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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 262

FusionGeneSummary for ABL1_SLC38A10

check button Fusion gene summary
Fusion gene informationFusion gene name: ABL1_SLC38A10
Fusion gene ID: 262
HgeneTgene
Gene symbol

ABL1

SLC38A10

Gene ID

25

124565

Gene nameABL proto-oncogene 1, non-receptor tyrosine kinasesolute carrier family 38 member 10
SynonymsABL|CHDSKM|JTK7|bcr/abl|c-ABL|c-ABL1|p150|v-ablPP1744
Cytomap

9q34.12

17q25.3

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase ABL1Abelson tyrosine-protein kinase 1bcr/c-abl oncogene proteinc-abl oncogene 1, receptor tyrosine kinaseproto-oncogene c-Ablproto-oncogene tyrosine-protein kinase ABL1v-abl Abelson murine leukemia viral oncogene homolog 1putative sodium-coupled neutral amino acid transporter 10
Modification date2018052720180523
UniProtAcc

P00519

Q9HBR0

Ensembl transtripts involved in fusion geneENST00000318560, ENST00000374759, 
ENST00000288439, ENST00000546352, 
Fusion gene scores* DoF score14 X 13 X 10=18202 X 2 X 2=8
# samples 232
** MAII scorelog2(23/1820*10)=-2.98423268414168
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: ABL1 [Title/Abstract] AND SLC38A10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABL1

GO:0006974

cellular response to DNA damage stimulus

15657060

HgeneABL1

GO:0006975

DNA damage induced protein phosphorylation

18280240

HgeneABL1

GO:0018108

peptidyl-tyrosine phosphorylation

7590236|9144171|10713049|11121037

HgeneABL1

GO:0038083

peptidyl-tyrosine autophosphorylation

10518561

HgeneABL1

GO:0042770

signal transduction in response to DNA damage

9037071|15657060

HgeneABL1

GO:0043065

positive regulation of apoptotic process

9037071

HgeneABL1

GO:0046777

protein autophosphorylation

10713049

HgeneABL1

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

15657060

HgeneABL1

GO:0051353

positive regulation of oxidoreductase activity

12893824

HgeneABL1

GO:0051444

negative regulation of ubiquitin-protein transferase activity

20823226

HgeneABL1

GO:0070301

cellular response to hydrogen peroxide

10713049

HgeneABL1

GO:0071901

negative regulation of protein serine/threonine kinase activity

11121037

HgeneABL1

GO:1990051

activation of protein kinase C activity

10713049

HgeneABL1

GO:2001020

regulation of response to DNA damage stimulus

9461559


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-ZG-A9LN-01AABL1chr9

133730483

+SLC38A10chr17

79246427

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000318560ENST00000374759ABL1chr9

133730483

+SLC38A10chr17

79246427

-
In-frameENST00000318560ENST00000288439ABL1chr9

133730483

+SLC38A10chr17

79246427

-
5CDS-intronENST00000318560ENST00000546352ABL1chr9

133730483

+SLC38A10chr17

79246427

-

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FusionProtFeatures for ABL1_SLC38A10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABL1

