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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26077

FusionGeneSummary for PAX5_PAX5

check button Fusion gene summary
Fusion gene informationFusion gene name: PAX5_PAX5
Fusion gene ID: 26077
HgeneTgene
Gene symbol

PAX5

PAX5

Gene ID

5079

5079

Gene namepaired box 5paired box 5
SynonymsALL3|BSAPALL3|BSAP
Cytomap

9p13.2

9p13.2

Type of geneprotein-codingprotein-coding
Descriptionpaired box protein Pax-5B-cell lineage specific activatorpaired box homeotic gene 5paired domain gene 5transcription factor PAX 5paired box protein Pax-5B-cell lineage specific activatorpaired box homeotic gene 5paired domain gene 5transcription factor PAX 5
Modification date2018052020180520
UniProtAcc

Q02548

Q02548

Ensembl transtripts involved in fusion geneENST00000358127, ENST00000523241, 
ENST00000520154, ENST00000377852, 
ENST00000377853, ENST00000522003, 
ENST00000520281, ENST00000414447, 
ENST00000523145, ENST00000446742, 
ENST00000377847, 
ENST00000358127, 
ENST00000523241, ENST00000520154, 
ENST00000377852, ENST00000377853, 
ENST00000522003, ENST00000520281, 
ENST00000414447, ENST00000523145, 
ENST00000446742, ENST00000377847, 
Fusion gene scores* DoF score7 X 8 X 2=1127 X 5 X 5=175
# samples 87
** MAII scorelog2(8/112*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAX5 [Title/Abstract] AND PAX5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW297549PAX5chr9

36901973

-PAX5chr9

36897675

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000358127ENST00000358127PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000358127ENST00000523241PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000358127ENST00000520154PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000358127ENST00000377852PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000358127ENST00000377853PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000358127ENST00000522003PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000358127ENST00000520281PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000358127ENST00000414447PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000358127ENST00000523145PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000358127ENST00000446742PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000358127ENST00000377847PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523241ENST00000358127PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523241ENST00000523241PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523241ENST00000520154PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523241ENST00000377852PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523241ENST00000377853PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523241ENST00000522003PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523241ENST00000520281PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523241ENST00000414447PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523241ENST00000523145PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523241ENST00000446742PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523241ENST00000377847PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520154ENST00000358127PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520154ENST00000523241PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520154ENST00000520154PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520154ENST00000377852PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520154ENST00000377853PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520154ENST00000522003PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520154ENST00000520281PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520154ENST00000414447PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520154ENST00000523145PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520154ENST00000446742PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520154ENST00000377847PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377852ENST00000358127PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377852ENST00000523241PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377852ENST00000520154PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377852ENST00000377852PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377852ENST00000377853PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377852ENST00000522003PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377852ENST00000520281PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377852ENST00000414447PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377852ENST00000523145PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377852ENST00000446742PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377852ENST00000377847PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377853ENST00000358127PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377853ENST00000523241PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377853ENST00000520154PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377853ENST00000377852PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377853ENST00000377853PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377853ENST00000522003PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377853ENST00000520281PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377853ENST00000414447PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377853ENST00000523145PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377853ENST00000446742PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377853ENST00000377847PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000522003ENST00000358127PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000522003ENST00000523241PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000522003ENST00000520154PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000522003ENST00000377852PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000522003ENST00000377853PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000522003ENST00000522003PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000522003ENST00000520281PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000522003ENST00000414447PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000522003ENST00000523145PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000522003ENST00000446742PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000522003ENST00000377847PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520281ENST00000358127PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520281ENST00000523241PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520281ENST00000520154PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520281ENST00000377852PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520281ENST00000377853PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520281ENST00000522003PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520281ENST00000520281PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520281ENST00000414447PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520281ENST00000523145PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520281ENST00000446742PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000520281ENST00000377847PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000414447ENST00000358127PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000414447ENST00000523241PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000414447ENST00000520154PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000414447ENST00000377852PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000414447ENST00000377853PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000414447ENST00000522003PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000414447ENST00000520281PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000414447ENST00000414447PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000414447ENST00000523145PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000414447ENST00000446742PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000414447ENST00000377847PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523145ENST00000358127PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523145ENST00000523241PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523145ENST00000520154PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523145ENST00000377852PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523145ENST00000377853PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523145ENST00000522003PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523145ENST00000520281PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523145ENST00000414447PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523145ENST00000523145PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523145ENST00000446742PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000523145ENST00000377847PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000446742ENST00000358127PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000446742ENST00000523241PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000446742ENST00000520154PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000446742ENST00000377852PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000446742ENST00000377853PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000446742ENST00000522003PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000446742ENST00000520281PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000446742ENST00000414447PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000446742ENST00000523145PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000446742ENST00000446742PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000446742ENST00000377847PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377847ENST00000358127PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377847ENST00000523241PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377847ENST00000520154PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377847ENST00000377852PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377847ENST00000377853PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377847ENST00000522003PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377847ENST00000520281PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377847ENST00000414447PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377847ENST00000523145PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377847ENST00000446742PAX5chr9

36901973

-PAX5chr9

36897675

+
intron-intronENST00000377847ENST00000377847PAX5chr9

36901973

-PAX5chr9

36897675

+

Top

FusionProtFeatures for PAX5_PAX5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAX5

Q02548

PAX5

Q02548


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PAX5_PAX5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PAX5_PAX5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PAX5_PAX5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PAX5_PAX5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePAX5C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human;UNIPROT
HgenePAX5C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgenePAX5C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human;UNIPROT
TgenePAX5C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human