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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26078

FusionGeneSummary for PAX5_TMEM9B

check button Fusion gene summary
Fusion gene informationFusion gene name: PAX5_TMEM9B
Fusion gene ID: 26078
HgeneTgene
Gene symbol

PAX5

TMEM9B

Gene ID

5079

56674

Gene namepaired box 5TMEM9 domain family member B
SynonymsALL3|BSAPC11orf15
Cytomap

9p13.2

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionpaired box protein Pax-5B-cell lineage specific activatorpaired box homeotic gene 5paired domain gene 5transcription factor PAX 5transmembrane protein 9B
Modification date2018052020180522
UniProtAcc

Q02548

Q9NQ34

Ensembl transtripts involved in fusion geneENST00000358127, ENST00000523241, 
ENST00000520154, ENST00000377852, 
ENST00000377853, ENST00000522003, 
ENST00000520281, ENST00000414447, 
ENST00000523145, ENST00000446742, 
ENST00000377847, 
ENST00000309134, 
ENST00000534025, ENST00000525069, 
ENST00000528117, 
Fusion gene scores* DoF score7 X 8 X 2=1123 X 3 X 3=27
# samples 83
** MAII scorelog2(8/112*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PAX5 [Title/Abstract] AND TMEM9B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A15S-01APAX5chr9

37033983

-TMEM9Bchr11

8977845

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000358127ENST00000309134PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000358127ENST00000534025PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000358127ENST00000525069PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000358127ENST00000528117PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000523241ENST00000309134PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000523241ENST00000534025PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000523241ENST00000525069PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000523241ENST00000528117PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000520154ENST00000309134PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000520154ENST00000534025PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000520154ENST00000525069PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000520154ENST00000528117PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000377852ENST00000309134PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000377852ENST00000534025PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000377852ENST00000525069PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000377852ENST00000528117PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000377853ENST00000309134PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000377853ENST00000534025PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000377853ENST00000525069PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000377853ENST00000528117PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5UTR-5UTRENST00000522003ENST00000309134PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5UTR-5UTRENST00000522003ENST00000534025PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5UTR-5UTRENST00000522003ENST00000525069PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5UTR-5UTRENST00000522003ENST00000528117PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000520281ENST00000309134PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000520281ENST00000534025PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000520281ENST00000525069PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000520281ENST00000528117PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000414447ENST00000309134PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000414447ENST00000534025PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000414447ENST00000525069PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000414447ENST00000528117PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5UTR-5UTRENST00000523145ENST00000309134PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5UTR-5UTRENST00000523145ENST00000534025PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5UTR-5UTRENST00000523145ENST00000525069PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5UTR-5UTRENST00000523145ENST00000528117PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000446742ENST00000309134PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000446742ENST00000534025PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000446742ENST00000525069PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000446742ENST00000528117PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000377847ENST00000309134PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000377847ENST00000534025PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000377847ENST00000525069PAX5chr9

37033983

-TMEM9Bchr11

8977845

-
5CDS-5UTRENST00000377847ENST00000528117PAX5chr9

37033983

-TMEM9Bchr11

8977845

-

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FusionProtFeatures for PAX5_TMEM9B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAX5

Q02548

TMEM9B

Q9NQ34

Enhances production of proinflammatory cytokines inducedby TNF, IL1B, and TLR ligands. Has a role in TNF activation ofboth the NF-kappaB and MAPK pathways.{ECO:0000269|PubMed:18541524}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PAX5_TMEM9B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PAX5_TMEM9B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PAX5TLE4, DAXX, RUNX1, MYB, ID3, EP300, TBP, RB1, MAPK1TMEM9BELAVL1, CLCN3, CLCN5, DNAJC13, TRDN, BIRC2, ABCB9, DNM3, GGA1, DCAKD, PDZD8, FLVCR1, ABCA3, C1orf43, DNM1, VANGL2, MYADM, FAM189B, DNM2, RIF1, ARFGEF2, JPH1, CLEC2D, TRAF2, YIF1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PAX5_TMEM9B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PAX5_TMEM9B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePAX5C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human;UNIPROT
HgenePAX5C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human