P00519

SLC38A10

Q9HBR0

Non-receptor tyrosine-protein kinase that plays a rolein many key processes linked to cell growth and survival such ascytoskeleton remodeling in response to extracellular stimuli, cellmotility and adhesion, receptor endocytosis, autophagy, DNA damageresponse and apoptosis. Coordinates actin remodeling throughtyrosine phosphorylation of proteins controlling cytoskeletondynamics like WASF3 (involved in branch formation); ANXA1(involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH(involved in signaling); or MAPT and PXN (microtubule-bindingproteins). Phosphorylation of WASF3 is critical for thestimulation of lamellipodia formation and cell migration. Involvedin the regulation of cell adhesion and motility throughphosphorylation of key regulators of these processes such asBCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiplereceptor tyrosine kinases and more particularly promotesendocytosis of EGFR, facilitates the formation of neuromuscularsynapses through MUSK, inhibits PDGFRB-mediated chemotaxis andmodulates the endocytosis of activated B-cell receptor complexes.Other substrates which are involved in endocytosis regulation arethe caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBLfamily of ubiquitin ligases that drive receptor down-regulationand actin remodeling. Phosphorylation of CBL leads to increasedEGFR stability. Involved in late-stage autophagy by regulatingpositively the trafficking and function of lysosomal components.ABL1 targets to mitochondria in response to oxidative stress andthereby mediates mitochondrial dysfunction and cell death. Inresponse to oxidative stress, phosphorylates serine/threoninekinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is alsotranslocated in the nucleus where it has DNA-binding activity andis involved in DNA-damage response and apoptosis. Many substratesare known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6,RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathwaywhen the DNA damage is too severe to be repaired. PhosphorylatesTP73, a primary regulator for this type of damage-inducedapoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' andregulates its processing in the apoptotic response to DNA damage.Phosphorylates PSMA7 that leads to an inhibition of proteasomalactivity and cell cycle transition blocks. ABL1 acts also as aregulator of multiple pathological signaling cascades duringinfection. Several known tyrosine-phosphorylated microbialproteins have been identified as ABL1 substrates. This is the caseof A36R of Vaccinia virus, Tir (translocated intimin receptor) ofpathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containingprotein A) of A.phagocytophilum. Pathogens can highjack ABL1kinase signaling to reorganize the host actin cytoskeleton formultiple purposes, like facilitating intracellular movement andhost cell exit. Finally, functions as its own regulator throughautocatalytic activity as well as through phosphorylation of itsinhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residuesleading to an enhancement of its transcriptional activatoractivity (By similarity). {ECO:0000250|UniProtKB:P00520,ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963,ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427,ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292,ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060,ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036,ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190,ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672,ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674,ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770,ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:28428613,ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171,ECO:0000269|PubMed:9461559}. Putative sodium-dependent amino acid/proton antiporter.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABL1chr9:133730483chr17:79246427ENST00000318560+31118_221831131Compositional biasNote=Poly-Ser
HgeneABL1chr9:133730483chr17:79246427ENST00000318560+31161_1211831131DomainSH3
HgeneABL1chr9:133730483chr17:79246427ENST00000318560+3111_601831131RegionNote=CAP
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000288439-714323_343304781TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000288439-714345_365304781TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000288439-714378_398304781TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000374759-716323_3433041120TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000374759-716345_3653041120TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000374759-716378_3983041120TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABL1chr9:133730483chr17:79246427ENST00000318560+311605_6091831131Compositional biasNote=Poly-Lys
HgeneABL1chr9:133730483chr17:79246427ENST00000318560+311782_10191831131Compositional biasNote=Pro-rich
HgeneABL1chr9:133730483chr17:79246427ENST00000318560+311897_9031831131Compositional biasNote=Poly-Pro
HgeneABL1chr9:133730483chr17:79246427ENST00000318560+311127_2171831131DomainSH2
HgeneABL1chr9:133730483chr17:79246427ENST00000318560+311242_4931831131DomainProtein kinase
HgeneABL1chr9:133730483chr17:79246427ENST00000318560+3111090_11001831131MotifNuclear export signal
HgeneABL1chr9:133730483chr17:79246427ENST00000318560+311381_4051831131MotifNote=Kinase activation loop
HgeneABL1chr9:133730483chr17:79246427ENST00000318560+311709_7151831131MotifNuclear localization signal 2
HgeneABL1chr9:133730483chr17:79246427ENST00000318560+311762_7691831131MotifNuclear localization signal 3
HgeneABL1chr9:133730483chr17:79246427ENST00000318560+311248_2561831131Nucleotide bindingNote=ATP
HgeneABL1chr9:133730483chr17:79246427ENST00000318560+311316_3221831131Nucleotide bindingNote=ATP
HgeneABL1chr9:133730483chr17:79246427ENST00000318560+311869_9681831131RegionDNA-binding
HgeneABL1chr9:133730483chr17:79246427ENST00000318560+311953_11301831131RegionNote=F-actin-binding
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000288439-714120_140304781TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000288439-714153_173304781TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000288439-714229_249304781TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000288439-714272_292304781TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000288439-71436_58304781TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000288439-7144_24304781TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000288439-71484_104304781TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000374759-716120_1403041120TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000374759-716153_1733041120TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000374759-716229_2493041120TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000374759-716272_2923041120TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000374759-71636_583041120TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000374759-7164_243041120TransmembraneHelical
TgeneSLC38A10chr9:133730483chr17:79246427ENST00000374759-71684_1043041120TransmembraneHelical


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FusionGeneSequence for ABL1_SLC38A10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ABL1_ENST00000318560_chr9_133730483_+_SLC38A10_ENST00000374759_chr17_79246427_-_999aa
MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRV
LGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS
DGKQKDGTFAAGGYMPPLRFKALTLSVVFGTMVGGILIPNVETILGLTGATMGSLICFICPALIYKKIHKNALSSQVVLWVGLGVLVVST
VTTLSVSEEVPEDLAEEAPGGRLGEAEGLMKVEAARLSAQDPVVAVAEDGREKPKLPKEREELEQAQIKGPVDVPGREDGKEAPEEAQLD
RPGQGIAVPVGEAHRHEPPVPHDKVVVDEGQDREVPEENKPPSRHAGGKAPGVQGQMAPPLPDSEREKQEPEQGEVGKRPGQAQALEEAG
DLPEDPQKVPEADGQPAVQPAKEDLGPGDRGLHPRPQAVLSEQQNGLAVGGGEKAKGGPPPGNAAGDTGQPAEDSDHGGKPPLPAEKPAP
GPGLPPEPREQRDVERAGGNQAASQLEEAGRAEMLDHAVLLQVIKEQQVQQKRLLDQQEKLLAVIEEQHKEIHQQRQEDEEDKPRQVEVH
QEPGAAVPRGQEAPEGKARETVENLPPLPLDPVLRAPGGRPAPSQDLNQRSLEHSEGPVGRDPAGPPDGGPDTEPRAAQAKLRDGQKDAA
PRAAGTVKELPKGPEQVPVPDPAREAGGPEERLAEEFPGQSQDVTGGSQDRKKPGKEVAATGTSILKEANWLVAGPGAETGDPRMKPKQV
SRDLGLAADLPGGAEGAAAQPQAVLRQPELRVISDGEQGGQQGHRLDHGGHLEMRKARGGDHVPVSHEQPRGGEDAAVQEPRQRPEPELG
LKRAVPGGQRPDNAKPNRDLKLQAGSDLRRRRRDLGPHAEGQLAPRDGVIIGLNPLPDVQVNDLRGALDAQLRQAAGGALQVVHSRQLRQ

