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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26255

FusionGeneSummary for PCM1_VEZT

check button Fusion gene summary
Fusion gene informationFusion gene name: PCM1_VEZT
Fusion gene ID: 26255
HgeneTgene
Gene symbol

PCM1

VEZT

Gene ID

5108

55591

Gene namepericentriolar material 1vezatin, adherens junctions transmembrane protein
SynonymsPTC4|RET/PCM-1VEZATIN
Cytomap

8p22

12q22

Type of geneprotein-codingprotein-coding
Descriptionpericentriolar material 1 proteinPCM-1hPCM-1pericentriolar material 1, PCM1vezatin
Modification date2018052320180519
UniProtAcc

Q15154

Q9HBM0

Ensembl transtripts involved in fusion geneENST00000325083, ENST00000519253, 
ENST00000524226, ENST00000518537, 
ENST00000518936, ENST00000327578, 
ENST00000436874, ENST00000261219, 
ENST00000356859, 
Fusion gene scores* DoF score8 X 7 X 5=2805 X 5 X 5=125
# samples 87
** MAII scorelog2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/125*10)=-0.836501267717121
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCM1 [Title/Abstract] AND VEZT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-AB36-01APCM1chr8

17869336

+VEZTchr12

95660133

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000325083ENST00000436874PCM1chr8

17869336

+VEZTchr12

95660133

+
Frame-shitENST00000325083ENST00000261219PCM1chr8

17869336

+VEZTchr12

95660133

+
5CDS-3UTRENST00000325083ENST00000356859PCM1chr8

17869336

+VEZTchr12

95660133

+
Frame-shitENST00000519253ENST00000436874PCM1chr8

17869336

+VEZTchr12

95660133

+
Frame-shitENST00000519253ENST00000261219PCM1chr8

17869336

+VEZTchr12

95660133

+
5CDS-3UTRENST00000519253ENST00000356859PCM1chr8

17869336

+VEZTchr12

95660133

+
Frame-shitENST00000524226ENST00000436874PCM1chr8

17869336

+VEZTchr12

95660133

+
Frame-shitENST00000524226ENST00000261219PCM1chr8

17869336

+VEZTchr12

95660133

+
5CDS-3UTRENST00000524226ENST00000356859PCM1chr8

17869336

+VEZTchr12

95660133

+
intron-3CDSENST00000518537ENST00000436874PCM1chr8

17869336

+VEZTchr12

95660133

+
intron-3CDSENST00000518537ENST00000261219PCM1chr8

17869336

+VEZTchr12

95660133

+
intron-3UTRENST00000518537ENST00000356859PCM1chr8

17869336

+VEZTchr12

95660133

+
intron-3CDSENST00000518936ENST00000436874PCM1chr8

17869336

+VEZTchr12

95660133

+
intron-3CDSENST00000518936ENST00000261219PCM1chr8

17869336

+VEZTchr12

95660133

+
intron-3UTRENST00000518936ENST00000356859PCM1chr8

17869336

+VEZTchr12

95660133

+
Frame-shitENST00000327578ENST00000436874PCM1chr8

17869336

+VEZTchr12

95660133

+
Frame-shitENST00000327578ENST00000261219PCM1chr8

17869336

+VEZTchr12

95660133

+
5CDS-3UTRENST00000327578ENST00000356859PCM1chr8

17869336

+VEZTchr12

95660133

+

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FusionProtFeatures for PCM1_VEZT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PCM1

Q15154

VEZT

Q9HBM0

Plays a pivotal role in the establishment of adherensjunctions and their maintenance in adult life. In case of Listeriainfection, promotes bacterial internalization by participating inmyosin VIIa recruitment to the entry site.{ECO:0000269|PubMed:15090598}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PCM1_VEZT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PCM1_VEZT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PCM1BBS4, KRT15, ING5, KIAA0368, KRT19, CCDC53, ABI2, EXOC8, EPS8, CEP72, PCNT, HAP1, EWSR1, HNRNPUL1, CLTC, MIB1, FUS, CEP131, PPIB, SIRT7, NEURL4, PAN2, CASK, E2F4, YWHAQ, LATS2, SAV1, CEP250, HAUS2, OBSL1, CCDC8, CSPP1, CCDC183, SLC25A41, SSFA2, RASSF8, RASSF7, IFT81, NTRK1, BTRC, MED4, HERC2, AHI1, CEP162, RPGRIP1L, CC2D2A, CEP128, LCA5, OFD1, CCDC138, CEP170, PIBF1, SSX2IP, WRAP73, HAUS1, HAUS4, KIAA0753, CCDC77, CCNB2, CEP350, CEP95, CSNK1A1, DSP, KIF20A, LUZP1, MCM10, MCRS1, MPRIP, NDC80, SMARCD2, TPGS1, SUPT5H, SSBP1, KIF7, SKA1, TSPYL1, SREK1IP1, CSNK1D, IFT172, CEP55, IFT20, CCDC14, HMMR, CFAP97, IPO5, KCTD12, SNRPE, SPICE1, ABCD3, ACOT9, ATP5L, CAMSAP1, CC2D1A, CCDC66, CEP120, CKAP2, FGFR1OP, HAUS3, HAUS5, HAUS6, HAUS7, HAUS8, IDH3B, IFT57, IFT74, NCKAP5L, RAE1, STAU1, TP53BP2, TTK, TXLNA, TXLNG, TBC1D31, WDR83, XRN1, ZNF280C, ACTR2, ANKRD26, BAIAP2, BICD1, BICD2, BTF3, C11orf49, KNSTRN, C2CD3, CAMSAP2, CCDC112, CCDC18, CCDC22, CCDC85C, CCDC92, CCNB1, CCP110, CDC123, CEP164, CEP192, CEP57L1, CEP63, CEP85, CEP89, CEP97, CKAP2L, CNOT10, COMMD2, COMMD4, CSNK1E, DAPK3, DIAPH3, ERC1, EXOC4, FOPNL, GNAO1, GPATCH1, IBTK, IQCB1, KIAA1328, KIF14, LRRC49, LRRCC1, MAGED1, MAP7D3, MED29, MIS18A, MIS18BP1, MOB4, MPHOSPH9, MYO9A, NAV1, NEDD1, NME7, NOL11, NUF2, ODF2L, ODF2, PCBP3, PKN2, PLK1, KIZ, PPP1R9B, IFT22, RRM2, SCLT1, SDCCAG3, SECISBP2, SMG5, SMG7, SPATA24, SPATS2, SPC24, SRGAP2, STRN4, TANC1, TCHP, TEX9, TNIP1, TRAF3IP1, TTC12, TTF2, TTLL4, TTLL5, CEP104, CEP290, CEP152, CEP135, CNTRL, FBF1, NINL, NIN, POC5, SASS6, RPGRIP1, STIL, CENPJ, CENPE, PPP2CA, PRKAR2B, DYNLL1, MAPRE1, SLAIN2, CEP170P1, PPP2R3C, YWHAE, YWHAZ, MTMR7, C6orf118, BIN3, CCDC172, LPXN, FAM81B, COG5, ING2, CCDC65, LCA5L, CCDC40, DKK3, NECAB2, ATG14, TSC1, RNF168VEZTMYO7A, CTNNA1, CTNNB1, CDH1, ELAVL1, PLEKHO2, TCTN2, TCTN3, EVC2, TMEM17, TMEM216, CTDNEP1, TPTE, VIPR2, C3AR1, TMED6, GPR21, FZD10, DLK2, CHRM4, IPPK


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PCM1_VEZT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PCM1_VEZT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePCM1C0036341Schizophrenia1CTD_human