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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26368

FusionGeneSummary for PDE10A_PSMB1

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE10A_PSMB1
Fusion gene ID: 26368
HgeneTgene
Gene symbol

PDE10A

PSMB1

Gene ID

10846

5689

Gene namephosphodiesterase 10Aproteasome subunit beta 1
SynonymsADSD2|HSPDE10A|IOLOD|LINC00473|PDE10A19HC5|PMSB1|PSC5
Cytomap

6q27

6q27

Type of geneprotein-codingprotein-coding
DescriptioncAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3',5' cAMP/cGMP phosphodiesterasedJ416F21.1 (phosphodiesterase 10A)phosphodiesterase 10A1 (PDE10A1)phosphodiesterase 10A7 (PDE10A7)proteasome subunit beta type-1macropain subunit C5multicatalytic endopeptidase complex subunit C5proteasome (prosome, macropain) subunit, beta type, 1proteasome beta 1 subunitproteasome component C5proteasome gamma chainproteasome subunit HC5testi
Modification date2018051920180523
UniProtAcc

Q9Y233

P20618

Ensembl transtripts involved in fusion geneENST00000366882, ENST00000354448, 
ENST00000539869, ENST00000535229, 
ENST00000262193, ENST00000462957, 
Fusion gene scores* DoF score5 X 3 X 4=608 X 6 X 4=192
# samples 58
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDE10A [Title/Abstract] AND PSMB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A1LE-01APDE10Achr6

165956928

-PSMB1chr6

170846428

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000366882ENST00000262193PDE10Achr6

165956928

-PSMB1chr6

170846428

-
5CDS-5UTRENST00000366882ENST00000462957PDE10Achr6

165956928

-PSMB1chr6

170846428

-
In-frameENST00000354448ENST00000262193PDE10Achr6

165956928

-PSMB1chr6

170846428

-
5CDS-5UTRENST00000354448ENST00000462957PDE10Achr6

165956928

-PSMB1chr6

170846428

-
In-frameENST00000539869ENST00000262193PDE10Achr6

165956928

-PSMB1chr6

170846428

-
5CDS-5UTRENST00000539869ENST00000462957PDE10Achr6

165956928

-PSMB1chr6

170846428

-
intron-3CDSENST00000535229ENST00000262193PDE10Achr6

165956928

-PSMB1chr6

170846428

-
intron-5UTRENST00000535229ENST00000462957PDE10Achr6

165956928

-PSMB1chr6

170846428

-

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FusionProtFeatures for PDE10A_PSMB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDE10A

Q9Y233

PSMB1

P20618

Plays a role in signal transduction by regulating theintracellular concentration of cyclic nucleotides. Can hydrolyzeboth cAMP and cGMP, but has higher affinity for cAMP and is moreefficient with cAMP as substrate. May play a critical role inregulating cAMP and cGMP levels in the striatum, a region of thebrain that contributes to the control of movement and cognition.{ECO:0000250|UniProtKB:Q8CA95, ECO:0000269|PubMed:17389385}. Component of the 20S core proteasome complex involved inthe proteolytic degradation of most intracellular proteins. Thiscomplex plays numerous essential roles within the cell byassociating with different regulatory particles. Associated withtwo 19S regulatory particles, forms the 26S proteasome and thusparticipates in the ATP-dependent degradation of ubiquitinatedproteins. The 26S proteasome plays a key role in the maintenanceof protein homeostasis by removing misfolded or damaged proteinsthat could impair cellular functions, and by removing proteinswhose functions are no longer required. Associated with the PA200or PA28, the 20S proteasome mediates ubiquitin-independent proteindegradation. This type of proteolysis is required in severalpathways including spermatogenesis (20S-PA200 complex) orgeneration of a subset of MHC class I-presented antigenic peptides(20S-PA28 complex). {ECO:0000269|PubMed:15244466,ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE10Achr6:165956928chr6:170846428ENST00000354448-222266_41255780DomainNote=GAF 2
HgenePDE10Achr6:165956928chr6:170846428ENST00000354448-222442_75955780DomainPDEase
HgenePDE10Achr6:165956928chr6:170846428ENST00000354448-22291_23455780DomainNote=GAF 1
HgenePDE10Achr6:165956928chr6:170846428ENST00000366882-323266_41255780DomainNote=GAF 2
HgenePDE10Achr6:165956928chr6:170846428ENST00000366882-323442_75955780DomainPDEase
HgenePDE10Achr6:165956928chr6:170846428ENST00000366882-32391_23455780DomainNote=GAF 1
HgenePDE10Achr6:165956928chr6:170846428ENST00000539869-222266_41265790DomainNote=GAF 2
HgenePDE10Achr6:165956928chr6:170846428ENST00000539869-222442_75965790DomainPDEase
HgenePDE10Achr6:165956928chr6:170846428ENST00000539869-22291_23465790DomainNote=GAF 1
HgenePDE10Achr6:165956928chr6:170846428ENST00000354448-222286_28755780RegionNote=Allosteric effector binding
HgenePDE10Achr6:165956928chr6:170846428ENST00000354448-222330_33155780RegionNote=Allosteric effector binding
HgenePDE10Achr6:165956928chr6:170846428ENST00000366882-323286_28755780RegionNote=Allosteric effector binding
HgenePDE10Achr6:165956928chr6:170846428ENST00000366882-323330_33155780RegionNote=Allosteric effector binding
HgenePDE10Achr6:165956928chr6:170846428ENST00000539869-222286_28765790RegionNote=Allosteric effector binding
HgenePDE10Achr6:165956928chr6:170846428ENST00000539869-222330_33165790RegionNote=Allosteric effector binding