>In-frame_ABL1_ENST00000318560_chr9_133730483_+_SLC38A10_ENST00000288439_chr17_79246427_-_660aa
MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRV
LGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS
DGKQKDGTFAAGGYMPPLRFKALTLSVVFGTMVGGILIPNVETILGLTGATMGSLICFICPALIYKKIHKNALSSQVVLWVGLGVLVVST
VTTLSVSEEVPEDLAEEAPGGRLGEAEGLMKVEAARLSAQDPVVAVAEDGREKPKLPKEREELEQAQIKGPVDVPGREDGKEAPEEAQLD
RPGQGIAVPVGEAHRHEPPVPHDKVVVDEGQDREVPEENKPPSRHAGGKAPGVQGQMAPPLPDSEREKQEPEQGEVGKRPGQAQALEEAG
DLPEDPQKVPEADGQPAVQPAKEDLGPGDRGLHPRPQAVLSEQQNGLAVGGGEKAKGGPPPGNAAGDTGQPAEDSDHGGKPPLPAEKPAP
GPGLPPEPREQRDVERAGGNQAASQLEGKASALQPPASGPGSGSPLPQPWGDAQVILGSPARPPFSFQPPAEQTPRRAFCSLPISSLLSG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ABL1_ENST00000318560_chr9_133730483_+_SLC38A10_ENST00000374759_chr17_79246427_-_2997nt
ATGTTGGAGATCTGCCTGAAGCTGGTGGGCTGCAAATCCAAGAAGGGGCTGTCCTCGTCCTCCAGCTGTTATCTGGAAGAAGCCCTTCAG
CGGCCAGTAGCATCTGACTTTGAGCCTCAGGGTCTGAGTGAAGCCGCTCGTTGGAACTCCAAGGAAAACCTTCTCGCTGGACCCAGTGAA
AATGACCCCAACCTTTTCGTTGCACTGTATGATTTTGTGGCCAGTGGAGATAACACTCTAAGCATAACTAAAGGTGAAAAGCTCCGGGTC
TTAGGCTATAATCACAATGGGGAATGGTGTGAAGCCCAAACCAAAAATGGCCAAGGCTGGGTCCCAAGCAACTACATCACGCCAGTCAAC
AGTCTGGAGAAACACTCCTGGTACCATGGGCCTGTGTCCCGCAATGCCGCTGAGTATCTGCTGAGCAGCGGGATCAATGGCAGCTTCTTG
GTGCGTGAGAGTGAGAGCAGTCCTGGCCAGAGGTCCATCTCGCTGAGATACGAAGGGAGGGTGTACCATTACAGGATCAACACTGCTTCT
GATGGCAAGCAAAAAGATGGCACCTTTGCAGCAGGGGGCTACATGCCCCCTCTCCGGTTTAAAGCACTTACCCTCTCTGTGGTGTTTGGA
ACCATGGTTGGTGGCATCCTTATCCCCAACGTGGAGACCATCCTGGGCCTCACAGGAGCGACCATGGGAAGCCTCATCTGCTTCATCTGC
CCGGCGCTGATCTACAAGAAAATCCACAAGAACGCACTTTCCTCCCAGGTGGTGCTGTGGGTCGGCCTGGGCGTCCTGGTGGTGAGCACT
GTCACCACACTGTCTGTGAGCGAGGAGGTCCCCGAGGACTTGGCAGAGGAAGCCCCTGGCGGCCGGCTTGGAGAGGCCGAGGGTTTGATG
AAGGTGGAGGCAGCGCGGCTCTCAGCCCAGGATCCGGTTGTGGCCGTGGCTGAGGATGGCCGGGAGAAGCCGAAGCTGCCGAAGGAGAGA
GAGGAGCTGGAGCAGGCCCAGATCAAGGGGCCCGTGGATGTGCCTGGACGGGAAGATGGCAAGGAGGCACCGGAGGAGGCACAGCTCGAT
CGCCCTGGGCAAGGGATTGCTGTGCCTGTGGGCGAGGCCCACCGCCACGAGCCTCCTGTTCCTCACGACAAGGTGGTGGTAGATGAAGGC
CAAGACCGAGAGGTGCCAGAAGAGAACAAACCTCCATCCAGACACGCGGGCGGAAAGGCTCCAGGGGTCCAGGGCCAGATGGCGCCGCCT
CTGCCCGACTCAGAAAGAGAGAAACAAGAGCCGGAGCAGGGAGAGGTTGGGAAGAGGCCTGGACAGGCCCAGGCCTTGGAGGAGGCGGGT
GATCTTCCTGAAGATCCCCAGAAAGTTCCAGAAGCAGATGGTCAGCCAGCTGTCCAGCCTGCAAAGGAGGACCTGGGGCCAGGAGACAGG
GGCCTGCATCCTCGGCCCCAGGCAGTGCTGTCTGAGCAGCAGAACGGCCTGGCGGTGGGTGGAGGGGAAAAGGCCAAGGGGGGACCGCCG
CCAGGCAACGCCGCCGGGGACACAGGGCAGCCCGCAGAGGACAGCGACCACGGTGGGAAGCCTCCCCTCCCAGCGGAGAAGCCGGCTCCA
GGGCCTGGGCTGCCGCCCGAGCCTCGCGAGCAGAGGGACGTGGAGCGAGCGGGTGGAAACCAGGCGGCCAGCCAGCTGGAGGAAGCTGGC
AGGGCGGAGATGCTGGACCACGCCGTCCTGCTTCAGGTGATCAAAGAACAGCAGGTGCAGCAAAAGCGCTTGCTGGACCAGCAGGAGAAG
CTGCTGGCGGTGATCGAGGAGCAGCACAAGGAGATCCACCAGCAGAGGCAGGAGGACGAGGAGGATAAACCCAGGCAGGTGGAGGTGCAT
CAAGAGCCCGGGGCAGCGGTGCCCAGAGGCCAGGAGGCCCCTGAAGGCAAGGCCAGGGAGACGGTGGAGAATCTGCCTCCCCTGCCTTTG
GACCCTGTCCTCAGAGCTCCTGGGGGCCGCCCTGCTCCATCCCAGGACCTTAACCAGCGCTCCCTGGAGCACTCTGAGGGGCCTGTGGGC
AGAGACCCTGCTGGCCCTCCTGACGGCGGCCCTGACACAGAGCCTCGGGCAGCCCAGGCCAAGCTGAGAGATGGCCAGAAGGATGCCGCC
CCCAGGGCAGCTGGCACTGTGAAGGAGCTCCCCAAGGGCCCGGAGCAGGTGCCCGTGCCAGACCCCGCCAGGGAAGCCGGGGGCCCAGAG
GAGCGCCTCGCAGAGGAATTCCCTGGGCAAAGTCAGGACGTTACTGGCGGTTCCCAAGACAGGAAAAAACCTGGGAAGGAGGTGGCAGCC
ACTGGCACCAGCATTCTGAAGGAAGCCAACTGGCTCGTGGCAGGGCCAGGAGCAGAGACGGGGGACCCTCGCATGAAGCCCAAGCAAGTG
AGCCGAGACCTGGGCCTTGCAGCGGACCTGCCCGGTGGGGCGGAAGGAGCAGCTGCACAGCCCCAGGCTGTGTTACGCCAGCCGGAACTG
CGGGTCATCTCTGATGGCGAGCAGGGTGGACAGCAGGGCCACCGGCTGGACCATGGCGGTCACCTGGAGATGAGAAAGGCCCGCGGGGGG
GACCATGTGCCTGTGTCCCACGAGCAGCCGAGAGGCGGGGAGGACGCTGCTGTCCAGGAGCCCAGGCAGAGGCCAGAGCCAGAGCTGGGG
CTCAAACGAGCTGTCCCGGGGGGCCAGAGGCCGGACAATGCCAAGCCCAACCGGGACCTGAAACTGCAGGCTGGCTCCGACCTCCGGAGG
CGACGGCGGGACCTTGGCCCTCATGCAGAGGGTCAGCTGGCCCCGAGGGATGGGGTCATCATTGGCCTTAACCCCCTGCCTGATGTCCAG
GTGAACGACCTCCGTGGCGCCCTGGATGCCCAGCTCCGCCAGGCTGCGGGGGGAGCTCTGCAGGTGGTCCACAGCCGGCAGCTTAGACAG

