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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26313

FusionGeneSummary for PCYOX1_MAST3

check button Fusion gene summary
Fusion gene informationFusion gene name: PCYOX1_MAST3
Fusion gene ID: 26313
HgeneTgene
Gene symbol

PCYOX1

MAST3

Gene ID

51449

23031

Gene nameprenylcysteine oxidase 1microtubule associated serine/threonine kinase 3
SynonymsPCL1-
Cytomap

2p13.3

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionprenylcysteine oxidase 1prenylcysteine lyasemicrotubule-associated serine/threonine-protein kinase 3
Modification date2018052320180523
UniProtAcc

Q9UHG3

O60307

Ensembl transtripts involved in fusion geneENST00000505044, ENST00000433351, 
ENST00000264441, ENST00000545138, 
ENST00000262811, ENST00000608648, 
Fusion gene scores* DoF score3 X 3 X 1=94 X 4 X 3=48
# samples 34
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCYOX1 [Title/Abstract] AND MAST3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePCYOX1

GO:0030327

prenylated protein catabolic process

10585463


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ876631PCYOX1chr2

70506593

+MAST3chr19

18261082

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000505044ENST00000262811PCYOX1chr2

70506593

+MAST3chr19

18261082

+
intron-intronENST00000505044ENST00000608648PCYOX1chr2

70506593

+MAST3chr19

18261082

+
3UTR-3UTRENST00000433351ENST00000262811PCYOX1chr2

70506593

+MAST3chr19

18261082

+
3UTR-intronENST00000433351ENST00000608648PCYOX1chr2

70506593

+MAST3chr19

18261082

+
intron-3UTRENST00000264441ENST00000262811PCYOX1chr2

70506593

+MAST3chr19

18261082

+
intron-intronENST00000264441ENST00000608648PCYOX1chr2

70506593

+MAST3chr19

18261082

+
intron-3UTRENST00000545138ENST00000262811PCYOX1chr2

70506593

+MAST3chr19

18261082

+
intron-intronENST00000545138ENST00000608648PCYOX1chr2

70506593

+MAST3chr19

18261082

+

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FusionProtFeatures for PCYOX1_MAST3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PCYOX1

Q9UHG3

MAST3

O60307

Involved in the degradation of prenylated proteins.Cleaves the thioether bond of prenyl-L-cysteines, such asfarnesylcysteine and geranylgeranylcysteine.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PCYOX1_MAST3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PCYOX1_MAST3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PCYOX1_MAST3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PCYOX1_MAST3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePCYOX1C0043094Weight Gain1CTD_human