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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26267

FusionGeneSummary for PCMTD1_RHOT1

check button Fusion gene summary
Fusion gene informationFusion gene name: PCMTD1_RHOT1
Fusion gene ID: 26267
HgeneTgene
Gene symbol

PCMTD1

RHOT1

Gene ID

115294

55288

Gene nameprotein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1ras homolog family member T1
Synonyms-ARHT1|MIRO-1|MIRO1
Cytomap

8q11.23

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionprotein-L-isoaspartate O-methyltransferase domain-containing protein 1mitochondrial Rho GTPase 1mitochondrial Rho (MIRO) GTPase 1rac-GTP binding protein-like proteinras homolog gene family, member T1
Modification date2018052320180527
UniProtAcc

Q96MG8

Q8IXI2

Ensembl transtripts involved in fusion geneENST00000360540, ENST00000544451, 
ENST00000519559, ENST00000522514, 
ENST00000521344, 
ENST00000333942, 
ENST00000358365, ENST00000583994, 
ENST00000545287, ENST00000354266, 
ENST00000394692, ENST00000581094, 
ENST00000580976, 
Fusion gene scores* DoF score12 X 6 X 10=7209 X 7 X 10=630
# samples 1914
** MAII scorelog2(19/720*10)=-1.92199748799873
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/630*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCMTD1 [Title/Abstract] AND RHOT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-DK-A1AC-01APCMTD1chr8

52773405

-RHOT1chr17

30509776

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000360540ENST00000333942PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
Frame-shiftENST00000360540ENST00000358365PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
5CDS-5UTRENST00000360540ENST00000583994PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
5CDS-5UTRENST00000360540ENST00000545287PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
5CDS-5UTRENST00000360540ENST00000354266PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
5CDS-5UTRENST00000360540ENST00000394692PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
5CDS-5UTRENST00000360540ENST00000581094PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
5CDS-intronENST00000360540ENST00000580976PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-3CDSENST00000544451ENST00000333942PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-3CDSENST00000544451ENST00000358365PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-5UTRENST00000544451ENST00000583994PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-5UTRENST00000544451ENST00000545287PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-5UTRENST00000544451ENST00000354266PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-5UTRENST00000544451ENST00000394692PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-5UTRENST00000544451ENST00000581094PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-intronENST00000544451ENST00000580976PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-3CDSENST00000519559ENST00000333942PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-3CDSENST00000519559ENST00000358365PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-5UTRENST00000519559ENST00000583994PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-5UTRENST00000519559ENST00000545287PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-5UTRENST00000519559ENST00000354266PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-5UTRENST00000519559ENST00000394692PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-5UTRENST00000519559ENST00000581094PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-intronENST00000519559ENST00000580976PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
Frame-shiftENST00000522514ENST00000333942PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
Frame-shiftENST00000522514ENST00000358365PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
5CDS-5UTRENST00000522514ENST00000583994PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
5CDS-5UTRENST00000522514ENST00000545287PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
5CDS-5UTRENST00000522514ENST00000354266PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
5CDS-5UTRENST00000522514ENST00000394692PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
5CDS-5UTRENST00000522514ENST00000581094PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
5CDS-intronENST00000522514ENST00000580976PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-3CDSENST00000521344ENST00000333942PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-3CDSENST00000521344ENST00000358365PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-5UTRENST00000521344ENST00000583994PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-5UTRENST00000521344ENST00000545287PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-5UTRENST00000521344ENST00000354266PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-5UTRENST00000521344ENST00000394692PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-5UTRENST00000521344ENST00000581094PCMTD1chr8

52773405

-RHOT1chr17

30509776

+
intron-intronENST00000521344ENST00000580976PCMTD1chr8

52773405

-RHOT1chr17

30509776

+

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FusionProtFeatures for PCMTD1_RHOT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PCMTD1

Q96MG8

RHOT1

Q8IXI2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PCMTD1_RHOT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PCMTD1_RHOT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PCMTD1ELAVL1, CUL5, MRPS11, NANOG, RPS14, SEPT3, UBCRHOT1AMFR, IRAK1, PINK1, PARK2, CFTR, ILK, PCSK9, ERLIN2, NXF1, TRAK2, PEX19, NTRK1, COQ9, APOOL, RHOT2, PTPN18, CDK20


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PCMTD1_RHOT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PCMTD1_RHOT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource