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Fusion gene ID: 26366 |
FusionGeneSummary for PDE10A_DDX23 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDE10A_DDX23 | Fusion gene ID: 26366 | Hgene | Tgene | Gene symbol | PDE10A | DDX23 | Gene ID | 10846 | 9416 |
| Gene name | phosphodiesterase 10A | DEAD-box helicase 23 | |
| Synonyms | ADSD2|HSPDE10A|IOLOD|LINC00473|PDE10A19 | PRPF28|SNRNP100|U5-100K|U5-100KD|prp28 | |
| Cytomap | 6q27 | 12q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3',5' cAMP/cGMP phosphodiesterasedJ416F21.1 (phosphodiesterase 10A)phosphodiesterase 10A1 (PDE10A1)phosphodiesterase 10A7 (PDE10A7) | probable ATP-dependent RNA helicase DDX23100 kDa U5 snRNP-specific proteinDEAD (Asp-Glu-Ala-Asp) box polypeptide 23DEAD box protein 23PRP28 homolog, yeastPRP28p homologU5 snRNP 100 kD protein | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9Y233 | Q9BUQ8 | |
| Ensembl transtripts involved in fusion gene | ENST00000366882, ENST00000354448, ENST00000539869, ENST00000535229, | ENST00000308025, ENST00000553182, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 4 X 3 X 3=36 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PDE10A [Title/Abstract] AND DDX23 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-AB2F-01A | PDE10A | chr6 | 166075435 | - | DDX23 | chr12 | 49239565 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000366882 | ENST00000308025 | PDE10A | chr6 | 166075435 | - | DDX23 | chr12 | 49239565 | - |
| 5UTR-5UTR | ENST00000366882 | ENST00000553182 | PDE10A | chr6 | 166075435 | - | DDX23 | chr12 | 49239565 | - |
| intron-3CDS | ENST00000354448 | ENST00000308025 | PDE10A | chr6 | 166075435 | - | DDX23 | chr12 | 49239565 | - |
| intron-5UTR | ENST00000354448 | ENST00000553182 | PDE10A | chr6 | 166075435 | - | DDX23 | chr12 | 49239565 | - |
| In-frame | ENST00000539869 | ENST00000308025 | PDE10A | chr6 | 166075435 | - | DDX23 | chr12 | 49239565 | - |
| 5CDS-5UTR | ENST00000539869 | ENST00000553182 | PDE10A | chr6 | 166075435 | - | DDX23 | chr12 | 49239565 | - |
| intron-3CDS | ENST00000535229 | ENST00000308025 | PDE10A | chr6 | 166075435 | - | DDX23 | chr12 | 49239565 | - |
| intron-5UTR | ENST00000535229 | ENST00000553182 | PDE10A | chr6 | 166075435 | - | DDX23 | chr12 | 49239565 | - |
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FusionProtFeatures for PDE10A_DDX23 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDE10A | DDX23 |