>In-frame_ABL1_ENST00000318560_chr9_133730483_+_SLC38A10_ENST00000288439_chr17_79246427_-_1980nt
ATGTTGGAGATCTGCCTGAAGCTGGTGGGCTGCAAATCCAAGAAGGGGCTGTCCTCGTCCTCCAGCTGTTATCTGGAAGAAGCCCTTCAG
CGGCCAGTAGCATCTGACTTTGAGCCTCAGGGTCTGAGTGAAGCCGCTCGTTGGAACTCCAAGGAAAACCTTCTCGCTGGACCCAGTGAA
AATGACCCCAACCTTTTCGTTGCACTGTATGATTTTGTGGCCAGTGGAGATAACACTCTAAGCATAACTAAAGGTGAAAAGCTCCGGGTC
TTAGGCTATAATCACAATGGGGAATGGTGTGAAGCCCAAACCAAAAATGGCCAAGGCTGGGTCCCAAGCAACTACATCACGCCAGTCAAC
AGTCTGGAGAAACACTCCTGGTACCATGGGCCTGTGTCCCGCAATGCCGCTGAGTATCTGCTGAGCAGCGGGATCAATGGCAGCTTCTTG
GTGCGTGAGAGTGAGAGCAGTCCTGGCCAGAGGTCCATCTCGCTGAGATACGAAGGGAGGGTGTACCATTACAGGATCAACACTGCTTCT
GATGGCAAGCAAAAAGATGGCACCTTTGCAGCAGGGGGCTACATGCCCCCTCTCCGGTTTAAAGCACTTACCCTCTCTGTGGTGTTTGGA
ACCATGGTTGGTGGCATCCTTATCCCCAACGTGGAGACCATCCTGGGCCTCACAGGAGCGACCATGGGAAGCCTCATCTGCTTCATCTGC
CCGGCGCTGATCTACAAGAAAATCCACAAGAACGCACTTTCCTCCCAGGTGGTGCTGTGGGTCGGCCTGGGCGTCCTGGTGGTGAGCACT
GTCACCACACTGTCTGTGAGCGAGGAGGTCCCCGAGGACTTGGCAGAGGAAGCCCCTGGCGGCCGGCTTGGAGAGGCCGAGGGTTTGATG
AAGGTGGAGGCAGCGCGGCTCTCAGCCCAGGATCCGGTTGTGGCCGTGGCTGAGGATGGCCGGGAGAAGCCGAAGCTGCCGAAGGAGAGA
GAGGAGCTGGAGCAGGCCCAGATCAAGGGGCCCGTGGATGTGCCTGGACGGGAAGATGGCAAGGAGGCACCGGAGGAGGCACAGCTCGAT
CGCCCTGGGCAAGGGATTGCTGTGCCTGTGGGCGAGGCCCACCGCCACGAGCCTCCTGTTCCTCACGACAAGGTGGTGGTAGATGAAGGC
CAAGACCGAGAGGTGCCAGAAGAGAACAAACCTCCATCCAGACACGCGGGCGGAAAGGCTCCAGGGGTCCAGGGCCAGATGGCGCCGCCT
CTGCCCGACTCAGAAAGAGAGAAACAAGAGCCGGAGCAGGGAGAGGTTGGGAAGAGGCCTGGACAGGCCCAGGCCTTGGAGGAGGCGGGT
GATCTTCCTGAAGATCCCCAGAAAGTTCCAGAAGCAGATGGTCAGCCAGCTGTCCAGCCTGCAAAGGAGGACCTGGGGCCAGGAGACAGG
GGCCTGCATCCTCGGCCCCAGGCAGTGCTGTCTGAGCAGCAGAACGGCCTGGCGGTGGGTGGAGGGGAAAAGGCCAAGGGGGGACCGCCG
CCAGGCAACGCCGCCGGGGACACAGGGCAGCCCGCAGAGGACAGCGACCACGGTGGGAAGCCTCCCCTCCCAGCGGAGAAGCCGGCTCCA
GGGCCTGGGCTGCCGCCCGAGCCTCGCGAGCAGAGGGACGTGGAGCGAGCGGGTGGAAACCAGGCGGCCAGCCAGCTGGAGGGTAAGGCC
TCCGCCCTACAGCCGCCTGCCTCAGGCCCAGGGAGCGGCAGCCCCCTCCCCCAGCCCTGGGGTGATGCCCAGGTCATCCTCGGGAGCCCT
GCCAGGCCCCCCTTCTCTTTCCAGCCGCCTGCTGAGCAGACCCCTCGGAGAGCTTTCTGCTCCCTTCCCATCAGCAGCTTGCTTTCTGGG
