	FusionGeneSummary
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Fusion gene ID: 26362

FusionGeneSummary for PDCD7_TAF15

Fusion gene summary

Fusion gene information	Fusion gene name: PDCD7_TAF15
	Fusion gene ID: 26362
		Hgene	Tgene
	Gene symbol	PDCD7	TAF15
	Gene ID	10081	8148
	Gene name	programmed cell death 7	TATA-box binding protein associated factor 15
	Synonyms	ES18\|HES18	Npl3\|RBP56\|TAF2N\|TAFII68
	Cytomap	15q22.31	17q12
	Type of gene	protein-coding	protein-coding
	Description	programmed cell death protein 7U11/U12 snRNP 59Kapoptosis-related protein ES18	TATA-binding protein-associated factor 2NRBP56/CSMF fusionTAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDaTATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)TATA box-bin
	Modification date	20180519	20180523
	UniProtAcc	Q8N8D1	Q92804
	Ensembl transtripts involved in fusion gene	ENST00000204549,	ENST00000588240, ENST00000592237, ENST00000311979,
Fusion gene scores	* DoF score	3 X 3 X 2=18	7 X 5 X 6=210
	# samples	4	7
	** MAII score	log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PDCD7 [Title/Abstract] AND TAF15 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Oncogene involved fusion gene, in-frame and retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BRCA	TCGA-LD-A7W5-01A	PDCD7	chr15	65421370	-	TAF15	chr17	34144720	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000204549	ENST00000588240	PDCD7	chr15	65421370	-	TAF15	chr17	34144720	+
5CDS-5UTR	ENST00000204549	ENST00000592237	PDCD7	chr15	65421370	-	TAF15	chr17	34144720	+
5CDS-5UTR	ENST00000204549	ENST00000311979	PDCD7	chr15	65421370	-	TAF15	chr17	34144720	+

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FusionProtFeatures for PDCD7_TAF15

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PDCD7 Q8N8D1	TAF15 Q92804
Promotes apoptosis when overexpressed. {ECO:0000250}.	RNA and ssDNA-binding protein that may play specificroles during transcription initiation at distinct promoters. Canenter the preinitiation complex together with the RNA polymeraseII (Pol II). {ECO:0000269\|PubMed:19124016}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PDCD7