| Plays a role in signal transduction by regulating theintracellular concentration of cyclic nucleotides. Can hydrolyzeboth cAMP and cGMP, but has higher affinity for cAMP and is moreefficient with cAMP as substrate. May play a critical role inregulating cAMP and cGMP levels in the striatum, a region of thebrain that contributes to the control of movement and cognition.{ECO:0000250|UniProtKB:Q8CA95, ECO:0000269|PubMed:17389385}. | Involved in pre-mRNA splicing and its phosphorylatedform (by SRPK2) is required for spliceosomal B complex formation.{ECO:0000269|PubMed:18425142}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PDE10A_DDX23 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PDE10A_ENST00000539869_chr6_166075435_-_DDX23_ENST00000308025_chr12_49239565_-_843aa MEDGPSNNASCFRRLTECFLSPNGRRAGXQKGPXCITFQGGKEAITDSXQRAGXRPGPEVFPIXRXKAASFKGXTSRRQPFSLSFPFQIC RKRTTAQRTRTRXGAGSEXEGPRSRQGWAQTGQGPXTIQLISWSRKRLXISEGQRLXEGXRGXTWXXEAXGPAIIPGGASGQEKGXGRSX GXAQVPLXSRTRGXSSKATAAGGGRAAEDAXRREEEKETVPRLGQEDVGRSSGTGTSGTQGEDGTGDQWKXGXGRAAEDPGREGXEQGTA CHXGALPGWHQKAAPNETSQXPEICFXVGCIXGHIHXLQPPVQRTAPGAVVRARLHCRHXPQAAEARAVTFLWRPNGEEANPGRKGAGGG KTPQTSXEGSQAALGXSSLVSEKVRXDDGQGLADLPXGLQHHHQRWQDPQSHPILERLFSAPTHLGGHXXVWLQGTNTYTASGNSHWATE SXHHWCGXDWQWQDSSLPHPSAGLDHHTSQNXQDRRVRPRPLCHHPGSHPXVGSTDXGRDHQVWETARYPHCGCHWWHLQRRPGLQAAHG LXDCDCYPWAFDXCAGEPLPGAEPLYLCGSGXGRXDDXHGLXARCPEDPGAHACQQPEARHGXGXGPXEDAGQLXVGKTXVPPNSHVHGH HAPSGGASGQELSSATCCGVHWLRRQAPXACGTEGLPHVRVRKEEKAAGNLGARLXPTHHYFCQPEEGLRRVGQIPGEDGVQCLHTARWK RPGAARVCVVQPQGWGQGYFGGYRCGWSWYXHPRCVYGCQLXYGQKYXRLHPPHWPHGTSRQEWGGHHLPHKRGLCCVLRAEASYPGKPS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PDE10A_ENST00000539869_chr6_166075435_-_DDX23_ENST00000308025_chr12_49239565_-_2530nt ATGGAAGATGGACCTTCTAATAATGCGAGCTGCTTCCGAAGGCTGACCGAGTGCTTCCTGAGCCCCAATGGCAGGAGAGCTGGCTGACAA AAAGGACCGTGATGCATCACCTTCCAAGGAGGAAAGGAAGCGATCACGGACTCCTGACAGAGAGCGGGATAGAGACCGGGACCGGAAGTC TTCCCCATCTAAAGATAGAAAGCGGCATCGTTCAAGGGATAGACGTCGAGGAGGCAGCCGTTCTCGCTCTCGTTCCCGTTCCAAATCTGC AGAAAGAGAACGACGGCACAAAGAACGAGAACGAGATAAGGAGCGGGATCGGAATAAGAAGGACCGAGATCGAGACAAGGATGGGCACAG ACGGGACAAGGACCGTAAACGATCCAGCTTATCTCCTGGTCGAGGAAAAGACTTTAAATCTCGGAAGGACAGAGACTCTAAGAAGGATGA AGAGGATGAACATGGTGATAAGAAGCCTAAGGCCCAGCCATTATCCCTGGAGGAGCTTCTGGCCAAGAAAAAGGCTGAGGAAGAAGCTGA GGCTAAGCCCAAGTTCCTCTCTAAAGCAGAACGAGAGGCTGAAGCTCTAAAGCGACGGCAGCAGGAGGTGGAAGAGCGGCAGAGGATGCT