1, VCAM1, IQCB1, ITGA4, CFTR, PARK2, BAG3, HECW2, AP3M1, HNRNPA2B1, SEC13, DDB2, RPP30, RPP38, SMEK1, PSME4, PYCRL, PSMG3, CDKN1B, HAUS2, KIFC3, KRT13, KRT15, TRIM27, TRAF1, MAPRE3, AMFR, SYVN1, PSMB9, UNK, ADRM1, ASNA1, CLIC4, HSD17B10, MRPS9, PEX19, PGK1, MED4, MCM2, MID1, ENPP1, FBXO7, PSMG2, PSMF1, PSMG1, MAPRE2, MAPRE1, CYLD |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDE10A_PSMB1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PDE10A | Q9Y233 | DB00975 | Dipyridamole | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | small molecule | approved |
Hgene | PDE10A | Q9Y233 | DB08811 | Tofisopam | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | small molecule | approved |
Hgene | PDE10A | Q9Y233 | DB01113 | Papaverine | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | small molecule | approved|investigational |
Hgene | PDE10A | Q9Y233 | DB08814 | Triflusal | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | small molecule | approved|investigational |
Tgene | PSMB1 | P20618 | DB00188 | Bortezomib | Proteasome subunit beta type-1 | small molecule | approved|investigational |
Tgene | PSMB1 | P20618 | DB08889 | Carfilzomib | Proteasome subunit beta type-1 | small molecule | approved|investigational |
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RelatedDiseases for PDE10A_PSMB1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PDE10A | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | PDE10A | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | PDE10A | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Hgene | PDE10A | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Tgene | PSMB1 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | PSMB1 | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
Tgene | PSMB1 | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |