	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 263

FusionGeneSummary for ABL2_ABL2

Fusion gene summary

Fusion gene information	Fusion gene name: ABL2_ABL2
	Fusion gene ID: 263
		Hgene	Tgene
	Gene symbol	ABL2	ABL2
	Gene ID	27	27
	Gene name	ABL proto-oncogene 2, non-receptor tyrosine kinase	ABL proto-oncogene 2, non-receptor tyrosine kinase
	Synonyms	ABLL\|ARG	ABLL\|ARG
	Cytomap	1q25.2	1q25.2
	Type of gene	protein-coding	protein-coding
	Description	tyrosine-protein kinase ABL2Abelson tyrosine-protein kinase 2abelson-related gene proteinc-abl oncogene 2, non-receptor tyrosine kinasetyrosine-protein kinase ARGv-abl Abelson murine leukemia viral oncogene homolog 2	tyrosine-protein kinase ABL2Abelson tyrosine-protein kinase 2abelson-related gene proteinc-abl oncogene 2, non-receptor tyrosine kinasetyrosine-protein kinase ARGv-abl Abelson murine leukemia viral oncogene homolog 2
	Modification date	20180523	20180523
	UniProtAcc	P42684	P42684
	Ensembl transtripts involved in fusion gene	ENST00000502732, ENST00000367623, ENST00000507173, ENST00000511413, ENST00000392043, ENST00000408940, ENST00000344730, ENST00000512653, ENST00000504405,	ENST00000502732, ENST00000367623, ENST00000507173, ENST00000511413, ENST00000392043, ENST00000408940, ENST00000344730, ENST00000512653, ENST00000504405,
Fusion gene scores	* DoF score	5 X 4 X 4=80	4 X 5 X 1=20
	# samples	6	6
	** MAII score	log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/20*10)=1.58496250072116 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ABL2 [Title/Abstract] AND ABL2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ABL2	GO:0018108	peptidyl-tyrosine phosphorylation	15886098
Hgene	ABL2	GO:0051353	positive regulation of oxidoreductase activity	12893824
Tgene	ABL2	GO:0018108	peptidyl-tyrosine phosphorylation	15886098
Tgene	ABL2	GO:0051353	positive regulation of oxidoreductase activity	12893824

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BG178591	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
ChiTaRS3.1			AL120022	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000502732	ENST00000502732	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000502732	ENST00000367623	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000502732	ENST00000507173	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000502732	ENST00000511413	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000502732	ENST00000392043	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000502732	ENST00000408940	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000502732	ENST00000344730	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000502732	ENST00000512653	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000502732	ENST00000504405	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000367623	ENST00000502732	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000367623	ENST00000367623	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000367623	ENST00000507173	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000367623	ENST00000511413	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000367623	ENST00000392043	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000367623	ENST00000408940	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000367623	ENST00000344730	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000367623	ENST00000512653	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000367623	ENST00000504405	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000507173	ENST00000502732	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000507173	ENST00000367623	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000507173	ENST00000507173	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000507173	ENST00000511413	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000507173	ENST00000392043	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000507173	ENST00000408940	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000507173	ENST00000344730	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000507173	ENST00000512653	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000507173	ENST00000504405	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000511413	ENST00000502732	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000511413	ENST00000367623	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000511413	ENST00000507173	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000511413	ENST00000511413	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000511413	ENST00000392043	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000511413	ENST00000408940	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000511413	ENST00000344730	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000511413	ENST00000512653	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000511413	ENST00000504405	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000392043	ENST00000502732	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000392043	ENST00000367623	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000392043	ENST00000507173	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000392043	ENST00000511413	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000392043	ENST00000392043	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000392043	ENST00000408940	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000392043	ENST00000344730	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000392043	ENST00000512653	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000392043	ENST00000504405	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000408940	ENST00000502732	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000408940	ENST00000367623	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000408940	ENST00000507173	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000408940	ENST00000511413	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000408940	ENST00000392043	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000408940	ENST00000408940	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000408940	ENST00000344730	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000408940	ENST00000512653	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000408940	ENST00000504405	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000344730	ENST00000502732	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000344730	ENST00000367623	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000344730	ENST00000507173	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000344730	ENST00000511413	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000344730	ENST00000392043	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000344730	ENST00000408940	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000344730	ENST00000344730	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000344730	ENST00000512653	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000344730	ENST00000504405	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000512653	ENST00000502732	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000512653	ENST00000367623	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000512653	ENST00000507173	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000512653	ENST00000511413	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000512653	ENST00000392043	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000512653	ENST00000408940	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000512653	ENST00000344730	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000512653	ENST00000512653	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000512653	ENST00000504405	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000504405	ENST00000502732	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000504405	ENST00000367623	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000504405	ENST00000507173	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000504405	ENST00000511413	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000504405	ENST00000392043	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000504405	ENST00000408940	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-3UTR	ENST00000504405	ENST00000344730	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000504405	ENST00000512653	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000504405	ENST00000504405	ABL2	chr1	179075500	+	ABL2	chr1	179075346	-
intron-intron	ENST00000502732	ENST00000502732	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000502732	ENST00000367623	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000502732	ENST00000507173	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000502732	ENST00000511413	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000502732	ENST00000392043	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000502732	ENST00000408940	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000502732	ENST00000344730	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000502732	ENST00000512653	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000502732	ENST00000504405	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000367623	ENST00000502732	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000367623	ENST00000367623	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000367623	ENST00000507173	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000367623	ENST00000511413	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000367623	ENST00000392043	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000367623	ENST00000408940	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000367623	ENST00000344730	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000367623	ENST00000512653	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000367623	ENST00000504405	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000507173	ENST00000502732	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000507173	ENST00000367623	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000507173	ENST00000507173	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000507173	ENST00000511413	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000507173	ENST00000392043	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000507173	ENST00000408940	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000507173	ENST00000344730	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000507173	ENST00000512653	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000507173	ENST00000504405	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000511413	ENST00000502732	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000511413	ENST00000367623	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000511413	ENST00000507173	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000511413	ENST00000511413	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000511413	ENST00000392043	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000511413	ENST00000408940	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000511413	ENST00000344730	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000511413	ENST00000512653	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000511413	ENST00000504405	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000392043	ENST00000502732	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000392043	ENST00000367623	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000392043	ENST00000507173	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000392043	ENST00000511413	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000392043	ENST00000392043	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000392043	ENST00000408940	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000392043	ENST00000344730	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000392043	ENST00000512653	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000392043	ENST00000504405	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000408940	ENST00000502732	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000408940	ENST00000367623	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000408940	ENST00000507173	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000408940	ENST00000511413	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000408940	ENST00000392043	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000408940	ENST00000408940	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000408940	ENST00000344730	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000408940	ENST00000512653	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000408940	ENST00000504405	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000344730	ENST00000502732	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000344730	ENST00000367623	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000344730	ENST00000507173	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000344730	ENST00000511413	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000344730	ENST00000392043	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000344730	ENST00000408940	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000344730	ENST00000344730	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000344730	ENST00000512653	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000344730	ENST00000504405	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000512653	ENST00000502732	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000512653	ENST00000367623	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000512653	ENST00000507173	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000512653	ENST00000511413	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000512653	ENST00000392043	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000512653	ENST00000408940	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000512653	ENST00000344730	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000512653	ENST00000512653	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000512653	ENST00000504405	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000504405	ENST00000502732	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000504405	ENST00000367623	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000504405	ENST00000507173	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000504405	ENST00000511413	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000504405	ENST00000392043	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000504405	ENST00000408940	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000504405	ENST00000344730	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000504405	ENST00000512653	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-
intron-intron	ENST00000504405	ENST00000504405	ABL2	chr1	179171335	+	ABL2	chr1	179171296	-

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FusionProtFeatures for ABL2_ABL2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ABL2 P42684	ABL2 P42684

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for ABL2_ABL2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ABL2_ABL2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for ABL2_ABL2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	ABL2	P42684	DB01254	Dasatinib	Tyrosine-protein kinase ABL2	small molecule	approved\|investigational
Tgene	ABL2	P42684	DB01254	Dasatinib	Tyrosine-protein kinase ABL2	small molecule	approved\|investigational

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RelatedDiseases for ABL2_ABL2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Statistics

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Fusion gene ID: 263

FusionGeneSummary for ABL2_ABL2

FusionProtFeatures for ABL2_ABL2

FusionGeneSequence for ABL2_ABL2

FusionGenePPI for ABL2_ABL2

RelatedDrugs for ABL2_ABL2

RelatedDiseases for ABL2_ABL2