TGAAGAAGAGAGGAAGAAAAGGAAACAGTTCCAAGACTTGGGCAGGAAGATGTTGGAAGATCCTCAGGAACGGGAACGTCGGGAACGCAG GGAGAGGATGGAACGGGAGACCAATGGAAATGAGGATGAGGAAGGGCGGCAGAAGATCCGGGAAGAGAAGGATAAGAGCAAGGAACTGCA TGCCATTAAGGAGCGTTACCTGGGTGGCATCAAAAAGCGGCGCCGAACGAGACATCTCAATGACCGGAAATTTGTTTTTGAGTGGGATGC ATCTGAGGACACATCCATTGACTACAACCCCCTGTACAAAGAACGGCACCAGGTGCAGTTGTTAGGGCGAGGCTTCATTGCAGGCATTGA CCTCAAGCAGCAGAAGCGAGAGCAGTCACGTTTCTATGGAGACCTAATGGAGAAGAGGCGAACCCTGGAAGAAAAGGAGCAGGAGGAGGC AAGACTCCGCAAACTTCGTAAGAAGGAAGCCAAGCAGCGCTGGGATGATCGTCATTGGTCTCAGAAAAAGTTAGATGAGATGACGGACAG GGACTGGCGGATCTTCCGTGAGGACTACAGCATCACCACCAAAGGTGGCAAGATCCCCAATCCCATCCGATCCTGGAAAGACTCTTCTCT GCCCCCACACATCTTGGAGGTCATTGATAAGTGTGGCTACAAGGAACCAACACCTATACAGCGTCAGGCAATTCCCATTGGGCTACAGAA TCGTGACATCATTGGTGTGGCTGAGACTGGCAGTGGCAAGACAGCAGCCTTCCTCATCCCTCTGCTGGTCTGGATCACCACACTTCCCAA AATTGACAGGATCGAAGAGTCAGACCAAGGCCCTTATGCCATCATCCTGGCTCCCACCCGTGAGTTGGCTCAACAGATTGAGGAAGAGAC CATCAAGTTTGGGAAACCGCTAGGTATCCGCACTGTGGCTGTCATTGGTGGCATCTCCAGAGAAGACCAGGGCTTCAGGCTGCGCATGGG TTGTGAGATTGTGATTGCTACCCCTGGGCGTTTGATTGATGTGCTGGAGAACCGCTACCTGGTGCTGAGCCGCTGTACCTATGTGGTTCT GGATGAGGCAGATAGGATGATTGACATGGGCTTTGAGCCAGATGTCCAGAAGATCCTGGAGCACATGCCTGTCAGCAACCAGAAGCCAGA CACGGATGAGGCTGAGGACCCTGAGAAGATGCTGGCCAACTTTGAGTCGGGAAAACATAAGTACCGCCAAACAGTCATGTTCACGGCCAC CATGCCCCCAGCGGTGGAGCGTCTGGCCAGGAGCTATCTTCGGCGACCTGCTGTGGTGTACATTGGCTCCGCAGGCAAGCCCCATGAGCG TGTGGAACAGAAGGTCTTCCTCATGTCAGAGTCAGAAAAGAGGAAAAAGCTGCTGGCAATCTTGGAGCAAGGCTTTGACCCACCCATCAT TATTTTTGTCAACCAGAAGAAGGGCTGCGACGTGTTGGCCAAATCCCTGGAGAAGATGGGGTACAATGCTTGCACACTGCACGGTGGAAA AGGCCAGGAGCAGCGAGAGTTTGCGTTGTCCAACCTCAAGGCTGGGGCCAAGGATATTTTGGTGGCTACAGATGTGGCTGGTCGTGGTAT TGACATCCAAGATGTGTCTATGGTTGTCAACTATGATATGGCCAAAAATATTGAAGATTACATCCACCGCATTGGCCGCACGGGACGAGC AGGCAAGAGTGGGGTGGCCATCACCTTCCTCACAAAAGAGGACTCTGCTGTGTTCTACGAGCTGAAGCAAGCTATCCTGGAAAGCCCAGT GTCTTCCTGTCCCCCCGAACTAGCCAACCACCCAGATGCCCAGCATAAGCCAGGCACCATCCTCACCAAGAAGCGCCGGGAAGAGACCAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PDE10A_ENST00000539869_chr6_166075435_-_DDX23_ENST00000308025_chr12_49239565_-_3291nt CCCAGGGCGCCAGCTTCGCCCTCGCCGCCGCGGCCGCGCTGCTCTTCGGCTCCGACATGGAAGATGGACCTTCTAATAATGCGAGCTGCT TCCGAAGGCTGACCGAGTGCTTCCTGAGCCCCAATGGCAGGAGAGCTGGCTGACAAAAAGGACCGTGATGCATCACCTTCCAAGGAGGAA AGGAAGCGATCACGGACTCCTGACAGAGAGCGGGATAGAGACCGGGACCGGAAGTCTTCCCCATCTAAAGATAGAAAGCGGCATCGTTCA AGGGATAGACGTCGAGGAGGCAGCCGTTCTCGCTCTCGTTCCCGTTCCAAATCTGCAGAAAGAGAACGACGGCACAAAGAACGAGAACGA