AACCTTTTATCTGCCTTACTCCCCTTTAAACACCTGCGGCATCGTCACATGGCTTGTGATTACCGTTTTATCTCCCTTGCTCCCCTTTAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ABL1_ENST00000318560_chr9_133730483_+_SLC38A10_ENST00000374759_chr17_79246427_-_3934nt
GGCCTTCCCCCTGCGAGGATCGCCATTGGCCCGGGTTGGCTTTGGAAAGCGGCGGTGGCTTTGGGCCGGGCTCGGCCTCGGGAACGCCAG
GGGCCCCTGGGTGCGGACGGGCGCGGCCAGGAGGGGGTTAAGGCGCAGGCGGCGGCGGGGCGGGGGCGGGCCTGGCGGGCGCCCTCTCCG
GGCCCTTTGTTAACAGGCGCGTCCCGGCCAGGCGGAGACGCGGCCGCGGCCATGGGCGGGCGCGGGCGCGCGGGGCGGCGGTGAGGGCGG
CTGGCGGGGCCGGGGGCGCCGGGGGGGCGCGCGGGCCGAGCCGGGCCTGAGCCGGGCCCGCGGACCGAGCTGGGAGAGGGGTTCCGGCCC
CCGACGTGCTGGCGCGGGAAAATGTTGGAGATCTGCCTGAAGCTGGTGGGCTGCAAATCCAAGAAGGGGCTGTCCTCGTCCTCCAGCTGT
TATCTGGAAGAAGCCCTTCAGCGGCCAGTAGCATCTGACTTTGAGCCTCAGGGTCTGAGTGAAGCCGCTCGTTGGAACTCCAAGGAAAAC
CTTCTCGCTGGACCCAGTGAAAATGACCCCAACCTTTTCGTTGCACTGTATGATTTTGTGGCCAGTGGAGATAACACTCTAAGCATAACT
AAAGGTGAAAAGCTCCGGGTCTTAGGCTATAATCACAATGGGGAATGGTGTGAAGCCCAAACCAAAAATGGCCAAGGCTGGGTCCCAAGC
AACTACATCACGCCAGTCAACAGTCTGGAGAAACACTCCTGGTACCATGGGCCTGTGTCCCGCAATGCCGCTGAGTATCTGCTGAGCAGC
GGGATCAATGGCAGCTTCTTGGTGCGTGAGAGTGAGAGCAGTCCTGGCCAGAGGTCCATCTCGCTGAGATACGAAGGGAGGGTGTACCAT
TACAGGATCAACACTGCTTCTGATGGCAAGCAAAAAGATGGCACCTTTGCAGCAGGGGGCTACATGCCCCCTCTCCGGTTTAAAGCACTT
ACCCTCTCTGTGGTGTTTGGAACCATGGTTGGTGGCATCCTTATCCCCAACGTGGAGACCATCCTGGGCCTCACAGGAGCGACCATGGGA
AGCCTCATCTGCTTCATCTGCCCGGCGCTGATCTACAAGAAAATCCACAAGAACGCACTTTCCTCCCAGGTGGTGCTGTGGGTCGGCCTG
GGCGTCCTGGTGGTGAGCACTGTCACCACACTGTCTGTGAGCGAGGAGGTCCCCGAGGACTTGGCAGAGGAAGCCCCTGGCGGCCGGCTT
GGAGAGGCCGAGGGTTTGATGAAGGTGGAGGCAGCGCGGCTCTCAGCCCAGGATCCGGTTGTGGCCGTGGCTGAGGATGGCCGGGAGAAG
CCGAAGCTGCCGAAGGAGAGAGAGGAGCTGGAGCAGGCCCAGATCAAGGGGCCCGTGGATGTGCCTGGACGGGAAGATGGCAAGGAGGCA
CCGGAGGAGGCACAGCTCGATCGCCCTGGGCAAGGGATTGCTGTGCCTGTGGGCGAGGCCCACCGCCACGAGCCTCCTGTTCCTCACGAC
AAGGTGGTGGTAGATGAAGGCCAAGACCGAGAGGTGCCAGAAGAGAACAAACCTCCATCCAGACACGCGGGCGGAAAGGCTCCAGGGGTC
CAGGGCCAGATGGCGCCGCCTCTGCCCGACTCAGAAAGAGAGAAACAAGAGCCGGAGCAGGGAGAGGTTGGGAAGAGGCCTGGACAGGCC
CAGGCCTTGGAGGAGGCGGGTGATCTTCCTGAAGATCCCCAGAAAGTTCCAGAAGCAGATGGTCAGCCAGCTGTCCAGCCTGCAAAGGAG