chr15:65421370

chr17:34144720

ENST00000204549

232_335

336

486

Coiled coil

Ontology_term=ECO:0000255

Hgene

PDCD7

chr15:65421370

chr17:34144720

ENST00000204549

236_278

336

486

Compositional bias

Note=Arg/Glu-rich

Hgene

PDCD7

chr15:65421370

chr17:34144720

ENST00000204549

4_129

336

486

Compositional bias

Note=Pro-rich

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

1_208

590

Compositional bias

Note=Gln/Gly/Ser/Tyr-rich

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

320_590

590

Compositional bias

Note=Arg/Gly-rich

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

1_208

593

Compositional bias

Note=Gln/Gly/Ser/Tyr-rich

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

320_590

593

Compositional bias

Note=Arg/Gly-rich

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

234_320

590

Domain

RRM

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

234_320

593

Domain

RRM

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

407_575

590

Region

Note=21 X approximate tandem repeats of D-R-[S%2CG](0%2C3)-G-G-Y-G-G

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

407_575

593

Region

Note=21 X approximate tandem repeats of D-R-[S%2CG](0%2C3)-G-G-Y-G-G

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

407_413

590

Repeat

Note=1

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

414_420

590

Repeat

Note=2

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

421_429

590

Repeat

Note=3

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

430_439

590

Repeat

Note=4

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

440_448

590

Repeat

Note=5

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

449_457

590

Repeat

Note=6

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

458_465

590

Repeat

Note=7

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

466_473

590

Repeat

Note=8

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

474_481

590

Repeat

Note=9

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

482_488

590

Repeat

Note=10

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

489_496

590

Repeat

Note=11

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

497_503

590

Repeat

Note=12

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

504_510

590

Repeat

Note=13

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

511_517

590

Repeat

Note=14

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

518_524

590

Repeat

Note=15

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

525_533

590

Repeat

Note=16

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

534_543

590

Repeat

Note=17

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

544_551

590

Repeat

Note=18

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

552_560

590

Repeat

Note=19

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

561_568

590

Repeat

Note=20

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

569_575

590

Repeat

Note=21

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

407_413

593

Repeat

Note=1

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

414_420

593

Repeat

Note=2

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

421_429

593

Repeat

Note=3

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

430_439

593

Repeat

Note=4

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

440_448

593

Repeat

Note=5

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

449_457

593

Repeat

Note=6

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

458_465

593

Repeat

Note=7

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

466_473

593

Repeat

Note=8

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

474_481

593

Repeat

Note=9

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

482_488

593

Repeat

Note=10

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

489_496

593

Repeat

Note=11

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

497_503

593

Repeat

Note=12

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

504_510

593

Repeat

Note=13

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

511_517

593

Repeat

Note=14

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

518_524

593

Repeat

Note=15

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

525_533

593

Repeat

Note=16

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

534_543

593

Repeat

Note=17

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

544_551

593

Repeat

Note=18

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

552_560

593

Repeat

Note=19

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

561_568

593

Repeat

Note=20

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

569_575

593

Repeat

Note=21

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000311979

354_385

590

Zinc finger

RanBP2-type

Tgene

TAF15

chr15:65421370

chr17:34144720

ENST00000588240

354_385

593

Zinc finger

RanBP2-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PDCD7

chr15:65421370

chr17:34144720

ENST00000204549

362_411

336

486

Coiled coil

Ontology_term=ECO:0000255

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FusionGeneSequence for PDCD7_TAF15

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

>In-frame_PDCD7_ENST00000204549_chr15_65421370_-_TAF15_ENST00000588240_chr17_34144720_+_927aa
MALPPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLPP
PPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEAPPPPADVLGDAALQRLRDRQWLEAVFGTPRRAGCPVPQRTHAGPSLGEVRARLLR
ALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVER
EQEIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKDSGSYGQSGGEQQSYSTYGNPGSQ
GYGQASQSYSGYGQTTDSSYGQNYSGYSSYGQSQSGYSQSYGGYENQKQSSYSQQPYNNQGQQQNMESSGSQGGRAPSYDQPDYGQQDSY
DQQSGYDQHQGSYDEQSNYDQQHDSYSQNQQSYHSQRENYSHHTQDDRRDVSRYGEDNRGYGGSQGGGRGRGGYDKDGRGPMTGSSGGDR
GGFKNFGGHRDYGPRTDADSESDNSDNNTIFVQGLGEGVSTDQVGEFFKQIGIIKTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSA
KAAIDWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPED
SRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRG
GGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGY

* Fusion transcript sequences (only coding sequence (CDS) region).