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FusionGeneSequence for PDE10A_PSMB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PDE10A_ENST00000366882_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_153aa
MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDN

>In-frame_PDE10A_ENST00000354448_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_153aa
MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDN

>In-frame_PDE10A_ENST00000539869_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_163aa
MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEGKGAVYSFDPVGSYQRDSFKAGGSA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PDE10A_ENST00000366882_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_459nt
ATGAGGATAGAAGAGAGGAAATCCCAACATTTAACAGGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTA
GATGAATTTGTATCTGAAAGTGTTAGTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGGAAAGGGGGCTGTA
TACAGCTTTGATCCAGTAGGGTCTTACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAAC
CAGGTTGGTTTTAAGAACATGCAGAATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATGCGGCTGGTGAAAGATGTCTTCATTTCT
GCGGCTGAGAGAGATGTGTACACTGGGGACGCACTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGG

>In-frame_PDE10A_ENST00000354448_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_459nt
ATGAGGATAGAAGAGAGGAAATCCCAACATTTAACAGGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTA
GATGAATTTGTATCTGAAAGTGTTAGTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGGAAAGGGGGCTGTA
TACAGCTTTGATCCAGTAGGGTCTTACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAAC
CAGGTTGGTTTTAAGAACATGCAGAATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATGCGGCTGGTGAAAGATGTCTTCATTTCT
GCGGCTGAGAGAGATGTGTACACTGGGGACGCACTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGG

>In-frame_PDE10A_ENST00000539869_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_489nt
ATGGAAGATGGACCTTCTAATAATGCGAGCTGCTTCCGAAGGCTGACCGAGTGCTTCCTGAGCCCCAGTTTGACAGATGAAAAAGTGAAG
GCATATCTTTCTCTTCACCCCCAGGTATTAGATGAATTTGTATCTGAAAGTGTTAGTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAG
AACAACAAATCAGAAGGAAAGGGGGCTGTATACAGCTTTGATCCAGTAGGGTCTTACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCA
AGTGCCATGCTACAGCCCCTGCTTGACAACCAGGTTGGTTTTAAGAACATGCAGAATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCC
ATGCGGCTGGTGAAAGATGTCTTCATTTCTGCGGCTGAGAGAGATGTGTACACTGGGGACGCACTCCGGATCTGCATAGTGACCAAAGAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_PDE10A_ENST00000366882_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_717nt
CCAGGCGGCGGCGGCCAAACTCCGCGGCGTCCCCAGGGCGCCAGCTTCGCCCTCGCCGCCGCGGCCGCGCTGCTCTTCGGCTCCGACATG
GAAGATGGACCTTCTAATAATGCGAGCTGCTTCCGAAGGCTGACCGAGTGCTTCCTGAGCCCCAAATGAGGATAGAAGAGAGGAAATCCC
AACATTTAACAGGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTAGATGAATTTGTATCTGAAAGTGTTA
GTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGGAAAGGGGGCTGTATACAGCTTTGATCCAGTAGGGTCTT
ACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAACCAGGTTGGTTTTAAGAACATGCAGA
ATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATGCGGCTGGTGAAAGATGTCTTCATTTCTGCGGCTGAGAGAGATGTGTACACTG
GGGACGCACTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGGAAGGACTGATCTGTGTGCTCTTATC

>In-frame_PDE10A_ENST00000354448_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_562nt
ATGAGGATAGAAGAGAGGAAATCCCAACATTTAACAGGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTA
GATGAATTTGTATCTGAAAGTGTTAGTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGGAAAGGGGGCTGTA
TACAGCTTTGATCCAGTAGGGTCTTACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAAC
CAGGTTGGTTTTAAGAACATGCAGAATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATGCGGCTGGTGAAAGATGTCTTCATTTCT
GCGGCTGAGAGAGATGTGTACACTGGGGACGCACTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGG
AAGGACTGATCTGTGTGCTCTTATCACCAATCAGTTCAGACCTGGTTGATTTTGTACTTTGGAACTGTACCTTGGATGGTTTTGTTTATT