GACCTGGGGCCAGGAGACAGGGGCCTGCATCCTCGGCCCCAGGCAGTGCTGTCTGAGCAGCAGAACGGCCTGGCGGTGGGTGGAGGGGAA
AAGGCCAAGGGGGGACCGCCGCCAGGCAACGCCGCCGGGGACACAGGGCAGCCCGCAGAGGACAGCGACCACGGTGGGAAGCCTCCCCTC
CCAGCGGAGAAGCCGGCTCCAGGGCCTGGGCTGCCGCCCGAGCCTCGCGAGCAGAGGGACGTGGAGCGAGCGGGTGGAAACCAGGCGGCC
AGCCAGCTGGAGGAAGCTGGCAGGGCGGAGATGCTGGACCACGCCGTCCTGCTTCAGGTGATCAAAGAACAGCAGGTGCAGCAAAAGCGC
TTGCTGGACCAGCAGGAGAAGCTGCTGGCGGTGATCGAGGAGCAGCACAAGGAGATCCACCAGCAGAGGCAGGAGGACGAGGAGGATAAA
CCCAGGCAGGTGGAGGTGCATCAAGAGCCCGGGGCAGCGGTGCCCAGAGGCCAGGAGGCCCCTGAAGGCAAGGCCAGGGAGACGGTGGAG
AATCTGCCTCCCCTGCCTTTGGACCCTGTCCTCAGAGCTCCTGGGGGCCGCCCTGCTCCATCCCAGGACCTTAACCAGCGCTCCCTGGAG
CACTCTGAGGGGCCTGTGGGCAGAGACCCTGCTGGCCCTCCTGACGGCGGCCCTGACACAGAGCCTCGGGCAGCCCAGGCCAAGCTGAGA
GATGGCCAGAAGGATGCCGCCCCCAGGGCAGCTGGCACTGTGAAGGAGCTCCCCAAGGGCCCGGAGCAGGTGCCCGTGCCAGACCCCGCC
AGGGAAGCCGGGGGCCCAGAGGAGCGCCTCGCAGAGGAATTCCCTGGGCAAAGTCAGGACGTTACTGGCGGTTCCCAAGACAGGAAAAAA
CCTGGGAAGGAGGTGGCAGCCACTGGCACCAGCATTCTGAAGGAAGCCAACTGGCTCGTGGCAGGGCCAGGAGCAGAGACGGGGGACCCT
CGCATGAAGCCCAAGCAAGTGAGCCGAGACCTGGGCCTTGCAGCGGACCTGCCCGGTGGGGCGGAAGGAGCAGCTGCACAGCCCCAGGCT
GTGTTACGCCAGCCGGAACTGCGGGTCATCTCTGATGGCGAGCAGGGTGGACAGCAGGGCCACCGGCTGGACCATGGCGGTCACCTGGAG
ATGAGAAAGGCCCGCGGGGGGGACCATGTGCCTGTGTCCCACGAGCAGCCGAGAGGCGGGGAGGACGCTGCTGTCCAGGAGCCCAGGCAG
AGGCCAGAGCCAGAGCTGGGGCTCAAACGAGCTGTCCCGGGGGGCCAGAGGCCGGACAATGCCAAGCCCAACCGGGACCTGAAACTGCAG
GCTGGCTCCGACCTCCGGAGGCGACGGCGGGACCTTGGCCCTCATGCAGAGGGTCAGCTGGCCCCGAGGGATGGGGTCATCATTGGCCTT
AACCCCCTGCCTGATGTCCAGGTGAACGACCTCCGTGGCGCCCTGGATGCCCAGCTCCGCCAGGCTGCGGGGGGAGCTCTGCAGGTGGTC
CACAGCCGGCAGCTTAGACAGGCGCCTGGGCCTCCAGAGGAGTCCTAGCACCTGCTGGCCATGAGGGCCACGCCAGCCACTGCCCTCCTC
GGCCAGCAGCAGGTCTGTCTCAGCCGCATCCCAGCCAAACTCTGGAGGTCACACTCGCCTCTCCCCAGGGTTTCATGTCTGAGGCCCTCA
CCAAGTGTGAGTGACAGTATAAAAGATTCACTGTGGCATCGTTTCCAGAATGTTCTTGCTGTCGTTCTGTTGCAGCTCTTAGTCTGAGGT
CCTCTGACCTCTAGACTCTGAGCTCACTCCAGCCTGTGAGGAGAAACGGCCTCCGCTGCGAGCTGGCTGGTGCACTCCCAGGCTCAGGCT
GGGGAGCTGCTGCGTCTGTGGTCAGGCCTCCTGCTCCTGCCAGGGAGCACGCGTGGTCTTCGGGTTGAGCTCGGCCGTGCGTGGAGGTGC
GCATGGCTGCTCATGGTCCCAACACAGGCTACTGTGAGAGCCAGCATCCAACCCCACGCTTGCAGTGACTCAGAATGATAATTATTATGA