>In-frame_PDCD7_ENST00000204549_chr15_65421370_-_TAF15_ENST00000588240_chr17_34144720_+_2781nt
ATGGCCCTGCCACCATTCTTCGGCCAGGGTCGCCCAGGCCCACCGCCCCCGCAGCCGCCGCCTCCTGCTCCTTTCGGCTGTCCGCCACCG
CCGCTGCCCTCCCCGGCTTTCCCGCCGCCTCTCCCCCAGCGGCCCGGCCCTTTTCCGGGGGCCTCCGCCCCCTTCCTTCAGCCTCCGCTG
GCTCTGCAGCCCCGAGCCTCCGCGGAGGCCTCCCGCGGCGGAGGCGGCGCTGGCGCCTTCTACCCGGTGCCACCACCGCCGCTGCCTCCT
CCGCCGCCCCAGTGTCGGCCCTTCCCGGGGACCGACGCCGGCGAGCGGCCGCGGCCACCGCCTCCCGGCCCGGGGCCGCCCTGGAGCCCG
CGGTGGCCTGAGGCGCCGCCGCCGCCGGCCGACGTGCTCGGGGATGCGGCCCTCCAACGCCTGCGCGACCGGCAGTGGCTGGAGGCGGTG
TTCGGGACCCCGCGGCGGGCAGGCTGTCCGGTGCCCCAGCGCACGCATGCCGGGCCCAGCCTTGGCGAAGTGCGCGCGCGATTGCTCCGG
GCTCTGCGCCTGGTGCGGCGGCTGCGCGGCCTGAGCCAGGCCCTGCGCGAGGCCGAAGCCGACGGCGCGGCCTGGGTCCTGCTGTACTCC
CAGACCGCGCCGCTGCGCGCGGAACTGGCCGAGCGGCTACAGCCGTTGACCCAGGCTGCCTATGTGGGCGAGGCGCGGAGGAGGCTGGAG
AGGGTCCGGCGCCGCCGGCTGCGGCTTCGCGAGAGGGCCCGGGAACGCGAGGCCGAGCGGGAGGCAGAGGCCGCGCGGGCAGTGGAACGC
GAGCAGGAGATTGACCGCTGGAGGGTGAAGTGTGTGCAGGAGGTGGAGGAGAAGAAGCGGGAGCAGGAACTCAAAGCAGCCGCTGATGGC
GTACTATCTGAAGTGAGGAAAAAACAAGCAGATACCAAAAGAATGGTGGACATTCTACGGGCTTTGGAGAAATTGAGGAAACTGAGGAAA
GAGGCTGCAGCGAGGAAAGATTCTGGAAGTTACGGTCAGTCTGGGGGTGAGCAGCAAAGTTATTCTACCTATGGAAATCCAGGCAGCCAA
GGCTATGGACAAGCATCACAAAGCTATTCTGGCTATGGGCAAACGACTGATTCCTCTTATGGACAGAACTACAGCGGTTACTCCAGTTAT
GGACAAAGTCAGTCAGGTTATTCACAGTCCTATGGTGGTTATGAGAATCAAAAGCAGAGCTCATATAGCCAGCAACCATATAATAACCAG
GGACAGCAGCAAAACATGGAATCATCAGGAAGCCAAGGTGGAAGAGCACCTTCCTATGACCAGCCAGACTATGGTCAACAAGATTCATAT
GACCAGCAGTCAGGCTATGATCAACATCAAGGCTCATATGATGAGCAGTCAAATTATGATCAGCAGCATGATTCCTATAGTCAAAACCAG
CAGTCCTATCATTCACAAAGGGAAAACTACAGCCACCACACACAAGATGACCGTCGTGATGTGAGTAGGTATGGAGAAGATAATAGAGGA
TATGGCGGGTCACAGGGAGGAGGTAGAGGGCGTGGGGGATATGACAAGGATGGAAGAGGTCCTATGACAGGATCAAGTGGTGGTGACCGC
GGTGGCTTCAAAAATTTTGGTGGTCACAGGGATTATGGACCCAGAACAGATGCTGATTCAGAATCTGATAATTCAGATAACAACACAATC
TTTGTGCAAGGACTTGGGGAGGGTGTGTCTACAGATCAAGTTGGGGAGTTCTTTAAACAAATAGGAATTATCAAGACAAATAAGAAGACC
GGAAAACCAATGATAAATCTTTATACAGACAAGGACACAGGAAAGCCAAAGGGGGAGGCAACAGTGTCATTTGATGACCCTCCTTCAGCT
AAGGCAGCCATTGACTGGTTTGATGGAAAAGAATTCCATGGCAACATCATTAAAGTGTCCTTTGCCACTAGAAGACCTGAATTCATGAGA
GGAGGTGGAAGTGGAGGTGGGCGGCGAGGCCGTGGAGGATATAGAGGTCGTGGAGGCTTTCAAGGGAGAGGTGGAGACCCCAAAAGTGGG
GATTGGGTTTGCCCTAATCCGTCATGCGGAAATATGAACTTTGCTCGAAGGAATTCCTGCAATCAGTGCAATGAGCCTAGACCAGAGGAC
TCTCGTCCCTCAGGAGGAGATTTCCGGGGGAGAGGCTACGGTGGAGAGAGGGGCTACAGAGGTCGTGGGGGCAGAGGTGGAGACCGAGGC
GGCTATGGTGGAGACAGAAGTGGGGGTGGCTATGGTGGAGACAGAAGCAGCGGTGGTGGCTACAGCGGAGATAGAAGTGGGGGCGGCTAT
GGTGGAGACAGAAGTGGGGGTGGCTATGGTGGGGACAGAGGCGGCGGCTATGGTGGGGACAGAGGAGGCGGCTATGGAGGAGACCGAGGA
GGTGGCTATGGAGGAGATCGAGGTGGCTATGGAGGAGACCGAGGTGGAGGCTATGGTGGAGACCGAGGAGGCTATGGAGGAGATCGAGGA
GGTTACGGAGGAGATCGAGGAGGTTATGGAGGAGATCGAGGAGGCTATGGAGGAGACAGAAGCCGGGGGGGCTATGGAGGAGACCGTGGT
GGTGGCAGTGGCTACGGTGGAGACCGAAGTGGAGGCTATGGAGGAGACAGGAGTGGTGGCGGCTATGGAGGAGACCGAGGTGGGGGCTAC

* Fusion transcript sequences (Full-length transcript).