GATAAGGAGCGGGATCGGAATAAGAAGGACCGAGATCGAGACAAGGATGGGCACAGACGGGACAAGGACCGTAAACGATCCAGCTTATCT CCTGGTCGAGGAAAAGACTTTAAATCTCGGAAGGACAGAGACTCTAAGAAGGATGAAGAGGATGAACATGGTGATAAGAAGCCTAAGGCC CAGCCATTATCCCTGGAGGAGCTTCTGGCCAAGAAAAAGGCTGAGGAAGAAGCTGAGGCTAAGCCCAAGTTCCTCTCTAAAGCAGAACGA GAGGCTGAAGCTCTAAAGCGACGGCAGCAGGAGGTGGAAGAGCGGCAGAGGATGCTTGAAGAAGAGAGGAAGAAAAGGAAACAGTTCCAA GACTTGGGCAGGAAGATGTTGGAAGATCCTCAGGAACGGGAACGTCGGGAACGCAGGGAGAGGATGGAACGGGAGACCAATGGAAATGAG GATGAGGAAGGGCGGCAGAAGATCCGGGAAGAGAAGGATAAGAGCAAGGAACTGCATGCCATTAAGGAGCGTTACCTGGGTGGCATCAAA AAGCGGCGCCGAACGAGACATCTCAATGACCGGAAATTTGTTTTTGAGTGGGATGCATCTGAGGACACATCCATTGACTACAACCCCCTG TACAAAGAACGGCACCAGGTGCAGTTGTTAGGGCGAGGCTTCATTGCAGGCATTGACCTCAAGCAGCAGAAGCGAGAGCAGTCACGTTTC TATGGAGACCTAATGGAGAAGAGGCGAACCCTGGAAGAAAAGGAGCAGGAGGAGGCAAGACTCCGCAAACTTCGTAAGAAGGAAGCCAAG CAGCGCTGGGATGATCGTCATTGGTCTCAGAAAAAGTTAGATGAGATGACGGACAGGGACTGGCGGATCTTCCGTGAGGACTACAGCATC ACCACCAAAGGTGGCAAGATCCCCAATCCCATCCGATCCTGGAAAGACTCTTCTCTGCCCCCACACATCTTGGAGGTCATTGATAAGTGT GGCTACAAGGAACCAACACCTATACAGCGTCAGGCAATTCCCATTGGGCTACAGAATCGTGACATCATTGGTGTGGCTGAGACTGGCAGT GGCAAGACAGCAGCCTTCCTCATCCCTCTGCTGGTCTGGATCACCACACTTCCCAAAATTGACAGGATCGAAGAGTCAGACCAAGGCCCT TATGCCATCATCCTGGCTCCCACCCGTGAGTTGGCTCAACAGATTGAGGAAGAGACCATCAAGTTTGGGAAACCGCTAGGTATCCGCACT GTGGCTGTCATTGGTGGCATCTCCAGAGAAGACCAGGGCTTCAGGCTGCGCATGGGTTGTGAGATTGTGATTGCTACCCCTGGGCGTTTG ATTGATGTGCTGGAGAACCGCTACCTGGTGCTGAGCCGCTGTACCTATGTGGTTCTGGATGAGGCAGATAGGATGATTGACATGGGCTTT GAGCCAGATGTCCAGAAGATCCTGGAGCACATGCCTGTCAGCAACCAGAAGCCAGACACGGATGAGGCTGAGGACCCTGAGAAGATGCTG GCCAACTTTGAGTCGGGAAAACATAAGTACCGCCAAACAGTCATGTTCACGGCCACCATGCCCCCAGCGGTGGAGCGTCTGGCCAGGAGC TATCTTCGGCGACCTGCTGTGGTGTACATTGGCTCCGCAGGCAAGCCCCATGAGCGTGTGGAACAGAAGGTCTTCCTCATGTCAGAGTCA GAAAAGAGGAAAAAGCTGCTGGCAATCTTGGAGCAAGGCTTTGACCCACCCATCATTATTTTTGTCAACCAGAAGAAGGGCTGCGACGTG TTGGCCAAATCCCTGGAGAAGATGGGGTACAATGCTTGCACACTGCACGGTGGAAAAGGCCAGGAGCAGCGAGAGTTTGCGTTGTCCAAC CTCAAGGCTGGGGCCAAGGATATTTTGGTGGCTACAGATGTGGCTGGTCGTGGTATTGACATCCAAGATGTGTCTATGGTTGTCAACTAT GATATGGCCAAAAATATTGAAGATTACATCCACCGCATTGGCCGCACGGGACGAGCAGGCAAGAGTGGGGTGGCCATCACCTTCCTCACA AAAGAGGACTCTGCTGTGTTCTACGAGCTGAAGCAAGCTATCCTGGAAAGCCCAGTGTCTTCCTGTCCCCCCGAACTAGCCAACCACCCA GATGCCCAGCATAAGCCAGGCACCATCCTCACCAAGAAGCGCCGGGAAGAGACCATCTTTGCCTGACACAGCACTCTTCCTGTGGGCTGA GGGCATCTCCAAAGCTGCCTGATGCCTGTTTTTCAGAACCCTCACATCCCTCTTTCCAGGTCCTCACTCTTGGGATATGGGGGCTTAGGA