>In-frame_ABL1_ENST00000318560_chr9_133730483_+_SLC38A10_ENST00000288439_chr17_79246427_-_2380nt
GGCCTTCCCCCTGCGAGGATCGCCATTGGCCCGGGTTGGCTTTGGAAAGCGGCGGTGGCTTTGGGCCGGGCTCGGCCTCGGGAACGCCAG
GGGCCCCTGGGTGCGGACGGGCGCGGCCAGGAGGGGGTTAAGGCGCAGGCGGCGGCGGGGCGGGGGCGGGCCTGGCGGGCGCCCTCTCCG
GGCCCTTTGTTAACAGGCGCGTCCCGGCCAGGCGGAGACGCGGCCGCGGCCATGGGCGGGCGCGGGCGCGCGGGGCGGCGGTGAGGGCGG
CTGGCGGGGCCGGGGGCGCCGGGGGGGCGCGCGGGCCGAGCCGGGCCTGAGCCGGGCCCGCGGACCGAGCTGGGAGAGGGGTTCCGGCCC
CCGACGTGCTGGCGCGGGAAAATGTTGGAGATCTGCCTGAAGCTGGTGGGCTGCAAATCCAAGAAGGGGCTGTCCTCGTCCTCCAGCTGT
TATCTGGAAGAAGCCCTTCAGCGGCCAGTAGCATCTGACTTTGAGCCTCAGGGTCTGAGTGAAGCCGCTCGTTGGAACTCCAAGGAAAAC
CTTCTCGCTGGACCCAGTGAAAATGACCCCAACCTTTTCGTTGCACTGTATGATTTTGTGGCCAGTGGAGATAACACTCTAAGCATAACT
AAAGGTGAAAAGCTCCGGGTCTTAGGCTATAATCACAATGGGGAATGGTGTGAAGCCCAAACCAAAAATGGCCAAGGCTGGGTCCCAAGC
AACTACATCACGCCAGTCAACAGTCTGGAGAAACACTCCTGGTACCATGGGCCTGTGTCCCGCAATGCCGCTGAGTATCTGCTGAGCAGC
GGGATCAATGGCAGCTTCTTGGTGCGTGAGAGTGAGAGCAGTCCTGGCCAGAGGTCCATCTCGCTGAGATACGAAGGGAGGGTGTACCAT
TACAGGATCAACACTGCTTCTGATGGCAAGCAAAAAGATGGCACCTTTGCAGCAGGGGGCTACATGCCCCCTCTCCGGTTTAAAGCACTT
ACCCTCTCTGTGGTGTTTGGAACCATGGTTGGTGGCATCCTTATCCCCAACGTGGAGACCATCCTGGGCCTCACAGGAGCGACCATGGGA
AGCCTCATCTGCTTCATCTGCCCGGCGCTGATCTACAAGAAAATCCACAAGAACGCACTTTCCTCCCAGGTGGTGCTGTGGGTCGGCCTG
GGCGTCCTGGTGGTGAGCACTGTCACCACACTGTCTGTGAGCGAGGAGGTCCCCGAGGACTTGGCAGAGGAAGCCCCTGGCGGCCGGCTT
GGAGAGGCCGAGGGTTTGATGAAGGTGGAGGCAGCGCGGCTCTCAGCCCAGGATCCGGTTGTGGCCGTGGCTGAGGATGGCCGGGAGAAG
CCGAAGCTGCCGAAGGAGAGAGAGGAGCTGGAGCAGGCCCAGATCAAGGGGCCCGTGGATGTGCCTGGACGGGAAGATGGCAAGGAGGCA
CCGGAGGAGGCACAGCTCGATCGCCCTGGGCAAGGGATTGCTGTGCCTGTGGGCGAGGCCCACCGCCACGAGCCTCCTGTTCCTCACGAC
AAGGTGGTGGTAGATGAAGGCCAAGACCGAGAGGTGCCAGAAGAGAACAAACCTCCATCCAGACACGCGGGCGGAAAGGCTCCAGGGGTC
CAGGGCCAGATGGCGCCGCCTCTGCCCGACTCAGAAAGAGAGAAACAAGAGCCGGAGCAGGGAGAGGTTGGGAAGAGGCCTGGACAGGCC
CAGGCCTTGGAGGAGGCGGGTGATCTTCCTGAAGATCCCCAGAAAGTTCCAGAAGCAGATGGTCAGCCAGCTGTCCAGCCTGCAAAGGAG
GACCTGGGGCCAGGAGACAGGGGCCTGCATCCTCGGCCCCAGGCAGTGCTGTCTGAGCAGCAGAACGGCCTGGCGGTGGGTGGAGGGGAA
AAGGCCAAGGGGGGACCGCCGCCAGGCAACGCCGCCGGGGACACAGGGCAGCCCGCAGAGGACAGCGACCACGGTGGGAAGCCTCCCCTC
CCAGCGGAGAAGCCGGCTCCAGGGCCTGGGCTGCCGCCCGAGCCTCGCGAGCAGAGGGACGTGGAGCGAGCGGGTGGAAACCAGGCGGCC
AGCCAGCTGGAGGGTAAGGCCTCCGCCCTACAGCCGCCTGCCTCAGGCCCAGGGAGCGGCAGCCCCCTCCCCCAGCCCTGGGGTGATGCC
CAGGTCATCCTCGGGAGCCCTGCCAGGCCCCCCTTCTCTTTCCAGCCGCCTGCTGAGCAGACCCCTCGGAGAGCTTTCTGCTCCCTTCCC
ATCAGCAGCTTGCTTTCTGGGAACCTTTTATCTGCCTTACTCCCCTTTAAACACCTGCGGCATCGTCACATGGCTTGTGATTACCGTTTT