>In-frame_PDCD7_ENST00000204549_chr15_65421370_-_TAF15_ENST00000588240_chr17_34144720_+_3133nt
CTCATGAGGAGCCACTCAGATTCCTGTCACTTCTCAAAGCATCTCCGTCGTGAACATGGCCCTGCCACCATTCTTCGGCCAGGGTCGCCC
AGGCCCACCGCCCCCGCAGCCGCCGCCTCCTGCTCCTTTCGGCTGTCCGCCACCGCCGCTGCCCTCCCCGGCTTTCCCGCCGCCTCTCCC
CCAGCGGCCCGGCCCTTTTCCGGGGGCCTCCGCCCCCTTCCTTCAGCCTCCGCTGGCTCTGCAGCCCCGAGCCTCCGCGGAGGCCTCCCG
CGGCGGAGGCGGCGCTGGCGCCTTCTACCCGGTGCCACCACCGCCGCTGCCTCCTCCGCCGCCCCAGTGTCGGCCCTTCCCGGGGACCGA
CGCCGGCGAGCGGCCGCGGCCACCGCCTCCCGGCCCGGGGCCGCCCTGGAGCCCGCGGTGGCCTGAGGCGCCGCCGCCGCCGGCCGACGT
GCTCGGGGATGCGGCCCTCCAACGCCTGCGCGACCGGCAGTGGCTGGAGGCGGTGTTCGGGACCCCGCGGCGGGCAGGCTGTCCGGTGCC
CCAGCGCACGCATGCCGGGCCCAGCCTTGGCGAAGTGCGCGCGCGATTGCTCCGGGCTCTGCGCCTGGTGCGGCGGCTGCGCGGCCTGAG
CCAGGCCCTGCGCGAGGCCGAAGCCGACGGCGCGGCCTGGGTCCTGCTGTACTCCCAGACCGCGCCGCTGCGCGCGGAACTGGCCGAGCG
GCTACAGCCGTTGACCCAGGCTGCCTATGTGGGCGAGGCGCGGAGGAGGCTGGAGAGGGTCCGGCGCCGCCGGCTGCGGCTTCGCGAGAG
GGCCCGGGAACGCGAGGCCGAGCGGGAGGCAGAGGCCGCGCGGGCAGTGGAACGCGAGCAGGAGATTGACCGCTGGAGGGTGAAGTGTGT
GCAGGAGGTGGAGGAGAAGAAGCGGGAGCAGGAACTCAAAGCAGCCGCTGATGGCGTACTATCTGAAGTGAGGAAAAAACAAGCAGATAC
CAAAAGAATGGTGGACATTCTACGGGCTTTGGAGAAATTGAGGAAACTGAGGAAAGAGGCTGCAGCGAGGAAAGATTCTGGAAGTTACGG
TCAGTCTGGGGGTGAGCAGCAAAGTTATTCTACCTATGGAAATCCAGGCAGCCAAGGCTATGGACAAGCATCACAAAGCTATTCTGGCTA
TGGGCAAACGACTGATTCCTCTTATGGACAGAACTACAGCGGTTACTCCAGTTATGGACAAAGTCAGTCAGGTTATTCACAGTCCTATGG
TGGTTATGAGAATCAAAAGCAGAGCTCATATAGCCAGCAACCATATAATAACCAGGGACAGCAGCAAAACATGGAATCATCAGGAAGCCA
AGGTGGAAGAGCACCTTCCTATGACCAGCCAGACTATGGTCAACAAGATTCATATGACCAGCAGTCAGGCTATGATCAACATCAAGGCTC
ATATGATGAGCAGTCAAATTATGATCAGCAGCATGATTCCTATAGTCAAAACCAGCAGTCCTATCATTCACAAAGGGAAAACTACAGCCA
CCACACACAAGATGACCGTCGTGATGTGAGTAGGTATGGAGAAGATAATAGAGGATATGGCGGGTCACAGGGAGGAGGTAGAGGGCGTGG
GGGATATGACAAGGATGGAAGAGGTCCTATGACAGGATCAAGTGGTGGTGACCGCGGTGGCTTCAAAAATTTTGGTGGTCACAGGGATTA
TGGACCCAGAACAGATGCTGATTCAGAATCTGATAATTCAGATAACAACACAATCTTTGTGCAAGGACTTGGGGAGGGTGTGTCTACAGA
TCAAGTTGGGGAGTTCTTTAAACAAATAGGAATTATCAAGACAAATAAGAAGACCGGAAAACCAATGATAAATCTTTATACAGACAAGGA
CACAGGAAAGCCAAAGGGGGAGGCAACAGTGTCATTTGATGACCCTCCTTCAGCTAAGGCAGCCATTGACTGGTTTGATGGAAAAGAATT
CCATGGCAACATCATTAAAGTGTCCTTTGCCACTAGAAGACCTGAATTCATGAGAGGAGGTGGAAGTGGAGGTGGGCGGCGAGGCCGTGG
AGGATATAGAGGTCGTGGAGGCTTTCAAGGGAGAGGTGGAGACCCCAAAAGTGGGGATTGGGTTTGCCCTAATCCGTCATGCGGAAATAT
GAACTTTGCTCGAAGGAATTCCTGCAATCAGTGCAATGAGCCTAGACCAGAGGACTCTCGTCCCTCAGGAGGAGATTTCCGGGGGAGAGG
CTACGGTGGAGAGAGGGGCTACAGAGGTCGTGGGGGCAGAGGTGGAGACCGAGGCGGCTATGGTGGAGACAGAAGTGGGGGTGGCTATGG
TGGAGACAGAAGCAGCGGTGGTGGCTACAGCGGAGATAGAAGTGGGGGCGGCTATGGTGGAGACAGAAGTGGGGGTGGCTATGGTGGGGA
CAGAGGCGGCGGCTATGGTGGGGACAGAGGAGGCGGCTATGGAGGAGACCGAGGAGGTGGCTATGGAGGAGATCGAGGTGGCTATGGAGG
AGACCGAGGTGGAGGCTATGGTGGAGACCGAGGAGGCTATGGAGGAGATCGAGGAGGTTACGGAGGAGATCGAGGAGGTTATGGAGGAGA
TCGAGGAGGCTATGGAGGAGACAGAAGCCGGGGGGGCTATGGAGGAGACCGTGGTGGTGGCAGTGGCTACGGTGGAGACCGAAGTGGAGG
CTATGGAGGAGACAGGAGTGGTGGCGGCTATGGAGGAGACCGAGGTGGGGGCTACGGAGGAGACCGAGGTGGCTATGGAGGCAAAATGGG
AGGAAGAAACGACTACAGAAATGATCAGCGCAACCGACCATACTGATGACTGTTTTGAATGTTCCTTTGTCTCTGACATGATCCATAGTG
AAATTGCCAGAGTTTTGCCTGCTGCTTTCCTCGTGGCCTCTTCTTGGGTAGTGAAATTAAGTGACATTTGGATTTTTATTTGGGTGGGAG
GGCTGGGACAGTTTTTCTTCTAGAAATGTCTGTTGAGATTTCCCCCTTTAGTTTCCAACCTTCTCCCCAACCCTTGGAGCTAAATGCGTT