>In-frame_PDE10A_ENST00000539869_chr6_165956928_-_PSMB1_ENST00000262193_chr6_170846428_-_648nt
CCCAGGGCGCCAGCTTCGCCCTCGCCGCCGCGGCCGCGCTGCTCTTCGGCTCCGACATGGAAGATGGACCTTCTAATAATGCGAGCTGCT
TCCGAAGGCTGACCGAGTGCTTCCTGAGCCCCAGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTAGATG
AATTTGTATCTGAAAGTGTTAGTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGGAAAGGGGGCTGTATACA
GCTTTGATCCAGTAGGGTCTTACCAGAGAGACTCCTTCAAGGCTGGAGGCTCAGCAAGTGCCATGCTACAGCCCCTGCTTGACAACCAGG
TTGGTTTTAAGAACATGCAGAATGTGGAGCATGTTCCGCTGTCCTTGGACAGAGCCATGCGGCTGGTGAAAGATGTCTTCATTTCTGCGG
CTGAGAGAGATGTGTACACTGGGGACGCACTCCGGATCTGCATAGTGACCAAAGAGGGCATCAGGGAGGAAACTGTTTCCTTAAGGAAGG
ACTGATCTGTGTGCTCTTATCACCAATCAGTTCAGACCTGGTTGATTTTGTACTTTGGAACTGTACCTTGGATGGTTTTGTTTATTAAAA


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FusionGenePPI for PDE10A_PSMB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDE10ATOP1, CSN1S1PSMB1EXOSC6, DCP2, VHL, DSTYK, RIOK3, CASP4, PASK, FANCG, PLK1, SLX1B, UBC, MYC, INSIG2, PSMA2, PCK1, BCL3, RAD23A, SHFM1, PSMB3, PSMB7, PSMB5, POMP, SERPINE1, PSMA4, SERPINB2, PSEN1, PSMB8, PSMA7, FKBP8, UCHL5, PSMB2, PSMA1, PSMA3, PSMA5, PSMA6, PSMB4, PSMB6, PSMC4, PSMD11, PSMD12, PSMD13, PSMD1, PSMD2, PSMD3, PSMD8, PSMD6, PSMC3, PSMC1, PSMD4, PSMC5, PSMC6, PSMC2, PSMD7, PSMD14, PSME1, PSME3, PSME2, PSMD5, PSMA8, PSMB10, UFM1, RBM8A, CCT5, UBE2A, UBE4B, SF3A1, NOTCH2, RPL5, RPL10A, UBE2V1, SNX3, RPL24, RPS23, RPL7A, FBXO28, SRSF2, SUGT1, RPS15A, EPAS1, FN1, VCAM1, IQCB1, ITGA4, CFTR, PARK2, BAG3, HECW2, AP3M1, HNRNPA2B1, SEC13, DDB2, RPP30, RPP38, SMEK1, PSME4, PYCRL, PSMG3, CDKN1B, HAUS2, KIFC3, KRT13, KRT15, TRIM27, TRAF1, MAPRE3, AMFR, SYVN1, PSMB9, UNK, ADRM1, ASNA1, CLIC4, HSD17B10, MRPS9, PEX19, PGK1, MED4, MCM2, MID1, ENPP1, FBXO7, PSMG2, PSMF1, PSMG1, MAPRE2, MAPRE1, CYLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDE10A_PSMB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePDE10AQ9Y233DB00975DipyridamolecAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Asmall moleculeapproved
HgenePDE10AQ9Y233DB08811TofisopamcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Asmall moleculeapproved
HgenePDE10AQ9Y233DB01113PapaverinecAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Asmall moleculeapproved|investigational
HgenePDE10AQ9Y233DB08814TriflusalcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Asmall moleculeapproved|investigational
TgenePSMB1P20618DB00188BortezomibProteasome subunit beta type-1small moleculeapproved|investigational
TgenePSMB1P20618DB08889CarfilzomibProteasome subunit beta type-1small moleculeapproved|investigational

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RelatedDiseases for PDE10A_PSMB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDE10AC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgenePDE10AC0005586Bipolar Disorder1PSYGENET
HgenePDE10AC0033975Psychotic Disorders1PSYGENET
HgenePDE10AC0349204Nonorganic psychosis1PSYGENET
TgenePSMB1C0029408Degenerative polyarthritis1CTD_human
TgenePSMB1C0031117Peripheral Neuropathy1CTD_human
TgenePSMB1C0948089Acute Coronary Syndrome1CTD_human