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FusionGenePPI for ABL1_SLC38A10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ABL1ATM, NTRK1, PTPN6, RB1, BRCA1, BCR, ABL1, PIK3R1, RAD51, ABI2, BCAR1, ATR, ABL2, CRKL, CREB1, JAK1, YTHDC1, GPX1, CAT, ABI1, TP53, SHC1, INPPL1, SOS1, SLC9A2, PRKDC, TP73, DOK1, ST5, ZAP70, RFX1, RAD9A, TERF1, HCK, GRB2, VAV1, MDM2, MTOR, ZDHHC16, SPTA1, SPTAN1, ARHGAP17, EVL, PSTPIP1, NEDD9, CABLES2, SORBS2, SH3BP1, CBL, TUB, GRB10, RYBP, PAK2, PAG1, RAN, NCK1, PLCG1, MICAL1, XRCC6, SORBS1, SHD, SHE, EPHB2, EPHA3, SRC, NCOA3, TOPBP1, HSP90AA1, HSPA4, NFKBIA, PARK2, STK4, NEDD4, BAG1, HSPA8, NEDD4L, PCNA, ANKRA2, YWHAQ, PSMA7, PSMA4, PSMD4, SH3KBP1, FGFR1OP, WRNIP1, JUN, GAB3, HUWE1, MDM4, DDB1, LRRK1, PIK3R2, AP2M1, UBASH3B, EPS15, CRK, AP2B1, BMP2K, REPS1, STON2, CBLB, AP2A1, WASF1, MAPT, PFDN4, PDE4D, PRDX1, EGFR, ERBB2, ERBB3, ERBB4, SOCS3, SOCS1, MUC1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAZ, SFN, XPO1, RASA1, DOK2, CDKN1B, PTGES3, HSPD1, UBC, CTNNB1, SRPK2, PARP1, USP7, LATS2, SPRR2A, CASP9, YAP1, FOS, CDK1, GTF2F1, CCND2, ACTA1, STUB1, CDON, MBP, SPAG9, MSH5, MAVS, RAPGEF1, PRKCZ, BCL2L1, CKAP4, DDX5, DRG1, EEF1G, EIF2A, EWSR1, FUS, HNRNPM, HSPE1, ILF3, LRRC59, RPL37, RPLP1, RPS21, SUB1, SHB, RTFDC1, LARS, NAA25, NARS, PAK4, PPM1B, GRAP2, HIPK2, CDKN1A, RPS6KB1, RIN1, EMD, TMPO, TRIM25, ANAPC15, DVL2, PLEKHA4SLC38A10HLA-DPA1, CD1B, NRG1, ERGIC3, NAAA, HTR3C, KIF5B, NCAPH, TOR1AIP2, EDEM2, SYP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ABL1_SLC38A10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneABL1P00519DB00619ImatinibTyrosine-protein kinase ABL1small moleculeapproved
HgeneABL1P00519DB06616BosutinibTyrosine-protein kinase ABL1small moleculeapproved
HgeneABL1P00519DB08896RegorafenibTyrosine-protein kinase ABL1small moleculeapproved
HgeneABL1P00519DB01254DasatinibTyrosine-protein kinase ABL1small moleculeapproved|investigational
HgeneABL1P00519DB04868NilotinibTyrosine-protein kinase ABL1small moleculeapproved|investigational
HgeneABL1P00519DB08901PonatinibTyrosine-protein kinase ABL1small moleculeapproved|investigational

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RelatedDiseases for ABL1_SLC38A10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABL1C0023473Myeloid Leukemia, Chronic3CTD_human;ORPHANET
HgeneABL1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human
HgeneABL1C0001418Adenocarcinoma1CTD_human
HgeneABL1C0014859Esophageal Neoplasms1CTD_human
HgeneABL1C0023903Liver neoplasms1CTD_human
HgeneABL1C0027659Neoplasms, Experimental1CTD_human
HgeneABL1C0032927Precancerous Conditions1CTD_human
HgeneABL1C0596263Carcinogenesis1CTD_human
HgeneABL1C1458155Mammary Neoplasms1CTD_human