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FusionGenePPI for PDCD7_TAF15

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
PDCD7	RNU11, FEZ1, HAP1, FEZ2, CALM1, ELAVL1, APP, SNRNP200, PRPF40A, WWOX, ZRSR2, RNU12, MARK2, RPL10, PCGF1, NANOG, POU5F1, SNRPN, ZCRB1, SNRPF, SNRPG, ZMAT5, SNRPE, SNRNP35	TAF15	SAFB, PRMT1, TAF7, TAF5, TAF13, TAF11, POLR2C, POLR2G, POLR2E, SF1, KAT2B, POLR2A, HIST2H2AC, HIST1H3A, HIST2H4A, CACNA1A, SIRT7, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, DDB1, TPR, SAP30BP, RNF168, SCARB2, TPM2, TMED9, MED26, PRMT8, FUS, RPA3, RPA2, RPA1, HIST3H3, CUL7, OBSL1, EZH2, SUZ12, EED, RNF2, BMI1, RPS6KB2, ACAA2, SFN, HNRNPA1, PPP1CB, MATR3, MED12, MCM2, NF2, DNPEP, KLHL8, TRIM25, BRCA1

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for PDCD7_TAF15

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for PDCD7_TAF15

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	TAF15	C0029463	Osteosarcoma	1	CTD_human
Tgene	TAF15	C0038356	Stomach Neoplasms	1	CTD_human

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Fusion gene ID: 26362

FusionGeneSummary for PDCD7_TAF15

FusionProtFeatures for PDCD7_TAF15

FusionGeneSequence for PDCD7_TAF15

FusionGenePPI for PDCD7_TAF15

RelatedDrugs for PDCD7_TAF15

RelatedDiseases for PDCD7_TAF15