AAACAATCCAACTCCCTAGCCCAGACCCTCAGGTCAGGAGGCCTGCGTGTGGGGCTGCAAAAGGAGAGGACGACGCTGTCGGAGGCAGGG AGAGCAAATTACCACAGCTTCTTGGCCCAGTTCTGCCCTTCTTTGCTTTGGGATTGCACTGGGCCATCAGCTCATGCCAGGCTATGGGGG CAGCCAGTTGGCATTGCTCCCCAGACTGAACAGAAACCTGGCCGCCGGATGGGACCTCCTTTGGCACAGACTTGACTGTGTAACTGCATA AACTGCAGTAGCATCATTGCCCTAGATGCCCCAGGAGACCTGGCACCATGAGGATTACAGACAGTGGAATCTTACTGTCATCTGGACAGC TGTTTTCCTGTTTGGATGGTAAAGGAAGTTGAGAGTCTTTAGACCTGTGCACAGCCCCGCACCAAGGGGTGCTGTATGCTCTAGGCATCC CCTCCCCCAGGGGATTTTCTAAGTAGATGGGGGGACACGGTGAACTGGCTGTGTCCATCTTTGTCACTGAGTGAAATCTCTGTTTTCTAT |
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FusionGenePPI for PDE10A_DDX23 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PDE10A | TOP1, CSN1S1 | DDX23 | CD2BP2, RNPS1, OTUB1, USP39, PRPF4, MEPCE, TP63, TP73, SNW1, TOP1, SF3A2, SIRT7, HNRNPA1, TERF1, TERF2IP, RNU4ATAC, RNU6ATAC, SF3A3, PHF5A, THOC5, SART1, PURA, PAXIP1, PRPF4B, WBP4, RPA3, RPA2, RPA1, ERG, STAU1, BRCA1, CUL7, OBSL1, SUZ12, GCFC2, PRPF3, IK, SNRNP40, PRPF6, SNRNP200, PRPF8, TFIP11, EFTUD2, PAXBP1, AAR2, RSRC1, SNRPD2, EAPP, TXNL4A, PRMT6, SNRPD1, BSG, ZBTB46, NTRK1, BCAS2, CPSF3, PRPF31, PSMA5, RPS7, XAB2, HNRNPR, PIP4K2A, PIP4K2B, PIP4K2C, MUS81, CEP164, KIFAP3, CERK, NAF1, SNRPE, SNRPG, SNRPF, SNRPN, SLC35G2, LSM5, TSSC4, ZNHIT2, DLD, DLST, TRIM25, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDE10A_DDX23 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PDE10A | Q9Y233 | DB00975 | Dipyridamole | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | small molecule | approved |
| Hgene | PDE10A | Q9Y233 | DB08811 | Tofisopam | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | small molecule | approved |
| Hgene | PDE10A | Q9Y233 | DB01113 | Papaverine | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | small molecule | approved|investigational |
| Hgene | PDE10A | Q9Y233 | DB08814 | Triflusal | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | small molecule | approved|investigational |
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RelatedDiseases for PDE10A_DDX23 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PDE10A | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Hgene | PDE10A | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | PDE10A | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | PDE10A | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
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